International Review of Research in Developmental Disabilities, Volume 54 shares the latest research on the interactions between families of individuals with intellectual and developmental disabilities and service delivery systems. Chapters discuss Strengthening service access for children of color with autism spectrum disorders, Assessing the service impact of early intervention on young children with IDD and their families, Family-professional partnership with refugee families whose children have disabilities, Post high school transition for individuals with Down syndrome, Supporting families and school professionals to be engaged partners in the transition to adulthood for young adults with disabilities, amongst other timely topics.

Advances in Virus Research, Volume 102, the latest release in this esteemed series, contains new, informative updates on the topic. First published in 1953, this series covers a diverse range of in-depth reviews, providing a valuable overview of the current field of virology. Updates to this release includes sections on the Development of model systems for plant rhabdovirus research, Dichorhaviruses and their mite vectors, Molecular modelling for better understanding Cucumovirus pathology, Modification of host-insect reactions by viruses, Gene Gangs of the Chloroviruses: Conserved Co-linear Monocistronic Gene Sets, Virus disease control by transgenic approach and attenuated virus, Virus effectors, Tobamovirus evolution, and more.

This book is a collective work draws on the perspective of social sciences, mobilizing perspectives from the sociology of science, the history of psychiatry, medical ethnography and public policy analysis. This initiative, which has no precedent in social sciences, is surrounded by an original, if not apparently paradoxical statement: considering that the deployment of these processes, strictly formal and depersonalized, is justified in becoming the rule in a society known as "individuals".

Imaging in Movement Disorders: Imaging in Atypical Parkinsonism and Familial Movement Disorders, Volume 142, addresses the use of imaging modalities across the spectrum of movement disorders and dementias. Over the last decades, advances in neuroimaging tools have played a pivotal role in expanding our understanding of disease aetiology and pathophysiology, identifying biomarkers to monitor disease progression, aiding differential diagnosis and in the identification of novel targets for therapeutic intervention. This updated volume covers PET Molecular Imaging in Atypical Parkinsonism, SPECT Molecular Imaging in Atypical Parkinsonism, Structural MRI in Atypical Parkinsonism, Functional MRI in Atypical Parkinsonism, and more.

Neglected Diseases: Extensive Space for Modern Drug Discovery provides in-depth reviews on the last progresses about neglected tropical diseases research. Topics covered in this volume include Leishmaniasis, Tripanosomiasis, Onchocerciasis and Ebolavirus infections, with insights on the future of the research on them. Part of the volume is devoted to recent contributions this field received from X-Ray crystallography.

Neuroepigenetics and Mental Illness, Volume 158, the latest release in the Progress in Molecular Biology and Translational Science series, seeks to provide the most topical, informative, and exciting monographs available on a wide variety of research topics related to prions, viruses, bacteria and eukaryotes. The series seeks to provide readers with in-depth knowledge of important molecular biological aspects of organismal physiology and function, with this release focusing on Neuroepigenetics in mental illness, Neuroepigenetics of development and neurodevelopmental disorder, Neuroepigenetics of aging and age-related neurodegenerative disorders, Neuroepigenetics of prenatal psychological stress, Neuroepigenetics of the HPA axis, Neuroepigenetics of the serotonergic system, and more.

The Opioid System as the Brain's Interface between Cognition and Motivation, Volume 239, focuses on the opioid system as the interface between the brain's cognitive and motivational systems. As the opioid system is widely distributed through the brain, particularly in areas implicated in cognition (hippocampus, prefrontal cortex, claustrum, thalamus) and motivation (hypothalamus, amygdala, pontine nuclei, periaqueductal gray and medulla), this book provides chapters that address ongoing research on topics such as the Brain's cognitive system, the Brain's motivational system, Antidepressant prescription patterns, Antidepressant-like effects of opioid receptor modulators, the Behavioral effects of antidepressant and anxiolytic drugs, and more.

Emerging Nanotechnologies in Immunology aims to deliver a systematic and comprehensive review of data concerning the nature of interaction and nano-related risks between the nanophamaceuticals currently in the pipeline of S&T development for skin, ocular, and nasal drug delivery, including absorption, toxicity, and the ability to distribute after systemic exposure. The scientific development of manufactured nanomaterials for drug delivery is increasing rapidly. One of the most prominent applications is topical drug delivery, where cutaneous, ocular, and nasal exposure becomes even more relevant. These targets are the first barrier that nanoparticles encounter when in contact with the human body. The contributors addresses a representative set of the broad spectrum of nanopharmaceuticals currently being used, including cationic lipid nanoparticles, polymeric PLGA, PLA nanoparticles, biomacromolecules-based nanoparticles, and other scaffolds tissue engineered skin substitutes. Regulation and risk is also covered, since the safety of these nanophamaceuticals still represents a barrier to their wide innovative use.

Professor Steve Peters is a Consultant Psychiatrist and author of the bestselling self-help book, The Chimp Paradox. He has years of experience as a clinician, an educator and has worked with some of the world's most successful athletes. His new book 'A Path through the Jungle' will help you to become robust and resilient. Professor Peters explains complex neuroscience in straightforward terms with his Chimp Management Mind Model Robust: Becoming robust means having plans in place to manage your own mind and whatever situations you meet in life. Resilient: is being able to bounce back and manage the challenges of life. Resilience is a skill. A Path through the Jungle offers a structured programme with exercises and practical real-life examples. This book will help you to improve in areas such as: * Managing stress and anxiety * Improved relationships * Emotional management * Grief and loss * Self-confidence * Peace of mind * Happiness * Managing stress

Profiles of Drug Substances, Excipients, and Related Methodology, Volume 43 presents comprehensive reviews of drug substances and additional materials, with critical review chapters that summarize information related to the characterization of drug substances and excipients. The series encompasses review articles and database compilations that fall within a variety of categories, with this release focusing on Ganciclovir, Mirtazapine, Tolfenamic Acid, Mid-Infrared Spectroscopy of Pharmaceutical Solids, and the Validation of Chromatographic Methods of Analysis: Application for drugs that derived from herbs.

Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications, Volume 42, provides a quantitative approach to problem-solving that is targeted to engineers. The book gathers the contributions of doctors, pharmacists, biologists, and chemists who give key information on the elements needed to model a complex machine like the human body. It presents information on diagnoses, administration and release of therapeutics, distribution metabolism and excretion of drugs, compartmental pharmacokinetics, physiologically-based pharmacokinetics, pharmacodynamics, identifiability of models, numerical methods for models identification, design of experiments, in vitro and in vivo models, and more. As the pharma community is progressively acknowledging that a quantitative and systematic approach to drug administration, release, pharmacokinetics and pharmacodynamics is highly recommended to understand the mechanisms and effects of drugs, this book is a timely resource.

Post-Authorization Safety Studies of Medicinal Products: The PASS Book bridges the gap in the literature by providing a complete look at post-authorization safety studies and important pharmacoepidemiology and pharmacovigilance aspects. It covers various types and limitations of active surveillance programs, including the use of large databases and disparate data sources for rapid signal detection, as well as novel and advanced design and analysis approaches for causal interference from observational data. This book serves as an important reference for pharmacovigilance scientists and pharmacoepidemiologists who are searching for the appropriate study design to answer safety research questions. Readers will be able to effectively and efficiently design and interpret findings from post-authorization safety studies with the goal of improving the benefit-risk balance of a drug in order to optimize patient safety.

Advances in Parasitology, Volume 100, the latest in a series first published in 1963, contains comprehensive and up-to-date reviews on all areas of interest in contemporary parasitology. The series includes medical studies of parasites of major influence, along with reviews of more traditional areas, such as zoology, taxonomy, and life history, which help to shape current thinking and applications. This new release includes sections on Human Parasitology and Parasitic Diseases: Heading Towards 2050, Environmental aspects, Structural and Physical Properties of Schistosome Eggs, and Interventions against parasitic diseases to safeguard childhood development.

Multivariate Analysis in the Pharmaceutical Industry provides industry practitioners with guidance on multivariate data methods and their applications over the lifecycle of a pharmaceutical product, from process development, to routine manufacturing, focusing on the challenges specific to each step. It includes an overview of regulatory guidance specific to the use of these methods, along with perspectives on the applications of these methods that allow for testing, monitoring and controlling products and processes. The book seeks to put multivariate analysis into a pharmaceutical context for the benefit of pharmaceutical practitioners, potential practitioners, managers and regulators. Users will find a resources that addresses an unmet need on how pharmaceutical industry professionals can extract value from data that is routinely collected on products and processes, especially as these techniques become more widely used, and ultimately, expected by regulators.

Apprentices to Genius: A tribute to Solomon H. Snyder, a volume in the Advances in Pharmacology series, presents a tribute to Dr. Solomon H. Snyder, highlighting chapters submitted from a broad range of his students. It covers many different areas of neuroscience and pharmacology, with this volume exploring how receptor binding and drug discovery, the emerging role of glutamate in the pathophysiology of mental illness, nitric oxide signaling in neurodegeneration and cell death, carboxypeptidase E and the identification of novel neuropeptides as potential therapeutic targets, the regulation of mitochondrial functions by TSPO, clozapine and its translational investigation, and more.

Progress in Medicinal Chemistry, Volume 57, provides a review of eclectic developments in medicinal chemistry, with this volume including chapters on the CaSR field, CFTR modulators in cystic fibrosis, macrocycles, VMAT2 inhibitors, and Big Data in Drug Discovery.

Advances in Parasitology, Volume 99, the latest in a series first published in 1963, contains comprehensive and up-to-date reviews on all areas of interest in contemporary parasitology. The series includes medical studies of parasites of major influence, along with reviews of more traditional areas, such as zoology, taxonomy, and life history, which help to shape current thinking and applications. This new release includes sections on climate change and NTDs, Leprosy, parasite cultures, molecular epidemiology of Anisakis and anisakiasis, evolution in triatomine vectors of Chagas disease, expanding the vector control toolbox for Malaria elimination, and parasites of the giant panda.

Design of Nanostructures for Versatile Therapeutic Applications focuses on antimicrobial, antioxidant and nutraceutical applications of nanostructured materials. Many books discuss these subjects, but not from a pharmaceutical point-of-view. This book covers novel approaches related to the modulation of microbial biofilms, antimicrobial therapy and encapsulate polyphenols as antioxidants. Written by an internationally diverse group of academics, this book is an important reference resource for researchers, both in biomaterials science and the pharmaceutical industry.

The study guide includes key learning objectives for each chapter, outlines of key sections, self-test questions, and sets of problems similar to those in the text to help you succeed in the course.

This volume on athletic injury is timely because it addresses many types of sports injuries and focuses not only on the treatments of these injuries, but also their prevention. The first paper was written after an extensive interview with the coaches of one of the most recognized football programs in the country. Dr. Kevin Chung's interviews with the Head and Assistant Coaches at the University of Michigan, Jim Harbaugh and Jedd Fisch, provided thoughtful insight on preventing sports injuries in the professional and college athletics.

Advances in Parasitology presents the latest developments in the field of parasitology. It covers topics such as Chagas Disease Diagnostic Applications, The Role of Spatial Statistics in the Control and Elimination of Neglected Tropical Diseases in Sub-Saharan Africa, and Host-Parasite Relationships and Life Histories of Trypanosomes in Australia. Specific chapters delve into targeting parasites to suppress malaria transmission and a focus on neglected tropical diseases, such as Trypanosomiasis, Schistosomiasis and Lymphatic Filariasis. This series includes medical studies of parasites of major influence, such as Plasmodium falciparum and trypanosomes, as well as reviews of more traditional areas, such as zoology, taxonomy and life history.

Providing intriguing insights for students, film buffs, and readers of various genres of fiction, this fascinating book delves into the psychology of 100 well-known fictional characters. Our favorite fictional characters from books and movies often display an impressive and wide range of psychological attributes, both positive and negative. We admire their resilience, courage, humanity, or justice, and we are intrigued by other characters who show signs of personality disorders and mental illness-psychopathy, narcissism, antisocial personality, paranoia, bipolar disorder, and schizophrenia, among many other conditions. This book examines the psychological attributes and motivations of 100 fascinating characters that include examples of both accurate and misleading depictions of psychological traits and conditions, enabling readers to distinguish realistic from inaccurate depictions of human behavior. An introductory section provides a background of the interplay between psychology and fiction and is followed by psychological profiles of 100 fictional characters from classic and popular literature, film, and television. Each profile summarizes the plot, describes the character's dominant psychological traits or mental conditions, and analyzes the accuracy of such depictions. Additional material includes author profiles, a glossary of psychological and literary terms, a list of sources, and recommended readings. Provides an engaging and entertaining way to learn about both positive psychology and mental health issues through the behavior of interesting and often familiar characters, leading to a better understanding of human behavior Helps readers distinguish realistic depictions of psychological disorders from inaccurate ones, providing a basis for avoiding negative mental health stereotypes and stigma associated with mental illness Covers a wide range of behaviors and psychological disorders arranged in a convenient format, making it easy to find and learn about particular topics that can be read in or out of order

Anxiety, the latest volume in the Vitamins and Hormones series first published in 1943, and the longest-running serial published by Academic Press, provides up-to-date information on the roles that hormones and other factors play in anxiety and stress. Each volume focuses on a single molecule or disease that is related to vitamins or hormones, with the topic broadly interpreted to include related substances, such as transmitters, cytokines, growth factors, and others thoroughly reviewed.

Drs. John C. Perkins and Michael E. Winters have assembled an expert team of authors on the topic of Sepsis in the Emergency Department. Article topics include: Defining and Diagnosing Sepsis; Appropriate Antibiotic Therapy; Severe Sepsis Resuscitation in Resource Limited Settings; Source Control in Severe Sepsis; Considerations in Special Populations with Severe Sepsis; Pediatric Severe Sepsis Resuscitation; The New Usual Care; Prehospital Sepsis Care; Endpoints of Sepsis Resuscitation; Pitfalls in the Diagnosis, Treatment, and Disposition of Severe Sepsis; Biomarkers in Sepsis; Vasopressors and Inotropes in Sepsis; and Sepsis Quality Measures and Performance Improvement.

Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology, containing comprehensive reviews of the most current research in applied microbiology. Users will find invaluable references and information on a variety of areas, including protozoan grazing of freshwater biofilms, metals in yeast fermentation processes, the interpretation of host-pathogen dialogue through microarrays, and the role of polyamines in bacterial growth and biofilm formation. Eclectic volumes are supplemented by thematic volumes on various topics, including Archaea and sick building syndrome.