Medical imaging now plays a major role in diagnosis, choice of therapy, and follow-up. However, patients are often intimidated by the multiple imaging modalities available, the indications for their use, the imposing equipment, what the examinations are like and how long they last, and the advantages and disadvantages of various procedures. This book is designed to provide explanations for these and other issues in order to relieve some of the anxiety related to medical imaging studies.

Toxicologic pathology integrates toxicology and the disciplines within it (such as biochemistry, pharmacodynamics and risk assessment) to pathology and its related disciplines (such as physiology, microbiology, immunology, and molecular biology).
"Fundamentals of Toxicologic Pathology 2e" updates the information presented in the first edition, including five entirely new chapters addressing basic concepts in toxicologic pathology, along with color photomicrographs that show examples of specific toxicant-induced diseases in animals. The current edition also includes comparative information that will prove a valuable resource to practitioners, including diagnostic pathologists and toxicologists.

NOW FEATURING:

25% brand new information, fully revised throughout

New chapters: Veterinary Diagnostic Toxicologic Pathology; Clinical Pathology; Nomenclature: Terminology for Morphologic Alterations; Techniques in Toxicologic Pathology

New color photomicrographs detailing specific toxicant-induced diseases in animals

Mechanistic information integrated from both toxicology and pathology discussing basic mechanisms of toxic injury and morphologic expression at the subcellular, cellular, and tissue levels"

Hoarding involves the acquisition of and inability to discard large numbers of possessions that clutter the living area of the person collecting them. It becomes a disorder when the behavior causes significant distress or interferes with functioning. Hoarding can interfere with activities of daily living (such as being able to sit in chairs or sleep in a bed), work efficiency, family relationships, as well as health and safety. Hoarding behavior can range from mild to life-threatening. Epidemiological findings suggest that hoarding occurs in 2-6% of the adult population, making it two to three times more common than obsessive-compulsive disorder. The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) now includes Hoarding Disorder as a distinct disorder within the OCD and Related Anxiety Disorders section, creating a demand for information about it. The Oxford Handbook of Hoarding and Acquiring is the first volume to detail the empirical research on hoarding. Including contributions from all of the leading researchers in the field, this comprehensive volume is divided into four sections in addition to introductory and concluding chapters by the editors: Phenomenology, Epidemiology, and Diagnosis; Etiology; Assessment and Intervention; and Hoarding in Special Populations. The summaries of research and clinical interventions contained here clarify the emotional and behavioral features, diagnostic challenges, and nature of the treatment interventions for this new disorder. This handbook will be a critical resource for both practitioners and researchers, including psychiatrists, psychologists, neurologists, epidemiologists, social workers, occupational therapists, and other health and mental health professionals who encounter clients with hoarding problems in their practice and research.

This issue covers the full gamut of infectious disease issues encountered in the ICU, including the approach to the febrile patient, management of septic shock, severe community-acquired pneumonia, management of ventilator-associated pneumonia, approach to the immunocompromised host, bloodstream infection, severe soft tissue infections, management of intra-abdominal sepsis, meningitis and brain abscess, treatment of fungal infections, acute infective endocarditis, new antimicrobial agents, antimicrobial stewardship, infection control, and C. difficile infection.

This book presents the most current scientific understanding behind most common pain disorders. Clinical scientists involved in pain science will gain a basic understanding of the causes of many types of pain and will be able to discuss various therapies with patients. Researchers new to pain science will gain an overall understanding of pain pathophysiology and targets for pain treatments. Covering every major aspect of pain science, from molecular and cellular pathways of pain to pain disorders and their treatments, Science of Pain bridges basic and clinical research like no other book on the topic. Edited by world-renowned pain scientist and Editor-in-Chief of the journal PAIN, Allan Basbaum, this book is an in-depth reference for basic and clinical scientists in pain research who must understand the basic science of pain, and help develop new treatment strategies for pain disorders.
* Presents the most current scientific understanding of neuroscience of pain, written by the world's leading experts
* Integrates basic neuroscience research and clinical aspects of pain disorders
* Covers both neurobiological basis and clinical treatment for a pain disorder (e.g., migraine, fibromyalgia, neuropathic pain, post-stroke pain)
* Covers pain pathways and mechanisms both in text and in full-color illustrations
* Includes topics specific to gender and age group addressing the trend in research toward developing individualized treatments

The detection and measurement of the dynamic interactions of proteins within the living cell are critical to our understanding of cell physiology and pathophysiology. With FRET microscopy and spectroscopy techniques, basic and clinical scientists can make such measurements at very high spatial and temporal resolution. But sources of background information about these tools are very limited, so this book fills an important gap. It covers both the basic concepts and theory behind the various FRET microscopy and spectroscopy techniques, and the practical aspects of using the techniques and analyzing the results. The critical tricks for obtaining a good FRET image and precisely quantitating the signals from living specimens at the nanomolecular level are explained. Valuable information about the preparation of biological samples used for FRET image analysis is also provided.
The methods covered include different types of microscopy systems and detectors (wide-field, confocal, multi-photon) as well as specialized techniques such as photobleaching FRET, FLIM-FRET microscopy, spectral imaging FRET, single molecule FRET, and time and image correlation spectroscopy. Starting from the basics, the chapters guide readers through the choice of probes to be used for FRET experiments and the selection of the most suitable experimental approaches to address specific biological questions. Up-to-date, consistently organized, and well-illustrated, this unique book will be welcomed by all researchers who wish to use FRET microscopy and spectroscopy techniques.

Psychological assessment is practiced in wide-ranging settings to address the varied clinical and administrative needs of veteran populations. Such assessment blends record review, clinical interviews of the veteran and collateral sources of information, behavioral observations, and psychological testing.
This book promotes the care and well-being of veterans by bringing together knowledgeable and experienced psychologists to discuss a range of psychological assessment methods and procedures. It aims to help patients and their families, healthcare providers, and concerned citizens gain an improved understanding of veterans' cognitive functioning, emotional states, personality traits, behavioral patterns, and daily functioning.
The book begins with a history of the psychological assessment of veterans and investigates its efficacy in different settings, including outpatient mental health, long-term care, primary care, home-based primary care, and telemental health. Later chapters address assessment of a variety of disorders or presenting problems, including substance use disorders, psychotic disorders, mood disorders and suicidal thoughts and behavior, PTSD and other anxiety disorders, attention-deficit/hyperactivity disorder, dementia, pain and pain-related disorders, and polytrauma. The book concludes with important special considerations, including assessment of symptom and performance validity, assessment of homeless veterans and health-related quality of life, and ethical, legal, and professional issues.
Psychological Assessment of Veterans provides an essential reference and guide for clinical psychologists, including those working in the subspecialties, and psychology trainees who work with veterans.

Peter J. Jannetta, the neurosurgeon/neuroscientist who has contributed so much to the evaluation and treatment of trigeminal neuralgia and other cranial nerve disorders brings together the most distinguished contributors in Trigeminal Neuralgia.
This seminal work collates and categorizes in one succinct volume what we understand about the various forms of face pain syndromes. By providing information on former beliefs, as well as current understanding, this book provides multiple options regarding diagnosis, medical treatment and operative intervention which will help decision making, develop knowledge and improve care of patients.
Trigeminal Neuralgia begins with an Introduction explaining where we were and what role those ideas have played in current thinking, all with the goal of giving the reader a basis for future thought. With each subsequent chapter - written by basic scientists and astute clinicians working in the area of facial pain - enigmas are clarified, solutions of apparently untreatable problems are presented, and a better understanding of how diagnoses and pathophysiology are evolving are presented.
This is a must read for all who would learn about neurogenic facial pain.

Anxiety is ubiquitous in everyday life and avoiding sources of anxiety is often at the core of our everyday choices and can even shape our life plans. But why are we all so anxious, when is this normal uniqueness as opposed to a diagnosable anxiety disorder, and why have anxiety disorders become more prevalent than ever? In All We Have to Fear, Horwitz and Wakefield argue that psychiatry has largely generated this epidemic by inflating our socially inconvenient, yet natural, fears into psychiatric disorders and ignoring our biologically designed natures, thus allowing the overdiagnosis of anxiety disorders and facilitating a culture of medicalization. The result is a society that is afraid of natural, biologically designed feelings of fear and, overall, anxious about feeling anxious. All We Have to Fear is a groundbreaking and fresh look at how to distinguish between anxiety conditions that are mental disorders, those that are natural reactions to threats, and those that are natural products of evolution. Building on the new science of evolutionary psychology, Horwitz and Wakefield demonstrate a mismatch between our basic biological natures and the environment that we have created for ourselves. Some of our natural anxiety is born from situations and objects that posed serious risks during prehistory, but that are no longer usually dangerous, for example, a city dweller who is terrified of snakes. This mismatch generates normal anxiety when there is, in fact, no real danger. Evolutionary psychology shows that beyond the context in which the symptoms occur, our biological heritage as a species must be considered in any psychiatric diagnosis as we are otherwise bewildered by our own primitive fears and beset by diffuse anxieties that seem to have no function in our lives. All We Have to Fear argues that only by paying attention to our evolutionary shaping can we understand ourselves, our fears, what is normal versus disordered in what we fear, and make informed choices about how to approach these fears. The mismatch between our natures, environment, and our fears is not pathological, but rather reveals the forces that shaped us and provides an "emotional time machine," shedding light on who we were when we were shaped as a species, and thus, allowing us more insight into who we are today.

This third volume of NMR Spectroscopy in the Undergraduate Curriculum continues the work we started with the first and second volumes in providing effective approaches for using nuclear magnetic resonance spectrometers as powerful tools for investigating a wide variety of phenomena at the undergraduate level. This volume focuses on upper-level courses and NMR spectroscopy across the curriculum. The applications and strategies in this volume will be helpful to those who are looking to transform their curriculum by integrating more NMR spectroscopy, to those who might not have considered NMR spectroscopy as a tool for solving certain types of problems, or for those seeking funding for a new or replacement NMR spectrometer.

This indispensable guide gives concise yet comprehensive descriptions of the pulse sequences commonly used on modern MRI scanners. The book consists of a total of 65 self-contained sections, each focused on a single subject. Written primarily for scientists, engineers, radiologists, and graduate students who are interested in an in-depth understanding of various MRI pulse sequences, it serves readers with a diverse set of backgrounds by providing both non-mathematical and mathematical descriptions.
The book is divided into five parts. Part I of the book describes two mathematical tools, Fourier transforms and the rotating reference frame, that are useful for understanding MRI pulse sequences. The second part is devoted to a wide variety of radiofrequency (RF) pulses, and the third part focuses on gradient waveforms. Data acquisition, image reconstruction, and physiological monitoring related to pulse sequence design form the subject of Part IV of the book. Once this foundation is established, Part V of the book describes the underlying principles, implementation, and selected applications of many pulse sequences commonly in use today.
The extensive topic coverage and cross-referencing makes this book ideal for beginners learning the building blocks of MRI pulse sequence design, as well as for experienced professionals who are seeking deeper knowledge of a particular technique.
-Explains pulse sequences, their components, and the associated image reconstruction methods commonly used in MRI
-Provides self-contained sections for individual techniques
-Can be used as a quick reference guide or as a resource for deeper study
-Includes both non-mathematical andmathematical descriptions
-Contains numerous figures, tables, references, and worked example problems

This brand-new book offers virtual hands-on experience to over 65 emergency procedures, allowing readers to rehearse them over again in their mind-then perform them on demand correctly. Colour drawings of each procedure that illuminate relevant anatomical structures and their relationship to each new step paired with full-colour photographs provide a realistic clinical view of the identical anatomy. Plus, each step is accompanied by concise text, allowing the illustrations and photographs to guide clinicians effortlessly through the procedure. Presents step-by-step, side-by-side full-color illustrated guidance. Uses a standard chapter organization for quick reference. Offers a brief description of each procedure. Features bulleted lists of clinical indications, oft-overlooked contraindications, and potential complications. Displays the essential equipment needed to perform the procedure. And more.

This introductory textbook of pharmacoeconomics is ideal for all those working in, aspiring to work in or interested in the pharmaceutical industry. It assumes no prior knowledge of this subject but is written at a level appropriate, for example, for those studying for a postgraduate degree or diploma in pharmaceutical medicine and who already have a first degree in science or medicine. Emphasizes how pharmacoeconomics can be of assistance in "real world" decision making. Covers the development of insuring, financing and delivery of health care in the developed world and the increasing role of governments. Explains the trend towards the critical scrutiny of health service activity. All topics explained assuming no specialist knowledge.

This book covers emerging trends in signal processing research and biomedical engineering, exploring the ways in which signal processing plays a vital role in applications ranging from medical electronics to data mining of electronic medical records. Topics covered include statistical modeling of electroencephalograph data for predicting or detecting seizure, stroke, or Parkinson's; machine learning methods and their application to biomedical problems, which is often poorly understood, even within the scientific community; signal analysis; medical imaging; and machine learning, data mining, and classification. The book features tutorials and examples of successful applications that will appeal to a wide range of professionals and researchers interested in applications of signal processing, medicine, and biology.

The Mechanics of Inhaled Pharmaceutical Aerosols, An Introduction provides a unique and comprehensive treatment of the mechanics of inhaled pharmaceutical aerosols. The book covers a wide range of topics and many new perspectives are given by drawing on research from a variety of fields. Novel, in-depth expositions of the most common delivery devices are given, including nebulizers, dry powder inhalers and propellant metered dose inhalers. The behaviour of aerosols in the respiratory tract is explained in detail, with complete coverage of the fundamentals of current deposition models.
The book begins by providing a comprehensive introduction to aspects of aerosol mechanics that are relevant to inhaled pharmaceutical aerosols. It then gives an exhaustive pedagogical description of the behaviour of evaporating and condensing droplets (both aqueous and propellant-based), an introductory chapter on lung geometry and inhalation patterns, and coverage of relevant aspects of fluid mechanics in the lung. Finally, the book provides invaluable, detailed coverage on the mechanics of common pharmaceutical aerosol delivery systems and deposition in the respiratory tract. Throughout the book are many detailed numerical examples that apply the salient concepts to typical inhaled pharmaceutical aerosols.
This book will be of interest to scientists and engineers involved in the research and development of inhaled pharmaceutical aerosol products. Experienced practitioners will find many new perspectives that will greatly enhance their understanding of this complex and rapidly growing field. For those delivering therapeutic agents to the lung, this book is a must-have. Students and academics will find this book an invaluable tool and for newcomers it is a worthy guide to the diverse fields that must be understood to work in the area of inhaled pharmaceutical aerosols.

This quick reference guide, with its easy-to-use format, can be used as a revision tool for professional examinations as well as a tutorial aid for lecturers. It will, therefore, be an essential purchase for trainees and specialists in anaesthesia, intensive care and emergency medicine as well as providing continuing medical education for established senior staff. * Illustrative case scenarios to emphasize the safe, modern approach to a wide variety of problems in the field of paediatric anaesthesia and intensive care * Topics reflecting the scope of current practice with questions and answers * Key references for further reading

This volume examines recent developments in the use of intelligent materials and systems for drug delivery. Controlled release technology is moving from being a simple carrier of active agents to becoming a powerful and flexible method that permits subtle modulation of the delivery profile based on the needs of the biological host. The chapters collected here cover recent advances in materials with responsive properties, novel concepts in controlled release technology, new applications, and microanalytical techniques for rapid and accurate measurements of small samples.

MCQs in Sports Medicine contains a wide selection of multiple choice questions covering all aspects of sports medicine at the level of the postgraduate diploma or MSc. The author provides a short review of each answer, with supporting references that lead the reader to more specific further reading. The topics covered are those typically encountered in clinical practice by the sports medicine professional, and may present to primary care, rheumatology or orthopaedic services.

With a wealth of sound practical advice, from the authors' years of extensive experience, this book will be invaluable for all those prescribing aerobic exercise programmes for cardiovascular health including: general practitioners, physiotherapists, nurses, exercise instructors and advisors.Covers traditional and contemporary approaches Many easy-to-use charts for the calculation of exercise intensities and aerobic exercise programmes Well referenced and thoroughly tested

This book is a thoughtful, informative, and practical guide for anyone involved in caring for the seriously and chronically ill or dying. The connection between spirituality and medicine has been receiving a lot of attention in both the scientific and lay presses recently, but research and
anecdotal evidence all indicate that spirituality is central to the care of the chronically ill and dying. It is therefore critical that healthcare providers who interact with seriously ill patients know how to address their spiritual needs.
This book presents current thinking on how spiritual care can be integrated into traditional caregiving. Part one discusses aspects of spirituality, such as presence, ethics, and relationships. Part two delves into a number of specific religious and theological traditions. Part three offers
practical applications and tools, including storytelling, psychotherapy, dance, music, and the arts. Part four focuses on patients' stories and reflections. The book concludes with appendices that have sample advance directives for Protestant, Catholic, Jewish, and Muslim patients.
Volume editor Christina Puchalski is the director of the George Washington Institute of Spirituality and Health. She is also an associate professor of medicine at the George Washington University Medical Center and an active practicing physician and medical educator. Dr. Puchalski is nationally and
internationally recognized as a pioneer in the integration of spirituality and healthcare. Chapters are authored by an impressive group of medical and religious experts, and patients' stories also appear throughout, offering real-world examples. The book features a foreword by theDalai
Lama.

After her diagnosis of triple negative breast cancer (TNBC), health journalist Patricia Prijatel did what any reporter would do: start investigating the disease, how it occurs, and how it's treated. While she learned that important research was emerging, she found a noticeable lack of resources on the disease, which affects 70,000 women a year and differs from hormone-positive breast cancer in important ways, including prognosis and treatment options. Hormone negative breast cancer disproportionately affects younger women and African-American women - and it can be more dangerous than other types of breast cancer. But there are many reasons to be hopeful, as Prijatel learned. Through her blog, Positives About Negative, she has met hundreds of women who have told her their stories and shared their fears, confusion, and frustration. After her recovery, she began writing this book to provide the first dedicated resource for women diagnosed with TNBC. Surviving Triple Negative Breast Cancer delivers research-based information on the biology of TNBC; the role of genetics, family history, and race; how to navigate treatment options; and a plethora of strategies to reduce the risk of recurrence, including diet and lifestyle changes. In clear, approachable language, Prijatel provides an accessible guide to understanding a pathology report and a vast array of scientific studies. Woven throughout the book are stories of women who have faced TNBC. These are mothers, wives, daughters, and sisters who went through a variety of medical treatments and then got on with life - one competes in triathlons, two had babies after being treated with chemo, one got remarried in her 50s, and one just celebrated the 30th birthday of the son she was nursing when she was diagnosed. With honesty and humor, Prijatel's inspiring story shows the heart of a survivor. Her message is that TNBC is a disease to take seriously, with proper and occasionally aggressive treatment, but it is not automatically a killer. Most women diagnosed with the disease do survive. Surviving Triple Negative Breast Cancer is a roadmap for women who want to be empowered through their treatment and recovery.

Research is finding a way to measure the problem. This seminal 2-volume book contains hundreds of the most useful measurement tools for use in clinical practice and in research. All measures are critiqued by the editors, who provide guidance on how to select and score them and the actual measures are wholly reproduced. This second volume, focusing on measures for use with adults, whose conditions of concerns are not focused on family relationships or couple relationships, includes an introduction to the basic principles of measurement, an overview of different types of measures, and an overview of the Rapid Assessment Inventories included herein. Volume II also contains descriptions and reviews of each instrument, as well as information on how they were selected and how to administer and score them. This book is designed as the definitive reference volume on assessment measures for both practice and research in clinical mental health. This fifth edition of Corcoran and Fischer's Measures for Clinical Practice and Research is updated with a new preface, new scales, and updated information for existing instruments, expanding and cementing its utility for members of all the helping professions, including psychology, social work, psychiatry, counseling, nursing, and medicine. Alone or as a set, these classic compendiums are powerful tools that clinicians and researchers alike will find an invaluable addition to - or update of - their libraries.