The Year Book of Neonatal and Perinatal Medicine brings you abstracts of the articles that reported the year's breakthrough developments in perinatology, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to the clinical management of your patients. There's no faster or easier way to stay informed! Chapters include The Fetus; Genetatics and Teratology; Respiratory Disorders; Infectious Diseases and Immunology; Cardiovascular System; Gastrointestinal Health and Nutrition; and Hematology, to name a few.

The impact of cardiovascular disease on an infant extends from the fetal period to well beyond childhood. Perinatalogists and neonatologists can impact maternal and fetal health through wide range of diagnostic modalities and interventional techniques. For our edition focused on cardiovascular health, we sought to encompass the breadth of knowledge that would be the most relevant for the bed side clinician. Our goal was to assemble contents that would allow a clinician to quickly peruse the journal, and then be prepared to make a medical decision. The interaction between cardiology and perinatology/neonatology includes genetics, diagnostics, interventions, counseling, routine stabilization and day to day care. Ultimately, the goal is to establish the foundation for a healthy adult. For this reason, we have even included chapters on topics that are significant on a day to day basis (such as the proper environment for a newborn) and a long term basis (like the overall neurodevelopmental impact of our interventions). Hopefully, whether in the middle of the night as an emergency reference or during the day as a reliable guide, this edition of Clinics in perinatology will be an important bedside tool for anyone that participates in the care of a patient with perinatal heart disease.

Bronchopulmonary dysplasia (BPD) as a chronic lung disease affecting preterm infants has been recognized for more than 45 years. However, little progress has been made in the prevention and treatment of the disease. BPD continues to be a major morbidity affecting preterm infants. Studies in pre-adolescent children demonstrate that the abnormal lung function from BPD persists well into childhood. Infants with BPD also have an increased risk for adverse neurodevelopmental outcome. Thus BPD imposes a significant burden of adverse health outcomes in preterm infants. The major risk factors for BPD are prematurity, mechanical ventilation, exposure to noxious insults such as oxygen, infections. New research data both in basic science and clinical studies have shed light on the pathogenesis, and possible new treatment or management strategies for the future. In the proposed issue of the Clinics in Perinatology, we would like to comprehensively cover BPD both from a basic science and clinical perspective. Our attempt is to balance new information along with classic topics. The proposed authors for the issue are recognized experts in the topic area/s. We hope that the issue will be of interest to a broad array of readership.

Recent advances in neonatal hematology, largely made by the authors of these chapters, are likely to generate wide spread and long-term improvements in outcomes, as well as reductions in costs of care. Publication of these advances in a single volume will facilitate dissemination of these techniques and practices. The advances include neuroprotection from erythropoietic stimulators, improved guidelines for platelet transfusions, evidence-based guidelines for FFP administration, improved diagnostic methods for genetic causes of severe neonatal jaundice, more accurate definitions of hematological perturbations in necrotizing enterocolitis and sepsis, and reduction in transfusions and in IVH rates by cord milking/delayed clamping.

In this issue the Guest Editors provide a contemporary look at the epidemiology, clinical manifestations, treatment and outcomes for neonatal-perinatal infections. Contributors include neonatologists, infectious disease, and critical care specialists with a wide variety of research interests in this arena. Readers will be exposed to the latest information on dosing of antibiotics, antivirals, and antifungals. This information is critical in the infant population given the rapid changes in physiology, metabolic pathways and renal elimination that occur over the first months of life. There is an extensive examination of infectious processes that commonly present in infants including meningitis, bloodstream infections, and urinary tract infections. Additional topics include infectious processes affecting the newborn (chorioamnionitis and TORCH infections) and premature infants (necrotizing enterocolitis). Specific pathogens are highlighted in articles on HSV, CMV/VZV, staphylococcal species, and Candida. Finally, the rationale for the most recent changes to guidelines for initiating therapy for early-onset neonatal sepsis are reviewed.

The Year Book of Neonatal and Perinatal Medicine brings you abstracts of the articles that reported the year's breakthrough developments in neonatal and perinatal medicine, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. There's no faster or easier way to stay informed! Chapters in this annual cover the most current information on all aspects of neonatal and perinatal medicine from genetics to labor and delivery to issues related to many key bodily systems (heart, respiratory, nervous system, etc.) of newborns. Other topics for 2004 include neurology, gastroenterology and nutrition, medical disorders of pregnancy, fetal evaluation, and neonatal behavior.

Over the past several decades, advances in neonatal nutrition have focused on the provision of early parenteral nutrition and the development of formulas and supplements that most closely approximate maternal breast milk. The overall outcomes for infants, including premature infants, have greatly benefited from these advances, but there are still many nutritional unknowns that impact the lives of neonates. This is an exciting time in neonatal nutrition as the focus has shifted from survival and growth, which are still important goals, to effects of each micro/macronutrient on development, prevention of disease states such as ROP, the effects of neonatal nutrition on future health as an adult, and opportunities to improve long-term neurodevelopmental outcomes by optimal early nutrition. This issue focuses on aspects of enteral and parenteral nutrition that are at the forefront of neonatal care: assessing growth, parenteral nutrition components (including alternate lipid formulations), optimal storage and use of human milk (including donor milk), post-discharge nutrition, and the effects of various micro/macronutrients on long-term developmental outcomes. It is anticipated that the study and implementation of many of these novel concepts into the care of neonates, many of whom are severely premature, will be of value to practitioners, researchers, and, most of all, patients.

This issue is expected to be in high demand, being extremely valuable to both neonatologists and maternal-fetal medicine physicians. The Guest Editors have put together a very comprehensive issue that looks at the premature infant. Topics include: Moderate Preterm. Late Preterm and Early Term Births: Epidemiology and Trends; Stillbirth Reduction Efforts and Impact on Early Births; Management of Indicated Early Term and Late Preterm Births; Physiological Underpinnings for Clinical Problems in Moderately Preterm, Late Preterm;Brain Maturation in the Second of Half of Pregnancy; Respiratory Disorders in Moderately Preterm, Late Preterm and Early Term Infants; Metabolic and Neurologic Issues in Moderately Preterm, Late Preterm and Early Term Infants; and Quality Initiatives Related to Moderately Preterm, Late Preterm and Early Term Births.

The application of neurophysiological examination techniques to the newborn infant has increased considerably in recent years. This book gives an up-to-date description of these techniques, and evaluates their importance in the care of newborn babies.

The Year Book of Neonatal and Perinatal Medicine brings you abstracts of the articles that reported the year's breakthrough developments in neonatal and perinatal medicine, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. There's no faster or easier way to stay informed Chapters in this annual cover the most current information on all aspects of neonatal and perinatal medicine from genetics to labor and delivery to issues related to many key bodily systems (heart, respiratory, nervous system, etc.) of newborns. Other topics for 2004 include neurology, gastroenterology and nutrition, medical disorders of pregnancy, fetal evaluation, and neonatal behavior.

Dr. Spitzer has created an issue devoted to the evidence-based pharmacologic care of the neonate. The issue opens with an important article on? A Quality Improvement Approach to Modifying Medication Use in the NICU. The expert authors he has secured have contributed articles in the areas of therapeutic drug monitoring, off-label use of medications in the NICU, antenatal and post-natal corticosteroids, antibiotics, antifungals, and antivirals, as well as bronchodilators and nitric oxide. Other articles also present evidence-based use of oxygen, dopamine, anesthetics and analgesics, and erythropoetin.

Topics include: MRI of the preterm and term neonate with hypoxic ischemic injury; MRI of neonatal infections; MRI of neonatal stroke; Neonates with seizures: What to consider, How to image?;? Metabolic diseases of the newborn; Fetal MRI: Imaging versus imagining?; Postmortum MRI: An alternative to autopsy?; MRI of spinal dysraphia: What to consider?; Diffusion Tensor Imaging of the neonatal spinal cord; How to prepare and care for a critical sick neonate in a MRI environment; Functional (BOLD) imaging of the newborn; Advanced functional MRI; Dedicated MR antennae for neonatal imaging; Shaken infant syndrome/ Imaging of child abuse; Congenital Cardiac Defects and MR guided planning of surgery; Congenital Cardiovascular Malformation: Non-invasive imaging; MR guided cardiovascular interventions in noenates and infants; Musculoskeletal imaging of the newborn.

The guest editors thoroughly examine prematurity for the perinatologist by supplying state-of-the art reviews on this topic.? Articles include: The integrated development of sensory organization; The normal sequence of sensory development in the fetus and newborn; The role of the limbic system in early development; The role of the olfactory system in early maternal orientation and feeding outcomes; Olfactory contributions to attachment and learning; The gustatory system in the newborn: implications for development of eating; The role of auditory development in early communication and attachment;?
The role of vision and state organization in early development; Epigenetic contributions to early developmental care; Supporting successful eating and growth; The scientific foundations for Kangaroo care;
The practice of individualized developmental care; and Designing environments for developmental care.

Drs. Fleischman and Iams present comprehensive review articles on the current state of science and medicine on the premature infant.The issue is divided into sections devoted to epidemiology, causes, outcomes, and controversies. Specific articles address stress, infection, inflammation, antenatal steroids, and ethical issues surrounding care at the edge of viability.

Delivery After Prior Cesarean is examined in the issue of Clinics in Perinatology, guest edited Drs. Mark Landon and Caroline Signore. Authorities in the field have come together to pen articles on topics such as Rising primary cesarean rates: VBAC vital statistics, Access to TOLAC, Medicolegal aspects of VBAC/TOL, Ethics, Midwifery and VBAC, Success rates and factors, Intrapartum management: induction, labor progression and monitoring, Uterine rupture: rates and prediction, Multiple repeat cesareans and the threat of placenta accrete, Maternal morbidity and mortality, Perinatal morbidity and mortality, and Long-term infant outcomes.

This issue of Clinics in Perinatology reviews Healthcare Associated Infections in the Neonatal Intensive Care Unit. Guest Editors Drs. Karen Fairchild and Richard Polin have assembled a panel of expert contributors to pen articles on Epidemiology and Risk Factors for NICU HAI: Genes and Environment; Strategies to Reduce NICU HAI: Line, Tube, and Hand Hygiene;? Candida in the NICU: Pros and Cons of Prophylaxis; MRSA in the NICU; New Concepts of Microbial Translocation in the Neonatal Intestine: Mechanisms and Prevention; Antibiotic Resistance in NICU Pathogens: Mechanisms, Clinical Impact, and Prevention; Biomarkers for LONS: Cytokines and Beyond; Heart Rate Variability: A Novel Physiomarker for Sepsis Detection in the NICU; Ventilator-Associated Pneumonia; Perinatal Infection and Prematurity; and Meningitis in Neonates: Bench to Bedside.

Early Onset Neonatal Sepsis is covered in this issue of Clinics in Perinatology, guest edited by Drs. Karen Fairchild and Richard Polin. Authorities in the field have come together to pen articles on Innate host defenses and risk for EONS, Group B streptococcus, Diagnosis and management of clinical chorioamnionitis, Molecular diagnostics of sepsis, Use of proteomics in the diagnosis of chorioamnionitis and neonatal sepsis, Adjunct laboratory tests in the diagnosis of EONS, Ureaplasma: role in diseases of prematurity, Meningitis in neonates, Adjunct immunologic therapies in neonatal sepsis, Pathophysiology and treatment of septic shock in neonates, and International perspective on EONS.

This issue of Clinics in Perinatology, guest edited by Drs. Alan Spitzer and Dan Ellsbury, examines Quality Improvement in Neonatal and Perinatal Medicine. The first part of the issue addresses Tools of Quality Improvement and includes articles on The Quality Chasm in Neonatal and Perinatal Medicine; Evaluating the Medical Evidence; The Vermont Oxford Network Database; The Pediatrix Clinical Data Warehouse; Role of Regional Collaboratives: The California Perinatal Quality Care Collaborative Model; A Primer on Quality Improvement Methodology; Using Statistical Process Control Methodology; Human Factors in Quality Improvement, Random Safety Audits, Root Cause Analysis, and Failure Mode and Effects Analysis; Collaboration Between Obstetricians and Neonatologists: Perinatal Safety Programs and Improved Clinical Outcomes; and Pay for Performance: A Business Strategy for Quality Improvement in Neonatal-Perinatal Medicine. The second part of this issue addresses Specific Applications of Documented Quality Improvement Methodology in Neonatal and Perinatal Medicine and includes articles on Delivery Room Intervention-Improving the Outcome, Reducing Retinopathy of Prematurity, Improving Breast Milk Use During and After the NICU Stay, Decreasing Catheter Related Bloodstream Infection, and Decreasing Bronchopulmonary Dysplasia.

Fetal Neurology is covered in this issue of Clinics in Perinatology, guest edited by Dr. Adre du Plessis. The genetic basis of normal brain development and its disorders is explored, including reviews on the prosencephalon, the cerebral cortex, and the cerebellum. Next, normal and abnormal circulatory support of the fetal brain is covered, with articles on normal fetal cerebral substrate supply, disorders of placental circulation and the fetal brain, and disorders of fetal circulation and the fetal brain. Toxic-metabolic causes of disturbed brain development is reviewed, including articles on primary disorders of metabolism and disturbed fetal brain development and maternal drug abuse and impaired fetal brain development. Next, a section on infectious-inflammatory causes of disturbed brain development includes articles on fetal viral infections and impaired brain development and fetal inflammation and impaired brain development. A section on disorders of labor and delivery covers fetal hypoxia insults and patterns of brain injury, the fetal heart rate response to hypoxia, and non-asphyxial hypoxic-ischemic brain injury during prolonged labor. The issue closes with a section on advances in fetal neurodiagnostic testing, including reviews on imaging the fetal brain, quantitative fetal heart rate techniques, and fetal magnetoencephalography for assessment of fetal neurologic function.

A concise clinical reference that facilitates the diagnosis of intrauterine and perinatally acquired infections was the goal in creating the Congenital and Perinatal Infections: A Concise Guide to Diagnosis. Information about the natural history, m- agement, and outcome of these infections is well detailed in many other sources and so has not been included. Rather, the focus of the book is diagnosis. The initial chapters provide general information about serological and nonserological assays that are used for the diagnosis of infections, and a chapter about the placenta includes details about histopathological findings that can be helpful with the diagnosis of congenital inf- tions. The remainder of the book is devoted to the diagnosis of specific congenital and/ or perinatal infections. As illustrated in the chapters about specific infections, the approach to diagnosis of a congenital or perinatally acquired infection in the neonate begins, when possible, with consideration and diagnosis of infection in the pregnant woman, knowledge of how the infection is transmitted, and the risk of that infection for the woman and her fetus or neonate. The possibility of congenital or perinatal infection in neonates is usually considered because of the diagnosis of, or concern about a s- cific infection in, a mother during pregnancy that can be transmitted to the neonate or because of clinical findings in the neonate at birth that suggest an infectious cause.

Here's a comprehensive, pocket-sized resource for the care of full-term newborns. It provides guidance on well-baby development, monitoring the newborn, non-acute disease management, patient education, and more. Concise and convenient, this is the perfect reference for anyone who cares for babies in the first hours of life. Presents cutting-edge chapters on prenatal diagnosis, screening, and genetics. Speeds information gathering with extensive charts and tables, procedures, laboratory observations and other essential data collected in appendices. Expedites access to vital information with a bulleted outline format. Offers relevant tables on cultural and religious considerations affecting care of the newborn. Enhances favorite figures to make visual information easier access. Adds Fast Facts, Pearls and Pitfalls and expert opinions to give you authority in a flash.

This is the ninth edition of a well-established, introductory text providing in-depth information on the care of the newborn, both normal and abnormal, full-term and pre-term, from minor to major abnormalities and illnesses. It provides an introduction to neonatology, concentrating on common conditions,for all health professionals concerned with care of the newborn.The concise, readable text facilitates the comprehension of content. The content is firmly evidence-based to ensure best practices. Key points listed throughout the text assist in learning and comprehension. Color photos illustrate important clinical conditions. Fully referenced to provide a current evidence base. Updated content reflects recent guidelines, developments in intensive care, pharmacology, and hepatitis C. A discussion of current issues includes vitamin K administration. Additional information is provided on the care of normal babies, including the parents' perspective. It provides an increased emphasis on the nursing/midwifery aspects.

Historically neither the health care system nor the government knew or wanted to know about SIDS. Bergman, who has worked with parents and with a small number of professionals, was president of the National SIDS Foundation (1972-77), got SIDS research into federal programs, and provided help for bereaved parents--counselling rather than jail. . . . This book is must reading for health care providers and for government health policymakers. It should be in all libraries. Rarely does a book offer so much insight into human need and into political medicine. Highly recommended. "Choice"

This is a very useful book that describes the valuable contribution that a dedicated public spirited pediatrician can make to promote the health of children in the United States. "JAMA"