Consumers demand quality milk with a reasonable shelf-life, a requirement that can be met more successfully by the milk industry through use of improved processes and technologies. Guaranteeing the production of safe milk also remains of paramount importance. Improving the safety and quality of milk provides a comprehensive and timely reference to best practice and research advances in these areas. Volume 1 focuses on milk production and processing. Volume 2 covers the sensory and nutritional quality of cow's milk and addresses quality improvement of a range of other milk-based products. The health aspects of milk, its role in the diet and milk-based functional foods are the focus of the opening section of Volume 2. Part two reviews essential aspects of milk quality, including milk microbial spoilage and chemical deterioration, sensory evaluation, factors affecting milk vitamin and mineral content and the impact of packaging on quality. Chapters in part three look at improving particular products, such as organic milk, goat milk and sheep milk. The impact of milk on the quality of yoghurt and cheese is also covered. With its distinguished editor and international team of contributors, volume 2 of Improving the safety and quality of milk is an essential reference for researchers and those in industry responsible for milk safety and quality.

Food safety is vital for consumer confidence, and the hygienic design of food processing facilities is central to the manufacture of safe products. Hygienic design of food factories provides an authoritative overview of hygiene control in the design, construction and renovation of food factories. The business case for a new or refurbished food factory, its equipment needs and the impacts on factory design and construction are considered in two introductory chapters. Part one then reviews the implications of hygiene and construction regulation in various countries on food factory design. Retailer requirements are also discussed. Part two describes site selection, factory layout and the associated issue of airflow. Parts three, four and five then address the hygienic design of essential parts of a food factory. These include walls, ceilings, floors, selected utility and process support systems, entry and exit points, storage areas and changing rooms. Lastly part six covers the management of building work and factory inspection when commissioning the plant. With its distinguished editors and international team of contributors, Hygienic design of food factories is an essential reference for managers of food factories, food plant engineers and all those with an academic research interest in the field.

Eggs are economical and of high nutritional value, yet can also be a source of foodborne disease. Understanding of the factors influencing egg quality has increased in recent years and new technologies to assure egg safety have been developed. Improving the safety and quality of eggs and egg products reviews recent research in these areas Volume 2 focuses on egg safety and nutritional quality. Part one provides an overview of egg contaminants, covering both microbial pathogens and chemical residues. Salmonella control in laying hens is the focus of part two. Chapters cover essential topics such as monitoring and control procedures in laying flocks and egg decontamination methods. Finally, part three looks at the role of eggs in nutrition and other health applications. Chapters cover dietary cholesterol, egg allergy, egg enrichment and bioactive fractions of eggs, among other topics. With its distinguished editors and international team of contributors, Volume 2 of Improving the safety and quality of eggs and egg products is an essential reference for managers in the egg industry, professionals in the food industry using eggs as ingredients and all those with a research interest in the subject.

Clinical and preclinical exploration of gene and cellular immunotherapy have seen rapid growth and interest with the development and approval of five Chimeric Antigen Receptor T-cell (CAR-T) products for lymphoma and myeloma and one Bispecific T-Cell Engager (BiTE) for acute lymphoblastic leukemia (ALL). These advances have dramatically improved the management of patients with relapsed refractory lymphoma, myeloma and leukemia. Gene and Cellular Immunotherapy for Cancer offers readers a comprehensive review of current cellular and gene-based immunotherapies. Divided into eighteen cohesive chapters, this book provides an in-depth and detailed look into cellular-based immunotherapies including CAR-T, TCR-T, TIL, Viral CTLs, NK cells in addition to T/NK cell engagers, focusing on their historical perspectives, biology, development and manufacturing, toxicities and more. Edited by two leading experts on gene and cellular immunotherapy, the book will feature chapters written by a diverse collection of recognized and up-and-coming experts and researchers in the field, providing oncologists, immunologists, researchers and clinical and basic science trainees with a bench to bedside view of the latest developments in the field.

The Microbiology of Respiratory System Infections reviews modern approaches in the diagnosis, treatment, and prophylaxis of respiratory system infections. The book is very useful for researchers, scientists, academics, medical practitioners, graduate and postgraduate students, and specialists from pharmaceutical and laboratory diagnostic companies. The book has been divided into three sections according to the types of respiratory pathogens. The first section contains reviews on the most common and epidemiologically important respiratory viruses, such as influenza virus, severe acute respiratory system coronavirus, and recently discovered Middle East respiratory syndrome coronavirus. The second section is devoted to bacterial and fungal pathogens, which discusses etiology and pathogenesis including infections in patients with compromised immune system, and infections caused by fungal pathogens, such as Aspergillus and Pneumocystis. The third section incorporates treatment approaches against different types of bacterial infections of the lower respiratory tract. This section reviews classical antimicrobial and phytomedical approaches as well as the application of nanotechnology against respiratory pathogens.

The Advances in Applied Microbiology series, first published in 1959, continues to be one of the most widely read and authoritative review sources in microbiology. The series contains comprehensive reviews of the most current research in applied microbiology, and includes recent research on the roles of fungal communities in soil nutrient recycling, the microbial nitrogen cycle in soil, and the inter-kingdom associations between soil bacteria, fungi, and mycorrhizal fungi.

The Diverse Faces of Bacillus cereus elucidates all characteristics of this microorganism, from its environmental and ecologic relevance, to its veterinary involvement, its clinical settings, most common B. cereus associated food poisoning episodes, and the newest airway disease pictures mimicking the inhalation of anthrax. Due to its environmental distribution, B. cereus may cause serious, even fatal human diseases. The organism shows many diverse faces, as it is not only a veterinary pathogen, but also used as a biocontrol agent to control vegetable decay due to its natural antimicrobial properties. Once considered as a mere colonizer or contaminant, Bacillus cereus is nowadays acquiring increasing importance as an agent of nosocomial infections. The book's target audience is familiar with this opportunistic pathogen and will benefit from this clear compendium on the classical and molecular techniques and procedures that may be adopted or followed to correctly identify this intriguing multi-faceted microorganism.

Zoonotic diseases pose a serious threat to global health and economy. Domestic and wild birds play crucial roles in transmission and spread of important zoonotic pathogens, with significant implications on human and avian health. Although zoonotic diseases have been extensively studied, information on various aspects of avian zoonotic pathogens have not been revisited or revised to any great extent. This book is a comprehensive and updated compilation of important zoonotic diseases that are transmitted by domestic and wild birds, and consists of 21 chapters that meticulously describe the (i) etiology and evolution, (ii) complex epidemiology, such as migration pathways in context of disease transmission, (iii) pathogenesis, (iv) clinical signs and necropsy findings, (v) diagnostics including latest molecular assays, and (vi) preventative and control strategies, with an emphasis on therapeutics and prophylaxis, of important zoonotic pathogens (bacterial, fungal, parasitic and viral) of avian origin in humans and birds. Each chapter is aptly supported by interactive tables and figures, and features an updated reference section. This book aims to create awareness and enlighten students of veterinary and human medicine on the role of birds in zoonoses, and would serve as a useful reference for working veterinarians, human doctors, and public health experts.

From Hippocrates to Lillian Wald-the stories of scientists whose work changed the way we think about and treat infection. Describes the genesis of the germ theory of disease by a dozen seminal thinkers such as Jenner, Lister, and Ehrlich. Presents the "inside stories" of these pioneers' struggles to have their work accepted, which can inform strategies for tackling current crises in infectious diseases and motivate and support today's scientists. Relevant to anyone interested in microbiology, infectious disease, or how medical discoveries shape our modern understanding This title is published by the American Society of Microbiology Press and distributed by Taylor and Francis in rest of world territories.

Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology, containing comprehensive reviews of the most current research in applied microbiology. Users will find invaluable references and information on a variety of areas, including protozoan grazing of freshwater biofilms, metals in yeast fermentation processes, the interpretation of host-pathogen dialogue through microarrays, and the role of polyamines in bacterial growth and biofilm formation. Eclectic volumes are supplemented by thematic volumes on various topics, including Archaea and sick building syndrome.

Published since 1959, Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology. The series contains comprehensive reviews of the most current research in applied microbiology. Recent areas covered include bacterial diversity in the human gut, protozoan grazing of freshwater biofilms, metals in yeast fermentation processes and the interpretation of host-pathogen dialogue through microarrays. Eclectic volumes are supplemented by thematic volumes on various topics, including Archaea and sick building syndrome. Impact factor for 2013: 2.243

The Common Cold vs. the Flu chart compares the causes, symptoms and treatment of these two respiratory problems. Images and text show normal & inflamed tissue, inflammation of the bronchial airway and middle ear infection. A point by point comparison chart is included. Heavy cover stock with protective varnish for durability.

This textbook covers the full spectrum of tuberculosis-related topics in a comprehensive yet easy-to-follow, readily accessible format. Filling a significant gap in tuberculosis literature, it addresses tuberculosis sensu latu, mirroring the content of the London Queen Mary University tuberculosis Diploma. Covering all aspects related to this condition, from prevention, diagnosis and treatment to public and global health, the book provides a broad overview of tuberculosis management. Further, it includes a wealth of case studies and exercises, making it an essential guide for all staff involved in tuberculosis management. Written by an international and interdisciplinary panel of experts, the book appeals to a broad readership including students, postdoctoral fellows, clinicians, researchers, and nurses, as well as public health officers working in tuberculosis control programs.

Microsporidia: Pathogens of Opportunity provides a systematic overview of the biology of this important pathogen. Written by leading experts in the field, the book combines background and basic information on microsporidia with descriptive methods and resources for working with the pathogen.Newly revised and updated for its second edition, Microsporidia will continue to be the standard text reference for these pathogenic protists, and is an indispensable research resource for biologists, physicians and parasitologists. The first edition of this book was published in 1999 and was the first systematic review of information that had accumulated on these pathogens since the publication of a 2 monograph series in Comparative Pathobiology in 1977. In the last decade there have been tremendous strides in our understanding of the biology of the Microsporidia. This has included the development of new information on genomics and proteomics of this organism as well as a new understanding of the population biology and genetic diversity of this organism. The new edition of this publication will provide systematic reviews of the biology of this pathogen by leading experts in the field. This will be combined with descriptions of the methods and resources for working with this pathogen.

THE #1 NEW YORK TIMES BESTSELLER 'Everything you need to know about one of the deadliest outbreaks in human history' Bill Gates 'Easily our fullest, richest, most panoramic history of the subject' New York Times Book Review In 1918, the world faced the deadliest pandemic in human history. What can the story of the so-called Spanish Flu teach us about the fight against present day crises, and how to prepare for future outbreaks? At the height of WWI, history's most lethal influenza virus erupted in an army camp in Kansas, moved east with American troops, then exploded, killing as many as 100 million people worldwide. It killed more people in twenty-four months than AIDS killed in twenty-four years, more in a year than the Black Death killed in a century. But this was not the Middle Ages, and 1918 marked the first collision of science and epidemic disease. Magisterial in its breadth of perspective and depth of research, The Great Influenza is ultimately a tale of triumph amid tragedy, which provides us with a precise and sobering model as we confront the aftermath of Covid-19 and future pandemics looming on the horizon.

Is cancer a contagious disease? In the late nineteenth century this idea, and attending efforts to identify a cancer "germ," inspired fear and ignited controversy. Yet speculation that cancer might be contagious also contained a kernel of hope that the strategies used against infectious diseases, especially vaccination, might be able to subdue this dread disease. Today, nearly one in six cancers are thought to have an infectious cause, but the path to that understanding was twisting and turbulent. A Contagious Cause is the first book to trace the century-long hunt for a human cancer virus in America, an effort whose scale exceeded that of the Human Genome Project. The government's campaign merged the worlds of molecular biology, public health, and military planning in the name of translating laboratory discoveries into useful medical therapies. However, its expansion into biomedical research sparked fierce conflict. Many biologists dismissed the suggestion that research should be planned and the idea of curing cancer by a vaccine or any other means as unrealistic, if not dangerous. Although the American hunt was ultimately fruitless, this effort nonetheless profoundly shaped our understanding of life at its most fundamental levels. A Contagious Cause links laboratory and legislature as has rarely been done before, creating a new chapter in the histories of science and American politics.

To stem the tide of foodborne illness, it is important to understand the source of the problem. This volume examines pathogenic bacteria, viruses, protozoan parasites, moulds, and mycotoxins in food. It also discusses food-associated antimicrobial resistance and lessons learned from an actual foodborne outbreak. The book also explores clinical aspects of foodborne illness. It is intended for students within the medical field but is also ideal as a reference book for scientists, technologists, and inspectors in public health-related fields who regularly contend with issues related to food microbiology, foodborne infections and intoxications, and food safety.

Viral hemorrhagic fevers have captured the imagination of the public and made their way into popular books and movies by virtue of their extreme virulence and mysterious origins. Since 2001, concerns have grown about the potential use of many hemorrhagic fever viruses as biological weapons. This has led to a resurgence in research to develop improved diagnostics, vaccines, and therapeutics-both for biodefense purposes and to treat naturally exposed persons. Written by international experts, Viral Hemorrhagic Fevers represents a major contribution to the virological literature and updates the state of knowledge of these dangerous illnesses. Topics include: A historical perspective and information on pathogenesis and immune responses Animal models, which are critical to the development of vaccines and therapeutics The roles of high-containment facilities and specially trained scientists in research Prevention and control, including diagnostics and vaccine development Old World Lassa and Lujo viruses and the New World Junin and Machupo viruses Guanarito viruses and their cellular receptors Bunyaviruses, including Rift Valley Fever, Crimean- Congo hemorrhagic fever, and hantaviruses that cause hemorrhagic fever with renal syndrome The Ebola and Marburg filoviruses Flaviviruses, including dengue fever, yellow fever, Kyanasur Forest, Alkhurma, and Omsk hemorrhagic fever viruses and other flaviviruses with hemorrhagic potential Virologists, clinicians, biomedical researchers, microbiologists, and others needing a rapid overview of the nature of these illnesses will find this book an essential resource on clinical and basic science aspects of many viral hemorrhagic fevers. The book will also provide researchers with a springboard to further inquiry in combating what has become a major global threat.

Food Safety Management: A Practical Guide for the Food Industry, Second Edition continues to present a comprehensive, integrated and practical approach to the management of food safety throughout the production chain. While many books address specific aspects of food safety, no other book guides you through the various risks associated with each sector of the production process or alerts you to the measures needed to mitigate those risks. This new edition provides practical examples of incidents and their root causes, highlighting pitfalls in food safety management and providing key insights into different means for avoiding them. Each section addresses its subject in terms of relevance and application to food safety and, where applicable, spoilage. The book covers all types of risks (e.g., microbial, chemical, physical) associated with each step of the food chain, making it an ideal resource.

In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize

It is not the presence of microorganisms, but their interaction with patients that determines their influence on wound healing. Documenting this critical but often ignored aspect of the treatment process, Microbiology of Wounds discusses the microbiology and biology of human wounds in relation to infection and non-healing. Gain the necessary scientific and clinical knowledge pertaining to chronic and acute wounds. The practice of wound healing is dynamic, infinitely complex, nonlinear, and prodigiously individualized to the patient. When one considers the myriad host variables that contribute to the disease state, understanding the intricacies of chronic wounds becomes even more difficult. This book presents the necessary scientific and clinical data pertaining to chronic and acute wounds, and discusses inflammation, epithelialization, granulation tissue, and tissue remodeling. It details techniques for treating chronic and acute wounds and covers the mode of action and efficacy of anti-infectives used in treating wounds. Microbiology of Wounds answers the call for a definitive reference on chronic and acute wounds.

Vector-borne diseases have increasingly emerged as significant causes of human illnesses worldwide, largely due to environmental changes (deforestation), population movements (migration and travelling), international trades, and buildup of drug resistance. These are presenting major challenge to the efficacy and use of conventional tools for controlling vector-borne diseases. Therefore, use of microbial approach for the control of vector-borne diseases is gaining importance. This book comprehensively reviews vector-borne diseases and their microbial control, emphasizing majorly on ecofriendly ways of microbial control.

How does it feel to confront a pandemic from the inside, one patient at a time? To bridge the gulf between a perilously unwell patient in quarantine and their distraught family outside? To be uncertain whether the protective equipment you wear fits the science or the size of the government stockpile? To strive your utmost to maintain your humanity even while barricaded behind visors and masks? Rachel is a palliative care doctor who looked after the most gravely unwell patients on the Covid-19 wards of her hospital. Amid the tensions, fatigue and rising death toll, she witnessed the courage of patients and NHS staff alike in conditions of unprecedented adversity. For all the bleakness and fear, she found that moments that could stop you in your tracks abounded. People who rose to their best, upon facing the worst, as a microbe laid waste to the population. Her new book, Breathtaking, is an unflinching insider's account of medicine in the time of coronavirus. Drawing on testimony from nursing, acute and intensive care colleagues - as well as, crucially, her patients - Clarke argue that this age of contagion has inspired a profound attentiveness to - and gratitude for - what matters most in life.

Genetically Modified and Irradiated Food: Controversial Issues: Facts versus Perceptions explains the technologies used in these processes so they can be understood by those in general public health, scientific organizations, politicians and opinion makers/policymakers. The facts presented include a massive amount of scientific evidence that these technologies are safe and can be beneficial. Because the world is facing a future with an increasing number of people, new technologies are needed to ensure enough safe and healthy food, thus technologies that have the potential to dramatically increase the availability of safe and healthy food should be welcomed by everybody.

Antimicrobial Peptides: Challenges and Future Perspectives covers the latest developments about antimicrobial peptides in the scenario of drug resistance. The book is divided into 16 chapters arranged in sequence and preceded by chapters on historical developments and their role as regulatory molecules in innate defense mechanism. Emphasis is given to purification techniques and characterization suitable for interdisciplinary research. Chapters provide an inventory of various antimicrobial peptides, from a diverse array of organisms such as bacteria, fungi, insects, amphibians, plants and mammals. A section on marine ecosystem broadens readers understanding on marine based antimicrobial peptides. Additional sections provide an informative overview on peptides with antiviral properties and those targeting multi-drug resistant bacteria. Recent reports and mechanism on resistance against antimicrobial peptides are also provided, along with key insights into the challenges and future perspectives of peptide drug development.