Addition, Elimination and Substitution: Markovnikov, Hofmann, Zaitsev and Walden: Discovery and Development discusses foundational reactions in organic chemistry and their major protagonists, contributions to synthesis, and history. Hofmann, Zaitsev, and Markovnikov are introduced, along with their major discoveries and contributions to organic chemistry. The history of controversies around Markovnikov's Rule are addressed. The book introduces Walden's original demonstration of configuration inversion, then discusses bimolecular elimination reactions, regioselective addition reactions, regiospecific alkene synthesis, and the development of modern reactions with configuration inversion. With its unique perspective, focus, and comprehensive coverage, this book belongs on the shelf of every organic chemist.

This book offers the foundation for research on nuclear medicine and low temperature plasma applications in multiple industries and daily life. This book is beneficial for those wishing to advance their knowledge of the physics of plasma medicine, plasma agriculture and industrial applications. It provides a comprehensive overview of the basic Fundamental Science of Low Temperature Plasma (FS-LTP) knowledge required for the practice of medical physics in modern medicine. This book provides a guide of nuclear medicine that is the exercise of using radionuclides in medicine for diagnosis, staging of disease, therapy and monitoring the response of a disease process. This book comprehensively covers a broad range of topic including but not limited to field of Plasma Oncology and Plasma Medicine with many applications including, agriculture, plasma processing, catalysis, and aerospace engineering.

Emerging Nanomaterials and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistance focuses on recent and emerging trends surrounding nanomaterials and nano-drug delivery approaches to combat antimicrobial resistance. The relationship between nanomaterials and antimicrobial activity needs to be deeply explored to meet the challenges of combating antimicrobial resistance. The content of this book is divided into three main topic areas, including (i) how to overcome the existing traditional approaches to combat antimicrobial resistance, (ii) applying multiple drug delivery mechanisms to target multi-drug resistant microbes, and (iii) how nanomaterials can be used as drug carriers. This is an important reference source for those looking to understand how nanotechnology plays an important role in combatting disease and infection. As antimicrobial resistance threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses, and fungi, this is a timely resource.

Progress in Medicinal Chemistry, Volume 61 provides a review of eclectic developments in medicinal chemistry, with each chapter written by an international board of authors.

New Targets for the Treatment of Hypertension and Associated Diseases, Volume 94 in the Advances in Pharmacology serial, highlights new advances in the field, with this new volume presenting interesting chapters on Cytochrome P450, 20-hydroxyeicosatetraenoic acid and GPR75 pathway in hypertension, Treatment of hypertension with soluble epoxide hydrolase inhibitors, Effects of allosteric modifiers of adenosine receptors in the heart, Orally active epoxyeicosatrienoic acid analogs in hypertension and renal injury, Drugs affecting the nitric oxide- cyclic GMP pathway in hypertension, Relaxin-2 and Serelaxin in renal and cardiac dysfunction in hypertension, and more.

Vaccine development is a complex and time consuming process that differs from the development of conventional pharmaceuticals. Primarily, vaccines are intended for use in healthy individuals as a preventative measure, requiring a long and rigorous process of research and many years of testing and development prior to clinical trials and regulatory approval. The average time for the development of vaccines to clinical is 12 to 15 years. Vaccine Development: From Concept to Clinic is a detailed overview of the development of new vaccines, covering the entire process and addresses all classes of vaccines from a processing, development and regulatory viewpoint. Utilising successful case studies the book will provide insight to the issues scientists face when producing a vaccine, the steps involved and will serve as an ideal reference tool regarding state-of-the-art vaccine development. This book is an ideal companion for any researchers working in vaccine discovery and development or with an interest in the field.

Quality, second edition, provides comprehensive application of regulatory guidelines and quality concepts and methodologies related to pharmaceutical manufacturing. It is an excellent resource for practitioners, those pursuing pharmaceutical related certifications, and for students trying to learn more about pharmaceutical manufacturing. This book provides the background theory, applied descriptions of the guidelines and concepts, plus questions and problems at the end of the chapters that will help provide practice for the reader to apply the concepts. In this book the authors share their combined 60+ years of extensive practical experience in the industry and in process improvement combined with detailed understanding of the needs of the industry and education system. This book provides real-life examples from industry and guidelines for practical application of tools that can be referenced by operators, engineers, and management. This book is fully revised, updated, and expanded with new content in areas such as QbD, Lean, Six Sigma, basic data analysis, and CAPA tools.

Advances in the Study of Behavior, Volume 54 highlights new advances in the field, with this new volume presenting interesting chapters on Mobbing in animals: a thorough review and proposed future directions, Learned components of courtship: a focus on gestures, choreographies and construction abilities, Sexual selection in the true bugs, and Brain-behavior relationships of cognition in vertebrates: lessons from amphibians, Pre-Copulatory and Copulatory Courtship in Male-Dimorphic Arthropods.

Combination Drug Delivery Approach as an Effective Therapy for Various Diseases explores the use of bioengineering tools in combination drug delivery approaches to control various diseases at different clinical stages of synergistic action, varying mechanisms of action, and during the suppression of drug resistance. The book presents fundamental knowledge on the experiential and experimental aspects of drug combination approaches in order to equip rational applications in preventing the emergence of resistance during the treatment of various diseases. It provides a holistic understanding of the principles behind formation, characterization, applications, regulations, toxicity, challenges and future perspectives of combination drug delivery approaches. It will be of interest to researchers and advanced graduate students in pharmaceutical science, chemistry, biology and medicine, as well as pharmaceutical companies and scientific organizations.

Advances in Parasitology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Neurosurgical Management of Psychiatric Disorders, Part A, Volume 266, the latest release in the Progress in Brain Research series, highlights new advances in the field with this new volume covering interesting chapters, including Pathophysiology and Animal Models of Psychiatric Disorders, Neuroimaging of Psychiatric Disorders, History of Psychosurgery, Ethics of Psychosurgery, Medicolegal Aspects and Regulatory Issues of Psychosurgery, Psychiatric Mimics of Neurosurgical Disorders, Seizures and Pseudoseizures: The Great Divide, Pitfalls of Psychiatric Patients Selection for Functional Neurosurgery, Modern Surgical Strategies for Management of Psychiatric Disorders, Neuromodulation for Behavioral Disorders, and more.

Nanotherapeutics in Cancer Vaccination and Challenges consolidates the current research on cancer nanomedicine and therapeutic cancer vaccination to explore the most effective and promising avenues. The book covers cancer vaccines before exploring nanotherapeutics, DNA and mRNA vaccines in cancer treatment. Finally, it considers regulatory and industrial perspectives on cancer vaccination and nanotherapeutics. This resource will be useful for pharmaceutical scientists and researchers focused on biomedical engineering, chemical engineering, vaccine development, and cancer immunotherapy, along with advanced students in these subjects. Cancer is arguably the most complex and challenging disease known to mankind. Over the last two-decades, significant advancements have been made in new and novel concepts of cancer nanomedicines. Therapeutic cancer vaccines may be utilized to inhibit further growth of advanced cancers and/or relapsed tumors that are refractory to conventional therapies, such as surgery, radiation therapy and chemotherapy.

SECTION 1: BASICS OF MRI 1. Basic Principles 2. T1, T2 Relaxations and Image Weighting 3. k-space and Scanning Parameters 4. Magnetic Resonance Instrumentation 5. Sequences I: Basic Principles and Classification 6. Sequences II: Accessory Techniques 7. Sequences III: When to Use What Sequences 8. Magnetic Resonance Imaging Artifacts 9. Magnetic Resonance Imaging Safety 10. Magnetic Resonance Imaging Contrast Media 11. Normal Signal Intensity on Magnetic Resonance Imaging 12. Principles of Interpretation: Neuroimaging 13. Principles of Interpretation: Body Imaging SECTION 2: MRI TECHNIQUES 14. 3 Tesla Magnetic Resonance Imaging 15. Magnetic Resonance Angiography 16. Diffusion Weighted Imaging 17. Magnetic Resonance Imaging Perfusion 18. Magnetic Resonance Spectroscopy 19. Neuroimaging Magnetic Resonance Imaging Techniques 20. Body Imaging Magnetic Resonance Imaging Techniques I 21. Body Imaging Magnetic Resonance Imaging Techniques II 22. Cardiac Magnetic Resonance Imaging Techniques 23. Lung Magnetic Resonance Imaging Techniques Index

Written for all therapists who want to understand this groundbreaking theory as it might actually show up in their day-to-day practice, this book offers a comprehensive approach to polyvagal-informed intervention. Worksheets and experiential exercises designed to map and shape autonomic response provide therapists with a road map for bringing polyvagal theory into their clinical practice.

Fundamentals of Nanotoxicology: Concepts and Applications provides an outline to fundamental concepts of nanotoxicology and their applications. The book opens historical oversights on nanotechnology, terminology, comparison of nanomaterial sizes, and an overview of regulations. It then goes on to cover types, classifications, sources and properties. It also delves into mechanisms of toxicity as well as health and safety assessments. Biomedical, agricultural, and food applications are explored, and ecotoxicology and the environmental impact on nanomaterials rounds out the book's overview of this topic. This book will be a helpful resource for understanding concepts and current knowledge to academics, advanced students, and researchers interested in entering or learning more about this interdisciplinary field of study.

Keeping children bodies, minds and emotions on task just got easier with this new book from self-regulation expert Teresa Garland. Featuring more than 200 practical and proven interventions, strategies and adaptation for helping children gain more control over their lives. Each chapter provides rich background and theoretical material to help the reader better understand the issues our children face.

Topics include:

* Basic and advanced methods to calm a child and to preventing outbursts and melt-downs

* Interventions to help with attention problems, impulse control, distractibility and the ability to sit still

* Stories and video-modeling for autism, along with techniques to quell repetitive behaviors

* Sensory strategies for sensitivity and craving

* Behavioral and sensory approaches to picky eating

* Ways to increase organization skills using technology and apps

* Strategies for managing strong emotions as well as techniques for releasing them