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Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology - Overview of the First Eukaryome Congress at Institut Pasteur. Paris, October 16-18, 2019. (Hardcover, 1st ed. 2020)
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Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology - Overview of the First Eukaryome Congress at Institut Pasteur. Paris, October 16-18, 2019. (Hardcover, 1st ed. 2020)
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Multiple demographic or economic parameters contribute to the
origin of emerging infections, for example: poverty, urbanization,
climate change, conflicts and population migrations. All these
factors are a challenge to assess the impact (present and future)
of parasitic diseases on public health. The intestine is a major
target of these infections; it is a nutrient-rich environment
harbouring a complex and dynamic population of 100 trillion
microbes: the microbiome. Most researches on the microbiome focus
on bacteria, which share the gut ecosystem with a population of
uni- and multi cellular eukaryotic organisms that may prey on them.
Our interest focuses on the families of eukaryotic microbes
inhabiting the intestine, called "intestinal eukaryome", that
include fungi, protists and helminths. Knowledge on the reciprocal
influence between the microbiome and the eukaryome, and on their
combined impact on homeostasis and intestinal diseases is scanty
and can be considered as an important emerging field. Furthermore,
the factors that differentiate pathogenic eukaryotes from
commensals are still unknown. This book presents an overview of the
science presented and discussed in the First Eukaryome Congress
held from October 16th to 18th, 2019 at the Pasteur Institute in
Paris. This book covers the following topics: Phylogenetic,
prevalence, and diversity of intestinal eukaryotic microbes; and
their (still enigmatic) historical evolution and potential
contributions to mucosal immune homeostasis. Integrative biology to
study the molecular cell biology of parasite-host interactions and
the multiple parameters underlining the infectious process. The
exploitation of tissue engineering and microfluidics to establish
three-dimensional (3D) systems that help to understand homeostasis
and pathological processes in the human intestine.
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