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Bipolar disorder is a lifelong challenge, but it doesn't have to rule your life. Join the many tens of thousands of readers who have used the science-based tools in this book to achieve greater balance and get the most out of treatment. Leading expert Dr. Monica Ramirez Basco helps you understand the nature of bipolar illness and recognize the early warning signs of mood swings. Step-by-step exercises (you can download and print additional copies of the forms as needed) give you greater insight into your own triggers, vulnerabilities, and strengths. Dr. Basco guides you to build the particular skills you need to withstand the seductive pull of manic episodes and escape the paralysis of depression. You'll also learn key strategies for managing stress, making healthy decisions, and solving problems. Vivid stories and examples illustrate how to put the techniques into action. Significantly revised, the second edition features a new structure, more succinct chapters, and streamlined exercises.
This timely resource compares single-photon emission tomography (SPECT), used mainly withTechnetium and iodine for routine clinical examinations, and positron emission tomography(PET) , employing short-lived radionuclides of carbon, oxygen, nitrogen, and fluorine in researchinvestigations.Presenting the logic behind why one approach is better than another in various circumstances,Radio pharmaceuticals details the use of radiolabelled substrates in measuring the effect of diseaseand drugs on regional metabolism and receptor concentration/occupancy .. . discusses factorsaffecting the selective retention of small metal complexes by various tissues .. . analyzes the interactionof small exogenous metal complexes with enzymes in vivo and the critical role of stereochemistry. . . explores the use of radio labelled compounds in the study of neuroactive compounds,neurotransmitters, enzyme inhibitors, and substrates in vivo .. . covers the design and pharmacologyof radiolabelled drugs as probes of site of action , selectivity and specificity, and pharmacokineticsin vivo .. . and more.Extensively referenced with over l 050 bibliographic citations, Radiopharmaceuticals is a state-ofthe-art guide for pharmacists; organic, medicinal , and radiopharmaceutical chemists; pharmacokineticists;nuclear medicine physicians and technologists; neurochemists; and governmentregulatory personnel .
This book provides an overview of the discovery and structure of IL-17, including its pathogenesis and role in chronic inflammation and autoimmunity. To capture the latest developments and product approvals the book also discusses the therapeutic advances and looks at emerging therapies targeting the IL-17 pathway. IL-17 is a pro-inflammatory cytokine that has a key role in inflammation, autoimmunity, and host defense in a number of inflammatory disorders such as rheumatoid arthritis, psoriatic arthritis and psoriasis, ankylosing spondylitis, multiple sclerosis, and inflammatory bowel disease. The discovery of the IL-17-Th17 pathway has seen exciting development in the field of immunology and inflammation research, which has led to a number of recent regulatory approvals.
The Practitioner's Path in Speech-Language Pathology: The Art of School-Based Practice bridges the gap between theory and practice, evidence-based practice and practice-based evidence, and the science and artistry of speech-language pathology. This book takes a critical look at areas related to wellness, professional development, and growth that can impact the personal self along with the professional self. It examines each area through an overview of inter-disciplinary research in addition to personal narratives illustrating key principles and strategies and offers the reader a professionally balanced perspective.The first section of the book helps us understand the importance of building a foundation for our clinical path through a discussion about scientific and evidence-based principles, different types of knowledge systems, and development of wisdom. The second section of the book helps us understand the importance of supporting our foundation through an introduction to reflection, counsel and care, balance and harmony, growth and detachment. The third section of the book includes chapters that serve as pillars of practice: organizational frameworks, materials and activities, measuring progress, best practices, and the importance of community. The fourth and final section of the book highlights shared vision, clinical expertise, emotional intelligence, leadership trends, the scholarship of teaching and learning, and research dissemination.This book challenges us to consider our own perceptions about the explicit nature of professional practice, and facilitates the development of four attitudes that can have a profound impact on both clinical success and professional satisfaction: "a scientific attitude", "a therapeutic attitude", "a professional attitude", and "a leadership attitude". It contains a blend of clinical evidence and research, practitioner views, common sense, philosophical stances, and historical overviews. "The Practitioner's Path in Speech-Language Pathology" is designed for students and practitioners who are actively involved with the process of knowledge acquisition, and targets issues we encounter along our path to becoming reflective practitioners, as they relate to the excellence behind and scholarship within teaching and learning.
Cognitive behaviour therapy has brought data-driven and data-yielding treatment to insomnia. Intended for clinical trainees and non-insomnia sleep specialists, this book offers: definition of insomnia; review of the conceptual; framework for treatment; overview of the components of therapy; session-by-session guide; and dialogues.
This is a fully-updated, comprehensive guide for trainees preparing for the MRCPsych CASC exam (Clinical Assessment of Skills and Competencies). Success in the CASC is the final step in being awarded the MRCPsych qualification, which signifies the physician has fulfilled the necessary training requirements and has passed the membership exams conducted by the Royal College of Psychiatrists. The book is presented in a clear layout and covers the full range of psychiatry subspecialties likely to be encountered on exam day.
All humans need space to think, to be and to process without constant distraction. This is especially true of adolescents and young adults, for whom identity formation is a consuming task. Social media has generated both a place for the creation of identity and an audience. But constant connection leaves little space without intrusion from others. For those with body dissatisfaction and/or eating disorders, living in today's world can be especially challenging, and viewing images on social media and other online formats can be devastating. Shauna Frisbie utilises phototherapy techniques to view client-selected images (whether they be of themselves or others) to help uncover underlying messages that are impacting their relationship to their bodies. Integrating concepts of healing narratives, neuroscience and phototherapy, this book will help any therapist promote self-compassion, self-reflection and healing in their clients.
Developed by experts in trauma psychiatry and psychology and grounded in adolescent developmental theory, this is a modular, assessment-driven treatment that addresses the needs of adolescents facing trauma, bereavement, and accompanying developmental disruption. Created by the developers of the University of California, Los Angeles PTSD Reaction Index (c) and the Persistent Complex Bereavement Disorder Checklist, the book links clinicians with cutting-edge research in traumatic stress and bereavement, as well as ongoing training opportunities. This innovative guide offers teen-friendly coping skills, handouts, and specialized therapeutic exercises to reduce distress and promote adaptive developmental progression. Sessions can be flexibly tailored for group or individual treatment modalities; school-based, community mental health, or private practice settings; and different timeframes and specific client needs. Drawing on multidimensional grief theory, it offers a valuable toolkit for psychologists, psychiatrists, counsellors, and others who work with bereaved and traumatized adolescents. Engaging multicultural illustrations and extensive field-testing give this user-friendly manual international appeal.
This book presents up-to-date information on one of the hottest topics in prostate cancer, namely bone metastases. The most recent developments with respect to biology, pathology, diagnosis, and treatment are described, providing readers with an excellent understanding of the mechanisms of metastasis formation, the characteristics of metastases, their aggressiveness, and prognostic factors for treatment response. The coverage includes discussion of all of the best available options (laboratory, radiology, and nuclear medicine) for achieving early diagnosis and both established and novel therapeutic approaches. Detailed information is provided on hormonal manipulations, bone-targeted agents, vaccines, taxanes, and other treatments that are enriching the therapeutic armamentarium. The editors can be considered leaders in the field, with great experience in diagnostic and clinical oncology and research, and the authors are experts in diverse specialties. This ensures a multidisciplinary approach, mirroring the current situation in which treatment in patients with bone metastases is undertaken by a team of specialists and health professionals in a variety of fields.
This is the first book to cover all aspects of the development of imaging biomarkers and their integration into clinical practice, from the conceptual basis through to the technical aspects that need to be considered in order to ensure that medical imaging can serve as a powerful quantification instrument capable of providing valuable information on organ and tissue properties. The process of imaging biomarker development is considered step by step, covering proof of concept, proof of mechanism, image acquisition, image preparation, imaging biomarker analysis and measurement, detection of measurement biases (proof of principle), proof of efficacy and effectiveness, and reporting of results. Sources of uncertainty in the accuracy and precision of measurements and pearls and pitfalls in gold standards and biological correlation are discussed. In addition, practical use cases are included on imaging biomarker implementation in brain, oncologic, cardiovascular, musculoskeletal, and abdominal diseases. The authors are a multidisciplinary team of expert radiologists and engineers, and the book will be of value to all with an interest in the quantitative imaging of biomarkers in personalized medicine.
Providing a detailed review of one of the most common clinical problems, elbow instability, this comprehensive text organizes the most up-to-date, evidence-based information on the rapidly advancing field of elbow surgery. Initial chapters focus on anatomy, biomechanics and the most currently utilized surgical approaches for the treatment of the unstable elbow. Subsequent chapters focus on the evaluation and surgical treatments of acute instabilities, such as simple dislocations and fracture-dislocations, as well as chronic instabilities, including chapters focusing on the non-operative and operative management of the throwing athlete. The final chapters describe additional treatment strategies for complex instabilities, focusing on external fixation, total elbow arthroplasty and elbow fusion. Each chapter includes background information, an evaluation section, a treatment algorithm, non-operative treatment strategies, surgical management, published outcomes and preferred methods of treatment from each author. A supplemental video section is also included, depicting frequently performed procedures. Written by experts in the field, The Unstable Elbow consolidates all of the current knowledge of elbow instability into a valuable resource for orthopedic surgeons and residents worldwide.
This state-of-the-art review on longevity focuses on centenarians, studied as a model of positive biology. The extraordinary rise in the elderly population in developed countries underscores the importance of studies on ageing and longevity in order to decrease the medical, economic and social problems associated with the increased number of non-autonomous individuals affected by invalidating pathologies. Centenarians have reached the extreme limits of human life span. Those in relatively good health, who are able to perform their routine daily tasks, are the best examples of extreme longevity, representing selected individuals in which the appearance of major age-related diseases - including cancer and cardiovascular diseases - has been consistently delayed or avoided. The relationship between causality and chance is an open discussion topic in many disciplines. In particular, ageing, the related diseases, and longevity are difficult to define as a consequence of causality, chance or both. Discussing the relevance of these different factors in the attainment of longevity, the book gathers contributions on genetic, epigenetic and phenotypic aspects of centenarians. The "positive biology" approach is applied to clarify the causes of positive phenotypes, as well as to explain the biological mechanisms of health and well-being with the aim of preventing and/or reducing frailty and disability in the elderly.
Diversified physicochemical injuries trigger Charnoly body (CB) formation as pleomorphic, electron-dense, multi-lamellar stacks of nonfunctional mitochondrial membranes in the most vulnerable cell. Free radicals induce downregulation of mitochondrial DNA, microRNA, AgNOR, and epigenetics to trigger CB molecular pathogenesis. CB is eliminated by energy (ATP)-driven lysosome-dependent charnolophagy as a basic molecular mechanism of intracellular detoxification to prevent acute and chronic diseases. Accumulation of CB at the junction of axon hillock and charnolosome (CS) at the synapses causes cognitive impairments; whereas, nonspecific induction of CB causes GIT stress, myelosuppression, alopecia, neurotoxicity, cardiotoxicity, and infertility in multidrug-resistant malignancies. Hence, stem cell-specific CB, charnolophagy, and CS agonists/antagonists are introduced as novel charnolopharmacotherapeutics for the successful treatment of cardiovascular diseases, neurodegenerative diseases, infectious diseases, drug addiction, and cancer. Nanoparticles to improve drug delivery, CS exocytosis, and disease-specific spatiotemporal charnolosomics employing correlative and combinatorial bioinformatics boost mitochondrial bioenergetics through balanced diet, exercise, and antioxidants. The book will be of interest to medical scientists and practitioners.
This book covers all aspects of the diagnosis and treatment of tumors of the jugular foramen - cranial base lesions that present particular diagnostic and management difficulties and remain challenging to remove despite advances in surgery and interventional neuroradiology. The authors have developed novel concepts and surgical techniques relating to management of the facial nerve, reconstruction of the cranial base, and resection of large tumors with intra- and extracranial extension. These techniques, as well as anatomic studies in cadavers, are presented by means of surgical photographs, illustrations, and videos. Tumors of the Jugular Foramen will be of interest to all specialists involved in the management of these challenging tumors, including neurosurgeons, ENT surgeons, neuroradiologists, neurologists, neurointensivists, radiotherapists, oncologists, and physiotherapists.
This atlas focuses on the imaging and treatment options available for giant intracranial aneurysms since 1990s in the beginning of the so-called modern endovascular era. During this period, there were significant advances made in the therapy of small intracranial aneurysms though the treatment of giant aneurysms continued to pose an insurmountable challenge. At the turn of this century, this grim scenario gradually improved with better understanding of the pathophysiology of giant intracranial aneurysms. This changed scenario in giant intracranial aneurysm therapy has been illustrated with the aid of informative clinical case studies. The clinical presentation of giant aneurysms in adults and children is described as are the merits of different imaging modalities explained and illustrated. Extensive consideration has been given to modern fusion imaging that has improved our insight into the nature of the disease. Endovascular treatment approaches (including illustrative open surgical approaches) and reconstructive and deconstructive strategies are fully documented, with careful attention given to factors that influence management strategies, treatment choice and complications.The atlas will be a valuable reference and practical aid for neuroradiologists, neurosurgeons, neurologists, fellowship trainees, postgraduate & graduate students.
Polymers for Controlled Drug Delivery addresses the challenges of designing macromolecules that deliver therapeutic agents that function safely and in concert with living organisms. The book primarily discusses classes of polymers and polymeric vehicles, including particulates, such as latexes, coacervates, ion-exchange resins, and liposomes, as well as non-particulate vehicles such as enteric coatings, mediators, and bioadhesives. Other topics discussed include diffusion; biodegradation-controlled delivery; animal model studies for toxicity, metabolism, and elimination testing; and FDA requirements for clinical studies. Drug delivery researchers will find this book to be an invaluable reference tool.
This technically oriented book on medicine as applied to extreme sports offers broad coverage of the field extending well beyond the usual focus on major trauma and acute injuries. In addition to the injuries and diseases associated with individual extreme sports, this book also addresses the topics of psychology, dermatology, ophthalmology, infectious diseases, physiology, nutrition, training, injury prevention strategies, rehabilitation, doping, treatment in hostile environments, and legal aspects. Innovative and less frequently considered topics are also discussed, such as recent advances in protective equipment and materials, the effects of exposure on whole-body vibration, and cold exposure risk management. More than 60 of the most authoritative experts from across the world have contributed to this book, drawing on their personal experiences and including practical examples whenever relevant. Both subject matter and illustrations have been selected with the utmost care, the latter including photographs of world-class athletes.The book's multidisciplinary approach to the subject ensures that it will be relevant to a wide readership.
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
This book addresses nearly every aspect of Y. pestis, approaching it from a new perspective. Topics covered include the history, epidemiology, physiology, ecology, genome, evolution, pathogenesis, host-pathogen interaction, big-data-driven research, vaccines, clinical aspects and future research trends. For centuries, scientists have sought to determine where Y. pestis, the most well-known bacterium and one that has caused a number of high-mortality epidemics throughout human history, comes from, what it is and how it causes the disease. This book works to answer these questions with the help of cutting-edge research results. It not only describes the history of plagues, but also stresses plagues' effects on human civilization and explores the interaction of Y. pestis with hosts, vectors and the environment to reveal the evolution and pathogenesis. The book offers a valuable guide for researchers and graduate students studying Y. pestis, and will also benefit researchers from other fields, such as infectious diseases, other pathogens and system biology, sharing key insights into bacterial pathogen studies.
This book reviews normal thymic structure and covers the histomorphology of benign and malignant tumors and rare lesions of the thymus, with detailed descriptions of over 300 full color photomicrographs accompanied by relevant clinical and radiology photographs and anatomical drawings. It includes chapters on the surgical pathology and cytology of thymic lesions (which is rarely described in the available literature), and all grades and stages of the most common thymic lesions. Written and edited by leading experts on pathology, the book highlights the expanded role of pathologists in patient care for thymic lesions. It will help students to understand thymic cytology and surgical pathology in detail and enable them to answer questions on thymic surgical resections and cytology cases in their pathology post-graduation examination. In addition, the book offers a comprehensive, richly illustrated guide to thymic pathology for clinicians, practicing pathologists, post-graduate residents and students alike.
This fully revised resource features: * Treatment plan components for 33 behaviorally based presenting problems * Over 1,000 prewritten treatment goals, objectives, and interventions plus space to record your own treatment plan options * A step-by-step guide to writing treatment plans that meet the requirements of most insurance companies and third-party payors The Group Therapy Treatment Planner, Second Edition provides all the elements necessary to quickly and easily develop formal treatment plans that satisfy the demands of HMOs, managed care companies, third-party payors, and state and federal review agencies. * A critical tool for mental health professionals developing formal treatment plans for working with a variety of groups * New edition features expanded coverage and outlines entirely new areas including utilizing group therapy to treat panic/agoraphobia, PTSD/trauma, adult ADHD, obsessive-compulsive disorder, and borderline personality disorder * Streamlined interventions and fully updated language make this edition easier to use and more clinically applicable * Saves you hours of time-consuming paperwork, yet offers the freedom to develop customized treatment plans * Organized around 33 main presenting problems with a focus on applying a group therapy approach to a wide variety of disorders * Over 1,000 well-crafted, clear statements describe the behavioral manifestations of each relational problem, long-term goals, short-term objectives, and clinically tested treatment options * Easy-to-use reference format helps locate treatment plan components by behavioral problem * Includes a sample treatment plan that conforms to the requirements of most third-party payors and accrediting agencies (including HCFA, JCAHO, and NCQA)
The Body Remembers, Volume 2: Revolutionizing Trauma Treatment continues the discussion begun more than fifteen years ago with the publication of the best-selling and beloved The Body Remembers: The Psychophysiology of Trauma and Trauma Treatment. This new book is grounded in the belief that the most important goal for any trauma treatment is to improve the quality of life of the client. Therefore, the first prerequisite is that the client be reliably stable and feel safe in his or her daily life as well as the therapy situation. To accomplish this, Babette Rothschild empowers both therapists and clients by expanding trauma treatment options. For clients who prefer not to review memories, or are unable to do so safely, new and expanded strategies and principles for trauma recovery are presented. And for those who wish to avail themselves of more typical trauma memory work, tools to make trauma memory resolution even safer are included. Being able to monitor and modulate a trauma client's dysregulated nervous system is one of the practitioner's best lines of defence against traumatic hyperarousal going amok-risking such consequences as dissociation and decompensation. Rothschild clarifies and simplifies autonomic nervous system (ANS) understanding and observation with her creation of an original full colour table that distinguishes six levels of arousal. Included in this table (and the discussion that accompanies it) is a new and essential distinction between trauma-induced hypoarousal and the low arousal that is caused by lethargy or depression. Combining an authoritative yet personal voice, Rothschild gives clinicians the space to recognise where they may have made mistakes-by sharing her own!-as well as a road map towards more effective practice in the future. This book is absolutely essential reading for anyone working with those who have experienced trauma. The full colour ANS table is also available from W.W. Norton as a laminated desk reference and a wall poster suitable for framing so this valuable therapeutic tool will always be at hand.
This book provides an introductory overview of advancements in platelet-rich plasma (PRP), focusing on current technologies and methods, new challenges and controversies, and avenues for further research. With many studies demonstrating a role for PRP in improving response to injury, this book aims to facilitate the application of this rapidly growing treatment option for trauma patients. Platelet Rich Plasma in Musculoskeletal Practice is a highly informative and carefully presented book, providing scientific and clinical insight for specialists who utilize PRP in daily practice, and for readers who are seeking to learn more about this effective injury treatment.
"Cleft Lip and Palate: Diagnosis and Management" is an unparalleled review of treatment concepts in all areas of cleft involvement presented by an international team of experienced clinicians. A unique feature of the book is that it largely consists of longitudinal facial and palatal growth studies of dental casts, photographs, panorexes, and cephalographs from birth to adolescence. Throughout the discussion of growth and treatment concepts, the importance of differential diagnosis in treatment planning is underscored. The underlying argument is that all the treatment goals good speech, facial aesthetics, dental occlusion, and psychological development may be realized without the need to sacrifice one for another. This updated third edition includes new chapters on further successful physiological treatment protocols, strategies for coping with psychological effects, the excellent clinical work being undertaken in Asia, future multicenter palatal growth studies, and other topics.
Keeping children bodies, minds and emotions on task just got easier with this new book from self-regulation expert Teresa Garland. Featuring more than 200 practical and proven interventions, strategies and adaptation for helping children gain more control over their lives. Each chapter provides rich background and theoretical material to help the reader better understand the issues our children face.
* Basic and advanced methods to calm a child and to preventing outbursts and melt-downs
* Interventions to help with attention problems, impulse control, distractibility and the ability to sit still
* Stories and video-modeling for autism, along with techniques to quell repetitive behaviors
* Sensory strategies for sensitivity and craving
* Behavioral and sensory approaches to picky eating
* Ways to increase organization skills using technology and apps
* Strategies for managing strong emotions as well as techniques for releasing them
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