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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Astrovirus Research - Essential Ideas, Everyday Impacts, Future Directions (Hardcover, 2013 ed.)
Loot Price: R4,872
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Astrovirus Research - Essential Ideas, Everyday Impacts, Future Directions (Hardcover, 2013 ed.)
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Astroviruses were first identified in the feces of children in
1975. Since then, they have been found in 3 to 20% of children with
diarrhea. Given that serological studies have demonstrated that up
to 90% of children have been exposed to at least one strain of
astrovirus by age 9, the prevalence of infection may be much
higher. Supporting this are studies demonstrating that astroviruses
can also be isolated in a subset of asymptomatic individuals,
suggesting that a proportion of infected individuals shed the virus
asymptomatically or for some time after the resolution of other
symptoms of infection. Asymptomatic carriers may be a major
reservoir for astroviruses in the environment and could contribute
to dissemination of the virus. Astroviruses are extremely stable in
the environment and can be transmitted nosocomially, directly from
infected individuals and potentially animals, and through
contaminated food and water. Although typically an acute disease,
astrovirus infection in premature infants may be associated with
the development of necrotizing enterocolitis and in new-onset
celiac disease in children. Immunocompromised children are even
more susceptible often developing persistent infections that lead
to wasting or even systemic infections associated with fatal
encephalitis. In spite of its importance, little is known about
astrovirus pathogenesis, molecular biology, epidemiology, or cell
biology. The goal of this book is to provide the latest and most
up-to-date information on this medically important and rapidly
evolving group of viruses. It will include sections on the history
of astroviruses and their disease in humans; information on viral
replication and immune responses; new information on how
astroviruses induce disease including the expression of a viral
enterotoxin regulating intestinal epithelial cell tight junctions,
the isolation and identification of new astrovirus genotypes in
mammals including humans, and astroviruses of veterinary
importance. Finally, the book will also introduce the complexity of
astrovirus epidemiology and potential as an important new zoonotic
disease, and its role in food-borne disease. This will be the first
book of its kind and will be of great interest to microbiologists,
virologists, infectious disease specialists, immunologists,
pediatricians, public health and food safety experts,
veterinarians, poultry industry specialists, and researchers and
clinicians interested in enteritis. "
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