Genetic Patterns in Neuroimaging is explored in this important Neuroimaging Clinics issue. Articles include: Brain imaging and genetic risk of congenital malformations; Understanding genetics in neuroimaging; Influence of genetics in neuropathology; Building a bridge between genomics and neuroradiology; Systems genetics approaches to neuroimaging phenotypes; Imaging genetic predictions at an individual level; Brain imaging and genetic risk in the pediatric population; Imaging phenotypes in cognitive diseases; Molecular imaging in genetics; Imaging phenotypes in psychiatric disease; Genomics of brain tumor imaging; Neuroimaging and genetic influence in post-treatment brain neoplasms; Imaging phenotypes in multiple sclerosis; Genetic markers and influences in cerebrovascular malformations, and more.

Evidence-Based Validation of Herbal Medicines brings together current thinking and practice in the areas of characterization and validation of natural products. This book reviews all aspects of evaluation and development of medicines from plant sources, including their cultivation, collection, phytochemical and phyto-pharmacological evaluation, and therapeutic potential. Emphasis is placed on describing the full range of evidence-based analytical and bio-analytical techniques used to characterize natural products, including -omic technologies, phyto-chemical analysis, hyphenated techniques, and many more.

Physical health and mental health are inextricably linked together. Moreover, as the biology of mental illnesses is gradually - and inexorably - being elucidated, the overlap between physical illnesses and mental illnesses has become even more apparent. These observations 'set the stage' for readers of this issue of Psychiatric Clinics in which a variety of articles are presented from all aspects of medicine - from emergency mental health to how burn patients heal and cope with the physical and mental outcomes, to coverage of issues such as prolonged stay in the intensive care unit, comorbidities in the elderly, food allergies, depression and other common primary care conditions, and childhood diabetes. A primer on interviewing techniques and role play is presented along with the role of nurses who cross both mental and physical aspects of healthcare and the essential role of a supportive family to the interdiscipinary team .

Because anesthesia and surgery affect every system in the body, there are many different forms of anesthesia. This issue will cover the risks to recovery of 6 major specialty areas in abdominal surgery, as well as major open and laparoscopic abdominal surgery.

Throughout history, arsenic has been used as an effective and lethal poison. Today, arsenic continues to present a real threat to human health all over the world, as it contaminates groundwater and food supplies. Handbook of Arsenic Toxicology presents the latest findings on arsenic, its chemistry, its sources and its acute and chronic effects on the environment and human health. The book takes readings systematically through the target organs, before detailing current preventative and counter measures. This reference enables readers to effectively assess the risks related to arsenic, and provide a comprehensive look at arsenic exposure, toxicity and toxicity prevention.

This issue of Surgical Oncology Clinics of North America, devoted to Imaging in Oncology, is edited by Dr. Vijay Khatri. Articles in this issue include: Imaging of Central Nervous Tumors; Role of Imaging in Head and Neck Malignancies; Imaging of Thoracic Cavity Tumor; Diagnostic Imaging of Hepatobiliary Malignancies; Recent Advances in Genito-Urinary Tract Tumors; Current Status of Imaging for Adrenal Glands; Radiology of Soft Tissue Tumors; Image-Guided Interventions in Oncology; Imaging of Pancreatic Neoplasms; Imaging of Primary Malignant Tumors of Peritoneal and Retroperitoneal Origin; Breast Tumor Imaging; and Application of Intraoperative Imaging in Oncology.

This issue of Emergency Medicine Clinics, edited by Drs. Stephen Borron and Ziad Kazzi focuses on emergencies arising from contact with Hazardous Materials. Article topics include: Selected classes and examples of dangerous industrial chemicals, weapons of mass destruction, and their syndromic identification; Hospital preparedness for chemical and radiological disasters; Personnel protection and decontamination of adults and children; Resources for toxicological information and assistance; Asphyxiants; Corrosives and irritants; Organophosphates and carbamates; Intentional and unintentional food, drug, and water contamination, and more!

Knowledge of cutaneous lymphomas has been growing significantly as a result of important discoveries in immunology, molecular biology, and immunohistochemistry. Improved clinical pathologic correlation and follow-up data, as well as the synergistic collaboration among different lymphoma registries and specialists from several academic medical centers have greatly contributed to the understanding of the difficult field of cutaneous lymphoproliferative disorders. While these advances have increased understanding of skin lymphomas, they have also produced an extensive and sometimes confusing litany of articles, studies, and classification schemes. This issue on Cutaneous Lymphomas in Surgical Pathology Clinics provides an organized and updated review of this challenging topic by leading experts. It bridges critical knowledge gaps in the diagnosis of cutaneous lymphomas. Sezary Syndrome, Mycosis Fungoides and variants are presented along with B-cell, CD30, lymphoproliferative disorders among others. In addition to multiple clinical and microscopic images, tables and algorithms are presented to aid in diagnosis and staging. Beyond its usefulness to general pathologists, dermatopathologists, and hematopathologists, this information is intended to be helpful for dermatologists, hematologists/oncologists, fellows, and residents.

Hospice care is one of the fastest-growing segments of the U. S. healthcare system, a trend that is expected to accelerate as the median age of the population continues to rise over the next three decades. Despite over forty percent of the population now dying while on hospice care, very little has been published on the ethical opportunities and challenges experienced in the everyday lives of those giving and receiving hospice care. This book is the first comprehensive collection devoted to analyzing distinctive ethical issues arising in the delivery of hospice care and designed to promote best ethical practices for hospice care professionals and organizations. Thirteen newly commissioned chapters by seventeen hospice experts populate three thematic sections of the book, each devoted to an aspect of the intersection between ethics and hospice care. Contributors have unique qualifications and abilities to articulate and respond to ethically significant phenomena that - while not always unique to hospice care - arise in especially poignant and complex ways when caring for patients enrolled in hospice. As the shift or return to home-based care at the end of life continues, hospice professionals and programs will be faced with a broader array of terminal illnesses, cultural beliefs and traditions, and patient and family values than ever before. Hospice will no longer be tailored solely to the final stage of cancer, but will need to accommodate patients whose illnesses are variable in their progression and whose treatment plans include many medical options. The ethical orientations and frameworks that have served hospice for the past 50 years will need to be supplemented and refined if hospice is to fulfill this changing social mission. Hospice Ethics explores a new paradigm for hospice ethics from a multi-disciplinary and provides an important educational resource for professional training in end of life care.

"Electroporation-Based Therapies for Cancer" reviews electroporation-based clinical studies in hospitals for various cancer treatments, including melanomas, head and neck cancers, chest wall breast carcinomas, and colorectal cancers, as well as research studies in the lab using cell lines, primary cells, and animals.

Cancer kills about one American per minute, amounting to over 500,000 deaths in the United States and millions, worldwide, each year. There is a critical need for safe, effective, and affordable alternative treatment modalities, especially for inoperable, recurring, and chemo-resistant cancers, that do not respond well to current treatment regimen. An electrical-pulse-mediated, enhanced drug delivery technique known as electroporation is one way to effectively treat these patients.

This technique is especially suitable for low- and middle-income countries, where lack of infrastructure and resources leads to cancer diagnoses at late stages. This quick, safe, effective, economical, out-patient-based technique is a boon to these patients for palliative and other care with enhanced quality of life. This book features discussions by interdisciplinary authors-including practicing oncological surgeons, medical professionals, and academic and other researchers-of the basics and clinical medical applications of electroporation.
Provides novel and recent clinical applications of electrochemotherapy for various cancers, including melanomas, sarcomas, superficial extreme melanoma, chest wall breast carcinoma, and colorectal cancersExtensive study of a number of cell lines, including human breast cancer, lung cancer, cervical cancer, leukemia, and mouse breast cancer using both reversible and irreversible electroporation techniquesIn vitro study of delivery of various commonly prescribed/administered breast cancer chemo and hormone drugs, such as Doxorubicin, Paclitaxel, Bleomycin, and Tamoxifen

Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to successful drug delivery to the eye. Hence ocular transporters and receptors are important targets for drug delivery. A significant advancement has been made in the field of ocular transport research and their role in drug delivery. In this book the cutting edge research being carried out in this field is compiled and summarized. The book focuses on key areas, including the anatomy and physiology of the eye, biology of ocular transporters and receptors, techniques in characterization of transporters and receptors, transporters and receptors in the anterior and posterior segment in the eye, the role of ocular transporters and receptors in drug delivery, and transporter-metabolism interplay in the eye.
Highly focused on ocular transportersMost up-to-date research compilationDetailed description of role of transporters and receptors in ocular drug discovery and delivery

A range of new and innovative tools used for preformulation and formulation of medicines help optimize pharmaceutical development projects. Such tools also assist with the performance evaluation of the pharmaceutical process, allowing any potential gaps to be identified. These tools can be applied in both basic research and industrial environment. Formulation tools for pharmaceutical development considers these key research and industrial tools.
Nine chapters by leading contributors cover: Artificial neural networks technology to model, understand, and optimize drug formulations; ME_expert 2.0: a heuristic decision support system for microemulsions formulation development; Expert system for the development and formulation of push-pull osmotic pump tablets containing poorly water-soluble drugs; SeDeM Diagram: an expert system for preformulation, characterization and optimization of tables obtained by direct compression; New SeDeM-ODT expert system: an expert system for formulation of orodispersible tablets obtained by direct compression; and 3D-cellular automata in computer-aided design of pharmaceutical formulations: mathematical concept and F-CAD software.
Coverage of artificial intelligence tools, new expert systems, understanding of pharmaceutical processes, robust development of medicines, and new ways to develop medicinesDevelopment of drugs and medicines using mathematical toolsCompilation of expert system developed around the world

Based on the 103rd annual meeting of the American Psychopathological Association, Long-Term Outcomes in Psychopathology Research: Rethinking the Scientific Agenda explores the long-term course of illness and functioning of individuals treated for mental health and substance use disorders and the outcomes research derived from these cases. Sections cover topics including: findings from long-term psychopathology outcome studies, problematic case definitions, differing perspectives on the concept of recovery, the need for continued long-term outcomes research, and research priorities for patients with chronic and severe disorders. The book employs the experiences of innovative mental health providers, reflecting the value of personal narratives in research conducted in cross-sectional increments with pre-formulated questions and response options. As psychiatry continues to refine its diagnostic categories and psychology demands greater attention to dimensionality, the need for interdisciplinary long-term studies is as critical as ever. This final volume in the American Psychopathological Association Series reflects on developments in outcomes research conducted in parallel with different disorders and offers suggestions for preserving long-term outcome studies as the mainstay of clinical knowledge.

First published in 1963, "Advances in Parasitology" contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology.
"Advances in Parasitology" includes medical studies on parasites of major influence, such as "Plasmodium falciparum" and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications.
Eclectic volumes are supplemented by thematic volumes on various topics, including control of human parasitic diseases and global mapping of infectious diseases. The 2010 impact factor is1.683.

* Informs and updates on all the latest developments in the field * Contributions from leading authorities and industry experts

Headache: Through the Centuries illuminates the history of headaches with a particular interest in how the disorder has been understood and treated since the earliest recorded accounts, dating from around 4000 BC. Different types of headache were being recognized as early as the 2nd century AD. Over the years, though, the classification of types of headache has changed so that headache patterns described in the past are often difficult to relate to present-day types of headache. Since that time, a great deal of material on the topic has become available, the full gamut of manifestations of the disorder has been described, and considerable insight into its mechanisms has been obtained, though no completely satisfactory explanation of the disorder has yet become available. Providing an extensive history and the development of our understanding of headache over the course of six millennia, Headache: Through the Centuries is thought-provoking and relevant reading for neurologists, medical historians, and anyone interested in headaches.

As the demand for healthy, attractive teeth increases, the methods and materials employed in restorative dentistry have become progressively more advanced. Non-metallic biomaterials for tooth repair and replacement focuses on the use of biomaterials for a range of applications in tooth repair and, in particular, dental restoration.
Part one reviews the structure, modification and repair of dental tissues. The properties of enamel and dentin and their role in adhesive dental restoration are discussed, along with biomineralization and biomimicry of tooth enamel, and enamel matrix proteins (EMPs) for periodontal regeneration. Part two goes on to discuss the processing, bonding and wear properties of dental ceramics, glasses and sol-gel derived bioactive glass ceramics for tooth repair and replacement. Dental composites for tooth repair and replacement are then the focus of part three, including composite adhesive and antibacterial restorative materials for dental applications. The effects of particulate filler systems on the properties and performance of dental polymer composites are considered, along with composite based oral implants, fibre reinforced composites (FRCs) as dental materials and luting cements for dental applications.
With its distinguished editor and international team of expert contributors, Non-metallic biomaterials for tooth repair and replacement provides a clear overview for all those involved in the development and application of these materials, including academic researchers, materials scientists and dental clinicians.
Discusses the properties of enamel and dentin and their role in adhesive dental restorationChapters also examine the wear properties of dental ceramics, glasses and bioactive glass ceramics for tooth repair and replacementDental composites and antibacterial restorative mateirals are also considered

The application of nuclear magnetic resonance (NMR) metabolomics in cancer research requires an understanding of the many possibilities that NMR metabolomics can offer, as well as of the specific characteristics of the cancer metabolic phenotype and the open questions in cancer research. NMR metabolomics in cancer research presents a detailed account of the NMR spectroscopy methods applied to metabolomics mixture analysis along with a discussion of their advantages and disadvantages. Following an overview of the potential use of NMR metabolomics in cancer research, the book begins with an examination of the cancer metabolic phenotype and experimental methodology, before moving on to cover data pre-processing and data analysis. Chapters in the latter part of the book look at dynamic metabolic profiling, biomarker discovery, and the application of NMR metabolomics for different types of cancer, before a concluding chapter discusses future perspectives in the field.
Focused description of NMR spectroscopy needed by cancer biologists who are starting to use metabolomicsCurrent overview of knowledge related to the cancer metabolic phenotype from the perspective of metabolomics applicationsInformation about the best practices in NMR metabolomics experimentation and data preprocessing as applied to different sample types

Offering a study of biological, biomedical and biocultural approaches, the second edition of "Human Growth and Development "is a valued resource for researchers, professors and graduate students across the interdisciplinary area of human development. With timely chapters on obesity, diet / lifestyle, and genetics, this editionis the only publication offering a biological, biomedical and biocultural approach. The second edition of "Human Growth and Development" includes contributions from the well-known experts in the field and is the most reputable, comprehensive resource available.
New chapters discussing genomics and epigenetics, developmental origins, body proportions and health and the brain and neurological development.Presented in the form of lectures to facilitate student programmingUpdated content highlighting the latest research on the relationship between early growth and later (adult) outcomes: the developmental origins of health and disease."

The Neonatal Resuscitation Program (R) (NRP (R)) course conveys an evidence-based approach to care of the newborn at birth and facilitates effective team-based care for healthcare professionals who care for newborns at the time of delivery. NRP utilizes a blended learning approach, which includes online testing and hands-on case-based simulation/debriefing that focus on critical leadership, communication, and team-work skills. The NRP, 8th Edition, introduces a new educational methodology to better meet the needs of health care professionals who manage the newly born baby. New in the 8th edition: Key Points at the beginning of each lesson. Quick response (QR) codes that enable the reader to view short videos about the topic on their mobile device. Lesson Review Questions grouped together at the end of each lesson. Quality Improvement Opportunities and Frequently Asked Questions in each lesson. New sections in Lesson 10 (Special Considerations) about resuscitation of the newborn with a myelomeningocele or an abdominal wall defect. Three Supplemental Lessons (Improving Resuscitation Team Performance, Resuscitation Outside the Delivery Room, and Bringing Quality Improvement to Your Resuscitation Team) that all NRP users to enhance their resuscitation knowledge and performance.

Drs. Stephen Bohan and Josh Kosowsky have assembled a panel of expert authors for this edition on Cardivascular Emergencies. Topics include: Ischemia, Heart Failure, Congenital Heart Disease, Supreventricular Dysrhythmias, Atrial Fibrillation, Uncommon Dysrhythmias, Electrophysiology, Pericardial Disease, and Cardiac Arrest.

This issue is divided into sections on diagnostic issues surrounding psychosomatic disorders, diverse conceptual models, biology of psychosomatic disorders, forensic issues, and treatment.? The issue covers both adult and children's psychosomatic medicine.? Among the specific topics explored are, neural imaging, inflammation, disability assessments, malingering, factitious disorder, educating residents, cultural issues, pain and fatigue.

Therapeutic protein drug products provides a comprehensive overview of therapeutic protein drug products, with an emphasis on formulation beginning in the laboratory, followed by manufacturing and administration in the clinic. A list of many commercial therapeutic drug products are described and include the product name, dosages, active concentration, buffer, excipients, Ph, container type and route of administration. The laboratory formulation sections focus on the most common buffers, excipients, and Ph ranges that are commonly tested in addition to systematic approaches. A brief section on biophysical and analytical analysis is also provided. Properties of therapeutic protein formulations are described and include opalescence, phase separation, color, and subvisible particles. An emphasis is placed on material and process testing to ensure success during manufacturing. The drug product manufacturing process, which includes the process of compounding to filling, is also covered. Methods of delivery in the clinic are addressed, as well as delivery strategies. Finally, a perspective on the regulatory requirements for therapeutic protein formulations is discussed.
Provides a list and description of commercially available therapeutic drug products and their formulationsA comprehensive and practical overview of protein formulation in the laboratory, manufacturing, and the clinicDiscusses recent topics including high protein concentration, phase separation, opalescence, and subvisible particles

Wound repair is an important and growing sector of the medical industry with increasingly sophisticated biomaterials and strategies being developed to treat wounds. Advanced wound repair therapies provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds.
Part one provides an introduction to chronic wounds, with chapters covering dysfunctional wound healing, scarring and scarless wound healing and monitoring of wounds. Part two covers biomaterial therapies for chronic wounds, including chapters on functional requirements of wound repair biomaterials, polymeric materials for wound dressings and interfacial phenomena in wound healing. In part three, molecular therapies for chronic wounds are discussed, with chapters on topics such as drug delivery, molecular and gene therapies and antimicrobial dressings. Part four focuses on biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair. Finally, part five covers physical stimulation therapies for chronic wounds, including electrical stimulation, negative pressure therapy and mechanical debriding devices.
With its distinguished editor and international team of contributors, Advanced wound repair therapies is an essential reference for researchers and materials scientists in the wound repair industry, as well as clinicians and those with an academic research interest in the subject.
Provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic woundsChapters include the role of micro-organisms and biofilms in dysfunctional wound healing, tissue-biomaterial interaction and electrical stimulation for wound healingCovers biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair

Evidence-based practice has become the benchmark for quality in healthcare and builds on rules of evidence that have been developed in psychology and other health-care disciplines over many decades. This volume aims to provide clinical neuropsychologists with a practical and approachable reference for skills in evidence-based practice to improve the scientific status of patient care. The core skills involve techniques in critical appraisal of published diagnostic-validity or treatment studies. Critical appraisal skills assist any clinician to evaluate the scientific status of any published study, to identify the patient-relevance of studies with good scientific status, and to calculate individual patient-probability estimates of diagnosis or treatment outcome to guide practice. Initial chapters in this volume review fundamental concepts of construct validity relevant to the assessment of psychopathology and cognitive abilities in neuropsychological populations. These chapters also summarize exciting contemporary development in the theories of personality and psychopathology, and cognitive ability, showing a convergence of theoretical and clinical research to guide clinical practice. Conceptual skills in interpreting construct validity of neuropsychological tests are described in detail in this volume. In addition, a non-mathematical description of the concepts of test score reliability and the neglected topic of interval estimation for individual assessment is provided. As an extension of the concepts of reliability, reliable change indexes are reviewed and the implication of impact on evidence-based practice of test scores reliability and reliable change are described to guide clinicians in their interpretation of test results on single or repeated assessments. Written by some of the foremost experts in the field of clinical neuropsychology and with practical and concrete examples throughout, this volume shows how evidence-based practice is enhanced by reference to good theory, strong construct validity, and better test score reliability.