Food Safety in Middle East provides the latest research data on food safety in the Arab countries of the Middle East and summarizes recent developments on food safety practices, policies, and legislations. Food safety is a hot issue in research over the last decade due to the surge in foodborne infections, particularly in this area. Data suggest the increase is due to the foods consumed by the increasing holidaymakers and tourists. This book sums up information published in scientific literature with additional reports, knowledge and expertise to help reduce foodborne illnesses in this growing area. Beginning with the introduction of Middle East's food culture, the book addresses the food safety status in the Middle East. It dives deep in biological hazards (foodborne infections, intoxications and toxicoinfections) and in chemical hazards in foods of the Middle East. Additionally, the book reviews current measures that are being used to control foodborne pathogens in common foods widely consumed in the area. Interestingly, important data on food safety knowledge, attitudes, and practices among food handlers in foodservice establishments in the Arab countries of the Middle East, are being thoroughly presented and analyzed. The book finally summarizes the current food safety legislations implemented at government level in certain Middle Eastern countries. It is a valuable reference for graduate students, researchers, librarians and professionals working in the food sector.

Targeted Cancer Imaging: Design and Synthesis of Nanoplatforms based on Tumour Biology reviews and categorizes imaging and targeting approaches according to cancer type, highlighting new and safe approaches that involve membrane-coated nanoparticles, tumor cell-derived extracellular vesicles, circulating tumor cells, cell-free DNAs, and cancer stem cells, all with the goal of pointing the way to developing precise targeting and multifunctional nanotechnology-based imaging probes in the future. This book is highly multidisciplinary, bridging the knowledge gap between tumor biology, nanotechnology, and diagnostic imaging, and thus making it suitable for researchers ranging from oncology to bioengineering. Although considerable efforts have been conducted to diagnose, improve and treat cancer in the past few decades, existing therapeutic options are insufficient, as mortality and morbidity rates remain high. One of the best hopes for substantial improvement lies in early detection. Recent advances in nanotechnology are expected to increase our current understanding of tumor biology, allowing nanomaterials to be used for targeting and imaging both in vitro and in vivo experimental models.

Microneedles explores the design, fabrication and use of microneedles for drug and vaccine delivery. This book discusses the contemporary status of the field, describing several areas in detail, including the distinct types of microneedles (dissolving, solid, coted, hollow and hydrogel-forming). The anatomy of the eye is also described to facilitate an understanding of microneedle-assisted ocular drug delivery. Finally, the book provides a detailed discussion of microneedle use in the field of diagnostics, with a chapter dedicated to the mathematical modeling of microneedle-mediated drug delivery. As microneedles can be used by research scientists in academia and in industry, this book will be ideal for regulatory scientists and graduate students who find the topic relevant to their area of study.

What happens to children with psychiatric disorders as they mature? Many children experience attention-deficit-hyperactivity disorder, depression, suicidal behavior, anxiety disorders, obsessive-compulsive disorder, schizophrenia, and conduct disorder. Long-term outcome of childhood disorders is becoming increasingly more important as clinicians, teachers, and parents take a broader, more comprehensive view of childhood disorders, their natural history, their developmental impact, later adolescent and adult functioning, and their possible multigenerational consequences. Developmental factors pertaining to the child, such as the age at onset and severity of the disorder, other comorbid conditions, the child's sex and IQ, and physical or neurological health, all seem important in influencing outcome. In addition, social factors, such as socioeconomic status, family composition, mental health of parents, family functioning, and child-rearing practices seem to affect outcome. Finally, the impact of treatment is also crucial because it provides a picture of long-term efficacy of various approaches. Do They Grow Out of It? Long-Term Outcomes of Childhood Disorders is a comprehensive review of this important area that familiarizes clinicians and others about long-term outcomes of childhood disorders. This book will guide their present interventions, which will improve long-term outcome in the future. Each chapter is written by a professional with expertise in both the disorder and its long-term sequelae. The authors critically review available information on long-term outcome of the particular childhood disorder; what factors, particularly treatments, influence this outcome; and what future research or clinical directions appear promising.

Prevention Science and Research in Intellectual and Developmental Disabilities, Volume 61 highlights the WHOs emphasis on the importance of adopting a public health approach. Chapters in the book include A Prevention Science Approach to Promoting Health for Those with Developmental Disabilities, From Surviving to Thriving: A New Conceptual Model to Advance Interventions to Support People with FASD Across the Lifespan, Disability-related Abuse in People with Intellectual and Developmental Disabilities: Considerations Across the Lifespan, Two Sides of the Same Coin: A Qualitative Study of Multiple Stakeholder Perspectives on Factors Affecting Implementation of Evidence-Based Practices for Children with Autism in Elementary Schools, and more. Other topics discussed include Family-Focused Interventions as Prevention and Early Intervention of Behavioral Problems in Children with Autism Spectrum Disorder, Body weight improvements associated with nutritional intervention for adults with IDD living in group homes: A randomized controlled trial, Lifestyle Intervention Adaptation to Promote Healthy Eating and Physical Activity of Youth with Intellectual and Developmental Disability, Cultural Adaptations of the Parents Taking Action Program for Youth with Autism Spectrum Disorder, and more.

Mental Health in a Digital World addresses mental health assessments and interventions using digital technology, including mobile phones, wearable devices and related technologies. Sections discuss mental health data collection and analysis for purposes of assessment and treatment, including the use of electronic medical records and information technologies to improve services and research, the use of digital technologies to enhance communication, psychoeducation, screening for mental disorders, the problematic use of the internet, including internet gambling and gaming, cybersex and cyberchondria, and internet interventions, ranging from online psychotherapy to mobile phone apps and virtual reality adjuncts to psychotherapy.

Regulatory Affairs in the Pharmaceutical Industry is a comprehensive reference that compiles all the information available pertaining to regulatory procedures currently followed by the pharmaceutical industry. Designed to impart advanced knowledge and skills required to learn the various concepts of regulatory affairs, the content covers new drugs, generic drugs and their development, regulatory filings in different countries, different phases of clinical trials, and the submission of regulatory documents like IND (Investigational New Drug), NDA (New Drug Application) and ANDA (Abbreviated New Drug Application). Chapters cover documentation in the pharmaceutical industry, generic drug development, code of Federal Regulation (CFR), the ANDA regulatory approval process, the process and documentation for US registration of foreign drugs, the regulation of combination products and medical devices, the CTD and ECTD formats, and much more.

Annual Reports in Medicinal Chemistry, Volume 57 in this long-running series, highlights new advances in the field with this new volume presenting interesting chapters on the Mechanism of action of the broadly acting antiviral drug remdesivir, Improving properties of the nucleobase analogue T-706 as a potential anti-SARS-CoV-2 and anti-influenza compound, Antivirals for RNA virus infections Anno 2020-2021, Broad spectrum antiviral fleximer nucleosides, SARS-CoV-2 main protease inhibitors, The search for antivirals to treat alphavirus infections, Inhibitors of Ebola Virus targeting Innate immune evasion, Uracil derivatives as non-nucleoside inhibitors of viral infections, and more.

Fully revised and updated, Processing Contaminants in Edible Oils, 2nd edition, presents the latest research on monochloropropanediol (MCPD) and glycidyl esters in edible oils. These potentially harmful contaminants are formed during the industrial processing of food oils during deodorization. A number of advancements in understanding these have been made since the publication of the first edition. These important changes, which impact industrial mitigation, analytical methods, toxicology and regulation, are highlighted for up-to-date reference. The mechanisms of formation for MCPD and glycidyl ester contaminants, as well as research identifying possible precursor molecules are reviewed, as are strategies which have been used successfully to decrease the concentrations of these contaminants. From the removal of precursor molecules before processing, modifications of deodorization protocol, to approaches for the removal of these contaminants after the completion of processing, methods of mitigating and eliminating contaminants are presented.

Cognitive behavioral therapy for insomnia (CBT-I) has emerged as the standard first-line treatment for insomnia. The number of patients receiving non-medication treatments is increasing, and there is a growing need to address a wide range of patient backgrounds, characteristics, and medical and psychiatric comorbidities. Adapting Cognitive Behavioral Therapy for Insomnia identifies for clinicians how best to deliver and/or modify CBT-I based on the needs of their patients. The book recommends treatment modifications based on patient age, comorbid conditions, and for various special populations.

Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data in Adverse Drug Reactions, Volume 43, first published in 1977, and continually published as a yearly update to the voluminous encyclopedia Meyler's Side Effects of Drugs, presents clinicians and medical investigators with a critical survey of new data and trends in adverse drug reactions and interactions. Topics covered in this new release include Central Nervous System Stimulants and Drugs that Suppress Appetite, Antidepressants, Lithium, Drugs of Abuse, Hypnotics and Sedatives, Antipsychotic Drugs, Antiepileptics, Opioid Analgesics and Narcotic Antagonists, Anti-Inflammatory and Antipyretic Analgesics and Drugs Used in Gout, and much more.

The book comprises three parts. The first part provides the state-of-the-art of robots for endoscopy (endorobots), including devices already available in the market and those that are still at the R&D stage. The second part focusses on the engineering design; it includes the use of polymers for soft robotics, comparing their advantages and limitations with those of their more rigid counterparts. The third part includes the project management of a multidisciplinary team, the health cost of current technology, and how a cost-effective device can have a substantial impact on the market. It also includes information on data governance, ethical and legal frameworks, and all steps needed to make this new technology available.

International Review of Research in Developmental Disabilities, Volume 60 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors, including updates on School-based Executive Function Interventions Reduce Caregiver Strain, Emergence of Fine Motor Skills in Down Syndrome, Capturing Positive Psychology in People with Intellectual and Developmental Disabilities: A Systematic Review of Constructs and Measures, Navigating with Blurry Maps: School Principals and Special Education Legal Knowledge, Statistical Techniques for Dealing with Small Samples in IDD Research, and more.

Advances in Parasitology, Volume 114, the latest release in this ongoing series, includes medical studies of parasites of major influence, along with reviews of more traditional areas, such as zoology, taxonomy and life history. Chapters in this update include Global Health Governance and the World Health Organization during COVID-19: Current and future impact on control of parasitic diseases towards WHO 2030 targets, Combatting Anthelmintic Resistance in Ruminants, New insights into the Cryptosporidium and cryptosporidiosis in human health and beyond, Control And Elimination Of Lymphatic Filariasis In Oceania: Prevalence, Geographical Distribution, Mass Drug Administration, and Surveillance In Samoa, 1998 To 2017.