Bronchopulmonary dysplasia (BPD) as a chronic lung disease affecting preterm infants has been recognized for more than 45 years. However, little progress has been made in the prevention and treatment of the disease. BPD continues to be a major morbidity affecting preterm infants. Studies in pre-adolescent children demonstrate that the abnormal lung function from BPD persists well into childhood. Infants with BPD also have an increased risk for adverse neurodevelopmental outcome. Thus BPD imposes a significant burden of adverse health outcomes in preterm infants. The major risk factors for BPD are prematurity, mechanical ventilation, exposure to noxious insults such as oxygen, infections. New research data both in basic science and clinical studies have shed light on the pathogenesis, and possible new treatment or management strategies for the future. In the proposed issue of the Clinics in Perinatology, we would like to comprehensively cover BPD both from a basic science and clinical perspective. Our attempt is to balance new information along with classic topics. The proposed authors for the issue are recognized experts in the topic area/s. We hope that the issue will be of interest to a broad array of readership.

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Recent advances in neonatal hematology, largely made by the authors of these chapters, are likely to generate wide spread and long-term improvements in outcomes, as well as reductions in costs of care. Publication of these advances in a single volume will facilitate dissemination of these techniques and practices. The advances include neuroprotection from erythropoietic stimulators, improved guidelines for platelet transfusions, evidence-based guidelines for FFP administration, improved diagnostic methods for genetic causes of severe neonatal jaundice, more accurate definitions of hematological perturbations in necrotizing enterocolitis and sepsis, and reduction in transfusions and in IVH rates by cord milking/delayed clamping.

In this issue the Guest Editors provide a contemporary look at the epidemiology, clinical manifestations, treatment and outcomes for neonatal-perinatal infections. Contributors include neonatologists, infectious disease, and critical care specialists with a wide variety of research interests in this arena. Readers will be exposed to the latest information on dosing of antibiotics, antivirals, and antifungals. This information is critical in the infant population given the rapid changes in physiology, metabolic pathways and renal elimination that occur over the first months of life. There is an extensive examination of infectious processes that commonly present in infants including meningitis, bloodstream infections, and urinary tract infections. Additional topics include infectious processes affecting the newborn (chorioamnionitis and TORCH infections) and premature infants (necrotizing enterocolitis). Specific pathogens are highlighted in articles on HSV, CMV/VZV, staphylococcal species, and Candida. Finally, the rationale for the most recent changes to guidelines for initiating therapy for early-onset neonatal sepsis are reviewed.

1 Zur Geschichte der Gynakopathologie.- 2 Entwicklung des Uterus, der Scheide und des ausseren Genitales.- 3 Entwicklungsstoerungen.- 4 Vulva.- 5 Vagina.- 6 Uterus.- 7 Zervix: Physiologie und Anatomie.- 8 Zervizitis (und Zervikovaginitis).- 9 Proliferations- und Reifungsstoerung der Portio und Metaplasiezone.- 10 Proliferations- und Reifungsstoerung im Zervixdrusenfeld.- 11 Tumorartige Lasionen der Ektozervix und des Zervixdrusenfeldes.- 12 Benigne Tumoren der Zervix.- 13 Dysplasien und Neoplasien des Plattenepithels der Zervix.- 14 Zervixkarzinom.- 15 Zervixmetastasen.- 16 Lymphome.- 17 Granulozytare Sarkome.- 18 Spezielle Tumoren des Kindesalters und junger Frauen.- 19 Endokrinologie, Orthologie, Funktionsdiagnostik und funktionelle Stoerungen des Endometriums.- 20 Endometritis.- 21 Endometriummetaplasie.- 22 Endometriumpolyp.- 23 Endometriumhyperplasie.- 24 Endometriumkarzinom.- 25 Metastasen des Uteruskoerpers.- 26 Mesenchymale Tumoren und verwandte Lasionen.- 27 Funktionelle Morphologie und Pathologie des Myometriums.- 28 Gefasse: Anatomie und Pathologie.- 29 Parakolpium, Parametrium, pelviperitoneales Weichgewebe.

The Year Book of Neonatal and Perinatal Medicine brings you abstracts of the articles that reported the year's breakthrough developments in neonatal and perinatal medicine, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. There's no faster or easier way to stay informed! Chapters in this annual cover the most current information on all aspects of neonatal and perinatal medicine from genetics to labor and delivery to issues related to many key bodily systems (heart, respiratory, nervous system, etc.) of newborns. Other topics for 2004 include neurology, gastroenterology and nutrition, medical disorders of pregnancy, fetal evaluation, and neonatal behavior.

Over the past several decades, advances in neonatal nutrition have focused on the provision of early parenteral nutrition and the development of formulas and supplements that most closely approximate maternal breast milk. The overall outcomes for infants, including premature infants, have greatly benefited from these advances, but there are still many nutritional unknowns that impact the lives of neonates. This is an exciting time in neonatal nutrition as the focus has shifted from survival and growth, which are still important goals, to effects of each micro/macronutrient on development, prevention of disease states such as ROP, the effects of neonatal nutrition on future health as an adult, and opportunities to improve long-term neurodevelopmental outcomes by optimal early nutrition. This issue focuses on aspects of enteral and parenteral nutrition that are at the forefront of neonatal care: assessing growth, parenteral nutrition components (including alternate lipid formulations), optimal storage and use of human milk (including donor milk), post-discharge nutrition, and the effects of various micro/macronutrients on long-term developmental outcomes. It is anticipated that the study and implementation of many of these novel concepts into the care of neonates, many of whom are severely premature, will be of value to practitioners, researchers, and, most of all, patients.

The 16 articles in this issue draw on the expertise of internationally recognized experts who have collectively provided cross-cutting reviews with a broad perspective on the current state of the field. The authors have provided succinct, up-to-date clinical perspectives and highlight current controversies and future challenges. As a result, this issue is a cutting-edge compendium of this complex and fast-moving field. Throughout the issue, the reader is encouraged to acquire a more comprehensive perspective by drawing connections between earlier and later articles that are thematically grouped around issues dealing with pathogenesis, diagnosis, and therapy. This issue underscores the vital importance of continued support to encourage and nurture collaboration among clinicians and scientists.

This issue is expected to be in high demand, being extremely valuable to both neonatologists and maternal-fetal medicine physicians. The Guest Editors have put together a very comprehensive issue that looks at the premature infant. Topics include: Moderate Preterm. Late Preterm and Early Term Births: Epidemiology and Trends; Stillbirth Reduction Efforts and Impact on Early Births; Management of Indicated Early Term and Late Preterm Births; Physiological Underpinnings for Clinical Problems in Moderately Preterm, Late Preterm;Brain Maturation in the Second of Half of Pregnancy; Respiratory Disorders in Moderately Preterm, Late Preterm and Early Term Infants; Metabolic and Neurologic Issues in Moderately Preterm, Late Preterm and Early Term Infants; and Quality Initiatives Related to Moderately Preterm, Late Preterm and Early Term Births.

The Guest Editors have assembled well published authors to present state-of-the-art clinical reviews devoted to resuscitation of the newborn and fetus. Articles are devoted to the following topics: fetal/intrauterine compromise; Cellular biology of end organ injury and strategies to prevent end organ injury; Role of oxygen in the DR; DR management of meconium stained infant; Role of medications in neonatal resuscitation; Delayed cord clamping; Post-resuscitation management; HIE and novel strategies for neuroprotection; Physiology of transition from intrauterine to extrauterine life; Resuscitation of preterm infants: Special considerations; Chest compressions and dysrhythmias in neonates; Resuscitation of infants with prenatally diagnosed anomalies; Ethical issues in neonatal resuscitation; Training programs in neonatal resuscitation: The Neonatal Resuscitation Program and Helping Babies Breathe; and Future of neonatal resuscitation.

The Year Book of Neonatal and Perinatal Medicine brings you abstracts of the articles that reported the year's breakthrough developments in neonatal and perinatal medicine, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. There's no faster or easier way to stay informed Chapters in this annual cover the most current information on all aspects of neonatal and perinatal medicine from genetics to labor and delivery to issues related to many key bodily systems (heart, respiratory, nervous system, etc.) of newborns. Other topics for 2004 include neurology, gastroenterology and nutrition, medical disorders of pregnancy, fetal evaluation, and neonatal behavior.

The application of neurophysiological examination techniques to the newborn infant has increased considerably in recent years. This book gives an up-to-date description of these techniques, and evaluates their importance in the care of newborn babies.

Dr. Spitzer has created an issue devoted to the evidence-based pharmacologic care of the neonate. The issue opens with an important article on? A Quality Improvement Approach to Modifying Medication Use in the NICU. The expert authors he has secured have contributed articles in the areas of therapeutic drug monitoring, off-label use of medications in the NICU, antenatal and post-natal corticosteroids, antibiotics, antifungals, and antivirals, as well as bronchodilators and nitric oxide. Other articles also present evidence-based use of oxygen, dopamine, anesthetics and analgesics, and erythropoetin.

More than half a million babies in the US are born prematurely every year - preterm birth is the leading cause of infant mortality and those who survive may face lifelong problems.? This issue of the Obstetrics and Gynecology Clinics discusses the epidemiology, outcomes and clinical prediction of preterm birth, and offers information on various therapies.

The Year Book of Neonatal and Perinatal Medicine brings you abstracts of the articles that reported the year's breakthrough developments in neontatology and perinatology, carefully selected from more than 500 journals worldwide. Dr. Avroy Fanaroff, Emeritus Professor as Case Western Reserve University, is a key opinion leader who has been a driving force in the field for many years. He authors many commentaries himself and has assembled top experts to select the most important journal articles and write commentaries that evaluate the clinical importance of each article and discuss its application to patient care. There's no faster or easier way to stay informed! This annual covers all aspects of care from the fetus, postnatal growth, labor and delivery, infectious diseases, respiratory disorders, cardiovascular health, and gastrointestinal health to name a few. The Year Book of Neonatal and Perinatal Medicine publishes annually in November.

Topics include: MRI of the preterm and term neonate with hypoxic ischemic injury; MRI of neonatal infections; MRI of neonatal stroke; Neonates with seizures: What to consider, How to image?;? Metabolic diseases of the newborn; Fetal MRI: Imaging versus imagining?; Postmortum MRI: An alternative to autopsy?; MRI of spinal dysraphia: What to consider?; Diffusion Tensor Imaging of the neonatal spinal cord; How to prepare and care for a critical sick neonate in a MRI environment; Functional (BOLD) imaging of the newborn; Advanced functional MRI; Dedicated MR antennae for neonatal imaging; Shaken infant syndrome/ Imaging of child abuse; Congenital Cardiac Defects and MR guided planning of surgery; Congenital Cardiovascular Malformation: Non-invasive imaging; MR guided cardiovascular interventions in noenates and infants; Musculoskeletal imaging of the newborn.

The guest editors thoroughly examine prematurity for the perinatologist by supplying state-of-the art reviews on this topic.? Articles include: The integrated development of sensory organization; The normal sequence of sensory development in the fetus and newborn; The role of the limbic system in early development; The role of the olfactory system in early maternal orientation and feeding outcomes; Olfactory contributions to attachment and learning; The gustatory system in the newborn: implications for development of eating; The role of auditory development in early communication and attachment;?
The role of vision and state organization in early development; Epigenetic contributions to early developmental care; Supporting successful eating and growth; The scientific foundations for Kangaroo care;
The practice of individualized developmental care; and Designing environments for developmental care.

Drs. Fleischman and Iams present comprehensive review articles on the current state of science and medicine on the premature infant.The issue is divided into sections devoted to epidemiology, causes, outcomes, and controversies. Specific articles address stress, infection, inflammation, antenatal steroids, and ethical issues surrounding care at the edge of viability.

A concise clinical reference that facilitates the diagnosis of intrauterine and perinatally acquired infections was the goal in creating the Congenital and Perinatal Infections: A Concise Guide to Diagnosis. Information about the natural history, m- agement, and outcome of these infections is well detailed in many other sources and so has not been included. Rather, the focus of the book is diagnosis. The initial chapters provide general information about serological and nonserological assays that are used for the diagnosis of infections, and a chapter about the placenta includes details about histopathological findings that can be helpful with the diagnosis of congenital inf- tions. The remainder of the book is devoted to the diagnosis of specific congenital and/ or perinatal infections. As illustrated in the chapters about specific infections, the approach to diagnosis of a congenital or perinatally acquired infection in the neonate begins, when possible, with consideration and diagnosis of infection in the pregnant woman, knowledge of how the infection is transmitted, and the risk of that infection for the woman and her fetus or neonate. The possibility of congenital or perinatal infection in neonates is usually considered because of the diagnosis of, or concern about a s- cific infection in, a mother during pregnancy that can be transmitted to the neonate or because of clinical findings in the neonate at birth that suggest an infectious cause.

Here's a comprehensive, pocket-sized resource for the care of full-term newborns. It provides guidance on well-baby development, monitoring the newborn, non-acute disease management, patient education, and more. Concise and convenient, this is the perfect reference for anyone who cares for babies in the first hours of life. Presents cutting-edge chapters on prenatal diagnosis, screening, and genetics. Speeds information gathering with extensive charts and tables, procedures, laboratory observations and other essential data collected in appendices. Expedites access to vital information with a bulleted outline format. Offers relevant tables on cultural and religious considerations affecting care of the newborn. Enhances favorite figures to make visual information easier access. Adds Fast Facts, Pearls and Pitfalls and expert opinions to give you authority in a flash.

Historically neither the health care system nor the government knew or wanted to know about SIDS. Bergman, who has worked with parents and with a small number of professionals, was president of the National SIDS Foundation (1972-77), got SIDS research into federal programs, and provided help for bereaved parents--counselling rather than jail. . . . This book is must reading for health care providers and for government health policymakers. It should be in all libraries. Rarely does a book offer so much insight into human need and into political medicine. Highly recommended. "Choice"

This is a very useful book that describes the valuable contribution that a dedicated public spirited pediatrician can make to promote the health of children in the United States. "JAMA"

Intracranial haemorrhage affects more than one liveborn term infant in a hundred. The range of aetiologies has been expanded from trauma due to breech or instrumental delivery, to birth asphyxia, haemorrhagic diathesis, infection and prenatal injury. A shift towards diagnosis in life has been brought about by the application of ultrasound, CT and NMR imaging. Survival of most affected infants has encouraged neonatologists and paediatric radiologists to describe their findings in the past decade, yielding a wealth of data. Medico-legal implications surrounding delivery and neonatal care have increased the demand for thorough description of perinatal intracranial events.

Perinatal Programming addresses the environment-dependent setting of fundamental life functions and dispositions for diseases in developmental periods during pregnancy and in early infancy. It provides a new view of the origins of health and diseases. To realize these associations may enable us to prevent diseases for the long term.This book reviews actual state-of-the-art knowledge in the perinatal programming field. The authors are internationally known scientists of this research area.