This volume summarizes the state-of-the-art technologies, key advances and future trends in the field of label-free biosensing. It provides detailed insights into the different types of solid-state, label-free biosensors, their underlying transducer principles, advanced materials utilized, device-fabrication techniques and various applications. The book offers graduate students, academic researchers, and industry professionals a comprehensive source of information on all facets of label-free biosensing and the future trends in this flourishing field. Highlights of the subjects covered include label-free biosensing with: * semiconductor field-effect devices such as nanomaterial-modified capacitive electrolyte-insulator-semiconductor structures, silicon nanowire transistors, III-nitride semiconductor devices and light-addressable potentiometric sensors * impedimetric biosensors using planar and 3D electrodes * nanocavity and solid-state nanopore devices * carbon nanotube and graphene/graphene oxide biosensors * electrochemical biosensors using molecularly imprinted polymers * biomimetic sensors based on acoustic signal transduction * enzyme logic systems and digital biosensors based on the biocomputing concept * heat-transfer as a novel transducer principle * ultrasensitive surface plasmon resonance biosensors * magnetic biosensors and magnetic imaging devices

Moreschi is renowned for its exacting standards and unique style, and for producing each and every pair on-site, from the arrival of the leather to boxing and dispatching to stores. The art of shoemaking is detailed throughout this richly illustrated book. Through conversations with the founder, the artisans' memories, and pictures of dozens of the factory's creations, a story unfolds that confirms the vast heritage of artisan culture that lies behind Italian production. Moreschi shoes have been worn by the likes of Richard Burton, Liam Neeson, Adrien Brody, Michael Jackson, James Brown, Johnny Cash, and also sports stars such as Michael Jordan, Novak Djokovic, and Alberto Tomba.

This lab manual is designed as a companion to "Evaluating Apparel Quality", 2nd Edition.

This book demonstrates how the new phenomena in the nanometer scale serve as the basis for the invention and development of novel nanoelectronic devices and how they are used for engineering nanostructures and metamaterials with unusual properties. It discusses topics such as superconducting spin-valve effect and thermal spin transport, which are important for developing spintronics; fabrication of nanostructures from antagonistic materials like ferromagnets and superconductors, which lead to a novel non-conventional FFLO-superconducting state; calculations of functional nanostructures with an exotic triplet superconductivity, which are the basis for novel nanoelectronic devices, such as superconducting spin valve, thin-film superconducting quantum interference devices (SQUIDs) and memory-elements (MRAM). Starting with theoretical chapters about triplet superconductivity, the book then introduces new ideas and approaches in the fundamentals of superconducting electronics. It presents various quantum devices based on the new theoretical approaches, demonstrating the enormous potential of the electronics of 21st century - spintronics. The book is useful for a broad audience, including researchers, engineers, PhD graduates, students and others wanting to gain insights into the frontiers of nanoscience.

This book provides a comprehensive overview of the photonic sensing field by covering plasmonics, photonic crystal, and SOI techniques from theory to real sensing applications. A literature review of ultra-sensitive photonic sensors, including their design and application in industry, makes this a self-contained and comprehensive resource for different types of sensors, with high value to the biosensor sector in particular. The book is organized into four parts: Part I covers the basic theory of wave propagation, basic principles of sensing, surface plasmon resonance, and silicon photonics; Part II details the computational modeling techniques for the analysis and prediction of photonic sensors; Part III and Part IV cover the various mechanisms and light matter interaction scenarios behind the design of photonic sensors including photonic crystal fiber sensors and SOI sensors. This book is appropriate for academics and researchers specializing in photonic sensors; graduate students in the early and intermediate stages working in the areas of photonics, sensors, biophysics, and biomedical engineering; and to biomedical, environmental, and chemical engineers.

This book gives a unified presentation of the research performed in the field of multiscale modelling in sheet metal forming over the course of more than thirty years by the members of six teams from internationally acclaimed universities. The first chapter is devoted to the presentation of some recent phenomenological yield criteria (BBC 2005 and BBC 2008) developed at the CERTETA center from the Technical University of Cluj-Napoca. An overview on the crystallographic texture and plastic anisotropy is presented in Chapter 2. Chapter 3 is dedicated to multiscale modelling of plastic anisotropy. The authors describe a new hierarchical multi-scale framework that allows taking into account the evolution of plastic anisotropy during sheet forming processes. Chapter 4 is focused on modelling the evolution of voids in porous metals with applications to forming limit curves and ductile fracture. The chapter details the steps needed for the development of dissipation functions and Gurson-type models for non-quadratic anisotropic plasticity criteria like BBC 2005 and those based on linear transformations. Chapter 5 describes advanced models for the prediction of forming limit curves developed by the authors. Chapter 6 is devoted to anisotropic damage in elasto-plastic materials with structural defects. Finally, Chapter 7 deals with modelling of the Portevin-Le Chatelier (PLC) effect. This volume contains contributions from leading researchers from the Technical University of Cluj-Napoca, Romania, the Catholic University of Leuven, Belgium, Clausthal University of Technology, Germany, Amirkabir University of Technology, Iran, the University of Bucharest, Romania, and the Institute of Mathematics of the Romanian Academy, Romania. It will prove useful to postgraduate students, researchers and engineers who are interested in the mechanical modeling and numerical simulation of sheet metal forming processes.

A scheduling system for Lean and just-in-time production, Kanban is a proven tool for reducing waste, inventory, and lead times. The implementation of Kanban, however, is a manually intensive action and conducting Kanban projects properly takes experience and direction. Until now, there has been a need for a book with detailed step-by-step guidelines on how to properly implement Kanban. Complete with color images, The Kanban Playbook: A Step-by-Step Guideline for the Lean Practitioner fills this need. This new book in The LEAN Playbook Series is your guide to proper Kanban implementation. It is ideal for Lean practitioners and facilitators looking for a training tool and guideline that can be used in the work area while improvements are being made. Like a football coach, you can use this playbook for quick reference to convey what's needed to facilitate effective Kanban projects. If for some reason you forget a "play" during the implementation, you can easily reference the playbook. You can follow page by page and use the playbook to facilitate successful Kanban projects, or you can go directly to certain topics and use it to help you implement that particular "play." The playbook includes color images from actual Kanban implementations. In addition to the images, a combination of short paragraphs and bulleted points walk you step by step through the process of implementing Kanban to reduce waste and bring about remarkable changes in your organization. Wasting little time on high-level theory, the book explains how to implement Kanban Card Systems, Two-Bin Systems, and In-Process Kanban (IPK). Looking for supplemental information or Lean coaching from Chris Ortiz? Go to www.leanplaybooks.com to receive ongoing support and advice on how to use The LEAN Playbook Series for training and implementation.

The second edition of a bestseller, Design Controls for the Medical Device Industry provides a comprehensive review of the latest design control requirements, as well as proven tools and techniques to ensure your company's design control program evolves in accordance with current industry practice. The text assists in the development of an effective design control program that not only satisfies the US FDA Quality System Regulation (QSR) and ISO 9001 and 13485 standards, but also meets today's third-party auditor/investigator expectations and saves you valuable time and money. The author's continual participation in FDA QSR inspections and Notified Body ISO audits is reflected in updates to all chapters and appendices of the book, now bursting at the seams with: New coverage of ISO 9001 and 13485 design control requirements More real-world examples from the medical device industry Additional detail for greater understanding and clarity Fresh templates for practical implementation Extensive references for further study The book addresses design control elements such as design planning, input, output, review, verification, validation, change, transfer, and history, as well as risk management inclusive of human factors and usability, biocompatibility, the FDA Quality System Inspection Technique (QSIT) for design controls, and medical device regulations and classes in the US, Canada, and Europe.

Strategic Excellence in the Architecture, Engineering, and Construction Industries is a process of applied strategic thinking designed to develop a strategy empowered with the agility to adapt to changing circumstances and to drive a high performing culture of ideal behaviors. It is infused with the insight and the thought leadership of the Shingo Model and the scientific thinking of Lean Six Sigma. The book goes beyond the classic approach to strategic planning by driving effective execution of the strategy through the embedment of collective ownership and organization-wide alignment into the entire process. Significant advances in strategic planning and management have been developed over decades of learning and practice. Many of those advances, however, have been developed in the manufacturing industry and have not been translated into terms easily applicable to the A/E/C (Architectural / Engineering / Construction) industry. This book incorporates current best practices from cutting edge organizations around the globe and presents those in a way that they can easily be applied to A/E/C organizations through an efficient and effective process.

This one-of-a-kind catalogue features the highest-quality complicated timepieces from the world's most luxurious watchmakers.

Updating the tools, principles, and methods presented in the bestselling first edition, this updated edition explains how to implement the authors' proven improvement methodology that unifies the Theory of Constraints with Lean and Six Sigma. The book uses a compelling novel format to demonstrate how to achieve superior on-time delivery along with unprecedented levels of profitability. Besides explaining how to implement the authors' unified improvement methodology, the book arms readers with a proven method for convincing management that using the improvement methodology outlined in the text will lead to significantly higher levels of profitability. This edition has been updated with an expanded appendix that includes more in-depth discussions of the tools covered in the first edition. This edition also sheds more light on the reasoning behind why the very best improvement results can be achieved by the unification of the Theory of Constraints, Lean, and Six Sigma (TLS). The appendix also provides additional detail about how the concepts covered in the book can be applied to your organization. The primary theme throughout this book is the focus on the unity and enhancement of improvement tools and methods. The book includes an appendix that allows readers to explore, in much more detail, the principles, tools, and techniques presented in the novel portion of the book. The authors detail a pioneering pathway for significant gains in profitability and market share for any company choosing to implement the methodologies that are presented. Some of the concepts, tools, and principles presented may seem counterintuitive to many readers, but if the principles are understood and followed, the exceptional results are sure to follow

The Innovation Factory takes a fresh look at the fine art of breakthrough innovation. What makes it unique is that it brings together an experienced scholar and a serial entrepreneur who share the same passion for understanding the processes and theories needed to innovate over and over again. The book marries theory with practical examples focusing on the Concept-Knowledge (C-K) Theory developed by the prestigious school Mines ParisTech. For the first time, you will discover the unknown story of the Swatch watch told by Elmar Mock, the creative engineering force behind the Swatch. In this book, he passionately tells how he helped to create this breakthrough innovation that saved the Swiss watch industry in the 1980s. Gilles Garel, a professor of management, relates this tale of epic innovation to C-K theory and both convincingly argue that organizations can channel creativity to develop breakthrough innovations that disrupt markets. Innovation is not just a case of acquiring aptitude. It is also a question of attitude: Innovators strive to remain creative and active. The book provides an overview of the characteristics and essential strengths of the successful Innovation Factory, Creaholic, based in Switzerland. The example of Creaholic helps readers grasp what breakthrough innovation is truly all about. The book's use of vibrant metaphors helps readers easily digest the ideas and concepts presented. The book concludes with thoughts about future directions for the watch industry.

Devoted to design principles, influences, appreciation, and application, this fully illustrated manual presents a thoroughly unique approach to becoming a professional furniture maker and designer. Examples of work suitable for both batch production and one-off commission work are discussed, as well as the tools and machinery required for a variety of working situations. Business efficiency methods are also explored, including the available professional help such as accountants and solicitors who may ease the paperwork side of running a business, in addition to the promotional aspects--exhibitions, press coverage, gallery display, and photography--that are so essential to growth. This handbook is indispensable to any self-employed craftsman, student, or woodworker looking to start a business.

With more than 500 illustrations, this book is perfect for craftsmen who want to set up a blacksmith shop, and for lovers of history and craft alike. This book describes and illustrates the equipment and techniques developed in more than six thousand years of working iron by hand.
Indeed, this unique book covers every aspect of a fascinating and little-known art, the fundamental craft on which the civilization of the Iron Age was built.

This invaluable, practical book is written by a watch repairer with over twenty years' experience. It is aimed principally at the novice mechanical watch repairer, although those with more experience will also find it most useful. Brimming with advice and useful tips, it provides step-by-step photographs with accompanying text and demonstrates how to maintain a mechanical watch, and how to identify problems and correct them. The author discusses the theory behind how a watch works and reveals how to take a watch apart and how to reassemble it without causing any damage. Each section of the book is related to a particular element within the watch, and the author clearly explains the function and design of each part.

Cutting-edge coverage of the new processes, materials, and technologies that are revolutionizing the manufacturing industry Expertly edited by a past president of the Society of Manufacturing Engineers, this state-of-the-art resource picks up where the bestselling Design for Manufacturability Handbook left off. Within its pages, readers will find detailed, clearly written coverage of the materials, technologies, and processes that have been developed and adopted in the manufacturing industry over the past sixteen years. More than this, the book also includes hard-to-find technical guidance and application information that can be used on the job to actually apply these cutting-edge processes and technologies in a real-world setting. Essential for manufacturing engineers and designers, Design for Manufacturability is enhanced by a host of international contributors, making the book a true global resource. * Information on the latest technologies and processes such as 3-D printing, nanotechnology, laser cutting, prototyping, additive manufacturing, and CAD/CAM software tools * Coverage of new materials including nano, smart, and shape-memory alloys, in steels, glass, plastics, and composites * Supplemental content includes tolerance charts, graphs, curriculum guides, certification practice, and videos

A facility-wide improvement initiative is expensive in terms of both time and money. Perhaps the most disappointing thing about them is that they often end up as temporary measures that may produce early results but are unsustainable in the long run. The unseen cost is that after they see such initiatives come and go, employees begin to see them as futile, temporary annoyances rather than the permanent improvements they are meant to be. The Shingo Model (TM) begins with culture informed by operational excellence principles that lead to an understanding of what aligns systems and tools and can set any organization on a path toward enterprise excellence with sustainable continuous improvement. The Shingo Model is not an additional program or another initiative to implement. Instead, it introduces Shingo Guiding Principles on which to anchor current initiatives. Ultimately, the Shingo Model informs a new way of thinking that creates the capability to consistently deliver ideal results to all stakeholders. This is enterprise excellence - the level of excellence achieved by Shingo Prize recipients. In Discover Excellence: An Overview of the Shingo Model and Its Guiding Principles, readers will learn the basics of the Shingo Model, discover the Three Insights of Enterprise Excellence (TM), and explore how the Shingo Guiding Principles inform the kind of ideal behaviors that lead to sustainable results. This book is the introduction to the Shingo Model and prepares the reader for a deeper dive into the Shingo Guiding Principles.

There is no recipe for success. If there were, we would all use it and it would cease to be effective. In reality there are many roads that can lead to success - the secret is to choose the right road for your organization. It takes skilled judgment to apply the right method, at the right time, under the right circumstances. Using sound judgment, we know when to act, when to coach, and when to delegate.

The art of tracking time has been evidenced for over 300 years in the Black Forest area of Germany. Cuckoo and singing bird clocks, early glass bell, trumpeter, Jockele, animation, and picture frame clocks all have in the Black Forest area by skilled clockmakers who have transformed the function of time into a true form of art through their clocks. Rick Ortenburger's important new study traces the development of this fascinating Black Forest clock industry between about 1700 and 1930. He provides useful information that will meet the collectors' need and increase the appreciation of the beautiful craft these clocks represent. Photographs in color and black and white of 600 different examples make the industry's evolution from early cottage farm houses to the later development of factories come to life.

Now in its sixth edition, this catalogue is a survey of the highest quality, complicated timepieces from the world's most luxurious watchmakers. Grand Complications provides a detailed overview of complicated watchmaking. This reference work for connoisseurs deals with each of the major horological complications by theme, from their history through to their most recent developments.

We hurtle ahead with technology, apps, and the newest innovation in a world where we seem to need constant online presence and "availability." You are in if you quickly adapt the newest technical "solution" and out if you wait too long or even have doubts about its usefulness. Information and communication technology (ICT) service providers, suppliers, and customers all try to make sense and make the most money out of technology developments and constant innovation with the help of frameworks, methodologies, best-practice approaches, and models. They continuously improve, align, integrate, and optimize but unfortunately don't apply that to safeguarding quality. We have created an environment where professionals of the tech sector are stimulated or forced to create, deliver and support poor products and services to ever increasing unhappy customers. This creates stress and moral dilemmas. We are living in a constant hyped up society without questioning (enough) what we are doing and if it makes sense. It's time for some critical thinking, reflection and contemplation. This book leads the reader along that path of critical thinking, reflecting, and contemplating and offers alternative ways for service providers, customers, and suppliers to interact with each other. In addition, it helps them conduct their business in such a way that customers as well as service providers and suppliers achieve satisfaction. Not just stated in a customer survey but crystallized in actual deeds. We don't have to make dramatic changes and overhauls to achieve a healthier and more productive way of doing business. It implies a different mindset, a different way of interacting and a different approach to and use of the many frameworks, models and methodologies being introduced ceaselessly. IT professionals are presented with practical guidelines regarding the use of those methodologies and models, the building and managing of healthy business relations and how to ensure quality delivery of products and services. The result will be a more satisfying and less stressful work environment for all parties involved.

The Christchurch Fusee Chain Gang is a detailed study of poverty, survival and bygone trades. With major new discoveries about the watch industry, and the characters that inhabited the small town of Christchurch in Dorset, Sue Newman explores the significance of watch making and other cottage industries that helped to keep the people of Christchurch out of the clutches of poverty. Have you ever wondered who invented the first clock or where the idea for watches came from? If so, this is the book for you. Sue Newman explores various explanations for the origin of the invention of the first clock, an accolade that is often attributed to a Pope named Gerbert in 920AD. The Christchurch Fusee Chain Gang charts the story of the increasing miniaturization of clocks which eventually transformed into watches and explores the significance of the fuse chain and what this industry meant to the inhabitants of Christchurch.

This long-awaited volume chronicles the horological work carried out in France, Germany, and North America and completes the fascinating history of precision timekeeping in recent time. In France, renowned clockmakers include the Berthouds, the Lepautes, Robin, Janvier, Lepine, LeRoy and Leroy, Bourdier, Jacot and Jarossay. In Germany the primary emphasis is on Riefler, Strasser, and Rohde, but the works of other important makers are also considered. America's contribution to precision timekeeping is chronicled including the works of Seth Thomas, Charles Fasoldt, William Bond and Son Co., E. Howard and Co. and others. Recent advancements in timekeeping include the W5, a clock created by Philip Woodward and the Littlemore clock created by Professor Hall, almost certainly the most accurate pendulum controlled clock the world has known. Over 500 beautiful color and black-and-white photographs illustrate the historical contributions of these eminent clockmakers.

As a departure from previous practice, this volume of Opuscula presents ten articles on a single theme: manuscript and print in late pre-modern Iceland, the period between the advent of print in the early sixteenth century to the establishment of the Icelandic State Broadcasting Service in the early twentieth. Throughout this period, manuscript transmission continued to exist side-by-side with print, the two media serving different, but overlapping, audiences and transmitting different, but overlapping, types of texts. The authors take their point of departure in recent developments within literary and cultural studies which focus on the artefactuality of texts and the social, historical and cultural contexts in which they are produced and consumed. The volumes title refers not only to the popular late medieval and early modern genre of exemplary and/or admonitory mirror literature -- several examples of which are discussed -- but also to the idea that both manuscripts and printed books are reflections of virtue in a broader sense.