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Nearly one million people take their own lives each year world-wide - however, contrary to popular belief, suicide can be prevented. While suicide is commonly thought to be an understandable reaction to severe stress, it is actually an abnormal reaction to regular situations. Something more than unbearable stress is needed to explain suicide, and neuroscience shows what this is, how it is caused and how it can be treated. Professor Kees van Heeringen describes findings from neuroscientific research on suicide, using various approaches from population genetics to brain imaging. Compelling evidence is reviewed that shows how and why genetic characteristics or early traumatic experiences may lead to a specific predisposition that makes people vulnerable to triggering life events. Neuroscientific studies are yielding results that provide insight into how the risk of suicide may develop; ultimately demonstrating how suicide can be prevented.
This is the first comprehensive textbook on the use of MRI in psychiatry covering imaging techniques, brain systems and a review of findings in different psychiatric disorders. The book is divided into three sections, the first of which covers in detail all the major MRI-based methodological approaches available today, including fMRI, EEG-fMRI, DTI, and MR spectroscopy. In addition, the role of MRI in imaging genetics and combined brain stimulation and imaging is carefully explained. The second section provides an overview of the different brain systems that are relevant for psychiatric disorders, including the systems for perception, emotion, cognition, and reward. The final part of the book presents the MRI findings that are obtained in all the major psychiatric disorders using the previously discussed techniques. Numerous carefully chosen images support the informative text, making this an ideal reference work for all practitioners and trainees with an interest in this flourishing field.
The new edition of this essential revision book has been expanded and updated to include a wealth of new material, making it an excellent revision aid for dentistry students of all levels. Authored by experienced academics and organised by key subject areas, this book is the perfect tool to help build confidence and prepare for multiple choice question examinations. The new edition includes: - Over 400 questions - Subject-based chapters, providing a focused revision plan - detailed explanations for each answer overleaf - practical tips on MCQ exam technique
This text provides a comprehensive review for practicing pathologists to understand the molecular biology, diagnostics, and predictive markers and implications for therapy of uterine cancer. While molecular based therapeutic strategies for uterine cancer are not as well developed as for some other organ sites, these are the most common gynecologic malignancies and there have been many important recent developments that are discussed in this volume. Comprehensive chapters address essential information about endometrial carcinoma, uterine mesenchymal tumors, and cervical carcinoma and include the pathogenesis of carcinoma and discuss molecular based classification, biomarkers, therapy, prevention, and hereditary cancers of the uterus. Precision Molecular Pathology of Uterine Cancer is a unique and one of a kind resource for practicing pathologists, pathologists in training and gynecologists.
The new edition of Major Incident Medical Management and Support is a vital component in the blended learning course from Advanced Life Support Group (ALSG), which aims to provide hospital staff at all levels with essential information on the preparation, management and support elements of dealing with casualties in a major incident. Split into five sections, each focuses on the elements requisite in preparing for, and responding, to a major incident. The first section discusses the epidemiology and incidences of major incidents and the structured approach to the hospital response. The second section contains the preparation required in planning for major incidents, including equipment and training. The third section covers the management of a major incident, concentrating on the clinical, nursing and management hierarchies. The fourth includes the various stages of support in a major incident, including declaring an incident and activating the plan, the reception, triage, definitive care and recovery phases of an incident. The final section focuses on special incidents which require additional consideration, including those involving hazardous chemicals, burns and children. Written in collaboration with the National Emergency Planning, Major Incident Medical Management and Support is an invaluable reference in the emergency department and beyond for staff needing to prepare for the rare, but inevitable, hospital major incidence response.
The field of Dermatology is expanding at a rapid pace -- new research findings and advanced treatment technologies have amplified the need for concise and up-to-date information on this dynamic area of medicine. Dermatology at a Glance provides medical students and trainees with a clear introduction to dermatological practice. This valuable resource covers essential components of dermatology, from patient consultation and basic procedures to advanced treatments of skin disorders. Illustrated with over 300 high-quality slides and full-colour photographs, this book is an ideal reference for those seeking to interview and examine patients, identify and diagnose skin diseases, and develop treatment plans. Now in its second edition, Dermatology at a Glance offers revised coverage of the epidemiology, pathogenesis, and presentations of various skin disorders, and examines central aspects of the British Association of Dermatologists core curriculum. New chapters on topics such as dermoscopy, diagnostic methods for lesions and rashes, cosmetic dermatology, and drug reactions reflect current research and practices. Perfect for revision and quick consultation with its highly visual approach Eight brand new chapters, including hidradenitis suppurativa, itch, and systemic and topical drugs Accompanied by a companion site featuring self-assessment resources and an image bank Dermatology at a Glance is an indispensable resource for medical students, dermatology specialty and primary care trainees.
Atlas of Endocrine Pathology provides a comprehensive compendium of photomicrographs of common and uncommon entities in endocrine pathology. The volume includes histologic features of normal features, reactive conditions, hyperplasia, and tumors. The most helpful diagnostic features are illustrated to provide direction and clues to the diagnosis of endocrine tumors. Furthermore, photomicrographs highlight the most pertinent diagnostic features in problematic diagnoses in endocrine pathology. Authored by a nationally and internationally recognized pathologist, Atlas of Endocrine Pathology is an important learning tool for those becoming familiar with the diverse entities encountered in endocrine pathology and a valuable reference for practicing pathologists faced with challenging diagnoses in endocrine pathology.
When analyzing the results of diagnostic imaging studies, the radiologist traditionally makes reference to particular features representative of normality or pathology. Most of these features are associated with images of the world around us. This pictorial issue contains nearly 400 illustrations and descriptions of more than 100 classic radiological signs of chest and abdominal diseases that are not named after authors but based on metaphors derived from contemplation of our environment. By correlating the results of computed tomography with these vivid descriptive images, readers will be able to memorize typical and often pathognomonic patterns of disease more quickly and more easily. This book will be of value for both radiology residents and more experienced radiologists.
The second edition of this book has been extensively revised and updated. There have been numerous scientific advances in the radiology, pathology and risk assessment of benign breast lesions since the publication of the first edition. The first edition concentrated on screen-detected lesions, which has since been rectified; new symptomatic and screen-detected lesions are discussed in the second edition and include: mastitis and breast abscesses, idiopathic granulomatous mastitis, diabetic mastopathy, phyllodes tumours, gynaecomastia and pseudoangiomatous stromal hyperplasia. The chapters on columnar cell lesions and mucocele- like lesions have been extensively updated. Where applicable, genetic analysis of the benign lesions, which is becoming part of personalised medicine in the field of breast cancer, has been included. The book also presents detailed analyses of the main models, such as the Gail Model, used to assess the subsequent risk of breast cancer in individuals. The current trend in the management of all cancers is preventative. Screening mammography detects early curable cancers as well as indeterminate lesions, the latter of which are invariably pathologically benign. The author has collated important benign lesions and, based on peer-reviewed publications, has documented the relative risk of subsequent cancer to allow the patient and the clinician to implement preventative measures where possible. This book will therefore serve as an essential component of multidisciplinary management of patients with symptomatic and screen-detected benign breast lesions.
Dermatopathology is a specialized branch of pathology in which there has been great progress as new techniques have become available to evaluate the pathology of the skin. Many of the advances in our knowledge and understanding of the skin and the diseases that affect it have been made by people with experience of both diagnostic pathology and clinical dermatology. With significant numbers of large textbooks available, there is a need to provide practical clinical information and concise criteria for pathologic diagnosis for pathologists and dermatologists looking for up-to-date diagnostic and management options.
A masterful, high-yield guide to the treatment of substance abuse issues, The ASAM Essentials of Addiction Medicine equips you with the expert know-how you need to provide effective help for your patients. Derived from The ASAM Principles of Addiction Medicine, 5th Edition - widely hailed as the definitive comprehensive clinical reference in the field - this companion resource presents the collective wisdom of hundreds of esteemed authorities on the art and science of addiction medicine. Yet, it does so in a succinct format that will appeal to specialists seeking a more streamlined, quick-access reference source. Find the authoritative answers you need on everything from the pharmacology of addiction through diagnosis, assessment, and early intervention; various forms of addiction management...treatment of individual patient populations; management of intoxication and withdrawal; pharmacologic and behavioral interventions; recovery programs; medical disorders and complications...co-occurring addiction and psychiatric disorders; pain and addiction; children and adolescents; and ethical, legal, and liability issues. Contribute to public health in the area of addiction thanks to a special introductory chapter entitled "A Public Health Approach to Prevention: The Health Professional's Role." Easily switch back and forth between the ASAMEssentials and the parent text thanks to a parallel chapter organization. Zero in on the most important, practical information thanks to highly focused, efficient coverage. Maximize your understanding and retention of vital concepts with the aid of key points summaries, review questions, and suggested readings in each chapter. Now with the print edition, enjoy the bundled interactive eBook edition , offering tablet, smartphone, or online access to: Complete content with enhanced navigation A powerful search that pulls results from content in the book, your notes, and even the web Cross-linked pages , references, and more for easy navigation Highlighting tool for easier reference of key content throughout the text Ability to take and share notes with friends and colleagues Quick reference tabbing to save your favorite content for future use
For many people, taking some form of medication is part of everyday life, whether for mild or severe illness, acute or chronic disease, to target infection or to relieve pain. However for most it remains a mystery as to what happens once the drug has been taken into the body: how do the drugs actually work? Furthermore, by what processes are new drugs discovered and brought to market? An Introduction to Medicinal Chemistry, sixth edition, provides an accessible and comprehensive account of this fascinating multidisciplinary field. Assuming little prior knowledge, the text is ideal for those studying the subject for the first time. Part one of the book introduces the principles of drug action via targets such as receptors and enzymes. The book goes on to explore how drugs work at the molecular level (pharmacodynamics), and the processes involved in ensuring a drug meets its target (pharmacokinetics). Further sections cover the processes by which drugs are discovered and designed, and what has to happen before a drug can be made available to the public. The book concludes with a selection of current topics in medicinal chemistry, and a discussion of various key drug groups. The subject is brought to life throughout by engaging case studies highlighting particular drugs and the stories behind their discovery and development. The Online Resource Centre features: For students: * Multiple Choice Questions to support self-directed learning * Web articles describing recent developments in the field and further information on topics covered in the book * Journal Club to encourage students to critically analyse the research literature * Molecular Modelling Exercises, with new exercises in Chem3D * New assignments to help students develop data analysis and problem solving skills For registered adopters of the book: * A test bank of additional multiple-choice questions, with links to relevant sections in the book * Answers to end-of-chapter questions. * Figures from the book, ready to download. * Power Point slides to accompany every chapter in the book.
Prehospital care is a growing area in medicine, and emergency
treatments are becoming more sophisticated as the potential to save
The fourth edition of this ABC has been thoroughly updated and
includes new chapters on nuclear and biological emergencies.
Each chapter gives concise and clear guidance and is accompanied
by excellent photographs and diagrams.
Edited and written by leading UK trauma authorities, this is a truly comprehensive and practical book for everyday use by emergency medicine staff, nurses, hospital doctors, paramedics, and ambulance services.
The aims and scope of this atlas include a complete review of the embryology of the normal heart, the normal cardiac anatomy along with a complete discussion of the terms and definitions used to identify and clarify both normal and abnormal anatomy. In addition, techniques of cardiac CT angiography as it pertains to imaging congenital abnormalities are discussed including radiation concepts and radiation saving techniques. The bulk of this book then goes on to completely review the field of adult congenital heart disease using text and more importantly a multitude of pictorial examples (in color and grey scale) to demonstrate the abnormalities. Drawings accompany each picture to better explain the example. Furthermore, difficult and complex anatomical examples are supplemented with digital images and movies to aid in illustrating and understanding the anatomy. Each general set of anomalies as well as each specific abnormality or set of abnormalities includes a concise and simple review of the embryology and epidemiology of the abnormality as well as a concise explanation of the anatomy of the abnormality. In addition, the methods to identify and recognize the abnormality by computed tomography is discussed. Finally, the prognosis and common treatment options for the anomaly are addressed within this comprehensive book.
An illustrated guide to oral and maxillofacial surgery, written by dental nurses for dental nurses Basic Guide to Oral and Maxillofacial Surgery will help you understand the role of the dental nurse in oral and maxillofacial surgical procedures. Written in a highly accessible style, comprehensive coverage includes anatomy of the head and neck, pain and anxiety control, assessment clinics, equipment selection, extractions, soft tissue lesions, and trauma and more complex procedures. Key features include: * Learning outcomes at the start of each chapter, and full-colour photographs and line drawings throughout * An overview of the maxillofacial team, the referral process and the legal aspects of maxillofacial procedures * Clear explanations of the various duties performed by dental nurses during oral and maxillofacial surgery Basic Guide to Oral and Maxillofacial Surgery is suitable for dental nurses working in practice or specialist maxillofacial units, and is also ideal for student dental nurses working towards the NEBDN National Diploma in Dental Nursing.
The field of gastrointestinal motility disorders has been expanding in recent times largely due to advances in diagnostic modalities. This coupled with new evidence to support best practices has increased the interest among clinical gastroenterologists, researchers, teachers and trainees.New advancesin the field of evaluation of functional bowel diseases and motility disorders, such as high-resolution manometry, 24-h pH impedance monitoring, Bravo capsule pH-metry, barostat, balloon expulsion test, barium and MR defecography, biofeedback, hydrogen breath tests, motility capsule (smartpill) etc. have significantly expanded the scope and outcome of treating such these disorders. However, presently there is nocomprehensiveguidethat coversall aspects of evaluation of GI motility.This contributed volumewill havechapters written by a panel of experts from the global academia, including from India, Singapore, Japan, Taiwan, Thailand, Europe and USA, integrating the body of knowledge on evaluation methods with evidence of best practices for the management of motility disorders. A chapter on how to set-up a manometry laboratory provides key information for clinicians and researchers who are planning to start working in this area. With 20 chapters in the book supported with numerous tables, flow charts, schematic diagrams and images, professionals will find it an essential reading.
A fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don't necessarily think of evolution. But evolution and cancer are closely linked, for the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer's evolutionary origins, researchers can come up with more effective, revolutionary treatments. Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer's ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn't mean we should give up on treating cancer-in fact, evolutionary approaches offer new and promising options for the disease's prevention and treatments that aim at long-term management rather than simple eradication. Looking across species-from sponges and cacti to dogs and elephants-we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future-and that we cannot win a war against evolution-treatments can become smarter, more strategic, and more humane. Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer's fundamental nature and our relationship to it.
Albert Hofmann, who died in 2008 aged 102, first synthesized lysergic acid diethylamide (LSD) in 1938, but the results of animal tests were so unremarkable that the chemical was abandoned. Driven by intuition, he synthesized it again in 1943, and serendipitously noticed its profound effects on himself. Although his work produced other important drugs, including methergine, hydergine and dihydroergotamine, it was LSD that shaped his career. After his discovery of LSD's properties, Hofmann spent years researching sacred plants. He succeeded in isolating and synthesizing the active compounds in the Psilocybe mexicana mushroom, which he named psilocybin and psilocin. During the 60s, Hofmann struck up friendships with personalities such as Aldous Huxley, Gordon Wasson, and Timothy Leary. He continued to work at Sandoz until 1971 when he retired as Director of Research for the Department of Natural Products. He subsequently served as a member of the Nobel Prize Committee, and was nominated by Time magazine as one of the most influential figures of the 20th century. In 2007, Albert Hofmann asked Amanda Feilding if she could publish his Problem Child, and shortly before his death he approved a new and updated translation of his autobiography (first published by McGraw Hill in 1979). It appears here for the first time in print.
In his most extraordinary audiobook, ?one of the great clinical writers of the twentieth century? ("The New York Times") recounts the case histories of patients lost in the bizarre, apparently inescapable world of neurological disorders. Oliver Sacks's "The Man Who Mistook His Wife for a Hat" tells the stories of individuals afflicted with fantastic perceptual and intellectual aberrations: patients who have lost their memories and with them the greater part of their pasts; patients no longer able to recognize people and common objects; patients stricken with violent tics and grimaces or who shout involuntary obscenities; patients whose limbs have become alien; patients who have been dismissed as retarded yet are gifted with uncanny artistic or mathematical talents.
If inconceivably strange, these brilliant tales remain, in Dr. Sacks's splendid and sympathetic telling, deeply human. They are studies of life struggling against incredible adversity, and they enable us to enter the world of the neurologically impaired to imagine with our hearts what it must be to live and feel as they do. A great healer, Sacks never loses sight of medicine's ultimate responsibility: ?the suffering, afflicted, fighting human subject.?
Human being's care and medicine as a science require that the knowledge and experience of the individual can be shared and enriched by comparison with many others. This is the goal of the authors - doctors belonging to different specialist fields (neurology, physical medicine and rehabilitation, radiology) - who have recognized the common need to communicate their experience in the treatment of muscle hyperactivity through botulinum toxin injection, hoping that the reverberation of sharing may increase one's own and others' knowledge. The authors describe the ultrasound-guided botulinum toxin injection for more than 80 muscles of the neck, of the trunk and of the upper limb and lower limb. For each muscle the handbook provides the description of the function, origin, insertion, innervation as well as injection sites and dosage. The collection of images is particularly rich (more than 300), including anatomical drawings, ultrasound images and clinical photographs. Potential readers: specialists in Physical Medicine, neurologists, radiologists.
Anatomy questions are asked in all parts of the FRCA examinations, and for many trainees it is a particularly daunting part of the exams. This important new book provides a comprehensive, exam-orientated clinical anatomy book for anaesthetists preparing for all parts of the FRCA. It covers all body regions, relating underlying anatomy to practical procedures and anatomical principles, spanning the breadth of the curriculum and comprising exam-style questions: a chapter of SAQ questions, one of OSCE stations, one of SOE questions and one of MCQs. The text is highly illustrated in full colour with ultrasound images, diagrams and photographs of cadaveric material and models. This is the first anatomy book specifically orientated for the FRCA exam, making it an essential resource for anaesthetists preparing for all parts of the FRCA examination.
This book is an ideal manual on the use of modern ultrasound in the diagnosis of breast pathology. It provides a comprehensive overview of current ultrasound techniques and explains the advantages and pitfalls of various ultrasound imaging modalities. Detailed attention is devoted to breast carcinoma, with guidance on differential diagnosis and presentation of pre- and postoperative ultrasound appearances. The most important benign breast diseases are also described and illustrated. Age-related features, including those seen in children and adolescents, are carefully analyzed, and an individual chapter is devoted to breast abnormalities in men. All aspects of lymph node appearances are reviewed in detail, with a special focus on the role of ultrasound in the evaluation of lymph node status. Ultrasound-guided breast interventions and imaging of breast implants are discussed in depth. This up-to-date and richly illustrated book will interest and assist specialists in ultrasound diagnostics, radiologists, oncologists, and surgeons.
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