Albert Hofmann, who died in 2008 aged 102, first synthesized lysergic acid diethylamide (LSD) in 1938, but the results of animal tests were so unremarkable that the chemical was abandoned. Driven by intuition, he synthesized it again in 1943, and serendipitously noticed its profound effects on himself. Although his work produced other important drugs, including methergine, hydergine and dihydroergotamine, it was LSD that shaped his career. After his discovery of LSD's properties, Hofmann spent years researching sacred plants. He succeeded in isolating and synthesizing the active compounds in the Psilocybe mexicana mushroom, which he named psilocybin and psilocin. During the 60s, Hofmann struck up friendships with personalities such as Aldous Huxley, Gordon Wasson, and Timothy Leary. He continued to work at Sandoz until 1971 when he retired as Director of Research for the Department of Natural Products. He subsequently served as a member of the Nobel Prize Committee, and was nominated by Time magazine as one of the most influential figures of the 20th century. In 2007, Albert Hofmann asked Amanda Feilding if she could publish his Problem Child, and shortly before his death he approved a new and updated translation of his autobiography (first published by McGraw Hill in 1979). It appears here for the first time in print.

This book is an essential manual for mental health professionals who work with young anxious children and their parents. Organised into a 10-session parenting-based course, the book provides parents with simple cognitive behavioural techniques for helping their children to manage their worries and fears. * The first manual designed specifically to help therapists take parents through a step-by-step approach to managing young anxious children * The manual's empirical focus is highly effective in treating anxiety disorders in children under the age of 10 * The provision of scripts throughout the book offer realistic illustrations of the techniques described * Stories and analogies included to explain the more complex concepts * Includes handouts which can be photocopied and useful additional materials

This new edition was recognized as a highly commended title by the British Medical Association at the 2017 BMA Medical Book Awards . Regarded by both students and instructors, Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 4th Edition , offers an integrated mechanism-based and systems-based approach to contemporary pharmacology and drug development. An easy-to-follow format helps first- and second-year students grasp challenging concepts quickly and efficiently. Each chapter presents a clinical vignette illustrating a therapeutic problem within a physiologic or biochemical system; followed by a discussion of the biochemistry, physiology, and pathophysiology of the system; and concluding with a presentation of the pharmacology of the drugs and drug classes that activate or inhibit the system by interacting with specific molecular and cellular targets. Chapters are integrated into sections that focus on organ systems and therapeutic areas of highest importance. Clear, concise illustrations highlight key points, and drug summary tables offer quick access to essential information. The Fourth Edition features: Comprehensive updates to all chapters, including recently approved drugs Nearly 40 popular and practical Drug Summary Tables with state-of-the-art information on clinical applications, serious and common adverse effects, contraindications, and therapeutic considerations A new chapter on drug transporters , and extensively revised information on drug-receptor interactions, pharmacodynamics, drug toxicity, and pharmacogenomics Key changes to Section 1: Fundamental Principles of Pharmacology, which now provides a comprehensive framework for material in all subsequent chapters Hundreds of meticulously updated and colorized illustrations , including many that are new or substantially modified to highlight new understanding of physiologic, pathophysiologic, and pharmacologic mechanisms

Comprised exclusively of clinical cases presenting injuries to and management of the rotator cuff, this concise, practical casebook will provide orthopedic surgeons with the best real-world strategies to properly manage the various kinds of cuff injury they may encounter. Each chapter is a case that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and management techniques used to treat it, as well as the case outcome, literature review and clinical pearls and pitfalls. Cases included illustrate different management strategies for rotator cuff surgery, including arthroscopic repair for tendonitis and tears, open and mini-open repair for severe tears, latissimus dorsi and pectoralis tendon transfer, arthroscopic debridement, hemiarthroplasty and total reverse arthroplasty, biological augmentation, and revision repair after retear and infection. Pragmatic and reader-friendly, Rotator Cuff Injuries: A Clinical Casebook is an excellent resource for orthopedic surgeons and sports medicine specialists confronted with both common and complex injuries to the rotator cuff.

The role that the social and behavioural sciences play in the daily practice of dentistry is now an essential part of all dentistry training, but it can often seem distant from the reality of daily clinical practice. Dentists often ask: what is sociology? Why do I need to know about psychology? Why do I need sociology and psychology to be an effective dentist? How can they help improve my clinical practice? This new textbook answers these important questions and shows how the social and behavioural sciences can inform the practice of dentistry and allied healthcare services in the twenty-first century. It provides a comprehensive, accessible introduction to sociology and psychology for students and members of the dental team with no prior knowledge of the subject, and although the book assumes little or no previous knowledge of psychology or sociology, it also provides enough depth to meet the needs of those with some background in these fields. Throughout, the links between sociology and psychology and everyday practice are emphasized and explained and theoretical concepts are put into the context of everyday clinical work. The authors have extensive experience in teaching and researching the social and behavioural sciences from undergraduate to post-doctoral levels. This book will be an indispensable teaching aid within dental health education, and other allied health and social care disciplines.

The new edition of this essential revision book has been expanded and updated to include a wealth of new material, making it an excellent revision aid for dentistry students of all levels. Authored by experienced academics and organised by key subject areas, this book is the perfect tool to help build confidence and prepare for multiple choice question examinations. The new edition includes: - Over 400 questions - Subject-based chapters, providing a focused revision plan - detailed explanations for each answer overleaf - practical tips on MCQ exam technique

The Manchester Triage System (MTS), the most widely used emergency medical triage system in the UK and Europe, is employed to prioritise the treatment of tens of millions of patients each year. MTS utilises an easy-to-understand and safe, risk-based system of prioritisation. Emergency Triage contains all the information necessary for an MTS user: as such, it is an essential text for all emergency department staff, in particular triage nurses. The book is both a training tool and a reference for daily use. Well-organized and well-written Updated evidence-based concepts of triage for modern emergency departments New charts for abuse and neglect in childhood, unwell newborn, unwell baby A new approach to fever in childhood An introduction to telephone triage and advice This book is a must-have tool for all practitioners working in emergency and urgent care. Titles of related interest: Paediatric Emergency Triage 9781118299012 Telephone Triage and Advice 9781118369388

This book presents an updated discussion of the chemical composition and biological properties of the main bee products. Specific attention is focused on the beneficial biological activities of bee products in human health. Honey, royal jelly, propolis, bee pollen and bee venom are used as nutriment and in traditional medicine. Their composition is rather variable and depends on the floral source and external factors, such as seasonal, environmental conditions and processing. Bee products are rich in several essential nutrients and non essential nutrients, as sugars, minerals, proteins, free amino acids, vitamins, enzymes and polyphenols, that seem to be closely related to their biological functions. The effects of these products in nutrition, aging and age-related diseases, cancer, neurodegenerative diseases and pathogen infections are discussed.

This comprehensive book provides practical guidance on the care of the critical patient in the emergency department. It focuses on the ED physician or provider working in a community hospital where, absent the consulting specialists found in a large academic center, the provider must evaluate and stabilize critically ill and injured patients alone. Structured in an easily accessible format, chapters present fundamental information in tables, bullet points, and flow diagrams. Emergency medicine scenarios covered across 38 chapters include acute respiratory failure, spinal cord Injuries, seizures and status epilepticus, care of the newborn, and end-of-life care. Written by experts in the field, Emergency Department Critical Care is an essential resource for practicing emergency physicians and trainees, internists and family physicians, advance practice nurses, and physician's assistants who provide care in emergency departments and urgent care centers.

In clear, lively prose, Harriet Lerner takes a bold look at women and the psychotherapists who work with them.

This book offers an in-depth discussion of the latest strategies in the field of drug design and their applications in various disorders, in order to encourage readers to undertake their own projects.It also includes the contemporary application of drug-designing methodologies to inspire others to further expand the utility of this field in other diseases.It is intended for advanced undergraduate and graduate students, postdocs, researchers, lecturers and professors in bioinformatics, computational biology, medicine, pharmaceutics and other related fields.

This book offers a practical tool for handling neuromuscular emergencies, and is divided by the main neuromuscular diseases on the basis of their anatomical and clinical location: diseases affecting the anterior horn of the spinal cord (tetanus), those that affect the nerve roots and nerves (SGB, multiple mononeuritis, porphyria), the neuromuscular junction (MG and botulism) and, lastly, muscle pathologies (rhabdomyolysis, malignant hyperthermia, periodic paralysis). It provides updated diagnostic/therapeutic protocols and decision-making algorithms for each pathology, and examines a range of scenarios on the basis of clinical cases. Emergencies in Neuromuscular Disease will be of interests for a wide variety of specialists including neurologist, neurophysiologists and anesthesiologists.

The book focuses on novel particulate technologies for the purpose of drug delivery to humans. Nowadays, macro and nano-scale particles are being investigated for targeted delivery of small and large biological macromolecules. The targeting of drugs can minimize the dosage regimen and reduces dose related potential toxicity of drug molecules, which in turn lead to increased potential compliance. Various types of organic, inorganic and polymer particles are currently being investigated. These are attracting the attention of the research workers in the field of drug delivery science and technology. This book covers polymersomes, inorganic- organic composites, gold nanoparticles biopolymer and synthetic polymer particles etc.All aspects of drug delivery in relation to each technology have been described including these advances, Easy to read and understand the content of each chapter Rich in up-to-date information regarding their application.

This book explores key developments in Non-medical Prescribing in the UK. Addressing the needs of countries in the European Market and beyond, which have been closely watching UK developments and would be interested in embedding or developing counterparts of their own. Featuring chapters by clinicians, leaders and practitioners in the UK Non-medical Prescribing arena, it identifies both current and potential future developments. Attention is paid to the different prescribing practices and governance within the four countries constituting the United Kingdom. Many lessons have been learned along the way and the purpose of this book is to share these lessons, together with best practice examples in connection with the implementation of nurse/health professional led patient care, implementation of patient centered practice, and governance. Designated Registered Practitioners who have completed an enhanced training now receive a professional body qualification which enables them to prescribe within their scope of practice as Non-medical Independent Prescribers and, providing that they are competent, from anywhere within the British National Formulary independently of doctors; for Nurses, this also includes most controlled drugs. The book will be of interest to policy makers and to forward-looking professionals and practitioners in the diverse European Health and Social Care market.

This book presents the latest findings on early repolarization syndrome (ERS). Readers will find essential information on ERS with regard to its etiology, epidemiology, clinical diagnosis and manifestation, genetic background, and risk stratification, as well as the relationship between ERS and Brugada syndrome. Further chapters discuss pharmacological and non-pharmacological therapies. Early repolarization (ER) pattern or J wave in the inferior and /or lateral leads was initially considered to be a benign electrocardiographic pattern and is often found in healthy young individuals. However, it was reported that ER or J wave was more frequently recognized in patients with idiopathic ventricular fibrillation (IVF) than in control subjects, and that there is a higher incidence of recurrent VF in case subjects with ER or J wave than in those without. This is the early repolarization syndrome or ERS, the theme of this contributed volume. ERS is diagnosed in patients with ER pattern or J wave in the inferior and /or lateral leads of the standard 12-lead electrocardiogram (ECG), who have been resuscitated from IVF. ERS is a relatively a new clinical entity in the field. This much-awaited contributed volume is one of the first references available in the market, an ideal resource for all cardiologists and electrophysiologists working on ERS and related topics.

This easy-to-consult guide describes new minimally invasive procedures for the treatment of vertebral lesions that are accompanied by fewer complications and side-effects, reduce the risks of anesthesia, and lower costs. Clear accounts are provided of CT and X-ray guided techniques for vertebral augmentation in different regions of the spine and for the treatment of vertebral tumors by means of cryoablation, radiofrequency ablation, and embolization. Helpful information is also provided on imaging, biomechanics, biopsy, and biomaterials. Like other books in the Springer series New Procedures in Spinal Interventional Neuroradiology, this practice-oriented volume will fill a significant gap in the literature and meet the need expressed by a large number of specialists (interventional neuroradiologists and radiologists, neurosurgeons, and orthopedists) for a topical and handy guide that specifically illustrates the presently available materials and methods.

Digestive diseases have always been a major threat to global health. Despite the rapid advances in various diagnostic modalities, many a time the final verdict can be elusive and present a diagnostic challenge for the attending doctor. The book presents 50 real life cases to illustrate an evidence based approach for the diagnosis, investigation and management of gastrointestinal diseases commonly encountered in everyday practice, with a special focus on the interpretation of endoscopic and radiological images. This book provides a pragmatic approach for medical students, residents, specialist trainees and specialists alike who have an interest in gastroenterology. Other healthcare providers, such as general practitioners, nurses and dieticians, will also benefit from these case illustrations. The authors of this book are based at the Institute of Digestive Disease, Chinese University of Hong Kong. This institute has contributed to major breakthroughs that have improved the clinical management of digestive diseases including, but not limited to, the advent of endoscopic therapies and minimally invasive surgery, molecular diagnostic tools for cancers and inflammatory bowel disease, and the development of novel treatments for acid peptic disease and viral hepatitis.

This book is an introduction to a comprehensive analysis of recent advances and clinical research in noninvasive mechanical ventilation (NIV) in Pulmonary, Critical Care, and Sleep Medicine. The objective of the book is to increase the knowledge and understanding of the reader in the best clinical practice in three main sections. A selected international group of experts in the field of noninvasive ventilation formed a panel to provide an update on the recent literature in the application and efficient utilization of NIV in Pulmonary, Critical Care, and Sleep Medicine. Each particular section will discuss the application of NIV in different disease process. The authors summarized the main results of the recent trials, clinical and technological advances, expert opinions, and practical guidelines. Chapters, summarized by expert committee, provide a "deep and exhaustive critical analysis and summary" of the recent advances in the field of NIV, presented as key points and/recommendations for the best clinical practice from articles published in the last decade. The content of the book will serve as a resource and a tool to the practicing physicians toward NIV. Main objective is to increase their proficiency in management of different pathophysiological aspects of the respiratory system. In this line, the book offers to the readers, who are seeking the latest recommendations, the future research directions in noninvasive mechanical ventilation. Table of contents describe and analyze, the items trend setters in noninvasive ventilation, organized in three main sections, "pulmonary", "critical care" and "sleep medicine", using the primary keyword related with term "noninvasive mechanical ventilation" as search term associated with "secondary keywords" studies from a period of 2018 to 2019. This searching methodology and analysis define this unique book to the approach in noninvasive mechanical ventilation for best clinical practice, research, clinical study designs and critical analysis, how noninvasive ventilation is current and trending. Based on this form of conception of book updated, editors and authors consider that this book opens a new and original vision for adequate knowledge and deep updated based on key publications in the period under review, very useful for clinical practice, studies designs and potential new trends in the use of noninvasive ventilation. As such, it is a unique update book resource in noninvasive ventilation in pulmonary, critical care and sleep medicine that may influence current clinical practice and future studies. With ultimate goal is better care and outcome for our patients.

Current techniques for studying biological macromolecules and their interactions are based on the application of physical methods, ranging from classical thermodynamics to more recently developed techniques for the detection and manipulation of single molecules. Reflecting the advances made in biophysics research over the past decade, and now including a new section on medical imaging, this new edition describes the physical methods used in modern biology. All key techniques are covered, including mass spectrometry, hydrodynamics, microscopy and imaging, diffraction and spectroscopy, electron microscopy, molecular dynamics simulations and nuclear magnetic resonance. Each method is explained in detail using examples of real-world applications. Short asides are provided throughout to ensure that explanations are accessible to life scientists, physicists and those with medical backgrounds. The book remains an unparalleled and comprehensive resource for graduate students of biophysics and medical physics in science and medical schools, as well as for research scientists looking for an introduction to techniques from across this interdisciplinary field.

This book provides detailed information on functional anatomy, physical examination, and clinical radiology of the shoulder with a view to enabling the clinician to identify the most suitable treatment approach to different shoulder joint pathologies. In addition, it describes the arthroscopic treatment techniques most frequently employed in patients with these conditions and presents numerous arthroscopic images detailing characteristic findings. The shoulder is widely regarded as the most complex joint in the human body, displaying the widest range of motion. Knowledge of normal and pathological anatomy, ability to perform a proper physical examination, and appropriate selection of imaging modalities and interpretation of imaging appearances, often in close collaboration with an imaging expert, are all vital for correct diagnosis and choice of treatment approach. Surgeons and trainees will find this richly illustrated book to be an excellent educational guide and an instructive source of stepwise guidance from clinical presentation to achievement of desired treatment outcomes.

Quickly acquire the knowledge and skills you need to confidently administer, score, and interpret the most popular neuropsychological assessment instruments

Neuropsychological testing can identify changes in cognition, behavior, and emotion; aid in determining the cause of a disorder or developmental problem; and assist clinicians in planning treatment and rehabilitation. To use these tests properly, professionals need an authoritative source of advice and guidance on how to administer, score, and interpret them. Now fully revised and in a second edition, "Essentials of Neuropsychological Assessment" is that source.

Completely updated to include the most current instruments, including the Delis-Kaplan Executive Function System (D-KEFS), the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV), the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV), and the Wechsler Memory Scale-Fourth Edition (WMS-IV), Essentials of Neuropsychological Assessment, Second Edition presents an overview of the assumptions, logic, knowledge base, and skills underlying the practice of neuropsychological assessment. Neuropsychological experts Nancy Hebben and William Milberg describe how clinical history, behavioral observations, and formal test results are used to make inferences about the contribution of brain dysfunction to psychological functioning.

Like all the volumes in the Essentials of Psychological Assessment series, this book is designed to help busy mental health professionals quickly acquire the knowledge and skills they need to make optimal use of major neuropsychological assessment instruments. Each concise chapter features numerous callout boxes highlighting key concepts, bulleted points, and extensive illustrative material, as well as test questions that help you gauge and reinforce your grasp of the information covered.

"Essentials of Neuropsychological Assessment," Second Edition provides comprehensive instruction on neuropsychological test administration, scoring, interpretation, and report writing. It also addresses practical and conceptual issues related to neuropsychological assessment in geriatric, pediatric, forensic, and other specialized settings.

Other titles in the Essentials of Psychological Assessment series:

Essentials of Assessment Report Writing

Essentials of WAIS-IV Assessment

Essentials of WISC-IV Assessment, Second Edition

Essentials of WIAT-II and KTEA-II Assessment

Essentials of WJ IIITM Cognitive Abilities Assessment

Essentials of WJ IIITM Tests of Achievement Assessment

Essentials of School Neuropsychological Assessment

Essentials of Cross-Battery Assessment, Second Edition

Essentials of KABC-II Assessment

Essentials of NEPSY Assessment

Essentials of Executive Function Assessment

Essentials of Processing Assessment

This second one of a two volume set will be of interest to medical microbiologists, practitioners, medical students and other health care providers who are engaged in management and treatment of pediatric viral infections. New evidence on topics related to better clinical management of patients is presented. The book may double as a clinical guide to care with algorithms, Practice Points and photographs and therefore aid the clinical decision making in management of sick children.

Every day, millions of children experience serious mental health issues, such as symptoms related to autism, psychosis, mania, depression, and anxiety. Moreover, many youth struggle with issues related to trauma, eating, sleep, disruptive behavior, and substance use. Most of these youth do not receive evidence-based treatments. Instead, they commonly receive untested, ineffective, and even harmful treatments. Child and Adolescent Psychotherapy presents the research-supported treatment packages and their individual components for every major mental health issue facing infants, children, and adolescents. Each chapter also identifies and analyzes other variables and resources that influence treatment: parents, assessment, comorbidity, demographics and medication. Useful resources are included for each mental health issued covered in the book. The chapters are organized in the same order as they appear in the DSM-5.

The purpose of this book is to provide a synthesis of the ever evolving field of pediatric viral infections. The most common and exotic pediatric viral infections are fully reviewed in this first one of a two volume set. All contributions are written by recognized experts in the field. The publication will appeal to medical microbiologists, practitioners, medical students and other health care providers with a pediatric interest. The known literature on viral infections in children is summarized and discussed in the light of changes in thinking as a result of novel and new evidence.