Therapeutic protein drug products provides a comprehensive overview of therapeutic protein drug products, with an emphasis on formulation beginning in the laboratory, followed by manufacturing and administration in the clinic. A list of many commercial therapeutic drug products are described and include the product name, dosages, active concentration, buffer, excipients, Ph, container type and route of administration. The laboratory formulation sections focus on the most common buffers, excipients, and Ph ranges that are commonly tested in addition to systematic approaches. A brief section on biophysical and analytical analysis is also provided. Properties of therapeutic protein formulations are described and include opalescence, phase separation, color, and subvisible particles. An emphasis is placed on material and process testing to ensure success during manufacturing. The drug product manufacturing process, which includes the process of compounding to filling, is also covered. Methods of delivery in the clinic are addressed, as well as delivery strategies. Finally, a perspective on the regulatory requirements for therapeutic protein formulations is discussed.
Provides a list and description of commercially available therapeutic drug products and their formulationsA comprehensive and practical overview of protein formulation in the laboratory, manufacturing, and the clinicDiscusses recent topics including high protein concentration, phase separation, opalescence, and subvisible particles

Remarkable advances have occurred since the Series 3 Fascicle published in 1995 with paradigm shifts in every dimension of our understanding of lung tumors including clinical, radiologic, histopathologic, cytopathologic, immunohistochemical, molecular and therapeutic aspects. The molecular revolution leading to effective targeted therapies and breakthroughs in immunotherapy for lung cancer have led to novel approaches incorporating the concept of personalized medicine for patients who historically had little hope. These advances have strengthened the place of pathologists to play a central role in the multidisciplinary team that is now needed to properly diagnose and manage lung cancer patients.

Wound repair is an important and growing sector of the medical industry with increasingly sophisticated biomaterials and strategies being developed to treat wounds. Advanced wound repair therapies provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds.
Part one provides an introduction to chronic wounds, with chapters covering dysfunctional wound healing, scarring and scarless wound healing and monitoring of wounds. Part two covers biomaterial therapies for chronic wounds, including chapters on functional requirements of wound repair biomaterials, polymeric materials for wound dressings and interfacial phenomena in wound healing. In part three, molecular therapies for chronic wounds are discussed, with chapters on topics such as drug delivery, molecular and gene therapies and antimicrobial dressings. Part four focuses on biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair. Finally, part five covers physical stimulation therapies for chronic wounds, including electrical stimulation, negative pressure therapy and mechanical debriding devices.
With its distinguished editor and international team of contributors, Advanced wound repair therapies is an essential reference for researchers and materials scientists in the wound repair industry, as well as clinicians and those with an academic research interest in the subject.
Provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic woundsChapters include the role of micro-organisms and biofilms in dysfunctional wound healing, tissue-biomaterial interaction and electrical stimulation for wound healingCovers biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair

In this book, the authors have placed culture in the forefront of their approach to study pain in an integrative manner. Culture should not be considered solely for knowing more about patients' values, beliefs, and practices. It should be studied with the purpose of unveiling its effects upon biological systems and the pain neuromatrix. The book discusses how a multidisciplinary and integrative approach to pain and analgesia should be considered. Some familiarity with the cultural background of patients and awareness of the provider's own cultural characteristics will allow the pain practitioner to better understand patients' values, attitudes and preferences. Knowledge of patients' cultural practices will allow determining the impact of culture on biological processes, including the origin and development of pain-related disease, and the patients' response to pharmacological and non-pharmacological treatments. Acknowledging the interactions of molecules, genes and culture could yield a more appropriate and effective personalized pain medicine. Furthermore, this approach has the potential to transform the way pain medicine is taught to young students and future pain professionals, and in so doing meet the need of trained clinicians who are versed in multiple disciplines and are able to use an integrative approach to diagnose and treat pain. A personalized medicine will have non-negligible positive effects in improving doctor patient relationships, patient satisfaction, adherence to treatment plans, and health outcomes and inequities. It is hoped that the material in this volume will appeal to a broad cross-section of health practitioners, students and academicians, including pain medicine specialists, psychiatrists, psychologists, social workers, mental health, community and public health workers, health policy makers, and health administrators.

"Progress in Medicinal Chemistry" provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems, including g-secretase modulators, P2X7 antagonists as therapeutic agents for CNS disorders, N-type calcium channel modulators for the treatment of pain, and more.

Extended timely reviews of topics in medicinal chemistryTargets and technologies relevant to the discovery of tomorrow s drugs.Analyses of successful drug discovery programmes"

This issue of Critical Care Clinics, Guest Edited by Paul Wischmeyer, MD features topics such as: Nutrition Guidelines In Critical Care: Consistency or Confusion?; Evolutionary Role of Nutrition and Metabolic Support in Critical Illness; Pre-operative Surgical Nutrition Programs; Fish Oil in Critical Illness: Mechanisms and Clinical Application; Glutamine in Critical Illness: The Time Has Come, The Time Is Now?; Immunosupression and Infection After Major Surgery: A Nutritional Deficiency?; Enteral Nutrition in Critical Care: Why Do We Starve Our Patients?

Medical imaging now plays a major role in diagnosis, choice of therapy, and follow-up. However, patients are often intimidated by the multiple imaging modalities available, the indications for their use, the imposing equipment, what the examinations are like and how long they last, and the advantages and disadvantages of various procedures. This book is designed to provide explanations for these and other issues in order to relieve some of the anxiety related to medical imaging studies.

Toxicologic pathology integrates toxicology and the disciplines within it (such as biochemistry, pharmacodynamics and risk assessment) to pathology and its related disciplines (such as physiology, microbiology, immunology, and molecular biology).
"Fundamentals of Toxicologic Pathology 2e" updates the information presented in the first edition, including five entirely new chapters addressing basic concepts in toxicologic pathology, along with color photomicrographs that show examples of specific toxicant-induced diseases in animals. The current edition also includes comparative information that will prove a valuable resource to practitioners, including diagnostic pathologists and toxicologists.

NOW FEATURING:

25% brand new information, fully revised throughout

New chapters: Veterinary Diagnostic Toxicologic Pathology; Clinical Pathology; Nomenclature: Terminology for Morphologic Alterations; Techniques in Toxicologic Pathology

New color photomicrographs detailing specific toxicant-induced diseases in animals

Mechanistic information integrated from both toxicology and pathology discussing basic mechanisms of toxic injury and morphologic expression at the subcellular, cellular, and tissue levels"

Hoarding involves the acquisition of and inability to discard large numbers of possessions that clutter the living area of the person collecting them. It becomes a disorder when the behavior causes significant distress or interferes with functioning. Hoarding can interfere with activities of daily living (such as being able to sit in chairs or sleep in a bed), work efficiency, family relationships, as well as health and safety. Hoarding behavior can range from mild to life-threatening. Epidemiological findings suggest that hoarding occurs in 2-6% of the adult population, making it two to three times more common than obsessive-compulsive disorder. The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) now includes Hoarding Disorder as a distinct disorder within the OCD and Related Anxiety Disorders section, creating a demand for information about it. The Oxford Handbook of Hoarding and Acquiring is the first volume to detail the empirical research on hoarding. Including contributions from all of the leading researchers in the field, this comprehensive volume is divided into four sections in addition to introductory and concluding chapters by the editors: Phenomenology, Epidemiology, and Diagnosis; Etiology; Assessment and Intervention; and Hoarding in Special Populations. The summaries of research and clinical interventions contained here clarify the emotional and behavioral features, diagnostic challenges, and nature of the treatment interventions for this new disorder. This handbook will be a critical resource for both practitioners and researchers, including psychiatrists, psychologists, neurologists, epidemiologists, social workers, occupational therapists, and other health and mental health professionals who encounter clients with hoarding problems in their practice and research.

This issue covers the full gamut of infectious disease issues encountered in the ICU, including the approach to the febrile patient, management of septic shock, severe community-acquired pneumonia, management of ventilator-associated pneumonia, approach to the immunocompromised host, bloodstream infection, severe soft tissue infections, management of intra-abdominal sepsis, meningitis and brain abscess, treatment of fungal infections, acute infective endocarditis, new antimicrobial agents, antimicrobial stewardship, infection control, and C. difficile infection.

The establishment of frank and honest communication is one of the most important early goals of psychotherapy. Indeed, the most prominent challenge in the early stages of treatment is to develop a comfortable relationship that allows disclosure. In this volume, the authors show that objectively interpreted personality measures can be applied in psychotherapeutic assessments to facilitate an understanding of the patient and a thriving treatment program.
Successful psychotherapy depends upon an early understanding of the patient's problems and personality and the establishment of attainable treatment goals. The extensive accumulated base of knowledge about personality and its maladjustment has become crucial when making treatment decisions about individuals in psychotherapy, and the field of personality assessment provides both methods and substantive information to support treatment-oriented evaluation.
The MMPI has a long tradition of providing personality information about clients in mental health settings since the 1940s. James Butcher participated in the creation of the Minnesota Multiphasic Personality Inventory (MMPI-2) in 1989, which has continued to be one of the most commonly used personality tests in clinical evaluation. Over a thousand studies have been conducted on the effectiveness of the MMPI in treatment related assessments. Here, Butcher and co-author Julia Perry explore the MMPI-2 as well as a new assessment tool, the Butcher Treatment Planning Inventory (BTPI). In using psychological evaluation techniques for treatment planning, many clinicians incorporate information from a broad base of instruments-clinical interview, projective testing, behavioral data, andpersonal history-and do not rely on data from a single source. Therefore, while this volume focuses on the use of the MMPI-2 and the BTPI in treatment planning, it will provide a context not to the exclusion of other measures.

This book presents the most current scientific understanding behind most common pain disorders. Clinical scientists involved in pain science will gain a basic understanding of the causes of many types of pain and will be able to discuss various therapies with patients. Researchers new to pain science will gain an overall understanding of pain pathophysiology and targets for pain treatments. Covering every major aspect of pain science, from molecular and cellular pathways of pain to pain disorders and their treatments, Science of Pain bridges basic and clinical research like no other book on the topic. Edited by world-renowned pain scientist and Editor-in-Chief of the journal PAIN, Allan Basbaum, this book is an in-depth reference for basic and clinical scientists in pain research who must understand the basic science of pain, and help develop new treatment strategies for pain disorders.
* Presents the most current scientific understanding of neuroscience of pain, written by the world's leading experts
* Integrates basic neuroscience research and clinical aspects of pain disorders
* Covers both neurobiological basis and clinical treatment for a pain disorder (e.g., migraine, fibromyalgia, neuropathic pain, post-stroke pain)
* Covers pain pathways and mechanisms both in text and in full-color illustrations
* Includes topics specific to gender and age group addressing the trend in research toward developing individualized treatments

The detection and measurement of the dynamic interactions of proteins within the living cell are critical to our understanding of cell physiology and pathophysiology. With FRET microscopy and spectroscopy techniques, basic and clinical scientists can make such measurements at very high spatial and temporal resolution. But sources of background information about these tools are very limited, so this book fills an important gap. It covers both the basic concepts and theory behind the various FRET microscopy and spectroscopy techniques, and the practical aspects of using the techniques and analyzing the results. The critical tricks for obtaining a good FRET image and precisely quantitating the signals from living specimens at the nanomolecular level are explained. Valuable information about the preparation of biological samples used for FRET image analysis is also provided.
The methods covered include different types of microscopy systems and detectors (wide-field, confocal, multi-photon) as well as specialized techniques such as photobleaching FRET, FLIM-FRET microscopy, spectral imaging FRET, single molecule FRET, and time and image correlation spectroscopy. Starting from the basics, the chapters guide readers through the choice of probes to be used for FRET experiments and the selection of the most suitable experimental approaches to address specific biological questions. Up-to-date, consistently organized, and well-illustrated, this unique book will be welcomed by all researchers who wish to use FRET microscopy and spectroscopy techniques.

Psychological assessment is practiced in wide-ranging settings to address the varied clinical and administrative needs of veteran populations. Such assessment blends record review, clinical interviews of the veteran and collateral sources of information, behavioral observations, and psychological testing.
This book promotes the care and well-being of veterans by bringing together knowledgeable and experienced psychologists to discuss a range of psychological assessment methods and procedures. It aims to help patients and their families, healthcare providers, and concerned citizens gain an improved understanding of veterans' cognitive functioning, emotional states, personality traits, behavioral patterns, and daily functioning.
The book begins with a history of the psychological assessment of veterans and investigates its efficacy in different settings, including outpatient mental health, long-term care, primary care, home-based primary care, and telemental health. Later chapters address assessment of a variety of disorders or presenting problems, including substance use disorders, psychotic disorders, mood disorders and suicidal thoughts and behavior, PTSD and other anxiety disorders, attention-deficit/hyperactivity disorder, dementia, pain and pain-related disorders, and polytrauma. The book concludes with important special considerations, including assessment of symptom and performance validity, assessment of homeless veterans and health-related quality of life, and ethical, legal, and professional issues.
Psychological Assessment of Veterans provides an essential reference and guide for clinical psychologists, including those working in the subspecialties, and psychology trainees who work with veterans.

The Global History of Paleopathology is the first comprehensive global compendium on the history of paleopathology, an interdisciplinary scientific discipline that focuses on the study of ancient disease. Offering perspectives from regions that have traditionally had long histories of paleopathology, such as the United States and parts of Europe, this volume also presents important work by an international roster of scholars who are writing their own regional and cultural histories in the field. The book identifies major thinkers and figures who have contributed to paleopathology, as well as significant organizations and courses that have sponsored scientific research and communication, most notably the Paleopathology Association. The volume concludes with an eye towards the future of the discipline, discussing methods and research at the leading edge of paleopathology, particularly those that employ the analysis of ancient DNA and isotopes.

Peter J. Jannetta, the neurosurgeon/neuroscientist who has contributed so much to the evaluation and treatment of trigeminal neuralgia and other cranial nerve disorders brings together the most distinguished contributors in Trigeminal Neuralgia.
This seminal work collates and categorizes in one succinct volume what we understand about the various forms of face pain syndromes. By providing information on former beliefs, as well as current understanding, this book provides multiple options regarding diagnosis, medical treatment and operative intervention which will help decision making, develop knowledge and improve care of patients.
Trigeminal Neuralgia begins with an Introduction explaining where we were and what role those ideas have played in current thinking, all with the goal of giving the reader a basis for future thought. With each subsequent chapter - written by basic scientists and astute clinicians working in the area of facial pain - enigmas are clarified, solutions of apparently untreatable problems are presented, and a better understanding of how diagnoses and pathophysiology are evolving are presented.
This is a must read for all who would learn about neurogenic facial pain.

Anxiety is ubiquitous in everyday life and avoiding sources of anxiety is often at the core of our everyday choices and can even shape our life plans. But why are we all so anxious, when is this normal uniqueness as opposed to a diagnosable anxiety disorder, and why have anxiety disorders become more prevalent than ever? In All We Have to Fear, Horwitz and Wakefield argue that psychiatry has largely generated this epidemic by inflating our socially inconvenient, yet natural, fears into psychiatric disorders and ignoring our biologically designed natures, thus allowing the overdiagnosis of anxiety disorders and facilitating a culture of medicalization. The result is a society that is afraid of natural, biologically designed feelings of fear and, overall, anxious about feeling anxious. All We Have to Fear is a groundbreaking and fresh look at how to distinguish between anxiety conditions that are mental disorders, those that are natural reactions to threats, and those that are natural products of evolution. Building on the new science of evolutionary psychology, Horwitz and Wakefield demonstrate a mismatch between our basic biological natures and the environment that we have created for ourselves. Some of our natural anxiety is born from situations and objects that posed serious risks during prehistory, but that are no longer usually dangerous, for example, a city dweller who is terrified of snakes. This mismatch generates normal anxiety when there is, in fact, no real danger. Evolutionary psychology shows that beyond the context in which the symptoms occur, our biological heritage as a species must be considered in any psychiatric diagnosis as we are otherwise bewildered by our own primitive fears and beset by diffuse anxieties that seem to have no function in our lives. All We Have to Fear argues that only by paying attention to our evolutionary shaping can we understand ourselves, our fears, what is normal versus disordered in what we fear, and make informed choices about how to approach these fears. The mismatch between our natures, environment, and our fears is not pathological, but rather reveals the forces that shaped us and provides an "emotional time machine," shedding light on who we were when we were shaped as a species, and thus, allowing us more insight into who we are today.

The word concussion used to be unheard of in youth sports a decade ago. The brain injury was indeed occurring, but coaches and parents were encouraging their youth athletes to "shake it off" after "getting their bell rung". Science and increased awareness about concussion are transforming the way youth parents, coaches, and players pursue athletics. Fear of incurring concussions, as well as incorrect information, is leading some parents to keep their children out of contact sports, such as football and soccer, where concussion is more prevalent. Back in the Game: Why Concussion Doesn't Have to End Your Athletic Career does not dwell on perpetuating fears, but rather, provides the most up-to-date understanding of the condition. This text includes a real-world discussion of what science and medicine knows, what parents and coaches need to understand about concussions, evaluation and treatment, and possible post-concussive issues, like depression. At the heart of this book, the authors delve into these issues, explaining them in a clear and understandable way. The expertise and experiences of noted sports neurologist Jeffrey Kutcher, MD, along with reporting and interviews by award-winning sports journalist Joanne C. Gerstner, makes this book a timely, relevant, and real discussion about concussions in youth sports. Athletes and professional coaches who have participated in the formation of this book include two-time Olympic gold medalist soccer player Kate Markgraf, former NHL/Team Canada head coach Andy Murray, champion X-Games snowboarder Ellery Hollingsworth, along with an array of youth parents, coaches, and athletes from across the country.

This third volume of NMR Spectroscopy in the Undergraduate Curriculum continues the work we started with the first and second volumes in providing effective approaches for using nuclear magnetic resonance spectrometers as powerful tools for investigating a wide variety of phenomena at the undergraduate level. This volume focuses on upper-level courses and NMR spectroscopy across the curriculum. The applications and strategies in this volume will be helpful to those who are looking to transform their curriculum by integrating more NMR spectroscopy, to those who might not have considered NMR spectroscopy as a tool for solving certain types of problems, or for those seeking funding for a new or replacement NMR spectrometer.

This indispensable guide gives concise yet comprehensive descriptions of the pulse sequences commonly used on modern MRI scanners. The book consists of a total of 65 self-contained sections, each focused on a single subject. Written primarily for scientists, engineers, radiologists, and graduate students who are interested in an in-depth understanding of various MRI pulse sequences, it serves readers with a diverse set of backgrounds by providing both non-mathematical and mathematical descriptions.
The book is divided into five parts. Part I of the book describes two mathematical tools, Fourier transforms and the rotating reference frame, that are useful for understanding MRI pulse sequences. The second part is devoted to a wide variety of radiofrequency (RF) pulses, and the third part focuses on gradient waveforms. Data acquisition, image reconstruction, and physiological monitoring related to pulse sequence design form the subject of Part IV of the book. Once this foundation is established, Part V of the book describes the underlying principles, implementation, and selected applications of many pulse sequences commonly in use today.
The extensive topic coverage and cross-referencing makes this book ideal for beginners learning the building blocks of MRI pulse sequence design, as well as for experienced professionals who are seeking deeper knowledge of a particular technique.
-Explains pulse sequences, their components, and the associated image reconstruction methods commonly used in MRI
-Provides self-contained sections for individual techniques
-Can be used as a quick reference guide or as a resource for deeper study
-Includes both non-mathematical andmathematical descriptions
-Contains numerous figures, tables, references, and worked example problems

This brand-new book offers virtual hands-on experience to over 65 emergency procedures, allowing readers to rehearse them over again in their mind-then perform them on demand correctly. Colour drawings of each procedure that illuminate relevant anatomical structures and their relationship to each new step paired with full-colour photographs provide a realistic clinical view of the identical anatomy. Plus, each step is accompanied by concise text, allowing the illustrations and photographs to guide clinicians effortlessly through the procedure. Presents step-by-step, side-by-side full-color illustrated guidance. Uses a standard chapter organization for quick reference. Offers a brief description of each procedure. Features bulleted lists of clinical indications, oft-overlooked contraindications, and potential complications. Displays the essential equipment needed to perform the procedure. And more.

This introductory textbook of pharmacoeconomics is ideal for all those working in, aspiring to work in or interested in the pharmaceutical industry. It assumes no prior knowledge of this subject but is written at a level appropriate, for example, for those studying for a postgraduate degree or diploma in pharmaceutical medicine and who already have a first degree in science or medicine. Emphasizes how pharmacoeconomics can be of assistance in "real world" decision making. Covers the development of insuring, financing and delivery of health care in the developed world and the increasing role of governments. Explains the trend towards the critical scrutiny of health service activity. All topics explained assuming no specialist knowledge.

This book covers emerging trends in signal processing research and biomedical engineering, exploring the ways in which signal processing plays a vital role in applications ranging from medical electronics to data mining of electronic medical records. Topics covered include statistical modeling of electroencephalograph data for predicting or detecting seizure, stroke, or Parkinson's; machine learning methods and their application to biomedical problems, which is often poorly understood, even within the scientific community; signal analysis; medical imaging; and machine learning, data mining, and classification. The book features tutorials and examples of successful applications that will appeal to a wide range of professionals and researchers interested in applications of signal processing, medicine, and biology.

The Mechanics of Inhaled Pharmaceutical Aerosols, An Introduction provides a unique and comprehensive treatment of the mechanics of inhaled pharmaceutical aerosols. The book covers a wide range of topics and many new perspectives are given by drawing on research from a variety of fields. Novel, in-depth expositions of the most common delivery devices are given, including nebulizers, dry powder inhalers and propellant metered dose inhalers. The behaviour of aerosols in the respiratory tract is explained in detail, with complete coverage of the fundamentals of current deposition models.
The book begins by providing a comprehensive introduction to aspects of aerosol mechanics that are relevant to inhaled pharmaceutical aerosols. It then gives an exhaustive pedagogical description of the behaviour of evaporating and condensing droplets (both aqueous and propellant-based), an introductory chapter on lung geometry and inhalation patterns, and coverage of relevant aspects of fluid mechanics in the lung. Finally, the book provides invaluable, detailed coverage on the mechanics of common pharmaceutical aerosol delivery systems and deposition in the respiratory tract. Throughout the book are many detailed numerical examples that apply the salient concepts to typical inhaled pharmaceutical aerosols.
This book will be of interest to scientists and engineers involved in the research and development of inhaled pharmaceutical aerosol products. Experienced practitioners will find many new perspectives that will greatly enhance their understanding of this complex and rapidly growing field. For those delivering therapeutic agents to the lung, this book is a must-have. Students and academics will find this book an invaluable tool and for newcomers it is a worthy guide to the diverse fields that must be understood to work in the area of inhaled pharmaceutical aerosols.