Immunofluorescence is a key diagnostic tool in dermatopathology, and essential in the diagnosis of connective tissue diseases, vasculitis and other cutaneous disorders. The need to interpret the results of immunofluorescence testing, and correlate these with histopathological results, is a key skill required not just of dermatopathologists but also, increasingly, of dermatologists who either read the slides themselves or use a pathology lab or academic referral centre. Handbook of Direct Immunofluorescence covers not only day-to-day findings but also less common patterns and rarities, and gives information on important diagnostic pitfalls. Each chapter is dedicated to a specific disease and is introduced by concise text that describes the clinical presentation and pathogenesis: then, multiple images show the range of histopathological and immunofluorescence findings associated with the disease in question. Key points Practical, clinically oriented coverage provides invaluable resource for dermato-, oral and general pathologists, as well as dermatologists Includes invaluable information on technical aspects (specimen procurement, transportation, etc) as well as guidance on interpreting histopathological and immunofluorescence findings Pattern-based approach serves as logical framework for reaching a diagnosis, as well as understanding when to order additional tests and how to recognise nonspecific findings

A Tribute to Paul Greengard, Volume 90, the latest release in the Advances in Pharmacology series presents a variety of chapters from the best authors in the field, with this release presenting a tribute to Paul Greengard.

The relationship between sleep and both mental and physical performance in athletes has become a key issue over the past several years. Sleep and Athletes: Physical Performance, Mental Performance, Injury Prevention, and Competitive Advantage for Athletes, Coaches, and Trainers aims to synthesize the growing scientific evidence in this area to help researchers, clinicians, and others interested in sport to understand the fundamentals of sleep health and how these factors relate to athletes. Serving as an important bridge between the sleep and athletics field, the book educates sleep professionals about how their field of expertise relates to various aspects of athletics, whilst educate sports professionals about the basics of sleep and how it relates to their field of expertise. This is accomplished by explaining some of the basics of sleep health; reviewing the literature on sleep disorders, treatments, risk factors for athletes; discussing ways that sleep health impacts physical and mental performance; and addressing key specific areas where these fields overlap. In all cases, this text will draw from the existing peer-reviewed literature, in order to provide evidence-based guidance that is objective and well-explained.

In the wake of disaster emergency responders are first on the scene and last to leave. They put concern for the lives of others over concern for their own lives, and work tirelessly to recover the bodies of the missing. Their heroic actions save lives, provide comfort to and care for the wounded and inspire onlookers, but at what cost to themselves? We now know that rescue workers who are exposed to mutilated bodies, mass destruction, multiple casualties, and life-threatening situations may become the hidden victims of disaster. The traumatic consequences of exposure can profoundly impact emergency responders, radiate to their families, and permeate the emergency organization. This much-needed new book, based on the authors' original research and clinical experience, describes the consequences of trauma exposure on police officers, fire fighters, and paramedics. Weaving data collected in large-scale quantitative studies with the personal stories of responders shared in qualitative interviews, this much-needed account explores the personal, organizational, and societal factors that can ameliorate or exacerbate traumatic response. Stress theory, organizational theory, crisis theory, and trauma theory provide a framework for understanding trauma responses and guiding intervention strategies. Using an ecological perspective, the authors explore interventions spanning prevention, disaster response, and follow-up, on individual, family, group, organizational, and community levels. They provide specific suggestions for planning intervention programs, developing trauma response teams, training emergency service responders and mental health professionals, and evaluating the effectiveness of services provided. Disaster, whether large-scale or small, underscores our ongoing vulnerability and the crucial need for response plans that address the health and well being of those who confront disaster on a daily basis. In the Line of Fire speaks directly to these emergency response workers as well as to the mental health professionals who provide them with services, the administrators who support their efforts, and the family members who wonder if their loved one will return home safely from work tonight.

Inflammation and Natural Products brings together research in the area of the natural products and their anti-inflammatory action in medical, nutraceutical and food products, addressing specific chronic inflammatory diseases like cancer and the mechanistic aspects of the mode of action of some key natural products. Inflammation is a complicated process, driven by infection or injury or genetic changes, which results in triggering signalling cascades, activation of transcription factors, gene expression, increased levels of inflammatory enzymes, and release of various oxidants and pro-inflammatory molecules in inflammatory cells. Excessive oxidants and inflammatory mediators have a harmful effect on normal tissue, including toxicity, loss of barrier function, abnormal cell proliferation, inhibiting normal function of tissues and organs and finally leading to systemic disorders. The emerging development of natural product formulations utilizing the unique anti-inflammatory compounds such as polyphenols, polysaccharides, terpenes, fatty acids, proteins and several other bioactive components has shown notable successes. Inflammation and Natural Products: Recent Development and Current Status provides a comprehensive resource, ranging from detailed explanation on inflammation to molecular docking strategies for naturally occurring compounds with anti-inflammatory activity. It is useful for graduate students, academic and professionals in the fields of pharmaceutical and medical sciences and specialists from natural product-related industries.