KEY POINTS Full colour throughout Over 1000 illustrations Combines the latest theories with modern practice All images also viewable on the Anshan web site - www.anshan.co.uk In his book Orthodontics in Clinical Practice, Massimo Rossi sets out a connection between the research field and the daily work of an orthodontist. Scientific data must be applied to individuals according to their own psychology and personality. Therefore a good orthodontist must choose, among various solutions, the best approach for his patient, always respecting the principle of informed consent. Modern orthodontics concerns not only young people but elderly patients as well. If the goal of dental treatment is the achievement of finding the optimum combination of function and aesthetics, then in many cases that cannot be done using prosthesis, implantology, and periodontology alone. By playing a fundamental role in the various interdisciplinary treatments of tooth care, orthodontics changes the concept of modern dentistry. This book provides a bridge between academic theory and clinical practice, encouraging connectivity and cooperation between the proponents of dental and surgical theory, and the orthodontic practitioners who carry out the treatments. It consists of 8 chapters, in which differing levels of treatment are described, the relationship between orthodontics and other fields of dentistry and medicine are explained, and orthognathic surgery is introduced, along with four case studies. Professor Rossi has over 30 years experience as both teacher and clinical orthodontist, with his own private practice. This book draws upon his vast experience of orthodontics, having seen and carried out the advancement of dental treatment in recent years. Originally in italian, Orthodontics in Clinical Practice is now published for the first time in English, to be made available to academics and practitioners worldwide.

In September 2009, the format of the written Radiology FRCR Part 2A examinations changed. The previous negatively-marked true-false MCQs have become obsolete, replaced by 'single best answer' (SBA)questions, with candidates selecting 1 of 5 options, without negative marking. The author team have themselves recently successfully sat the FRCR exam, and have prior experience in the SBA format, making them ideally suited to write such a book, and have produced an excellent revision guide for the new format exam. There are 750 stem questions covering all 6 modules, including a separate section with a 75 questions-per-module 'mock' examination which readers can use to test themselves against the clock, under examination conditions, to hone their technique. The questions have been extensively researched and cross-checked, with relevant topics being drawn from major radiology textbooks, as well as current radiological journals such as Clinical Radiology and Radiographics. Answers are given with detailed explanations and references are provided, which can also be used for further reading as appropriate. As a bonus the authors pass on their own proven exam tips and techniques. Key Points - Authors recently sat exams themselves - Over 700 questions

"Pharmaceutical Pharmacology", encompassing 78 chapters, is divided into four major comprehensive parts. Part A deals with general pharmacology, pharmacology of peripheral nervous system and pharmacology of central nervous system. Part B is concerned with pharmacology of cardiovascular system, drugs acting on the hemopoetic system, drugs acting on the urinary system, autocoids and drugs acting on the respiratory system. Part C contains chapters on drugs acting on the gastrointestinal tract, pharmacology of endocrine system, chemotherapy and principles of toxicology. Part D discusses mainly clinical pharmacy, pharmacotherapy, important disorders of organ system and their management, therapeutic drug monitoring and concept of essential drugs and rational drug use.To provide a realistic approach to the understanding of the subject, each chapter commences with a crisp introduction followed by classification, treatment of each class of drugs with reference to important 'drugs' vis-a-vis pharmacological actions, pharmacokinetic actions, mechanism of action, therapeutic uses, dosage regimens, adverse drug reactions, drug interaction, etc. The text is profusely illustrated with labelled diagrams, graphics and lucid explanations. It provides the reader an explicit route starting from the molecular understanding of receptors and drug activities to the therapeutic applications of the most important class of drugs.

The FRCR examination was recently changed and now comprises two modules: physics and radiological anatomy. The anatomy module is new, and consists of 20 radiological images, with 5 questions on each image, 100 questions in all. The anatomy examination lasts for 75 minutes and incorporates 20 separate images (cases) with 5 questions per case, producing a total of 100 questions. The cases will be presented at computer work-stations, with separate written answer sheets for completion. In this book we present 5 complete `mock' anatomy examinations, with a total of 500 questions. We have stayed true to the lay out of the RCR sample questions and answer sheets to ensure familiarity. The anatomical structures should not be ambiguous and, if necessary, there will be more than one arrow to indicate the appropriate structure (a concept that has been included in some of the example questions in this book). As a rule, the candidate should make an attempt to answer ALL questions in the exam as there is no negative marking. It is advised that answers be as complete as possible, for instance the use of `left' or `right' if this can be derived from the image, or rather than simply stating `acromion', use the `acromion process of the scapula' - if you have the knowledge, use it! This book should not be used as a primary revision tool, rather a practice aid to test the candidate against the clock in exam conditions and highlight any areas of weakness or imaging examinations that the candidate may be unfamiliar with. Primary revision is suggested by using traditional anatomy alongside radiology-based anatomy textbooks. It is also necessary to experience everyday radiological investigations, and even more specialist investigations, as essentially any type of radiological image can be used for assessment of anatomical knowledge in this examination. The authors provide explanatory answers, and have also included extra images to accompany their explanations. In addition there are references to key revision resources, and they have also given advice on exam technique. They have first hand experience of running courses on the new format FRCR anatomy exam, and are therefore the perfect authors for the subject. Key Points 100% relevant to the new format Authors run FRCR Part 1 courses 500 questions

This publication encapsulates the work of this highly respected British therapist. "Precision Therapy" is an extremely practical book that describes how to initiate healing processes. It is eclectic in nature and free from dogma and jargon. The book is designed for the therapist-healer who does not have the need, the time or the inclination to subject clients to protracted mind games. Its practicality is illustrated in the training material: each page is a script or a prompt-sheet that can be adapted easily to deal effectively with most problems in a matter of hours rather than weeks or months. It is a comprehensive manual of fast, effective hypnoanalytic techniques designed for the professional.

In this never-before-seen memoir, Bergen-Belsen survivor Hannah Pick-Goslar shares incredibly powerful words on the final untold portrait of her childhood friend, Anne Frank. The inspiring and heartbreaking true story of two best friends torn apart and reunited against all odds.

When Hannah Pick-Goslar's family fled Nazi Germany for Amsterdam, she struck up a close friendship with her next-door neighbour; precocious, outspoken and fun-loving Anne Frank. Hannah instantly warmed to happy-go-lucky Anne and for seven blissful years, the inseparable pair navigated school, boys and coming of age in Amsterdam's Rivierenbuurt neighbourhood. But in 1942, life quickly changed for the thirteen-year-old girls.

The Nazi occupation of Amsterdam meant the friends were separated without warning. Hannah called on Anne, but there was no trace of her friend or her precious diary. Hannah was tormented over the fate of Anne, wondering if, by some stroke of fortune she had escaped danger and was alive and well elsewhere. It wasn't until Hannah reached her darkest point, imprisoned with her family in Bergen-Belsen concentration camp, that she had an astonishing chance reunion with Anne. Desperate to save her friend who was weak and struggling to survive, Hannah risked everything to toss packages filled with food and clothes over a barbed-wire fence. Hannah only learned of Anne's death after her liberation, when Otto Frank came to visit her in hospital. From that day, Otto became a second father to Hannah, making sure that she was always looked after.

In this groundbreaking memoir, Hannah Pick-Goslar shares an intimate portrait of Anne Frank, the young Jewish diarist who has captured the hearts of millions of readers around the world.

This portable guide to radiology nursing provides comprehensive information about this emerging specialty in a concise format designed for speedy information retrieval. Written for both practicing nurses and new orientees, it outlines general procedures and protocols, along with requisite information for patient care in specialized areas of radiology. It discusses care for all patient populations including morbidly obese, pediatric, geriatric, and oncology and addresses vascular access, infection control, teamwork, and sterile technique in the radiology setting. The book encompasses over 50 different IR procedures, and also describes emergency situations in radiology and how to respond to them. With an emphasis on inter-professional care, the book demystifies complex procedures and includes clinical "pearls" from seasoned experts in radiology nursing. The book's format features consistently organized chapters, bulleted information "at a glance," an introduction, objectives, and summary in each chapter, and case studies to reinforce radiological interventions. The guide will be a welcome addition to the arsenal of radiology, emergency, and clinical care nurses as well as new orientees. This book was originally published under the Fast Facts series by Springer Publishing Company.

Professor Steve Peters is a Consultant Psychiatrist and author of the bestselling self-help book, The Chimp Paradox. He has years of experience as a clinician, an educator and has worked with some of the world's most successful athletes. His new book 'A Path through the Jungle' will help you to become robust and resilient. Professor Peters explains complex neuroscience in straightforward terms with his Chimp Management Mind Model Robust: Becoming robust means having plans in place to manage your own mind and whatever situations you meet in life. Resilient: is being able to bounce back and manage the challenges of life. Resilience is a skill. A Path through the Jungle offers a structured programme with exercises and practical real-life examples. This book will help you to improve in areas such as: * Managing stress and anxiety * Improved relationships * Emotional management * Grief and loss * Self-confidence * Peace of mind * Happiness * Managing stress

Remarkable advances have occurred since the Series 3 Fascicle published in 1995 with paradigm shifts in every dimension of our understanding of lung tumors including clinical, radiologic, histopathologic, cytopathologic, immunohistochemical, molecular and therapeutic aspects. The molecular revolution leading to effective targeted therapies and breakthroughs in immunotherapy for lung cancer have led to novel approaches incorporating the concept of personalized medicine for patients who historically had little hope. These advances have strengthened the place of pathologists to play a central role in the multidisciplinary team that is now needed to properly diagnose and manage lung cancer patients.

"Progress in Medicinal Chemistry" provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems, including g-secretase modulators, P2X7 antagonists as therapeutic agents for CNS disorders, N-type calcium channel modulators for the treatment of pain, and more.

Extended timely reviews of topics in medicinal chemistryTargets and technologies relevant to the discovery of tomorrow s drugs.Analyses of successful drug discovery programmes"

People with mental illness commonly describe the stigma and discrimination they face as being worse than their main condition. Discrimination can pervade every part of their daily life - their personal life, working life, sense of citizenship, their ability to maintain even a basic standard of living. Though things have certainly improved in the past 50 years, discrimination against the mentally ill is still a major problem throughout the world. It can manifest itself in subtle ways, such as the terminology used to describe the person or their illness, or in more obvious ways - by the way the mentally ill might be treated and deprived of basic human rights. Should we just accept such discrimination as deeply rooted and resistant to change, or is this something that we can collectively change if we understand and commit ourselves to tackling the problem? Shunned presents clearly for a wide readership information about the nature and severity of discrimination against people with mental illness and what can be done to reduce this. The book features many quotations from people with mental illness showing how this has affected their home, personal, social, and working life. After showing, both from personal accounts and from a thorough review of the literature, the nature of discrimination, the book sets out a clear manifesto for change. Written by a leading figure in mental health in a lively and accessible manner, the book presents a fascinating and humane portrayal of the problem of stigma and discrimination, and shows how we can work to reduce it.

This third volume of NMR Spectroscopy in the Undergraduate Curriculum continues the work we started with the first and second volumes in providing effective approaches for using nuclear magnetic resonance spectrometers as powerful tools for investigating a wide variety of phenomena at the undergraduate level. This volume focuses on upper-level courses and NMR spectroscopy across the curriculum. The applications and strategies in this volume will be helpful to those who are looking to transform their curriculum by integrating more NMR spectroscopy, to those who might not have considered NMR spectroscopy as a tool for solving certain types of problems, or for those seeking funding for a new or replacement NMR spectrometer.

This volume examines recent developments in the use of intelligent materials and systems for drug delivery. Controlled release technology is moving from being a simple carrier of active agents to becoming a powerful and flexible method that permits subtle modulation of the delivery profile based on the needs of the biological host. The chapters collected here cover recent advances in materials with responsive properties, novel concepts in controlled release technology, new applications, and microanalytical techniques for rapid and accurate measurements of small samples.

Psychosis is possibly the most feared symptom of mental health disorders, other than suicide, as the sufferer loses touch with reality and can be an extreme danger to themselves and occasionally others. It is particularly associated with schizophrenia, but also manic episodes of bipolar disorder, extreme stress and emotional trauma and substance abuse. Erica Crampton, a former psychosis/schizophrenia patient and now mental health activist and writer, and Stephen Lawrie, Professor of Psychiatry in Edinburgh, UK, have come together to write this practical and positive guide to the tools for recovery to help people with psychosis, or at risk of developing psychosis, and their family and friends, lead a happier, more rewarding life. Written in the style of a travel guide, with lifestyle and wellbeing advice to improve outcomes as well as guidance on conventional treatments, each approach is given a `sanity check' regarding its reliability.

This book focuses on broadly defined areas of chemical information science- with special emphasis on chemical informatics- and computer-aided molecular design. The computational and cheminformatics methods discussed, and their application to drug discovery, are essential for sustaining a viable drug development pipeline. It is increasingly challenging to identify new chemical entities and the amount of money and time invested in research to develop a new drug has greatly increased over the past 50 years. The average time to take a drug from clinical testing to approval is currently 7.2 years. Therefore, the need to develop predictive computational techniques to drive research more efficiently to identify compounds and molecules, which have the greatest likelihood of being developed into successful drugs for a target, is of great significance. New methods such as high throughput screening (HTS) and techniques for the computational analysis of hits have contributed to improvements in drug discovery efficiency. The SARMs developed by Jurgen and colleagues have enabled display of SAR data in a more transparent scaffold/functional SAR table. There are many tools and databases available for use in applied drug discovery techniques based on polypharmacology. The cheminformatics approaches and methodologies presented in this volume and at the Skolnik Award Symposium will pave the way for improved efficiency in drug discovery. The lectures and the chapters also reflect the various aspects of scientific enquiry and research interests of the 2015 Herman Skolnik award recipient.

Surviving critical illness is not always the happy ending we imagine for patients. Many ICU survivors suffer from a range of long-lasting physical and psychological issues such end stage renal disease, congestive heart failure, cognitive impairment, neuromuscular weakness, and depression or anxiety, which affect their overall quality of life and ability to lead productive lives. This lingering burden or 'legacy' of critical illness is now recognized as a major public health issue, with major efforts underway to understand how it can be prevented, mitigated, or treated. The Textbook of Post-ICU Medicine: The Legacy of Critical Care discusses the science of the recovery process and the innovative treatment regimens which are helping ICU survivors regain function as they heal following trauma or disease. Describing the major clinical syndromes affecting ICU survivors, the book delineates established or postulated biological mechanisms of the post-acute recovery process, and discusses strategies for treatment and rehabilitation to promote recovery in the ICU and in the long term. The chapters are written by an interdisciplinary panel of leading clinicians and researchers working in the field. The book serves as a unique reference for general practitioners, internists and nurses caring for long term ICU survivors as well as specialists in intensive care medicine, neurology, psychiatry, and rehabilitation medicine.

A simple, go-to guide to treating chronic pain with trigger point therapy for physical therapists, bodyworkers, and patients From the bestselling author of The Concise Book of Trigger Points This pocket-sized guide covers practical information about the trigger points-the painful knots that can form in tissues like muscles and fascia-that are central to addressing acute and chronic pain with massage, bodywork, and physical therapy. Full-color illustrations and charts help practitioners, students, and patients identify trigger points and address referred pain patterns with ease. The first chapter introduces relevant information on fascia and myofascial meridians and provides an overview of trigger point symptoms, classification, and formation. Subsequent chapters are organized by muscle group and feature concise-yet comprehensive-sections on each of the main skeletal muscles and their trigger points. Common conditions, such as headaches and back pain, are explored for all of the muscle groups, including the muscles of the: * Face, head, and neck * Trunk and spine * Shoulder and arm * Forearm and hand * Hip and thigh * Leg and foot Written in clear, accessible language, this essential guide offers a wealth of knowledge to the lay reader, the student, or the practitioner.

This book has built on the work that was presented in the previous Fascicles of the Third and Fourth Series. The authors' vast experience has led to new understanding of many aspects of pituitary pathology. With modern immunostaining and molecular techniques, classification of pituitary disease is becoming easier. Furthermore, the availability of targeted therapies has augmented the role of the pathologist in determining an accurate diagnosis. This updated volume addresses modern techniques and their application to treatment of pituitary neoplasms but retains the detailed foundation of morphology in a lushly illustrated tome, the cornerstone of the AFIP fascicles.

From a leader in the field of psychotherapy, this new book is the first dedicated to the topic of the fear of contamination. The fear of contamination is the driving force behind compulsive washing, the most common manifestation of obsessive compulsive disorder. This is one of the most extraordinary of all human fears. It is complex, powerful, probably universal, easily provoked, intense, and difficult to control. Usually the fear is caused by physical contact with a contaminant and spreads rapidly and widely. The book starts by defining the disorder, before considering the various manifestations of this fear, examining both mental contamination and contact contamination, and feelings of disgust.Most significantly, it develops a theory for how this problem can be treated, providing clinical guidelines - based around cognitive behavioural techniques.

The second edition of this award-winning textbook has been thoroughly revised and updated throughout. Building on the success of the first edition, the book continues to address the History and Practice of Forensic Psychiatry, Legal Regulation of the Practice of Psychiatry, Psychiatry in relation to Civil Law, Criminal Law, and Family Law. Important sections such as Special Issues in Forensic Psychiatry, Law and the Legal System, and Landmark Cases in Mental Health Law are included. Designed to meet the needs of practitioners of forensic psychiatry, for residents in forensic psychiatry, and those preparing for the specialty examination in Forensic Psychiatry of the American Board of Psychiatry and Neurology, this volume will also answer the many questions faced by mental health professionals, mental health administrators, correctional health professionals and correctional health administrators, attorneys, judges, probation and parole officers and administrators all of whom, at one time or another, require a substantive presentation of the entire field of forensic psychiatry in the USA.

Alcohol has played a major part in British life for centuries. It has led do the rise and fall of governments, financed wars, provoked civil disorder and even acts of terrorism. In this book, two of the leading authorities on alcohol and its problems take a look at the UK and its alcohol addiction.