This book is the second edition of Atlas of Oral Microbiology: From Healthy Microflora to Disease (ISBN 978-0-12-802234-4), with two new features: we add about 60 pictures of 14 newly isolated microbes from human dental plaque, at the same time, we re-organize the content of this book and provide more research progress about the oral microbiome bank of China, the invasion of oral microbiota into the gut, and the relationships between Oral Microflora and Human Diseases. This book is keeping up with the advanced edge of the international research field of oral microbiology. It innovatively gives us a complete description of the oral microbial systems according to different oral ecosystems. It collects a large number of oral microbial pictures, including cultural pictures, colonies photos, and electron microscopy photos. It is by far the most abundant oral microbiology atlas consists of the largest number of pictures. In the meantime, it also described in detail a variety of experimental techniques, including microbiological isolation, culture, and identification. It is an atlas with strong practical function. The editors and writers of this book have long been engaged in teaching and research work in oral microbiology and oral microecology. This book deserves a broad audience, and it will meet the needs of researchers, clinicians, teachers, and students major in biology, dental medicine, basic medicine, or clinical medicine. It can also be used to facilitate teaching and international academic exchanges.

This second volume chronicles the later stages of the outbreak of SARS-Cov-2 (COVID-19) and delineates the role of several disciplines in therapeutic and control measures highliting the response from specific coutries of note and efforts to repurpose and produce new therapeutics and vaccines. By addressing considerations of efficacy and safety of drugs and chemicals used to combat COVID-19, virtually in real-time, this book documents and highlights the advances in science and place the toxicology, pharmaceutical science, public health and medical community in a better position to advise in future epidemics.

The Book provides knowledge on the diversity of disease causing microbes including bacteria, viruses, fungi and Protozoans- the major diseases they cause and the environmental factors that influence the occurrence, transmission and spread of microbes along with the epidemiological factors determining the occurrence of disease.

This book discusses the organ-specific systemic manifestations of COVID-19. The initial chapters of the book review the origin and evolution of the coronaviruses, followed by pathogenesis and immune response during COVID-19 infection. The book also provides insight into the role of angiotensin-converting enzyme 2 in the onset of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis. It summarizes the neurological aspects of SARS-CoV2, including transmission pathways, mechanisms of invasion into the nervous system, and mechanisms of neurological disease. It also delineates the association of severe disease with high blood plasma levels of inflammatory cytokines and inflammatory markers in SARS-CoV-2 infection. Lastly, it discusses the perturbation of gut microbiota by SARS-CoV-2 and uncovers the potential risk of virus infection on reproductive health.

This book describes the issues of human health and healthcare from the point of view of hygiene monitoring and maintenance. Also, the perspectives on the effects of microbial cell structures, metabolism, communities and interactions on health and hygiene are included. Besides microbiological screening of patients, surfaces, air space etc. this book introduces some key bacteriological, virological and fungal risks in the clinical setting. It describes routes of contamination inside hospitals, and into our body. The means for prevention of the spreading of unwanted microbes are presented as well. Protection mechanisms of the bodily system and the balances of the human microbiome are discussed with respect to intrusions via the respiratory or digestive systems or damaged skin. The risks during operations or invasive treatments are highlighted, together with means for avoiding them. Examples of biofilm formation on the devices or on the body surfaces, latent infections, contagion mechanisms, as well as prevalent risks such as mycobacterial infections, antibiotic resistant strains, intracellular pathogens, nosocomial viruses, lowered host defences, Clostridium difficile, salmonellas, legionellas are included in the chapters of this book. Important developments such as personalized medicine, point-of-care diagnostics, arthroscopy, improved drug delivery, pre- and probiotic treatments, monitoring of the normal flora and its beneficial effects are also discussed.

The main objective of this book has been to analyze in depth and discuss the different aspects related to the design and elaboration of cell-enclosing microcapsules, even the regulatory features and clinical trials under development. These improvements will lead to progression in this therapeutic approach which may become one day closer to a realistic proposal for clinical application.

The advances in drug delivery technology have enabled a new era of drug discovery and development. In this regard, cell microencapsulation is a technology that opens new venues and possibilities to the administration of new active principles and may be the key to solve several issues related to the correct administration of new therapeutic agents to finally success in the clinical setting.

The editors believe that this technology may have important applicability not only in the field of drug delivery (to treat diseases such as cancer, neurodegenerative disorders, metabolic diseases etc) but also in cellular therapy and tissue regeneration among others.

Due to the organization of the chapters, this book can be read at different levels and readers may analyze from basic aspects of encapsulation, biomaterials, clinical applications and regulatory and industrial issues of this technology. Due to this, the book could be useful for both graduate and PhD students belonging to the pharmaceutical, engineering and biomedical fields. Nevertheless, we hope that this book is also useful to expert researchers who may find information and new ideas about the cell microencapsulation area.

This unique book provides excellent examples of ongoing, leading-edge research related to viruses, especially COVID-19. It is written from the viewpoint of various scientific fields including materials science. It introduces and describes viruses (submicroscopic infectious agents that replicate inside the living cells of an organism), various infections caused by viruses (human to human, human to other organisms to humans, humans to materials to humans, etc.), not only from the viewpoint of medical research but also from other scientific disciplines. A major focus of the book is the COVID-19 virus. Highlighted topics include the evolution of COVID-19, transmission of virus particles through the air, virus spread through various materials, detection of the virus by testing wastewater, the development and testing of vaccines and therapeutic drugs, and the preparation for future viruses and pandemics. This includes reform in funeral services to properly and safely accommodate very large numbers of bodies in a pandemic, like those seen in New York City when it was the epicenter for the virus in the United States. This book serves as an excellent and very informative guide (practical book) for engineers and researchers of various backgrounds and as a great academic textbook.

This volume discusses the latest protocols used by scientists to understand ZIKV and how to mitigate its presence. These studies will benefit in the detection, diagnosis, management, treatment, and prevention of this infection. The chapters in this book cover techniques in virus isolation, purification, and ways to titrate the virus; recent advancements made in the development of modified molecular techniques; and a discussion on Zika virus itself to help readers better understand this pathogen. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Zika Virus: Methods and Protocols is a valuable resource for both novice and expert scientists interested in learning more about this important topic.

Gut Microbiome and Behavior, the latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the gut microbiome on the brain and behavior, fully encapsulating the latest research in the field and defining the scope of this influence to outline potential mechanisms and possible implications.

Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology, containing comprehensive reviews of the most current research in applied microbiology. Users will find invaluable references and information on a variety of areas, including protozoan grazing of freshwater biofilms, metals in yeast fermentation processes, the interpretation of host-pathogen dialogue through microarrays, and the role of polyamines in bacterial growth and biofilm formation. Eclectic volumes are supplemented by thematic volumes on various topics, including Archaea and sick building syndrome.

Applications of High Resolution Mass Spectrometry: Food Safety and Pesticide Residue Analysis is the first book to offer complete coverage of all aspects of high resolution mass spectrometry (HRMS) used for the analysis of pesticide residue in food. Aimed at researchers and graduate students in food safety, toxicology, and analytical chemistry, the book equips readers with foundational knowledge of HRMS, including established and state-of-the-art principles and analysis strategies. Additionally, it provides a roadmap for implementation, including discussions of the latest instrumentation and software available. Detailed coverage is given to the application of HRMS coupled to ultra high-performance liquid chromatography (UHPLC-HRMS) in the analysis of pesticide residue in fruits and vegetables and food from animal origin. The book also discusses extraction procedures and the challenges of sample preparation, gas chromatography coupled to high resolution mass spectrometry, flow injection-HRMS, ambient ionization, and identification of pesticide transformation products in food. Responding to the fast development and application of these new procedures, this book is an essential resource in the food safety field.

Host-Microbe Interactions, the latest volume in the Progress in Molecular Biology series, provides a forum for the discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their respective fields, along with abundant references. This volume is dedicated to the subject of host-microbe interactions.

Skin Diseases of Cattle in the Tropics: A Guide to Diagnosis and Treatment is a clinical and practical guide to help animal scientists, field veterinarians, veterinary students, and technicians make appropriate and differential diagnoses. It features quizzes of clinical cases, along with multiple images of characteristic lesions and laboratory findings of major skin diseases (and diseases with skin manifestations) that are prevalent in tropical areas, notably the Sub-Saharan African countries. This self-learning and easy-to-use instructional guide, a unique offering in the field of animal science and veterinary medicine, provides essential and foundational information about relevant skin conditions that are followed by illustrated flow charts of laboratory diagnoses and summaries of respective diseases. This title makes the subject accessible for practicing veterinarians and animal scientists, and is particularly useful for those who have neither seen nor had the chance to see these diseases in the field or clinics. Such diseases are important not only in the tropics, but may be encountered in many countries in subtropical and temperate zones.

Leeuwenhoek's Legatees and Beijerinck's Beneficiaries: A History of Medical Virology in The Netherlands offers a tour of the history of Dutch medical virology. Beginning with the discovery of the first virus by Martinus Beijerinck in 1898, the authors investigate the reception and redefinition of his concept in medical circles and its implications for medical practice. The relatively slow progress of these areas in the first half of the twentieth century and their explosive growth in the wake of molecular techniques are examined. The surveillance and control of virus diseases in the field of public health is treated in depth, as are tumour virus research and the important Dutch contributions to technical developments instrumental in advancing virology worldwide. Particular attention is paid to oft forgotten virus research in the former Dutch colonies in the East and West Indies and Africa.

The Vaccine Book, Second Edition provides comprehensive information on the current and future state of vaccines. It reveals the scientific opportunities and potential impact of vaccines, including economic and ethical challenges, problems encountered when producing vaccines, how clinical vaccine trials are designed, and how to introduce vaccines into widespread use. Although vaccines are now available for many diseases, there are still challenges ahead for major diseases, such as AIDS, tuberculosis, and malaria. This book is designed for students, researchers, public health officials, and all others interested in increasing their understanding of vaccines. It answers common questions regarding the use of vaccines in the context of a rapidly expanding anti-vaccine environment. This new edition is completely updated and revised with new and unique topics, including new vaccines, problems of declining immunization rates, trust in vaccines, the vaccine hesitancy, and the social value of vaccines for the community vs. the individual child's risk.

Statistical Aspects of the Microbiological Examination of Foods, Third Edition, updates some important statistical procedures following intensive collaborative work by many experts in microbiology and statistics, and corrects typographic and other errors present in the previous edition. Following a brief introduction to the subject, basic statistical concepts and procedures are described including both theoretical and actual frequency distributions that are associated with the occurrence of microorganisms in foods. This leads into a discussion of the methods for examination of foods and the sources of statistical and practical errors associated with the methods. Such errors are important in understanding the principles of measurement uncertainty as applied to microbiological data and the approaches to determination of uncertainty. The ways in which the concept of statistical process control developed many years ago to improve commercial manufacturing processes can be applied to microbiological examination in the laboratory. This is important in ensuring that laboratory results reflect, as precisely as possible, the microbiological status of manufactured products through the concept and practice of laboratory accreditation and proficiency testing. The use of properly validated standard methods of testing and the verification of 'in house' methods against internationally validated methods is of increasing importance in ensuring that laboratory results are meaningful in relation to development of and compliance with established microbiological criteria for foods. The final chapter of the book reviews the uses of such criteria in relation to the development of and compliance with food safety objectives. Throughout the book the theoretical concepts are illustrated in worked examples using real data obtained in the examination of foods and in research studies concerned with food safety.

Ebola Virus Disease: From Origins to Outbreak covers Ebola virus disease in its entirety from its origins through major outbreaks in the past to the present day outbreak. It contains information on the West Saharan response to Ebola as well as highlights from the field in West Africa from Dr. Qureshi and Dr. Chughtai, helping to solve the primary question of what's next and aiding in formulating a path forward. With a growing awareness of the devastating effects of this viral disease and an influx of topical research, this book provides the information the global community of researchers, clinicians and students need to better inform their research and study of Ebola virus disease.

This new, fully revised second edition of Fundamentals of Molecular Virology is designed for university students learning about virology at the undergraduate or graduate level. Chapters cover most of the major virus families, emphasizing the unique features of each virus family. These chapters are designed to tell stories about the viruses covered, and include information on discovery, diseases and pathogenesis, virus structure, steps in viral replication, and interaction with cellular signaling pathways. This approach portrays the "personality" of each virus, helping students to learn the material and to build up their knowledge of virology, starting with smaller and simpler viruses and proceeding to more complex viruses.

Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews, providing a valuable overview of the current field of virology.

Viral Infections and Antiviral Therapies provides comprehensive coverage of viral infections and their transmission. Coverage includes antiviral agents, therapeutics, their mechanisms and treatment strategies. The book is organized into four sections, including an introduction to antiviral therapies, viral infections and their transmission, antiviral agents and therapeutics, and a market overview and future developments. The chapters in each section of the book discuss various key topics that are contributed to by an international group of leading experts.

Published since 1959, Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology. The series contains comprehensive reviews of the most current research in applied microbiology, and includes recent research on the roles of fungal communities in soil nutrient recycling, the microbial nitrogen cycle in soil, and the inter-kingdom associations between soil bacteria, fungi, and mycorrhizal fungi.

Foodborne pathogens continue to cause major public health problems worldwide and have escalated to unprecedented levels in recent years. In this book, major foodborne diseases and the key food safety issues are discussed elaborately. In addition, emerging and reemerging microbial agents and other food safety related topics are discussed. This book also addresses the challenges facing both developed and developing countries to ensure food safety in the development of new food products and processing technologies, internationalization of food trade, safety of foods derived from biotechnology, microbiological risks, and emergence of new and antibiotic-resistant pathogens, particularly from emerging pathogens. This book was written so that readers can easily understand content aimed at enhancing continuing global efforts to deliver safe food and improve health and environmental conditions in developing countries. The book is useful in getting the latest information in food safety and foodborne pathogens. The comprehensive contents include coverage of: Foodborne microbial agents and their growth, survival, and death in food Emerging and reemerging foodborne pathogens Emergence of drug-resistant pathogens Impact of climate change on foodborne pathogens Technology for rapid and accurate detection of foodborne pathogens Risk analysis, assessment, and pathogen management in food Strategies to destroy or control foodborne pathogens Biosecurity issues and the implications of new regulatory guidelines Worldwide food safety status

The HIV pandemic continues to levy a heavy burden on the human race world-wide. The estimated number of people who became newly infected with HIV in 2009 was 2.6 million; most of these individuals live in Sub-Saharan Africa, followed by India and Southeast Asia. An estimated 370,000 new cases of pediatric infections occurred globally in 2009 (or more than 1,000 new infections every day), practically all of them through mother-to-child transmission. Up to 40% of all new infant HIV infections occur during breastfeeding. While breastfeeding by HIV-infected mothers is not recommended in the U.S. and other resource-rich settings where safe replacement feeding is easily available, the situation is different in many resource-limited settings, where replacement feeding is not safe or available and carries a high risk of infections (diarrhea, pneumonia) and infant malnutrition. Mothers in such settings are faced with a difficult dilemma: to breastfeed their infants in order to provide their infants with its many benefits (nutritional, immunologic, cognitive), but to also risk transmitting HIV. These challenges have prompted an intensive search for new prophylactic and therapeutic strategies in order to prevent infants from acquiring HIV infection through breastfeeding. In this book, expert HIV researchers critically review every aspect of this highly evolving and topical subject. The opening chapters deal with the epidemiology, global magnitude and biologic mechanisms of HIV-1 transmission from mother to child through breastfeeding and include considerations of the virus (quantity, compartments, characteristics) and the host (genetic, immunity-innate, cellular, humoral). The effects of breastfeeding on the HIV-infected mother's health and nutritional status, and the social and cultural issues associated with the practice of breastfeeding are also discussed. The next few chapters provide cutting-edge reviews of the latest approaches to prevention of HIV transmission to the infant through breastfeeding, including antiretroviral strategies, nutritional and immune-based approaches, and treatment of expressed breast milk. The remaining chapters provide a fascinating review of the many iterations this subject has received, as reflected in the several different sets of guidelines for infant feeding by HIV-infected mothers issued by the World Health Organization, and a debate by leading scientists on whether HIV-infected mothers should breastfeed their infants-in resource-limited and in resource-rich settings. A comprehensive overview of the current state of implementing the new evidence for prevention of breastfeeding transmission of HIV all over the world is also presented. Essential reading for the many disciplines of scientists and clinicians working on HIV/AIDS and other retroviruses, pediatricians, obstetricians/gynecologists, as well as all health-care professionals interested in expanding their understanding on the subject.