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Books > Medicine > Other branches of medicine > Pathology
Addressing the early clinical diagnosis of Alzheimer disease, this book was written to evaluate the relevance of current research on the subject. It uncovers the present lack of clinical utility in research methodologies such as neuro-imaging, drug challenges, electro-encephalographic studies and brain biopsy. The essays addressing each of these issues will provide the reader with a perspective on the role of each technology in clinical practice and an in-depth introduction to the technologies and research findings in each of the areas reviewed.
This fascinating book describes the history, and epidemiology in both man and animals, and clinical features of this zoonosis. It reveals detailed information pertaining to the basic science aspects of the interaction of Coxiella burnetii, the etiologic agent of Q (Query) fever, with the host and the immune response of the host to this unique pathogen. This one-of-a-kind work uses the rules of epidemiological evidence to determine whether or not Coxiella burnetii is a perinatal pathogen for man. This interesting, easy-to-understand text concludes with chapters dealing with the antibiotic susceptibility of Coxiella burnetii and the studies that resulted in a vaccine that now can be used to prevent this infection. This volume is an absolute must for all microbiologists, respirologists, infectious disease physicians and veterinarians.
Estimation of the Time Since Death remains the foremost authoritative book on scientifically calculating the estimated time of death postmortem. Building on the success of previous editions which covered both the early and later postmortem periods this edition includes a new chapter on DNA/RNA degradation and further new content on drug testing in hair, thus widening the scope of the material. Chapters have been improved, updated and expanded, and include new and additional images to enhance the text. A unique work of synthesis combining rigorous science with practical guidance, this update reinforces the book's reputation as an invaluable resource - and also the standard - for the estimation of the time since death.
First published in 1990. Routledge is an imprint of Taylor & Francis, an informa company.
To start with, we feel that we should explain why the book has been entitled Cholera Toxins. In fact, the enterotoxin secreted by Vibrio cholerae, which is p- marily responsible for causation of the disease, is conventionally known as or referred to as cholera toxin, or CT. By using the word "toxins" (in its plural form), we wanted to cover all of the different types of toxins-and not just CT-produced by V. cholerae. We could have used the title Toxins of Vibrio cholerae, but we believe that Cholera Toxins is simpler and equally as expressive. However, due to its relative importance, the story of CT covers most of this book. Also, compared to all other toxins of V. cholerae, CT has been investigated more extensively. This book was jointly written by us. It is not a multiauthor book in which each expert writes one chapter. In that respect our task is harder. On the other hand, it has given us the unique opportunity to present the entire subject in the way that we conceived it. Besides, our objective is to cater to the needs of not only active research scientists but also students from different disciplines-microbiology, molecular physiology and pharmacology, basic medicines, etc. -and as such, we have attempted to present the subject in a way that will be appreciated by general readers. Further, we have provided some information that students and predoctoral researchers may find useful at the end of the book.
This book captures some of the essential developments, both historical and current, relating to the human retroviruses and the diseases they cause. It describes detailed molecular biology and epidemiology of human T-leukemia virus type 1 (HTLV-1).
Binder-Ready Edition: This loose-leaf copy of the full text is a convenient, accessible, and customizable alternative to the bound book. With this binder-ready edition, students can personalize the text to match their unique needs! Develop the strong foundation in pathophysiology you need to guide your patient care! Exploring the etiology, pathogenesis, clinical manifestations, and treatment of diseases and disorders, Pathophysiology, 7th Edition focuses on the major alterations in the homeostasis of body systems to provide you with a unifying framework. Current scientific findings and relevant global research are integrated throughout the book, with chapters organized by body system, beginning with an illustrated review of anatomy and normal physiology. Each chapter includes a discussion of the disease processes and abnormalities that may occur, with a focus on the pathophysiologic concepts involved. Practical learning resources emphasize critical thinking and help simplify this rigorous subject. Updated, full-color illustrations and photos throughout enable you to visualize disease and disease processes and gain a clearer understanding of the material. Easy-to-read style is simplified by input from readability experts, and includes many tables, boxes, and figures to highlight key content. Thorough content updates include the latest information on new treatment advances, over 100 new figures for improved clarity, and much more throughout the text. Global Health Care boxes highlight global healthcare concerns such as COVID-19, HIV/AIDS, Ebola, and more, with information on prevalence, mechanism of disease, and transmission. User-friendly learning resources in the text include chapter outlines, bolded key terms, key questions, Key Points boxes, Clinical Judgment challenges, and chapter summaries. Pediatric and Geriatric Considerations boxes include brief analyses of age-related changes associated with specific body systems. More than 1,000 illustrations help clarify complex pathophysiological concepts and make the book visually appealing. NEW! Next Generation NCLEX (R) (NGN)-style case studies on the companion Evolve website help strengthen your clinical judgment skills in preparation for the new item types on the exam. NEW! COVID-19 coverage includes the most current scientific findings, prevalence, mechanism of disease, transmission, and treatment implications.
This publication is a collection of essays on the biology of intracellular parasitisms where both bacterial and protozoan parasites are discussed. The juxtaposition of authors representing fields of research emphasizes the many common problems facing intracellular parasites and the hosts that harbor them. In addition, numerous illustrations of how different parasites and host attempt to solve these problems in different ways are provided. The book includes one or more chapters on Bdellovibrio, Chlamydia, Rickettsia, Coxiella, Legionella, Shigellae, Mycobacterium, Microsporidium, Plasmodium, and Toxoplasma. The authors frequently speculate and generalize on the subject matter discussed.
This new volume provides exhaustive knowledge on a wide range of natural products and holistic concepts that have provided promising in the treatment of leishmaniasis. Including the major natural therapies as well as traditional formulations, over 300 medicinal plants and 150 isolated compounds that are reported to have beneficial results in the treatment of the disease are explored in this comprehensive work. This book also acts as an important resource on various anti-inflammatory plants used to treat various inflammatory conditions of the disease.
Based on papers presented at the XI International Congress for Tropical Medicine and Malaria, this publication provides an authoritative evaluation of treatment and control of helminth parasite infections. A section on leprosy and a brief review of malaria vaccination are included. A comprehensive review of the history of schistosomiasis control programs presents information unavailable elsewhere. This book is of special interest to professionals concerned with health problems of less developed countries and in particular to public health officials, epidemiologists and clinicians dealing with patients in or returning from the tropics.
This informative text is divided into eight chapters, each of which presents a comprehensive review of natural and acquired host defense mechanisms in a major mycotic disease. The chapters are written by distinguished scientists whose studies have contributed significantly to the understanding of the immunology of the mycoses. This text should provide a valuable reference for researchers, practicing clinicians, and new investigators entering this expanding field.
Written expressly for the surgical pathologist, the pathology resi-dent and the urologic surgeon, this volume describes the histopathologic appearances of diseases affecting the prostate and the seminal vesicles. The introductory chapter includes a dis-cussion on the role and limitations of immunohistochemistry and fine needle aspiration in the diagnosis of prostatic carcinoma. In the pathologic descriptions the main emphasis is placed on microscopic differential diagnosis. Many conditions are discussed including pro-static calculi, benign nodular hyperplasia, tumors of prostatic urethra, therapy-induced changes, and rare carcinomas. Many dia-grams, charts, tables and 221 photomicrographs complement the text.
The first in a new series created to acknowledge the explosion of knowledge in fields related to infectious disesases and clinical microbiology. Thirteen contributions focus on organisms which are of major medical importance in this country or which have contributed to an understanding of pathology.
Five Stars. "Best book available if you want to learn about molecular techniques applied to clinical pathology." - Ruben A., Amazon Reviewer Five Stars. "Easy read. helped me to pass ASCP molecular bio certification exam." - Amazon Reviewer The only book you need to become certified. "Excellent book, full of details and clinical information. In addition, it describes very complexed concepts in a very easy way to understand including comprehensive diagrams." - Ruben G., Amazon Reviewer MB(ASCP) must read. "This is a must read for those laboratory professionals trying to advance their knowledge in molecular diagnostics especially for those people taking the MB(ASCP) exam. Sure it helped me pass the exam." - JR, Amazon Reviewer Meet the challenges of this rapidly expanding field: Molecular diagnostics continues to grow in importance in the clinical laboratory. This respected text will prepare your students with a grounding in the fundamental principles of molecular biology. current methods, and their clinical applications. With a focus on the application of molecular concepts to diagnostic purposes, the text explains and illustrate the use and interpretation of molecular-based assays in patient care. Now with an expanded discussion of nucleic acid sequencing, with added emphasis on next generation sequencing (NGS), and updated coverage of proteomics and mass spectrometry applications, your students will have the most current information available today.
A complete and balanced overview of all aspects of immunocytochemistry is presented providing a clear understanding of their impact on experiment. All available techniques and many diagnostic and research applications are included, as well as practical step-by-step instructions for carrying out recommended methods. Intended for the novice as well as the experienced researchers.
In the post-genomic era, cancer is a genetic disease. However, cancer genotype does not always equal cancer phenotype. Cancers with the same genetic abnormalities don't always behave the same. Understanding and eradicating cancers will require an appreciation for cancer's ecology. This book is the first to comprehensively explore and critically appraise cancer microenvironments and host interactions with an eye towards exploiting our understanding for new treatments. The team of contributors share amongst them impressive experiences at the laboratory bench and in the clinic. These physician-scientists have dedicated themselves to the tension between the urgency for cures and the technical challenges of discovery. The target audience includes clinical oncologists, clinical hematologists, research oncologists, research hematologists, immunologists, stem cell researchers, oncology and hematology fellows (trainees), oncology educators (graduate and undergraduate levels), and course book for graduate students and undergraduate students.
This book covers several aspects of inhalation toxicology ranging from inhalation drug abuse to battlefield chemical inhalation lung injury, and emphasizes pathophysiology and therapy.
In this completely revised and updated second edition of DNA
Vaccines: Methods and Protocols, W. Mark Saltzman presents a
comprehensive collection of DNA vaccine protocols, written by
leading experts in the groundbreaking field of DNA vaccination.
Divided into five sections, this volume contains state-of-the-art
and practical procedures on the latest DNA vaccine technology. Part
I contains DNA vaccine design protocols, focusing on methods that
achieve optimal expression in host cells. Part II is dedicated to
presenting methods for DNA delivery, and covers both the range of
administration methods available for vaccine administration and a
variety of techniques for improving the efficiency of delivery into
cells. Part III discusses current available methods, including
adjuvant and prime-boost approaches, for enhancing the potency of
DNA vaccines. Part IV describes several key areas of application in
the field, including allergy, avoidance of autoimmunity, and
neonate and infant vaccine response. DNA Vaccines: Methods and
Protocols, Second Edition concludes with a review of protocols for
vaccine production and purification, and applicable quality control
methods.
This book is a collection of works that canvass many of the recent developments in various areas of connective tissue research. It focuses on the structure of the components, molecular organization and pathology of the extracellular matrix.
Ensuring Global Food Safety: Exploring Global Harmonization, Second Edition, examines the policies and practices of food law which remain top contributors to food waste. This fully revised and updated edition offers a rational and multifaceted approach to the science-based issue of "what is safe for consumption?" and how creating a globally acceptable framework of microbiological, toxicological and nutritional standards can contribute to the alleviation of hunger and food insecurity in the world. Currently, many laws and regulations are so stringent that healthy food is destroyed based on scientifically incorrect information upon which laws and regulations are based. This book illuminates these issues, offering guidelines for moving toward a scientifically sound approach to food safety regulation that can also improve food security without putting consumers at risk.
Understanding Human Anatomy and Pathology: An Evolutionary and Developmental Guide for Medical Students provides medical students with a much easier and more comprehensive way to learn and understand human gross anatomy by combining state-of-the-art knowledge about human anatomy, evolution, development, and pathology in one book. The book adds evolutionary, pathological, and developmental information in a way that reduces the difficulty and total time spent learning gross anatomy by making learning more logical and systematic. It also synthesizes data that would normally be available for students only by consulting several books at a time. Anatomical illustrations are carefully selected to follow the style of those seen in human anatomical atlases but are simpler in their overall configuration, making them easier to understand without overwhelming students with visual information. The book's organization is also more versatile than most human anatomy texts so that students can refer to different sections according to their own learning styles. Because it is relatively short in length and easily transportable, students can take this invaluable book anywhere and use it to understand most of the structures they need to learn for any gross anatomy course.
Cutting-edge accounts of special topics from various fields of forensic pathology and death scene investigation. The authors explore new avenues for analyzing the pathology of death from starvation (child neglect), head injuries inflicted by glass bottles, the clinical and pathological features of primary cerebral neoplasms, obesity as it is relevant to the forensic pathologist, and infant and early childhood asphyxial death. Other areas of interest covered include suicide, viral myocarditis in sudden death cases, curious death scene phenomena (hiding, covering and undressing), forensic entomology, the interpretation of toxicological findings, anabolic-androgenic-steroid abuse, and autopsy findings of subendocardial hemorrhages.
This book examines several recent, major developments in the field of nutritional pathology, providing enhanced, current understanding of the role that altered or disturbed nutrition plays in the pathogenesis of disease. It is intended for students in pathology, nutrition, and biochemistry.
"...excellent, well-organized, and timely." -Lester Packer and Enrique Cardenas, University of Southern California, Los Angeles, from the Series Preface The liver is a vital organ that is responsible for a wide range of functions, most of which are essential for survival. The multitude of functions the liver performs makes it vulnerable to a wide range of diseases. Mitochondrial dysfunction plays an important role in many liver diseases including drug-induced liver injury, alcoholic liver disease, and nonalcoholic fatty liver disease. Mitochondria in Liver Disease gathers the most current research regarding the role of mitochondria in the liver and various diseases to which it is susceptible. The book is separated into two sections, the first of which highlights the latest developments in mitochondrial research. It includes cutting-edge topics such as the regulation of mitochondrial respiration using hydrogen sulfide and the regulation of mitochondrial fusion-fission via the endoplasmic reticulum. The second section reviews the most current research on the role of mitochondria in a wide range of liver diseases. It also addresses novel topics such as the importance of liver mitochondrial constituents as biomarkers of liver injury in plasma and as regulators of the immune system. Mitochondria in Liver Disease represents the current state of knowledge and research on mitochondrial roles in liver diseases. Written by a group of global experts, it provides an authoritative and comprehensive overview of the latest advances and methods that mark key starting points for future research.
The neoplasms found in the female genital tract are numerous and growing more complex. Cytology and Surgical Pathology of Gynecologic Neoplasms has been written to provide a practical reference for practicing pathologists and cytopathologists in a quick and concise fashion. The primary focus of this book is on gynecological tumors, specifically common ones and their benign mimics. Emphasis is placed on morphologic recognition, resolving common diagnostic problems seen in routine practices, and discussion of current classification of gynecologic malignancies. Special references to the differential diagnosis and pitfalls of each entity are included. The role of cytology and its correlation with histology is richly illustrated and discussed. Also presented is the practical use of ancillary studies such as molecular diagnostic testing and immunohistochemistry. With a unique emphasis on the correlation between cytology and surgical pathology, Cytology and Surgical Pathology of Gynecologic Neoplasms provides a ready reference for both the practicing pathologist and pathologist in training in finding quick answers to their diagnostic challenges. |
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