'Bad Science' hilariously exposed the tricks that quacks and journalists use to distort science, becoming a 400,000 copy bestseller. Now Ben Goldacre puts the $600bn global pharmaceutical industry under the microscope. What he reveals is a fascinating, terrifying mess. Doctors and patients need good scientific evidence to make informed decisions. But instead, companies run bad trials on their own drugs, which distort and exaggerate the benefits by design. When these trials produce unflattering results, the data is simply buried. All of this is perfectly legal. In fact, even government regulators withhold vitally important data from the people who need it most. Doctors and patient groups have stood by too, and failed to protect us. Instead, they take money and favours, in a world so fractured that medics and nurses are now educated by the drugs industry. The result: patients are harmed in huge numbers. Ben Goldacre is Britain's finest writer on the science behind medicine, and 'Bad Pharma' is the book that finally prompted Parliament to ask why all trial results aren't made publicly available - this edition has been updated with the latest news from the select committee hearings. Let the witty and indefatigable Goldacre show you how medicine went wrong, and what you can do to mend it.

The Annual Update compiles reviews of the most recent developments in experimental and clinical intensive care and emergency medicine research and practice in one comprehensive reference book. The chapters are written by well recognized experts in these fields. The book is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

Fathom, an experimental memoir, explores the hinterland of the narrator's mind. The narrative of Fathom focuses on a tantalising fragment from the past. `I think I saw a lot of blood' and other odd surfacings from memory are explored through the work of psychoanalysis. Much like a kind of detective work to begin with, the narrative unravels the depths that appear in psychotic breakdown. Identity is evoked through three personas of the self: the puppet, the puppet-master and She-who-knows. Poetic in style, though something of a detective story, the first-person narrative is richly layered - Plath, Shakespeare, Sophocles and pop songs all have their place. Highly concentrated, structured in three parts, non-linear in chronology and highly metaphoric, Fathom appeals to those with a deep interest in mental health and all types of therapy.

This comprehensive and self-contained text presents the fundamentals of optical imaging from the viewpoint of both ray and wave optics, within a single volume. Comprising three distinct parts, it opens with an introduction to electromagnetic theory, including electromagnetic diffraction problems and how they can be solved with the aid of standard numerical methods such as RCWA or FDTD. The second part is devoted to the basic theory of geometrical optics and the study of optical aberrations inherent in imaging systems, including large-scale telescopes and high-resolution projection lenses. A detailed overview of state-of-the-art optical system design provides readers with the necessary tools to successfully use commercial optical design software. The final part explores diffraction theory and concludes with vectorial wave propagation, image formation and image detection in high-aperture imaging systems. The wide-ranging perspective of this important book provides researchers and professionals with a comprehensive and rigorous treatise on the theoretical and applied aspects of optical imaging.

The leading reference on personality disorders and their treatment, this authoritative work is now significantly revised with 80% new content reflecting important advances in the field. Preeminent experts provide in-depth coverage of conceptual and taxonomic issues, psychopathology, epidemiology and longitudinal course, etiology and development, and specific diagnoses. Diagnostic issues are explored and available assessment instruments discussed. All available evidence-based treatments are reviewed in consistently organized chapters that cover theoretical and empirical foundations as well as clinical strategies, facilitating comparison of the various approaches. New to This Edition *Incorporates more than 15 years of major research advances; includes 21 chapters on new topics. *Critically examines DSM-5 diagnostic criteria. *Chapters on additional treatments--mentalization-based treatment, schema-focused therapy, transference-based psychotherapy, and systems training for emotional predictability and problem solving. *Chapters on cutting-edge topics such as dimensional models, longitudinal studies, and personality pathology in children and adolescents. *Chapters on specific diagnoses: antisocial/psychopathic, borderline, and obsessive-compulsive personality disorder. *Integrative section introductions by the editors. See also Integrated Treatment for Personality Disorder, edited by W. John Livesley, Giancarlo Dimaggio, and John F. Clarkin, which weaves multiple well-established intervention strategies into a systematic modular approach.

Mindfulness has emerged as a valuable component of treatment for adults with attention-deficit/hyperactivity disorder (ADHD). This concise manual presents an evidence-based group intervention specifically tailored to the needs of this population. The Mindful Awareness Practices for ADHD (MAPs) program helps participants cultivate self-regulation of attention, emotions, and behavior; awareness of ADHD challenges; self-acceptance; and self-compassion. With a stepwise teaching approach and meditation periods that are shorter than in other mindfulness programs, MAPs is designed to optimize learning. Included are step-by-step instructions for conducting the eight sessions, scripts for guided meditations, 33 reproducible handouts, and "Adaptation for Individual Therapy" boxes. Purchasers get access to a companion website where they can download printable copies of the handouts and audio recordings of the guided practices.

Do you find yourself always fighting with your nearest and dearest, distancing yourself through silence, or blaming others for the failure of your relationship?

For so many women anger is a destructive force which perpetuates all the harmful dynamics of our most intimate relationships. In this inspirational book, renowned psychotherapist Harriet Lerner shows how all women, regardless of age, background or experience, can turn anger into a constructive force.

Focusing largely on the family, 'The Dance of Anger' provides the reader with the insights and practical skills to stop behaving in the old predictable ways and to begin to use anger to establish a more positive approach to significant relationships.

In the 1940s and 1950s, Albert Schweitzer was one of the best-known figures on the world stage. Courted by monarchs, world statesmen, and distinguished figures from the literary, musical, and scientific fields, Schweitzer was awarded the Nobel Peace Prize in 1952, cementing his place as one of the great intellectual leaders of his time. Schweitzer is less well known now but nonetheless a man of perennial fascination, and this volume seeks to bring his achievements across a variety of areas-philosophy, theology, and medicine-into sharper focus. To that end, international scholars from diverse disciplines offer a wideranging examination of Schweitzer's life and thought over the course of forty years. Albert Schweitzer in Thought and Action gives readers a fuller, richer, and more nuanced picture of this controversial but monumental figure of twentieth-century life-and, in some measure, of that complex century itself.

Re-examining psychiatric interventions from a cultural-historical and political-economic perspective, Szasz demonstrates that the main problem that faces mental health policymakers today is adult dependency. Millions of Americans, diagnosed as mentally ill, are drugged and confined by doctors for non-criminal conduct, go legally unpunished for the crimes they commit, and are supported by the state - not because they are sick, but because they are unproductive and unwanted. Obsessed with the twin beliefs that misbehaviour is a medical disorder and that the duty of the state is to protect adults from themselves, we have replaced criminal-punitive sentences with civil-therapeutic programmes. The result is the relentless loss of individual liberty and erosion of personal responsibility - symptoms of the transformation of a Constitutional Republic into a Therapeutic State, unconstrained by the rule of law.

Concise, fact-based and packed with images and illustrations The EACVI Echo Handbook is the perfect companion for making both every day and complex clinical decisions. Designed and written by leading experts in the field of echocardiography for use in the clinical arena, this practical handbook provides the necessary information for reviewing, or consulting while performing or reporting on an echo or making clinical decisions based on echo findings. Disease-focussed and succinct, it covers the information needed to accurately perform and interpret echocardiograms, including how to set up the echo-machine to optimize an examination and how to perform echocardiographic disease assessment; the clinical indicators, procedures and contraindications. Linked to EACVI recommendations and the EACVI Core Curriculum The EACVI Echo Handbook is an essential and easily accessible manual on using echocardiography for sonographers and trainee cardiologists that should never be left behind when performing an echocardiogram.

This comprehensive book serves as a review for the Fellow of Interventional Pain Practice (FIPP) exam and functions as a concise guide for all interventional pain doctors. Through educational initiatives, it helps to promote consensus-building among experts on the effectiveness of existing techniques and avenues for advancement of therapeutic performances. The book is divided into four sections (head and neck, thoracic, lumbar and sacral/pelvic), and each chapter is devoted to the safe, standardized approach to interventional procedures. To prepare both the examiner and the examinee for the FIPP examination, each chapter contains the relevant C-arm images and outlines the most common reasons for "unacceptable procedures performance" and "potentially unsafe procedures performance." Distinguishing it from many of the previous guides, it also includes labeled fluoroscopic high quality images and focuses on the current FIPP-examined procedures with all accepted approaches. Written and edited by world leaders in pain, Interventional Pain guides the reader in study for FIPP Exam and offers a consensus on how interventional procedures should be performed and examined.

This book is an up-to-date and comprehensive reference on lipidology. It will serve as a stimulus to the reader to continue to learn about the ever changing and fascinating field of therapeutic lipidology. It will also empower readers to improve and extend the lives of the patients they so conscientiously serve.

Psychopathology has been designed to provide students with a comprehensive coverage of both psychopathology and clinical practice, including extensive treatment techniques for a range of mental health issues. The text is designed to be accessible to students at a range of different learning levels, from first year undergraduates to post-graduate researchers and those undergoing clinical training. Psychopathology is primarily evidence and research based, with coverage of relevant research from as recently as 2013, making it useful to researchers as well as clinicians. The emphasis in the book is on providing students with a real insight into the nature and experience of mental health problems, both through the written coverage and by providing a range of video material covering personal accounts of mental health problems. The text is integrated with a wide variety of teaching and learning features that will enable facilitators to teach more effectively, and students to learn more comprehensively. Many of these features have been updated for the new edition and new material has been included to reflect the changes in DSM-5. Features include Focus Points that discuss contentious or topical issues in detail, Research Methods boxes showing how clinical psychologists do research on psychopathology, and Case Histories detailing a range of mental health problems. Online resources An all new student website is available at www.wiley-psychopathology.com. The website houses a huge variety of new digital material including more than 50 instructional and supplementary videos covering descriptions of symptoms and aetiologies, examples of diagnosis and diagnostic interviews, recounted personal experiences of people with mental health problems, and discussions and examples of treatment. The site also contains hundreds of new student quizzes, as well as revision flashcards, student learning activities, discussion topics, lists of relevant journal articles (many of which provide free links to relevant articles published in Wiley Blackwell journals), and topics for discussion related to clinical research and clinical practice. A fully updated lecturer test bank has also been developed including over 1,000 questions, as well as suggested essay questions and these can be accessed by instructors on our lecturer book companion site.

Use breathwork to transform every area of your life. New science has revealed the effectiveness of breathwork to balance the body, relieve stress, control anxiety, boost self-esteem and more. In a beautifully illustrated package, Breathwork gives you 50 step-by-step practices that you can use at home, each with expert advice on body position, depth of breath, speed of breath, visualization, duration and repetition. Techniques include conscious connected breathing, pranayama and qigong breathwork. With internationally renowned author and teacher Nathalia Westmacott-Brown, you'll learn how to breathe mindfully and with control, using different breath practices for targeted outcomes - from overcoming insomnia to releasing anger or relieving depression. Breathing with purpose can help you to heal - and become the healthiest and happiest you can be.

In recent years the field of regional anesthesia, in particular peripheral and neuraxial nerve blocks, has seen an unprecedented renaissance following the introduction of ultrasound-guided regional anesthesia. This comprehensive, richly illustrated book discusses traditional techniques as well as ultrasound-guided methods for nerve blocks and includes detailed yet easy-to-follow descriptions of regional anesthesia procedures. The description of each block is broken down into the following sections: definition; anatomy; indications; contraindications; technique; drug choice and dosage; side effects; potential complications and how to avoid them; and medico-legal documentation. A checklist record for each technique and a wealth of detailed anatomical drawings and illustrations offer additional value. Regional Nerve Blocks in Anesthesia and Pain Medicine provides essential guidelines for the application of regional anesthesia in clinical practice and is intended for anesthesiologists and all specialties engaged in the field of pain therapy such as pain specialists, surgeons, orthopedists, neurosurgeons, neurologists, general practitioners, and nurse anesthetists.

With an increasing number of Muslims living in the West, and studies suggesting that mental illness may be more prevalent and chronic amongst Muslim cultural groups, there is a pressing need for appropriate treatment options. This book provides mental health professionals with a practical guide to delivering culturally adapted therapy to Muslim immigrants, refugees, and those with a Muslim religious or cultural background. It takes into account the religious, spiritual, social and cultural dimensions of individuals, framing elements such as mindfulness, emotion regulation and sleep problems within well-known Islamic terms and concepts. The book covers issues such as prominent somatic symptoms, multiple comorbidities, low education, ongoing life difficulties and mental health stigma. As Multiplex Therapy is transdiagnostic, targeting anxiety and mood disorders, the treatment is applicable to a large proportion of patients. Each chapter guides the reader through therapy sessions, giving clinicians an invaluable everyday manual for delivering treatment.

The Body Remembers, Volume 2: Revolutionizing Trauma Treatment continues the discussion begun more than fifteen years ago with the publication of the best-selling and beloved The Body Remembers: The Psychophysiology of Trauma and Trauma Treatment. This new book is grounded in the belief that the most important goal for any trauma treatment is to improve the quality of life of the client. Therefore, the first prerequisite is that the client be reliably stable and feel safe in his or her daily life as well as the therapy situation. To accomplish this, Babette Rothschild empowers both therapists and clients by expanding trauma treatment options. For clients who prefer not to review memories, or are unable to do so safely, new and expanded strategies and principles for trauma recovery are presented. And for those who wish to avail themselves of more typical trauma memory work, tools to make trauma memory resolution even safer are included. Being able to monitor and modulate a trauma client's dysregulated nervous system is one of the practitioner's best lines of defence against traumatic hyperarousal going amok-risking such consequences as dissociation and decompensation. Rothschild clarifies and simplifies autonomic nervous system (ANS) understanding and observation with her creation of an original full colour table that distinguishes six levels of arousal. Included in this table (and the discussion that accompanies it) is a new and essential distinction between trauma-induced hypoarousal and the low arousal that is caused by lethargy or depression. Combining an authoritative yet personal voice, Rothschild gives clinicians the space to recognise where they may have made mistakes-by sharing her own!-as well as a road map towards more effective practice in the future. This book is absolutely essential reading for anyone working with those who have experienced trauma. The full colour ANS table is also available from W.W. Norton as a laminated desk reference and a wall poster suitable for framing so this valuable therapeutic tool will always be at hand.

The second editon of this popular ultrasound book expands the reader's understanding of the clinical applications of ocular ultrasound through a case study approach. With the addition of high-quality video segments of examination techniques not currently available in any other format, this edition appeals to a broader range of practitioners in the field by presenting the subject starting at the basic level and progressing to the advanced. The book is appealing to practitioners involved in ocular ultrasound, including ophthalmic technicians, ophthalmologists, optometrists, radiologists and emergency room physicians who, on occasion, are involved in the practice of ophthalmic ultrasound.

What this book reveals so clearly is that, when probed, the notion of normality is fragile and shifting. It is not clear who decides what being normal means in any historical moment, or who is entitled to say. Nonetheless, concerns with conforming, fitting in, and being accepted are deeply pervasive. For most, being normal is a goal, and deviation from accepted norms feels like failure. Yet many people do not really feel normal. When sexuality, gender, health, ethnic group or any other common variation on the dominant theme is at play someone can feel out of step with this elusive standard. Others depend on being different to be creative, radical and discerning. Readers may conclude that it is our very uniqueness as individuals that makes us usual, and that we rely on our edge dwellers for cultural growth. This fascinating book explores these issues and more.

This surgical atlas, featuring a wealth of color photographs, provides detailed step-by-step descriptions of a wide range of open head and neck procedures, including radical and conservative (organ preservation, functional) approaches, aesthetic and reconstructive surgeries with the use of axial and free flaps, and surgery within the narrow confines of the skull base. Individual chapters are dedicated to surgery of the nose and paranasal sinuses, larynx and trachea, thyroid, salivary glands, mandible, face and lips, and neck, the repair of external nose defects, the use of axial and free flaps, and surgical treatment of temporal bone malignancy. The atlas will be a comprehensive practical reference for clinicians in the various specialties involved in head and neck surgery, including otolaryngologists, head and neck surgeons, plastic surgeons, maxillofacial surgeons and surgical oncologists. It will assist practitioners in achieving the high level of competence that is essential owing to the large number of vital structures in the head and neck region.

This atlas of echocardiography presents more than 100 cases of adult congenital heart disease, from diagnosis to treatment follow-up. The coverage is broad, encompassing atrial and ventricular septal defects, patent ductus arteriosus, cyanotic adult congenital heart disease, and numerous other anomalies, as well as findings on fetal echocardiography. For each disease, all echocardiographic images and views which proved of diagnostic value are arranged sequentially, with inclusion of transesophageal echocardiographic images whenever appropriate. Additional pertinent information is provided relating to diagnosis and treatment, and key teaching points are highlighted. The superb quality of the illustrations and the range of cases considered (including many rare ones) ensure that this atlas will be of great value for cardiology residents and fellows and highly relevant to day-to-day practice.

This open access book marks the first historical overview of the autism rights branch of the neurodiversity movement, describing the activities and rationales of key leaders in their own words since it organized into a unique community in 1992. Sandwiched by editorial chapters that include critical analysis, the book contains 19 chapters by 21 authors about the forming of the autistic community and neurodiversity movement, progress in their influence on the broader autism community and field, and their possible threshold of the advocacy establishment. The actions covered are legendary in the autistic community, including manifestos such as "Don't Mourn for Us", mailing lists, websites or webpages, conferences, issue campaigns, academic project and journal, a book, and advisory roles. These actions have shifted the landscape toward viewing autism in social terms of human rights and identity to accept, rather than as a medical collection of deficits and symptoms to cure.

This detailed book aims to provide readers with critical information to accomplish the synthesis of nanosystems for the purpose of supramolecular entities complexing with drugs, targeted drug delivery system characterization, as well as the study of the physical-chemical interactions that govern the stability and properties of these systems. Beginning with a collection of chapters on drug delivery platforms such as cyclodextrins, micelles, liposomes, polymeric, nanotubes, and more, the volume continues with coverage of the study of nanotechnology systems using different biophysical techniques such as DSC, ITC, solid and liquid NMR spectroscopy, and electrochemistry. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Supramolecules in Drug Discovery and Drug Delivery: Methods and Protocols serves as an ideal guide for researchers working toward drug delivery mechanisms that can tailor their physical chemical properties and enhance their efficacy, while retaining their structures intact.

This book reviews the imaging features associated with selected classes of pharmaceuticals and drugs on brain, head and neck, and spine and explains the implications of the imaging findings for the neuroradiologist and the clinician. Some agents produce characteristic abnormalities with distinctive imaging features, while others have a spectrum of manifestations on imaging. Still further agents produce rather nonspecific changes on imaging, requiring a differential diagnosis. In this book, informative cases are depicted by rich images, with concise accompanying explanatory text that reviews the class of agent and the mechanism of action and discusses image interpretation and its significance.