Fungal growths affect both human and animal well-being. Many natural pathogens of laboratory animals alter host physiology, rendering the host unsuitable for experimental uses. While the number and prevalence of few pathogens have declined considerably, many still turn up in laboratory animals and represent unwanted variables in research. Investigators using laboratory animals in biomedical experimentation should be aware of the profound effects that many of these agents can have on research. What does the future hold regarding the natural pathogens of laboratory animals? The selection of an animal model must carefully address issues of the type of human disease to mimic, the parameters to follow, and the collection of the appropriate data to answer those questions being asked. Overall, animal models of fungal infection will continue to deepen our understanding of how these infections occur. This book provides a valuable source of information to biological and biomedical scientists and to clinical and doctoral researchers working in the area of fungal infections and diseases of laboratory animal species.

Fungi range from being microscopic, single-celled yeasts to multicellular and heterotrophic in nature. Fungal communities have been found in vast ranges of environmental conditions. They can be associated with plants epiphytically, endophytically, or rhizospherically. Extreme environments represent unique ecosystems that harbor novel biodiversity of fungal communities. Interest in the exploration of fungal diversity has been spurred by the fact that fungi perform numerous functions integral in sustaining the biosphere, ranging from nutrient cycling to environmental detoxification, which involves processes like augmentation, supplementation, and recycling of plant nutrients--a particularly important process in sustainable agriculture. Fungal communities from natural and extreme habitats help promote plant growth, enhance crop yield, and soil fertility via direct or indirect plant growth promoting (PGP) mechanisms of solubilization of phosphorus, potassium, and zinc, production of ammonia, hydrogen cyanides, phytohormones, Fe-chelating compounds, extracellular hydrolytic enzymes, and bioactive secondary metabolites. These PGP fungi could be used as biofertilizers, bioinoculants, and biocontrol agents in place of chemical fertilizers and pesticides in eco-friendly manners for sustainable agriculture and environments. Along with agricultural applications, medically important fungi play significant role for human health. Fungal communities are useful for sustainable environments as they are used for bioremediation which is the use of microorganisms' metabolism to degrading waste contaminants (sewage, domestic, and industrial effluents) into non-toxic or less toxic materials by natural biological processes. Fungi could be used as mycoremediation for the future of environmental sustainability. Fungi and fungal products have the biochemical and ecological capability to degrade environmental organic chemicals and to decrease the risk associated with metals, semi-metals, and noble metals either by chemical modification or by manipulating chemical bioavailability. The two volumes of "Recent Trends in Mycological Research" aim to provide an understanding of fungal communities from diverse environmental habitats and their potential applications in agriculture, medical, environments and industry. The books are useful to scientists, researchers, and students involved in microbiology, biotechnology, agriculture, molecular biology, environmental biology and related subjects.

Microbes are ubiquitous in nature. Among microbes, fungal communities play an important role in agriculture, the environment, and medicine. Vast fungal diversity has been associated with plant systems, namely epiphytic fungi, endophytic fungi, and rhizospheric fungi. These fungi associated with plant systems play an important role in plant growth, crop yield, and soil health. Rhizospheric fungi, present in rhizospheric zones, get their nutrients from root exudates released by plant root systems, which help with their growth, development, and microbe activity. Endophytic fungi typically enter plant hosts through naturally occurring wounds that are the result of plant growth, through root hairs, or at epidermal conjunctions. Phyllospheric fungi may survive or proliferate on leaves depending on material influences in leaf diffuseness or exudates. The diverse nature of these fungal communities is a key component of soil-plant systems, where they are engaged in a network of interactions endophytically, phyllospherically, as well as in the rhizosphere, and thus have emerged as a promising tool for sustainable agriculture. These fungal communities promote plant growth directly and indirectly by using plant growth promoting (PGP) attributes. These PGP fungi can be used as biofertilizers and biocontrol agents in place of chemical fertilizers and pesticides for a more eco-friendly method of promoting sustainable agriculture and environments. This first volume of a two-volume set covers the biodiversity of plant-associated fungal communities and their role in plant growth promotion, the mitigation of abiotic stress, and soil fertility for sustainable agriculture. This book should be useful to those working in the biological sciences, especially for microbiologists, microbial biotechnologists, biochemists, and researchers and scientists of fungal biotechnology.

Plant endophytes are a potential source for the production of bioactive compounds that can fight against devastating diseases in both plants and humans. Among these endophytic microorganisms, endophytic fungi are one of the dominant group of microorganisms with a potential role in plant growth promotion and the discovery of noble bioactive natural products. Endophytic fungi possess several bioactivities like anticancer, antimicrobial, insecticidal, plant growth stimulants, crop protection, phytoremediation, etc. Presence of modular biosynthetic genes clusters like PKS and NRPS in several endophytic fungi underscores the need to understand and explore such organisms. This volume presents and demonstrates the applied aspects of endophytic fungi. Practical applications of such endophytes are discussed in detail, including studies in pharmaceutical development and agricultural management of important microbial diseases. The beneficial effects that endophytic fungi provide to host plants-enhancing growth, increasing fitness, strengthening tolerance to abiotic and biotic stresses through secondary metabolites-are also discussed. The reader is provided with a comprehensive and detailed understanding of such relationships between endophytic fungi and their host.

Fungi are eukaryotic microorganisms that include both unicellular and multicellular species. They have a worldwide distribution and a wide range of applications in diverse sectors, from environmental, food and medicine to biotechnological innovations. Fungal biochemical genetics involves the study of the relationships between genome, proteome and metabolome, and the underlying molecular processes in both native and bioengineered fungi. This book provides a valuable resource on the challenges and potential of fungal biotechnology and related bioengineering and functional diversity for various industrial applications in the food, environmental, bioenergy and biorefining, and the biopharma sectors. In comparison to previous and related publications in the area of applied myco-biotech-engineering, this book bridges a knowledge gap in the areas related to prospects and investment as well as intellectual and technical issues. This book also provides information on recent commercial and economic interests in the area by juxtaposing the developments achieved in recent worldwide research and its many challenges.

The book reviews key developments in downy mildew research, including the disease, its distribution, symptomatology, host range, yield losses, and disease assessment; the pathogen, its taxonomy, morphology, phylogeny, variability, sporulation, survival and perpetuation, spore germination, infection, pathogenesis, seed infection, disease cycle, epidemiology, forecasting, and fine structures. The book also elaborates the mechanisms of host resistance (biochemical, histological, genetic, and molecular, including cloning and the mapping of R-genes), disease resistance breeding strategies, and the genetics of host-parasite interactions. It explores disease management based on cultural, chemical, biological, host resistance, and integrated approaches; and provides suggestions for future research areas. This book offers a comprehensive guide to an economically important disease, reviewing in detail the extant body of literature. Divided into 16 chapters, each of which includes a wealth of photographs, graphs, histograms, tables, figures, flow charts, micrographs etc., it represents an invaluable source of information for all researchers, teachers, students, industrialists, farmers, policymakers, and all others who are interested in growing healthy and profitable cruciferous crops all over the world.

Forest Fungi: Biodiversity, Conservation, Mycoforestry and Biotechnology explores sustainable option aspects of forest fungal research, from the selection of hosting plants, isolation, identification, fermentation, identification of secondary metabolites, omics-tools for better understanding the plant–fungus Interactions. Forests are the world’s greatest repository of terrestrial biomass, soil carbon and biodiversity. They provide a variety of provisioning, supporting, regulatory and cultural ecosystem services, which are crucial for the survival of human beings. Fungi play key roles in forest ecosystems as mutualists, saprobes and pathogens.

This book covers both the molecular basics of fungal stress response strategies as well as biotechnological applications thereof. The complex regulatory mechanisms of stress response pathways are presented in a concise and well-readable manner. Also, light will be shed on the interconnection of pathways responding to different types of stress. Profound knowledge of stress responses in yeast and filamentous fungi is crucial for further optimization of industrial processes. Applications are manifold, for example in fungicide development, for improving the resistance of crop plants to fungal pathogens, but also in medicine to help curing fungal infections. The book targets researchers from academia and industry, as well as graduate students interested in microbiology, mycology and biomedicine.

White biotechnology, or industrial biotechnology as it is also known, refers to the use of living cells and/or their enzymes to create industrial products that are more easily degradable, require less energy, create less waste during production and sometimes perform better than products created using traditional chemical processes. Over the last decade considerable progress has been made in white biotechnology research, and further major scientific and technological breakthroughs are expected in the future. Fungi are ubiquitous in nature and have been sorted out from different habitats, including extreme environments (high temperature, low temperature, salinity and pH), and may be associated with plants (epiphytic, endophytic and rhizospheric). The fungal strains are beneficial as well as harmful for human beings. The beneficial fungal strains may play important roles in the agricultural, industrial, and medical sectors. The fungal strains and their products (enzymes, bioactive compounds, and secondary metabolites) are very useful for industry (e.g., the discovery of penicillin from Penicillium chrysogenum). This discovery was a milestone in the development of white biotechnology as the industrial production of penicillin and antibiotics using fungi moved industrial biotechnology into the modern era, transforming it into a global industrial technology. Since then, white biotechnology has steadily developed and now plays a key role in several industrial sectors, providing both high value nutraceutical and pharmaceutical products. The fungal strains and bioactive compounds also play an important role in environmental cleaning. This volume covers the latest developments and research in white biotechnology with a focus on diversity and enzymes.

Bioremediation is the use of microorganisms' metabolism to degrade waste contaminants (sewage, domestic, and industrial effluents) into non-toxic or less toxic materials by natural biological processes. Volume 2 offers new discussion of remediation through fungi-or mycoremediation-and its multifarious possibilities in applied remediation engineering and the future of environmental sustainability. Fungi have the biochemical and ecological capability to degrade environmental organic chemicals and to decrease the risk associated with metals, semi-metals, noble metals, and radionuclides, either by chemical modification or by manipulating chemical bioavailability. Additional expanded texts shows the capability of these fungi to form extended mycelia networks, the low specificity of their catabolic enzymes, and their use against pollutants as a growth substrate, making these fungi well suited for bioremediation processes. Their mycelia exhibit the robustness of adapting to highly limiting environmental conditions often experienced in the presence of persistent pollutants, which makes them more useful compared to other microbes. Despite dominating the living biomass in soil and being abundant in aquatic ecosystems, however, fungi have not been exploited for the bioremediation of such environments until this added Volume 2. This book covers the various types of fungi and associated fungal processes used to clean up waste and wastewaters in contaminated environments and discusses future potential applications.

This book provides essential molecular techniques and protocols for analyzing microbes that are useful for developing novel bio-chemicals, such as medicines, biofuels, and plant protection substances. The topics and techniques covered include: microbial diversity and composition; microorganisms in the food industry; mass cultivation of sebacinales; host-microbe interaction; targeted gene disruption; function-based metagenomics to reveal the rhizosphere microbiome; mycotoxin biosynthetic pathways; legume-rhizobium symbioses; multidrug transporters of yeast; drug-resistant bacteria; the fungal endophyte piriformospora indica; medicinal plants; arbuscular mycorrhizal fungi; biosurfactants in microbial enhanced oil recovery; and biocontrol of the soybean cyst nematode with root endophytic fungi; as well as microbe-mediated drought tolerance in plants.

Current research lays emphasis on exploring natural products for use in nutraceuticals and pharmaceuticals to overcome various side effects of synthetic drugs. Fungi occupy an eminent position among natural sources of food and medicinal importance since ancient times. Many fungal species have been eaten as food and used in folk medicine for the treatment of many human ailments as mentioned in traditional medical literature. However, scanty information is available pertaining to the nutraceutical and pharmaceutical importance of fungi which merits an extensive review. This book spotlights the use value macrofungi in human health. Macrofungi with health benefitting properties largely belong to Basidiomycota followed by Ascomycota growing indoor (cultivated) and outdoor (wild). We endeavoured to throw light on the benefits of macrofungal taxa in relation to their food and medicinal significance in human life. We provided knowledge pertaining to the ethnomycological significance of macrofungi with respect to their uses as food and medicine by the people inhabiting different parts of the world. This book highlights the nutritional composition and bioactive compounds present in macrofungi. We also focused on the pharmacological activities of macrofungi contributing towards their medicinal value against several human disorders. We cited many commercially available nutraceutical and pharmaceutical products of macrofungal origin. This work will hopefully serve as a basic reference for general public, mycologists, researches and industry men, interested in consumption, research and marketing of macrofungi.

This book covers the applications of fungi used in biorefinery technology. As a great many different varieties of fungal species are available, the text focuses on the various applications of fungi for production of useful products including organic acids (lactic, citric, fumaric); hydrolytic enzymes (amylase, cellulases, xylanases, ligninases, lipases, pectinases, proteases); advanced biofuels (ethanol, single cell oils); polyols (xylitol); single cell protein (animal feed); secondary metabolites; and much more.

This book provides a detailed and up-to-date overview of all aspects of yeast cell surface engineering, including fundamental principles, practical strategies for the construction of engineered yeasts, as well as medical and industrial applications. The technique makes it possible to add eukaryotic modifications to the surface-displayed proteins/peptides, which is of significant value in basic and applied research. Generally referred to as an arming (molecular display) technology, it allows yeast to be used as a whole-cell biocatalyst for a range of purposes, including bio-energy production, pollutant removal, recovery of rare metal ions, and preparation of functional cells, all of which are comprehensively covered in the book. Among the medical applications discussed are in vitro antibody preparation and the production of oral vaccines. In addition, it presents the latest advances in protein engineering and high-throughput screening for directed evolution of enzymes. The book enables graduate students and researchers to gain a deeper, comprehensive understanding of the technology, and offers further inspiration for researchers and industrial experts in this rapidly evolving field.

This book provides in-depth reviews of the role of Rhizobium in agriculture and its biotechnological applications. Individual chapters explore topics such as: the occurrence and distribution of Rhizobium; phenotypic and molecular characteristics of Rhizobium; impact of Rhizobium on other microbial communities in the rhizosphere; N2-fixation ability of Rhizobium; Rhizobium and biotic stress; Rhizobium-mediated restoration of an ecosystem; in silico analysis of the rhizobia pool; further biotechnological perspectives of Rhizobium.

Introductory Paper: Fungal Dimorphism (D. Kerridge). Molecular Genetics of Morphogenic Processes: Molecular Control of Conidiogenesis in Aspergillus nidulans (W.E. Timberlake). Physics and Genetic Mapping of Candida albicans (B.B. Magee et al.). Cell Biology and Biochemsitry: Morphological Aspects of Fungal Dimorphism (M. Borgers). Nature and Control of Cell Wall Biosynthesis (M.G. Shepperd, P.K. Gopal). Dimorphism and Pathogenesis: Pathogenicity of Wangiella Dermatitidis (A. Polak, D.M. Dixon). Do Dimorphic Fungi More Easily Escape Host Defences and Treatment? (D.A. Stevens). Diagnosis and Treatment of Mycoses: Diagnosis of Histoplasmosis (J. Wheat). Morphological Aspects of Antifungal Agents (H. Yamaguchi et al.). 28 additional articles. Index.

Fungal nanobiotechnology has emerged as one of the key technologies, and an eco-friendly, as a source of food and harnessed to ferment and preserve foods and beverages, as well as applications in human health (antibiotics, anti-cholesterol statins, and immunosuppressive agents), while industry has used fungi for large-scale production of enzymes, acids, biosurfactants, and to manage fungal disease in crops and pest control. With the harnessing of nanotechnology, fungi have grown increasingly important by providing a greener alternative to chemically synthesized nanoparticles.

This book presents a broad perspective on saponins as important natural products with a key role in plant defense. The presence of saponins has been reported in several plant species, and many types of saponins have been found to exhibit significant antifungal activities. In addition to their role in plant defense, saponins are of increasing interest for drug research, as they are active ingredients in several traditional medicines and hold potentially valuable pharmacological properties. In this book, the authors briefly introduce readers to saponin accumulation in various plant organs, with a specific focus on their structure classification and diversity. Readers will find detailed information on the saponin structure-activity relationship and saponins' vital role in sustainable agriculture as a chemical barrier to pathogen attack. The latest techniques for isolating, identifying, and quantifying saponins are also discussed. In the closing chapter, the authors outline the recent metabolic engineering strategies applied to improve saponin glycosides production and their potential applications in plant disease resistance. This book and the companion volume Bioactive Molecules in Plant Defense: Signaling in Growth and Stress offer vital resources for all researchers and students interested in plant pathology, mycology and sustainable agriculture.

Fungi are not like us - they are entirely, magically, something else. Welcome to the astonishing secret world of fungi. Aliya Whiteley has always been in love with fungi - from a childhood taking blurry photographs of strange fungal eruptions on Exmoor to a career as a writer inspired by their surreal and alien beauty. This love for fungi is a love for life, from single-cell spores to the largest living organism on the planet; a story stretching from Aliya's lawn into orbit and back again via every continent. Despite their familiar presence, there's still much to learn about the eruption, growth and decay of their interconnected world. From fields, feasts and fairy rings to death caps, puffballs and ambrosia beetles, this is an intoxicating personal journey into the life of extraordinary organism, one that we have barely begun to understand.

This new edition provides a comprehensive look at the molecular genetics and biochemical basis of fungal biology, covering important model organisms such as Aspergilli while also integrating advances made with zygomycetes and basidiomycetes. This book groups a total of 15 chapters authored by expert scholars in their respective fields into four sections. Five chapters cover various aspects of gene expression regulation. These range from regulation in organismal interactions between parasitic fungi and their host plant, heavy metal stress and global control of natural product genes to conidiation and regulation through RNA interference. Two chapters are dedicated to signal transduction, highlighting MAP-kinase-dependent signaling and heterotrimeric G-proteins. Fungal carbohydrates are the subject of the third section, which addresses both polymeric cell wall carbohydrates and trehalose as an important, low molecular weight carbohydrate. The fourth section emphasizes the metabolism of major elements (carbon, nitrogen, sulfur) and critical cellular pathways for primary and secondary products.

Fungal nanobionics has great prospects for developing new products with industrial, agriculture, medicine and consumer applications in a wide range of sectors. The fields of chemical engineering, agri-food, biochemical, pharmaceuticals, diagnostics and medical device development all employ fungal products, with fungal nanomaterials currently used in a wide range of applications, ranging from drug development to food industry and agricultural sector. The fungal agents emerge as an environmentally friendly, clean, non-toxic agent for the biogenic metal nanoparticles and employs both intracellular and extracellular methods. The simplicity of scaling up and downstream processing and the presence of fungal mycelia affording an increased surface area provide key advantages. In addition, the larger spectrum of synthesized nanoparticle morphologies and the substantially faster biosynthesis rate in cell-free filtrate (due to the higher amount of proteins secreted in fungi) make this a particularly enticing route. Understanding the diversity of fungi in assorted ecosystems, as well as their interactions with other microorganisms, animals and plants, is essential to underpin real and innovative technological developments and the applications of metal nanoparticles in many disciplines including agriculture, catalysis, and biomedical biosensors. Importantly, biogenic fungal nanoparticles show significant synergistic characteristics when combined with antibiotics and fungicides to offer substantially greater resistance to microbial growth and applications in nanomedicine ranging from topical ointments and bandages for wound healing to coated stents.

This is the fourth updated and revised edition of a well-received book that emphasises on fungal diversity, plant productivity and sustainability. It contains new chapters written by leading experts in the field. This book is an up-to-date overview of current progress in mycorrhiza and association with plant productivity and environmental sustainability. The result is a must hands-on guide, ideally suited for agri-biotechnology, soil biology, fungal biology including mycorrrhiza and stress management, academia and researchers. The topic of this book is particularly relevant to researchers involved in mycorrhiza, especially to food security, plant microbe interaction and environmental protection. Mycorrhizas are symbioses between fungi and the roots of higher plants. As more than 90% of all known species of plants have the potential to form mycorrhizal associations, the productivity and species composition and the diversity of natural ecosystems are frequently dependent upon the presence and activity of mycorrhizas. The biotechnological application of mycorrhizas is expected to promote the production of food while maintaining ecologically and economically sustainable production systems.

This volume describes the more relevant secondary metabolites of different fungi with current information on their biosynthesis and molecular genetics. Bolstered with color illustrations and photographs, the book describes the possible application of molecular genetics to directed strain improvement in great detail. The needs for future developments in this field are also discussed at length

Written by authorities in the field, "Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites" provides a cutting-edge perspective on fungal secondary metabolism and underlying genetics and is a valuable resource for scientists, researchers, and educators in the field of fungal biology.