Nearly 44 million people have Alzheimer's or related dementia worldwide, according to the Alzheimer's Disease International organization. That number is expected to double every 20 years. Unlike other books on the market, Alzheimer's Disease: Understanding Biomarkers, Big Data, and Therapy covers recent advancements in cognitive, clinical, neural, and therapeutic aspects of Alzheimer's and other forms of dementia. First, readers are introduced to cognitive and clinical studies, focusing on the different types of memory impairment, past and future thinking. This includes the prevalence of depression, its relationship to other symptoms, and the quality of life for those with Alzheimer's disease. In addition, the book discusses recent studies on memory dysfunction in advanced-stage Alzheimer's disease, in comparison to early-stage, including a chapter on the underlying factors in the transition from mild cognitive impairment to Alzheimer's diagnosis. Following this section, the book presents recent studies on the role of different cortical and subcortical structures in the development of various symptoms in Alzheimer's disease, as well as different neural biomarkers underlying the development and treatment of the disease. In the last section of the book, therapeutic aspects of Alzheimer's disease, focusing on behavioral and pharmacological treatments of sleep disorders, memory problems, and depression, are reviewed. The book aids readers in understanding the advances in research and care, making it a prime tool for all clinicians, psychologists, researchers, neurologists, and caregivers of dementia patients.

The contents are focused for the young budding intensivists and critical care students, but the book will surely be a useful bedside reference guide for anybody handling extracorporeal therapy in critically ill patients. The chapters are concise; discuss the techniques with diagrammatic representation, along with the management, with key points at the end of each chapter. It covers recent indications in the field of ECT like apheresis, ECMO for sepsis and eCPR, which may bring changes in the clinical practice of critical care physicians. This book will also help postgraduate students and young aspiring intensivists to prepare for various national and international examinations. It should be an invaluable resource for critical care professionals across the country. The book provides best practices in renal replacement therapy and extracorporeal membrane oxygenation in a comprehensive and practical. It has been divided into 2 sections comprising of 48 chapters covering clinical and practical aspects of extracorporeal therapy: including differences in pediatric population and separate MCQs chapters on RRT and ECMO for critical care students preparing for various exams. The individual sections provide expert guidance on managing critically ill patients on RRT and ECMO including the technical aspects of initiating the therapy and handling the machines. Newer usages of ECT for toxicology, Sepsis and Extracorporeal CO2 removal have been extensively highlighted as separate chapters. The book provides streamlined content supplemented by algorithms, checklists, tables, figures and key points at the end of each chapter for reference. Written by eminent experts in the field of Nephrology, Critical Care, Cardiac Anesthesia, the book is a nice blend of academic and clinical expertise. An ideal bedside reference guide for all intensivists, critical care physicians and students, ICU nurses, dialysis technicians and perfusionists managing patients on RRT and ECMO.

Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth.

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Advances in Pharmacology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Water containing significant amounts of inorganic and organic contaminants can have serious environmental consequences and serious health implications when ingested. Contamination of Water: Health Risk Assessment and Treatment Strategies takes an interconnected look at the various pollutants, the source of contamination, the effects of contamination on aquatic ecosystems and human health, and what the potential mitigation strategies are. This book is organized into three sections. The first section examines the sources of potential contamination. This includes considering the current scenario of heavy metal and pesticide contamination in water as well as the regions impacted due to industrialization, mining, or urbanization. The second section goes on to discuss water contamination and health risks caused by toxic elements, radiological contaminants, microplastics and nanoparticles, and pharmaceutical and personal care products. This book concludes with a section exploring efficient low-cost treatment technologies and remediation strategies that remove toxic pollutants from water. Contamination of Water incorporates both theoretical and practical information that will be useful for researchers, professors, graduate students, and professionals working on water contamination, environmental and health impacts, and the management and treatment of water resources.

The Practical Guide to Clinical Research and Publication provides a comprehensive overview of the key foundations of epidemiology, statistics and epidemiological studies. This book presents the most important terms and knowledge in the field from a medical point-of-view. Sections contain numerous, clinically-oriented examples and drawings to facilitate understanding and clarify the relation to clinic and practice. The book contains many graphics and key points for easier understanding and is written using bullet points for ease of use and comprehension. It is ideal for physicians and clinical researchers who want to use it as guidance for clinical research or teaching.