This book is an excellent summary of contemporary knowledge of the clinical pathogenesis and manifestations of hypoxic-ischemic encephalopathy and birth asphyxia.

This text presents a state-of-the-art review of asphyxial brain injury to the fetus and new born, a leading source of both neonatal mortality and long-term neurologic disability. Beginning with an historical overview of birth-related injury, followed by an epidemiologic review of the relationship of birth injury to later neuromotor disability, it provides a detailed analysis and exhaustive review of each aspect. The contributors are among the most knowledgeable international authorities in the field; they have synthesized a uniformity of medical and scientific quality, clarity of style, and thoroughness of scope. Continual emphasis is placed on the material's relevance and usefulness to clinicians; equally important is the emphasis on communication between clinicians and basic neuroscientists.

The book's first section provides an overview of the history and epidemiology of birth-related brain injury and its relationship to later neuromotor disability. The next section examines mechanisms of injury from a cellular and molecular perspective, including: and examination of the neurotoxic cascade; cytokine-mediated brain damage; the roles of glucose and acidsosis on neuronal injury; cerebral energy depletion; apoptosis and necrosis; the roles of neuronal and vascular nitric oxide; and free radical-mediated processes. The following section deals with clinical birth asphyxia, and includes chapters on prenatal injury, intrapartum injury, clinical management, neuroimaging, and hypothermia as a potential intervention. The lastsection discusses the medico-legal aspects of asphyxial brain injury. Throughout the various chapters, the authors have preserved the important context of normal development, with an emphasis on the need for fundamental pathogenetic data, to allow for rational approaches to prevention and treatment.

The task of paediatricians and neonatologists in coming years will be to better understand the mechanism of brain damage, the prediction of disability, and the introduction of efficacious neuroprotective strategies. To that end, this volume deserves wide recognition by physicians in all disciplines related to neonatal care, including paediatricians, neonatologists, neurologists, obstetricians, family practitioners, nurses and legal counsel.

Clinics in Developmental Medicine No. 190Fourth edition of the most comprehensive examination of newborn behavior availableWell established and used globally as a research instrument and in clinical practiceCase studies from a range of disciplines and settings enrich this editionNew administration guidelines and refined scoring criteria for researchers and clinicians

The Neonatal Behavioral Assessment Scale (NBAS) is the most comprehensive examination of newborn behaviour available today and has been used in clinical and research settings around the world for more than 35 years. The scale assesses the newborn's behavioral repertoire with 28 behavioral items and also includes an assessment of the infant's neurological status on 20 items. The NBAS items cover the following domains of neonatal functioning: autonomic regulation; motor organization; state organization and regulation and attention/social interaction.
The first part of this new edition book describes in detail the procedures involved in administering and scoring the NBAS. This is followed by chapters setting the assessment in the context of psychological influences around birth, the relationship between the examiner, infant and parents, and what we know about newborn motor behaviour. After a chapter on the use of the NBAS in research settings, the final part comprises descriptions by professionals around the world of its use in clinical practice.

Since the time it was first published, the NBAS has been used in hundreds of studies to examine the effects of a wide range of pre- and perinatal variables. This new edition therefore contains an updated review of research using the NBAS. Because the NBAS is being used increasingly as a way of promoting a positive relationship between parent and child, the new edition also includes new guidelines for clinicians. New guidelines and numerous refinements in the administration and scoring have now been added, and a section describing advances in our understanding of motor behaviour has been added. Finally, new chapters present the uses of the NBAS in a range of contexts around the world, highlighting the wide range of research and clinical applications of the NBAS.

Readership:
Paediatricians, neonatologists, all those involved in the examination of the newborn infant including, for example, nurses, psychologists, infancy specialists, lactation consultants, home visitors, occupational therapists, physical therapists, early intervention specialists, social workers and other allied health professionals (all of whom attend NBAS training courses)

This book constitutes the refereed proceedings of the First International Workshop on Perinatal, Preterm and Paediatric Image Analysis, PIPPI 2022, held in conjunction with the 25th International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2022, in Singapore, Singapore, in September 2021. The 10 full papers and 1 short papers presented at PIPPI 2022 were carefully reviewed and selected from 12 submissions. PIPPI 2022 workshop complements the main MICCAI conference by providing a focused discussion of perinatal and paediatric image analysis, including the application of sophisticated analysis tools to fetal, neonatal and paediatric imaging data.

Major advances in the diagnosis and treatment of oral clefts have been made in the past 50 years, and recent genetics and epidemiological studies have led to new theories about the causes of cleft lip and palate. Addressing issues that are relevant to clinicians, researchers and family members, this book is a comprehensive, well-illustrated, and up-to-date account of the many facets of this common disorder. The authors describe the embryological and molecular mechanisms of cleft causation, present and illustrate the genetic and epidemiological methods used to identify risk factors for oral clefts, and describe treatments by the various professionals of the cleft team. A section is also devoted to the integration of research findings into public health practice, including ethical and financial considerations. The book draws together such diverse disciplines as craniofacial development, gene mapping, epidemiology, medicine, ethics, health economics, and health policy and management, and it will be an invaluable reference work.

A must-have reference for the entire NICU, Goldsmith's Assisted Ventilation of the Neonate, 7th Edition, is the only fully comprehensive, evidence-based guide to all aspects of this fast-changing field. Easy to use and multidisciplinary in scope, this trusted reference provides authoritative guidance on contemporary management of neonatal respiratory diseases, with an emphasis on evidence-based pharmacologic and technologic advances that improve outcomes and quality of life in newborns. It's an outstanding resource for neonatologists and NICU professionals to acquire new knowledge and techniques in this critical area of neonatal care. Covers all aspects of both basic and advanced respiratory management of neonates: general principles and concepts; assessment, diagnosis and monitoring methods; therapeutic respiratory interventions; adjunctive interventions; and special situations and outcomes. Provides updated content on rapidly changing technology and guidelines for assisted ventilation, with up-to-date descriptions of bedside methodologies and the rationale for providing all types of ventilator care in infants. Contains new chapters on respiratory gas conditioning, diagnosis and management of PPHN, care of the infant with CDH, gaps in knowledge, and future directions. Includes significant updates on cardiovascular assessment and management, as well as complications of respiratory support. Provides extensive, full-color visual support with photographs, drawings, charts and diagrams, and radiographic images throughout. Features more than 30 appendices that help you quickly find normal values, assessment charts, ICU flow charts, procedure steps and other useful, printable forms. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Written by a multidisciplinary team of medical and nursing experts, this fully-updated second edition provides evidence-based coverage of all frequently seen neonatal conditions. Divided into chapters based on body-systems, each section includes discussion of relevant embryology, anatomy and physiology.

Designed for real-life practice in the ward, each chapter includes clear guidelines for procedure and discussion of best practice. Case studies are used throughout to aid discussion of specific equipment, conditions, and situations.

An essential resource for neonatal nursing and midwifery students, as well as practicing neonatal nurses, this acclaimed text may also be of use to junior doctors beginning neonatology.Evidence-based theory clearly linked to application in the ward with case studies throughoutProcedure and equipment guidelines included, with specific recommendations for practiceAccessible format designed for easy reading and referenceHighly illustrated with relevant diagrams and pictures

Neural tube defects, spina bifida, anencephalus, and encephalocoele, are among the commonest severe congenital abnormalities in most countries. The last decade has seen many advances, including the use of antenatal diagnosis by chemical and ultrasound methods, population screening, and many new findings in epidemiology, culminating in the demonstration of the protective effect of folic acid on recurrences. The progress in both antenatal diagnosis and in aetiological research on neural tube defects has been particularly dramatic, and may well anticipate developments in regard to other congenital abnormalities. Primary prevention now appears as an attainable goal. This book presents a critical review of the extensive findings of epidemiological studies, discusses several methodological issues of wider relevance such as ascertainment, seasonal variation, ethical and legal issues. As well as providing a unique resource in regard to neural tube defects, much of the material is relevant to those with wider interests in the prevention, antenatal diagnosis, and control of major diseases.

Placenta accreta comprises a spectrum of disorders where all or part of the placenta becomes attached to the muscular wall of the uterus, which can result in life-threatening hemorrhage at the time of delivery. Previous surgical procedures (including cesarean delivery) and placenta previa are important risk factors, and the incidence is dramatically increasing. This important practical guide to how clinicians should diagnose and manage placenta accreta will be an invaluable reference for all obstetricians and maternal-fetal specialists.

This book analyzes the effects of parental smoking on all aspects of reproduction and child development. With contributions from respected and authoritative specialists, it includes new research findings and new methods of data analysis, with particular emphasis on social class factors. The authors discuss how smoking affects placental, fetal, and child development. Important subjects covered include the relationships between smoking and pre-eclampsia, ectopic pregnancy. Sudden Infant Death Syndrome, and respiratory disease in children. The final chapters discuss research related to health education and the prevention of maternal smoking. This comprehensive volume will be of interest to obstetricians, pediatricians, epidemiologists, and those involved in public health medicine.

This 2006 handbook of neonatal endocrinology provides a wealth of practical information on the diagnosis and management of suspected endocrine pathology. Interpretation of endocrine function in the newborn period can be difficult, because of the transition following hormonal influences of the mother and placenta. The situation is even more complex in infants born prematurely. The unique format presented here is clinically orientated from presentation, diagnosis and management, including immediate, medium and long-term. It clearly explains and describes how and when samples should be taken, order of priority, sample volumes required, length of time one can expect before results are available and normal values. This book gives guidance as to what to tell parents, providing addresses of support groups. This is very much a practical 'hands-on, how-to' approach with flow-charts. It also provides a formulary and investigation methodology section and a brief description of physiology.

Newborn babies are examined at around 6 to 72 hours after their birth to rule out major congenital abnormalities and reassure the parents that their baby is healthy. This practical text is a step-by-step guide for all practitioners who undertake this clinical examination. It is particularly valuable for midwives and nurses undertaking Examination of the Newborn modules as well as a useful reference work for those already performing this role. It provides midwives and other practitioners involved in neonatal examination with a comprehensive guide to the holistic examination of the newborn infant. Examination of the Newborn encourages the reader to view each mother and baby as unique, taking into account their experiences preconceptually, antenatally and through childbirth. The text covers: * the role of the first examination as a screening tool; * normal fetal development; * parents' concerns and how to respond to them; * the impact of antenatal diagnostic screening; * the events of labour and birth; * the clinical examination of the neonate; * the identification and management of congenital abnormalities; * accountability and legal issues. This new edition is thoroughly revised throughout to meet current Nursing and Midwifery Council (NMC), General Medical Council (GMC) and National Screening Committee standards. It reflects the new standards and key performance indicators (KPIs) from Public Health England (2016b). Case scenarios, model answers, questions and further reading help the reader to apply the content to their own practice.

It has been close to six decades since Watson and Crick discovered the structure of DNA and more than ten years since the human genome was decoded. Today, through the collection and analysis of a small blood sample, every baby born in the United States is screened for more than fifty genetic disorders. Though the early detection of these abnormalities can potentially save lives, the test also has a high percentage of false positives-inaccurate results that can take a brutal emotional toll on parents before they are corrected. Now some doctors are questioning whether the benefits of these screenings outweigh the stress and pain they sometimes produce. In Saving Babies?, Stefan Timmermans and Mara Buchbinder evaluate the consequences and benefits of state-mandated newborn screening - and the larger policy questions they raise about the inherent inequalities in American medical care that limit the effectiveness of this potentially life - saving technology. Drawing on observations and interviews with families, doctors, and policy actors, Timmermans and Buchbinder have given us the first ethnographic study of how parents and geneticists resolve the many uncertainties in screening newborns. Ideal for scholars of medicine, public health, and public policy, this book is destined to become a classic in its field.

The definitive guide to sonography in obstetrics and gynecology-thoroughly updated and enhanced by the addition of teaching cases This acclaimed guide is a clinically relevant reference text, an atlas, and a teaching/learning resource. Presented in full color and enriched by more than 2,000 illustrations, it expertly examines the full spectrum of disorders and conditions likely to be encountered in gynecologic and maternal-fetal care. You will find expert, all-inclusive coverage of everything from sonographic operating instruments and screening the fetal patient for syndromes and anomalies, to diagnosing the female patient for cysts, infertility, and incontinence. This edition has been updated to include coverage of the latest procedures and diagnostic guidelines for the use of sonography in ob/gyn, including 3D and 4D US and enhanced image processing, contrast enhanced sonography, ultrasound guided fetal therapy, sonographic evaluation of pelvic pain, and much more. The Eighth Edition also features an extensive series of teaching cases. Each case consists of the patient's medical history, representative US images, cineloop videos, Q&A, and teaching points with references. Fleischer's Sonography in Obstetrics & Gynecology, Eighth Edition opens with general obstetric sonography, covering such pivotal topics as normal pelvic anatomy and fetal echocardiography, before moving into fetal anomalies and disorders. Risk assessment and therapy, including first trimester screening and amniocentesis, are explored in the next section, while the remaining parts of the book focus on maternal disorders, gynecologic sonography, and the newest complementary imaging modalities.

This study examines the organization of social responsibility in the USA, in particular of critically ill newborn children. Drawing on medical records and interviews with parents and medical staff, the book investigates two neonatal intensive care units, showing the traumas of extreme medical measures, and the sufferings of infants. The accounts are by turns disturbing and heroic, as parents and staff attempt to take charge of the infants' care, redefining their roles as adults and parents, and coping with sometimes awful contingencies. Rather than treating responsibility as an ethical issue, the book focuses on how responsibility is socially produced and sustained. It questions how staff members encourage parents to take responsibility, but keep them from interfering in medical matters, and how parents encourage staff vigilance when they are novices attempting to supervise the experts. The authors conclude that it is not sufficient simply to be responsible individuals. Instead, people must learn to be responsible in an organizational world, and organizations must learn how to support responsible individuals.

Every year in the United States, 12 per cent of all births are preterm births, 5 per cent of all babies need help to breathe at birth, and 3 per cent of neonates are born with at least one severe malformation. Many of these babies are hospitalized in a neonatal intensive care unit. Annie Janvier and her husband, Keith Barrington, are both pediatricians who specialize in the care of these sick babies and are internationally known for their research in this area. In 2005, when their daughter Violette was born extremely prematurely, four months before her due date, they faced the situation "from the other side" as parents. Despite knowing the scientific facts, they knew nothing about the experience itself. "Knowing how a respirator works did not help me be the mother of a baby on a respirator," writes Annie. She did not know how to navigate the guilt, the uncertainty, the fears, the predictions of providers, and the responses of friends and family. In a society obsessed with goals, performance, efficiency, and high percentages, she discovered that the daily lack of control that new parents of sick babies face changes their lives. And that, for physician parents, it also changes the way they practice medicine. Most of the articles and books written about premature babies and neonatal intensive care units examine the technological and medical aspects of neonatology. Breathe, Baby, Breathe!, however, is written in the voice of a parent-doctor and tells the story of Violette and her parents, alongside the stories of other fragile babies and their families with different journeys and different outcomes. With the story of Violette at the core of the book, the interwoven stories and empirical articles provide essential insights into the medical world of premature birth. This original and clever blend of narrative and evidence provides a new, experiential view of the way forward during a parental crisis.

Cancer in pregnancy, although thankfully a relatively uncommon occurrence, presents physicians and their patients with a major dilemma. The urge to use the highest tolerable doses of chemotherapy, high doses of irradiation and surgery has to be weighed carefully against their risks to the unborn baby. This book is the very first to attempt to quantify these risks and provide physicians with a core of knowledge that will be very relevant to making sound clinical decisions in the face of sometimes conflicting interests. The volume evaluates the results of the Motherisk Program, which was set up specifically to address this problem, and reviews maternal and fetal outcomes from a sizeable database of the most common cases of cancer in pregnancy. In reviewing this program and the experience of others in this area, this volume sets out to create a clinically relevant tool for oncologists, obstetrician-gynecologists, perinatologists and neonatologists.

I Medizinethische theoretische Voraussetzungen.- 1 Relevante Aspekte der Medizinethik.- 2 Philosophische Anthropologie und Ethik.- 3 Ethische Herausforderungen in der Frauenheilkunde durch moderne Technologien.- II Ethische Analyse medizinischer Praxis.- 4 Reproduktionsmedizin.- 5 Schwangerschaft um die Jahrtausendwende.- 6 Pranataldiagnostik und -therapie.- 7 Schwangerschaft und Geburt nach reproduktionsmedizinischen Interventionen.- 8 Schwangerschaftsabbruch in den deutschsprachigen Landern.- 9 Geburt um die Jahrtausendwende.- 10 Schwangerschaft bei hirntoter Mutter.- 11 Der Einfluss ethischen Denkens auf Gegenwart und Zukunft von Gynakologie und Geburtshilfe.- Anhang A: Begleitbroschure der Landesfrauenklinik Salzburg fur Eltern nach gluckloser Schwangerschaft.- Anhang B: Informationen zu gesetzlichen Regelungen und Erklarungen von offiziell gebrauchten Begriffen.- Anhang C: Gesetzestexte.- Fortpflanzungsmedizingesetz (FmedG).- Embryonenschutzgesetz (EschG).- Deutsches Strafgesetzbuch (StGB 218, 219).- OEsterreichisches Strafgesetzbuch (StGB 96-98).- Schweizerisches Strafgesetzbuch (StGB 119, 120).- Literatur.

The fourth edition of this popular resource features step-by-step skill instruction and practice-focused exercises covering maternal and fetal evaluation and immediate newborn care. Developed by a distinguished editorial board, the Perinatal Continuing Education Program (PCEP) is a comprehensive, self-paced education program in 4 volumes. This book features 8 units covering information and skills for obstetric evaluation and neonatal resuscitation (consistent with AAP guidelines) as well as units to provide the necessary information for initial stabilization of a newborn. The neonatal resuscitation unit has been updated to reflect the new NRP (R), 8th Edition, guidelines. TOPICS INCLUDE Is the Mother Sick? Is the Fetus Sick? Fetal Age, Growth, and Maturity Fetal Well-being Is the Baby Sick? Recognizing and Preventing Problems in the Newborns Pulse Oximetry Resuscitating the Newborn Gestational Age- and Size-Associated Risk Factors Thermal Environment Hypoglycemia Blood Glucose Screenings And more...

50 Studies Every Pediatrician Should Know presents key studies that have shaped the current clinical practice of pediatrics. Selected using a rigorous methodology, the studies cover topics including: allergy immunology, behavioral, cardiology, dermatology, endocrinology, ENT, general pediatrics, hematology, infectious disease, neonatology, nephrology, neurology, oncology, ophthalmology, orthopedics, and pulmonary. For each study, a concise summary is presented with an emphasis on the results and limitations of the study, and its implications for practice. An illustrative clinical case concludes each review, followed by brief information on other relevant studies. This is one of the only books of its kind to present a collection of the most influential clinical trials in pediatrics that are detailed enough to be used on rounds, but still easily digestible.

Lung disease affects more than 600 million people worldwide. While some of these lung diseases have an obvious developmental component, there is growing appreciation that processes and pathways critical for normal lung development are also important for postnatal tissue homeostasis and are dysregulated in lung disease. This book provides an authoritative review of fetal and neonatal lung development and is designed to provide a diverse group of scientists, spanning the basic to clinical research spectrum, with the latest developments on the cellular and molecular mechanisms of normal lung development and injury-repair processes, and how they are dysregulated in disease. The book covers genetics, omics, and systems biology as well as new imaging techniques that are transforming studies of lung development. The reader will learn where the field of lung development has been, where it is presently, and where it is going in order to improve outcomes for patients with common and rare lung diseases.

This pocket atlas explains how to use pulmonary graphics as a valuable adjunct for patient management. Actual patterns commonly encountered in neonatal practice are presented side-by-side with schematic illustrations that take apart the graphic and identify its key features, accompanied by brief explanatory text. The book addresses the principles of real-time pulmonary graphics, discusses waveforms and loops, and examines how both are affected by mechanical ventilation and disease states. A series of clinical cases brings key points to life.

Mental health problems during and immediately after pregnancy are a major concern across the world. As well as affecting the health of the mother, they can have significant, harmful, and long term effects on the infant if not dealt with effectively. Perinatal Psychiatry honours the work of Channi Kumar, one of the seminal figures in the history of perinatal psychiatry, and presents a comprehensive multidisciplinary review of the field. Bringing together the leading researchers in the area, it covers the causes of perinatal mental health problems, the biology of perinatal depression and its more extreme form, puerperal psychosis, as well as psychosocial and psychological interventions, hormonal and neural substrates of perinatal depression, and risk factors and epidemiology.

This book presents the latest evidence-based guidelines for perinatal management and is designed to help obstetricians and neonatologists minimize complications and offer patients the best possible care. Since 1960, there has been a significant increase in basic and clinical investigations on normal and pathological pregnancy in the developed world. This has provided insights into the physiopathology of pregnant women, fetuses and newborns and led to the development of new technologies, bringing about a new medical subspecialty: perinatal medicine. The book is divided into eight main sections: The first examines basic periconceptional care and discusses the ethical aspects of perinatology. The next section focuses on prenatal considerations, such as the nutritional aspects of gestation and puerperium, physical exercise during pregnancy, routine laboratory tests, prenatal care of multiple gestations and the role of the neonatologist in prenatal care. The third and fourth sections then explore fetal evaluation, and clinical intercurrences in pregnancy, respectively. The next section addresses pregnancy complications: prevention, diagnosis and management. The sixth section covers the basic aspects of congenital infections and the seventh examines labor and delivery aspects. Lastly, the final section includes chapters on neonatal assistance. Written by leading experts in obstetrics, neonatology, and perinatology, this thoroughly updated, comprehensive resource reflects the latest information in all areas, including genetics and imaging.

Caring for the well newborn is an essential element of everyday midwifery practice. Providing a comprehensive guide to the problems associated with newborn babies, Care of the Newborn by Ten Teachers is a key textbook for trainee midwives. The ten teachers involved in writing this book are drawn from all over the UK and bring together a wealth of experience in midwifery and neonatal nursing teaching and practice. The emphasis is on caring for the normal neonate, with deviations from the normal threaded throughout. Taking a holistic approach, each chapter links theory and practice, with explicit reference to professional standards and guidelines. As well as infant feeding, skin care and thernal care practice, this book covers signs and causes of common problems such as jaundice, infections, respiratory problems, and birth injury, providing care and treatment strategies for the neonate and family. This easy-to-follow full colour design, with superb diagrams and photographs and helpful features such as key points, case histories and chapters overviews, makes this essential reading for all student midwives, as well as those on post-qualifying courses in neonatal care. It is also a useful reference for practising midwives and neonatal nurses.