This book is a history of medicines and the commercial actors that make and sell them, covering the 140 years since the modern pharmaceutical industry came into being. It is written in a lively and accessible way, aiming at a general audience that combines historical narrative with fascinating case studies on drug discovery and commercialization, from the rat poison that became warfarin, to a cardiovascular treatment that was turned into Viagra. In a non-partisan way it also examines some of the less noble manifestations of corporate behavior, concluding with an agenda for reform.It is hard to think of anything nobler than to bring to the world a medicine that saves lives. And over 140 years of history, the pharmaceutical industry has produced a range of remarkable products, albeit typically with external scientific and financial support. Making medicines is a very big and profit-driven business, and the industry does not always make the right products for the right people, or at the right prices.The industry wields immense power over lives and economies. How has it risen to this position of dominance? Are the interests of the industry and the public in balance? What should we admire about the industry? What should we criticise and seek to change? The importance of this book lies in the fact that we are all stakeholders in this industry whether or not we own shares, so we all need answers to these questions.Related Link(s)

Theory and Applications of Nonparenteral Nanomedicines presents thoroughly analysed data and results regarding the potential of nanomedicines conceived by diverse non-parenteral routes. In the context of nanotechnology-based approaches, various routes such as oral, pulmonary, transdermal, delivery and local administration of nanomedicine have been utilized for the delivery of nanomedicine. This book discusses the non-parenteral application of nanomedicine, its regulatory implications, application of mucus penetrating nanocarrier, and detailed chapters on development of nanomedicines developed for drug delivery by various route. Beginning with a brief introduction to the non-parenteral delivery of nanomedicine and the safety and regulatory implications of the nanoformulations, further chapters discuss the physiology of the biological barriers, the specificity of the nanocarriers as well as their multiple applications. Theory and Applications of Nonparenteral Nanomedicines helps clinical researchers, researchers working in pharmaceutical industries, graduate students, and anyone working in the development of non-parenteral nanomedicines to understand the recent progress in the design and development of nanoformulations compatible with non-parenteral applications.

Climate change and environmental pollution remain two primary areas of concern in today's world. These detrimental influences continue to have a strong impact on various aspects of humanity, specifically public health in tropical regions. Researchers have seen neglected tropical diseases (NTDs) affected by climate change and anthropogenic impacts. Climate Change and Anthropogenic Impacts on Neglected Tropical Diseases is a pivotal reference source that provides vital research on the association of environmental pollutants and global warming with viruses in tropical regions. While highlighting topics such as pathogenicity, travel impact, and economic impacts, this publication explores the developments and trends in these areas of medicine and ecology, as well as prevention strategies to be used for educational and sensitization purposes. This book is ideally designed for doctors, medical practitioners, ecologists, epidemiologists, environmentalists, world health organizations, researchers, biologists, policymakers, academicians, and students.

The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials.

Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book.

Since 1994, the Boston Change Process Study Group (BCPSG) has published articles on the most fundamental of therapeutic concepts: change. However, the BCPSG s evolving interests and points of focus have been wide-ranging, if always thematically linked by a connection to change. With Change in Psychotherapy: A Unifying Paradigm, the evolution of the group s thinking and work has been collected into a book for the first time.

The Group s initial areas of research have since been recognized as central to psychotherapeutic thought. For example, the BCPSG has long focused on bringing insights from the study of infancy to bear on thinking about psychoanalytic processes. In its earliest work, the group looked to early development as a source of inspiration and knowledge, and as a possible way to illuminate change processes in psychotherapy. Today, developmental researchers and neuroscientists increasingly locate keys to psychological health and development in the earliest interactions between mother and infant. This book, which consists of significant papers by the BCPSG, traces the group s contributions to psychoanalytic topics of note, including: the location of the implicit, the creation of meaning, the moment-by-moment clinical process, and the subjective experience of the therapist. The book also includes new introductions to selected chapters, which provide background on the original intent and reception of each article. Change in Psychotherapy presents the essential findings from an internationally acclaimed group of analysts in a single volume for the first time. In this, it is a truly groundbreaking work."

Computer vision and machine intelligence paradigms are prominent in the domain of medical image applications, including computer assisted diagnosis, image guided radiation therapy, landmark detection, imaging genomics, and brain connectomics. Medical image analysis and understanding are daunting tasks owing to the massive influx of multi-modal medical image data generated during routine clinal practice. Advanced computer vision and machine intelligence approaches have been employed in recent years in the field of image processing and computer vision. However, due to the unstructured nature of medical imaging data and the volume of data produced during routine clinical processes, the applicability of these meta-heuristic algorithms remains to be investigated. Advanced Machine Vision Paradigms for Medical Image Analysis presents an overview of how medical imaging data can be analyzed to provide better diagnosis and treatment of disease. Computer vision techniques can explore texture, shape, contour and prior knowledge along with contextual information, from image sequence and 3D/4D information which helps with better human understanding. Many powerful tools have been developed through image segmentation, machine learning, pattern classification, tracking, and reconstruction to surface much needed quantitative information not easily available through the analysis of trained human specialists. The aim of the book is for medical imaging professionals to acquire and interpret the data, and for computer vision professionals to learn how to provide enhanced medical information by using computer vision techniques. The ultimate objective is to benefit patients without adding to already high healthcare costs.

Alginates in Drug Delivery explores the vital precepts, basic and fundamental aspects of alginates in pharmaceutical sciences, biopharmacology, and in the biotechnology industry. The use of natural polymers in healthcare applications over synthetic polymers is becoming more prevalent due to natural polymers' biocompatibility, biodegradability, economic extraction and ready availability. To fully utilize and harness the potential of alginates, this book presents a thorough understanding of the synthesis, purification, and characterization of alginates and their derivative. This book collects, in a single volume, all relevant information on alginates in health care, including recent advances in the field. This is a highly useful resource for pharmaceutical scientists, health care professionals and regulatory scientists actively involved in the pharmaceutical product and process development of natural polymer containing drug delivery, as well as postgraduate students and postdoctoral research fellows in pharmaceutical sciences.

Fighting the Opioid Epidemic: The Role of Providers and the Clinical Laboratory in Understanding Who Is Vulnerable covers the important aspects that are essential in fighting the opioid epidemic. This succinct reference highlights how the toxicology laboratory can play a vital role in fighting the opioid epidemic by implementing a robust system for drugs of abuse testing as well as drug testing in pain management patients. It targets health care professionals in a technical manner, discussing polymorphisms of important genes that may be associated with increased vulnerability of alcohol and drug addiction to an individual.

Immunopathology, Volume 107 in the Advances in Virus Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Viral Immunopathology will cover how the immune system, innate or adaptive, is often at the root of viral pathogenesis. This is true in diverse host systems including vertebrates, plants and insects. This volume will present the latest findings in this interesting and important area of research, and will include human, plant, fish, and insect viruses. Different kingdoms have evolved very diverse immune responses to virus infection but the common theme - namely, that effects of viruses on host immune systems can condition the induction of viral disease - will unify this concept across kingdoms.

Critiquing the Psychiatric Model is the first Volume of the Ethics International Press Critical Psychology and Critical Psychiatry Series. Understanding the current systems of psychology and psychiatry is profoundly important. So is exploring alternatives. The Critical Psychology and Critical Psychiatry Series presents solicited chapters from international experts on a wide variety of underexplored subjects. This is a series for mental health researchers, teachers, and practitioners, for parents and interested lay readers, and for anyone trying to make sense of anxiety, depression, and other emotional difficulties. Critiquing the Psychiatric Model sets out to present a clear picture of the current "mental disorder paradigm," one that claims an ability to "diagnose and treat mental disorders" and that provides "medication" as its primary treatment. Critiquing the Psychiatric Model traces the history of the psychiatric model and its "diagnostic manual" and identifies its flaws and problem areas by presenting more than twenty solicited chapters from experts worldwide.