THE TRUE CRIME BOOK OF THE YEAR AND SUNDAY TIMES TOP 10 BESTSELLER 'One of the most fascinating books I have read in a long time. Engrossing, a haunting page-turner. A book I could not put down' The Times, BOOKS OF THE YEAR __________ Meet the forensic pathologist, Dr Richard Shepherd. He solves the mysteries of unexplained or sudden death. He has performed over 23,000 autopsies, including some of the most high-profile cases of recent times; the Hungerford Massacre, the Princess Diana inquiry, and 9/11. He has faced serial killers, natural disaster, 'perfect murders' and freak accidents. His evidence has put killers behind bars, freed the innocent, and turned open-and-shut cases on their heads. Yet all this has come at a huge personal cost. Unnatural Causes tells the story of not only the cases and bodies that have haunted him the most, but also how to live a life steeped in death. Thoughtful, revealing, chilling and always unputdownable, if you liked All That Remains, War Doctor and This is Going to Hurt you'll love this. **Pre-order Dr Richard Shepherd's new book THE SEVEN AGES OF DEATH now** __________ 'Gripping, grimly fascinating, and I suspect I'll read it at least twice' Evening Standard 'A deeply mesmerising memoir of forensic pathology. Human and fascinating' Nigella Lawson 'An absolutely brilliant book. I really recommend it, I don't often say that but it's fascinating' Jeremy Vine, BBC Radio 2 'Puts the reader at his elbow as he wields the scalpel' Guardian 'Fascinating, gruesome yet engrossing' Richard and Judy, Daily Express 'Fascinating, insightful, candid, compassionate' Observer

Based on papers presented at the XI International Congress for Tropical Medicine and Malaria, this publication provides an authoritative evaluation of treatment and control of helminth parasite infections. A section on leprosy and a brief review of malaria vaccination are included. A comprehensive review of the history of schistosomiasis control programs presents information unavailable elsewhere. This book is of special interest to professionals concerned with health problems of less developed countries and in particular to public health officials, epidemiologists and clinicians dealing with patients in or returning from the tropics.

To start with, we feel that we should explain why the book has been entitled Cholera Toxins. In fact, the enterotoxin secreted by Vibrio cholerae, which is p- marily responsible for causation of the disease, is conventionally known as or referred to as cholera toxin, or CT. By using the word "toxins" (in its plural form), we wanted to cover all of the different types of toxins-and not just CT-produced by V. cholerae. We could have used the title Toxins of Vibrio cholerae, but we believe that Cholera Toxins is simpler and equally as expressive. However, due to its relative importance, the story of CT covers most of this book. Also, compared to all other toxins of V. cholerae, CT has been investigated more extensively. This book was jointly written by us. It is not a multiauthor book in which each expert writes one chapter. In that respect our task is harder. On the other hand, it has given us the unique opportunity to present the entire subject in the way that we conceived it. Besides, our objective is to cater to the needs of not only active research scientists but also students from different disciplines-microbiology, molecular physiology and pharmacology, basic medicines, etc. -and as such, we have attempted to present the subject in a way that will be appreciated by general readers. Further, we have provided some information that students and predoctoral researchers may find useful at the end of the book.

This informative text is divided into eight chapters, each of which presents a comprehensive review of natural and acquired host defense mechanisms in a major mycotic disease. The chapters are written by distinguished scientists whose studies have contributed significantly to the understanding of the immunology of the mycoses. This text should provide a valuable reference for researchers, practicing clinicians, and new investigators entering this expanding field.

Written expressly for the surgical pathologist, the pathology resi-dent and the urologic surgeon, this volume describes the histopathologic appearances of diseases affecting the prostate and the seminal vesicles. The introductory chapter includes a dis-cussion on the role and limitations of immunohistochemistry and fine needle aspiration in the diagnosis of prostatic carcinoma. In the pathologic descriptions the main emphasis is placed on microscopic differential diagnosis. Many conditions are discussed including pro-static calculi, benign nodular hyperplasia, tumors of prostatic urethra, therapy-induced changes, and rare carcinomas. Many dia-grams, charts, tables and 221 photomicrographs complement the text.

The first in a new series created to acknowledge the explosion of knowledge in fields related to infectious disesases and clinical microbiology. Thirteen contributions focus on organisms which are of major medical importance in this country or which have contributed to an understanding of pathology.

Vaccines against antigenically stable pathogens, or pathogens that only exist in a limited number of serotypes, have been very successful in the past and have drastically decreased the incidence and lethality of many diseases. However, when it comes to highly variable pathogens or viruses that exist in multiple serotypes, the traditional methods for vaccine development have reached their limits. This volume highlights the development of vaccines against such challenging pathogens. Novel approaches for immunogen design, including structure-guided vaccine development and vaccines targeting glycans, as well as adjuvants and animal models used for testing possible vaccine candidates are outlined and discussed in detail. Given its scope, the book will appeal to scientists in the fields of infectious diseases, microbiology and medicine.

A complete and balanced overview of all aspects of immunocytochemistry is presented providing a clear understanding of their impact on experiment. All available techniques and many diagnostic and research applications are included, as well as practical step-by-step instructions for carrying out recommended methods. Intended for the novice as well as the experienced researchers.

In the post-genomic era, cancer is a genetic disease. However, cancer genotype does not always equal cancer phenotype. Cancers with the same genetic abnormalities don't always behave the same. Understanding and eradicating cancers will require an appreciation for cancer's ecology.

This book is the first to comprehensively explore and critically appraise cancer microenvironments and host interactions with an eye towards exploiting our understanding for new treatments. The team of contributors share amongst them impressive experiences at the laboratory bench and in the clinic. These physician-scientists have dedicated themselves to the tension between the urgency for cures and the technical challenges of discovery.

The target audience includes clinical oncologists, clinical hematologists, research oncologists, research hematologists, immunologists, stem cell researchers, oncology and hematology fellows (trainees), oncology educators (graduate and undergraduate levels), and course book for graduate students and undergraduate students.

This book covers several aspects of inhalation toxicology ranging from inhalation drug abuse to battlefield chemical inhalation lung injury, and emphasizes pathophysiology and therapy.

In this completely revised and updated second edition of DNA Vaccines: Methods and Protocols, W. Mark Saltzman presents a comprehensive collection of DNA vaccine protocols, written by leading experts in the groundbreaking field of DNA vaccination. Divided into five sections, this volume contains state-of-the-art and practical procedures on the latest DNA vaccine technology. Part I contains DNA vaccine design protocols, focusing on methods that achieve optimal expression in host cells. Part II is dedicated to presenting methods for DNA delivery, and covers both the range of administration methods available for vaccine administration and a variety of techniques for improving the efficiency of delivery into cells. Part III discusses current available methods, including adjuvant and prime-boost approaches, for enhancing the potency of DNA vaccines. Part IV describes several key areas of application in the field, including allergy, avoidance of autoimmunity, and neonate and infant vaccine response. DNA Vaccines: Methods and Protocols, Second Edition concludes with a review of protocols for vaccine production and purification, and applicable quality control methods.
This collection of up-to-date protocols demonstrates the tremendous progress that has been made in the field of DNA vaccination since the initial appearance of this new vaccination strategy. Given current enthusiasm for the magnificent potential for this technology among the scientific community, researchers will find tremendous value in this updated and enhanced molecular methods guide.

This book is a collection of works that canvass many of the recent developments in various areas of connective tissue research. It focuses on the structure of the components, molecular organization and pathology of the extracellular matrix.

This book examines several recent, major developments in the field of nutritional pathology, providing enhanced, current understanding of the role that altered or disturbed nutrition plays in the pathogenesis of disease. It is intended for students in pathology, nutrition, and biochemistry.

This book provides a practical guide for all those working in or with Medical Examiner Services in England and Wales. It is an adjunct to the e-learning and face-to-face training required to fulfil the Medical Examiner and Medical Examiner Officer roles. Medical Examiner Services also work closely with a wide range of stakeholders including bereavement and mortuary teams, Coroners and their Officers, Registrars, Funeral Directors and those working in clinical governance and patient safety. This book provides an essential overview of all aspects of the Medical Examiner system for anyone working in these areas, or in any aspect of the support and management of the deceased and bereaved. A concise guide including the knowledge base required to develop and run a Medical Examiner Service Content is completely aligned with required training Written by those with direct experience of establishing and working with Medical Examiner Services Relevant to a wide range of stakeholders who work with patients and the bereaved

The neoplasms found in the female genital tract are numerous and growing more complex. Cytology and Surgical Pathology of Gynecologic Neoplasms has been written to provide a practical reference for practicing pathologists and cytopathologists in a quick and concise fashion. The primary focus of this book is on gynecological tumors, specifically common ones and their benign mimics. Emphasis is placed on morphologic recognition, resolving common diagnostic problems seen in routine practices, and discussion of current classification of gynecologic malignancies. Special references to the differential diagnosis and pitfalls of each entity are included. The role of cytology and its correlation with histology is richly illustrated and discussed. Also presented is the practical use of ancillary studies such as molecular diagnostic testing and immunohistochemistry. With a unique emphasis on the correlation between cytology and surgical pathology, Cytology and Surgical Pathology of Gynecologic Neoplasms provides a ready reference for both the practicing pathologist and pathologist in training in finding quick answers to their diagnostic challenges.

Understanding Human Anatomy and Pathology: An Evolutionary and Developmental Guide for Medical Students provides medical students with a much easier and more comprehensive way to learn and understand human gross anatomy by combining state-of-the-art knowledge about human anatomy, evolution, development, and pathology in one book. The book adds evolutionary, pathological, and developmental information in a way that reduces the difficulty and total time spent learning gross anatomy by making learning more logical and systematic. It also synthesizes data that would normally be available for students only by consulting several books at a time. Anatomical illustrations are carefully selected to follow the style of those seen in human anatomical atlases but are simpler in their overall configuration, making them easier to understand without overwhelming students with visual information. The book's organization is also more versatile than most human anatomy texts so that students can refer to different sections according to their own learning styles. Because it is relatively short in length and easily transportable, students can take this invaluable book anywhere and use it to understand most of the structures they need to learn for any gross anatomy course.

A collection of cutting-edge reviews of many of the key recent medical and legal advances in forensic science. These critical surveys concentrate on common pathological entities likely to be encountered in daily forensic routine, as well as on specific pathological conditions rarely seen in the autopsy room. Complementing rather than replacing the classic textbooks in forensic pathology, the authors explore new avenues for analyzing the pathology of burned bodies, traumatic brain injury, death by drug abuse, sudden cardiac death, sudden infant death and neonaticide, and fatalities resulting from kicking and trampling. Other areas of interest include accidental autoerotic deaths, hypothermia fatalities, injuries from resuscitation procedures, the interpretation of alcohol levels in different specimens, and the potential forensic differential diagnoses and interpretation of iliopsoas muscle hemorrhage in the light of autopsy.

Infection by flaviviruses such as dengue virus serotypes (DENV 1-4), Japanese encephalitis virus (JEV), tick-borne encephalitis virus (TBE), yellow fever virus (YFV) and West Nile virus (WNV) impact millions of lives and cause tens of thousands of mortalities each year. Dengue is a global public health emergency especially since there is no preventative vaccine or antiviral treatment for dengue disease. Dengue: Methods and Protocols offers the increasing number of dengue researchers a one-stop protocol book with techniques compiled from the leading laboratories working on dengue. Chapters cover topics such as dengue virus isolation from clinical samples, quantification of human antibodies against the virus, assays to quantify the virus particles, the widely used mouse model to study dengue pathogenesis, vaccine and antiviral efficacies. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Dengue: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies on dengue research.

1 Anatomische Grundlagen.- 1.1 Zahnentwicklung.- 1.2 Zahngewebe.- 1.2.1 Dentin.- 1.2.2 Schmelz.- 1.2.3 Wurzelzement.- 1.2.4 Zahnpulpa.- 1.2.5 Parodontium.- 2 Anomalien der Zahne.- 2.1 Stoerungen der Schmelzbildung.- 2.2 Stoerungen der Dentinbildung.- 2.3 Farbanomalien der Zahne.- 3 Karies.- 3.1 Schmelzkaries.- 3.1.1 Fissurenkaries.- 3.1.2 Approximalkaries.- 3.2 Dentinkaries.- 3.2.1 Dentinkaries vor Schmelzkavitat.- 3.2.2 Dentinkaries nach Schmelzkavitat.- 3.2.3 Zonen der Dentinkaries.- 3.3 Chronische Karies.- 3.4 Zementkaries.- 3.5 Strahlenkaries.- 4 Veranderungen der Pulpa.- 4.1 Regressive Veranderungen der Pulpa.- 4.2 Traumatische Veranderungen der Pulpa.- 4.3 Entzundungen der Pulpa (Pulpitis).- 4.3.1 Akute Pulpitis.- 4.3.2 Chronische Pulpitis.- 4.3.2.1 Formen der chronischen Pulpitis.- 4.3.2.2 Wurzelfullung.- 5 Parodontopathien.- 5.1 Gingivitis.- 5.1.1 Akute Gingivitis.- 5.1.1.1 Akute nekrotisierende, ulzeroese Gingivitis (Plaut-Vincent-Gingivitis).- 5.1.2 Gingivaabszess.- 5.2 Chronische Gingivitis.- 5.2.1 Chronische fibrosierende Gingivitis durch Medikamente.- 5.2.1.1 Phenytoin.- 5.2.1.2 Ciclosporin.- 5.2.1.3 Nifedipin.- 5.2.2 Hormonal beeinflusste chronische Gingivitis.- 5.3 Epulis.- 5.3.1 Epulis granulomatosa.- 5.3.2 Epulis fibromatosa (oder fibrosa, fibrase Hyperplasie).- 5.3.3 Riesenzellepulis, peripheres Riesenzellgranulom (Epulis gigantocellularis).- 5.4 Parodontitis.- 5.4.1 Apikale Parodontitis.- 5.4.1.1 Akute apikale Parodontitis.- 5.4.1.2 Periapikaler Abszess.- 5.4.1.3 Chronische apikale Parodontitis.- 6 Odontogene Zysten.- 6.1 Definition und Einteilung.- 6.2 Allgemeine Gesichtspunkte der Zystenentwicklung.- 6.3 Klinik der Zysten.- 6.4 Klassifikation.- 6.5 Entzundlich bedingte Zysten.- 6.5.1 Radikulare Zysten.- 6.5.2 Residualzysten.- 6.6 Dysontogenetische Zysten.- 6.6.1 Primordialzysten (Keratozysten).- 6.6.2 Follikulare Zysten.- 6.6.3 Durchbruchszysten (Eruptionszysten).- 6.6.4 Gingivale Zysten.- 6.6.5 Kalzifizierende odontogene Zysten.- 6.6.6 Paradentale Zysten.- 6.6.7 Glandulare odontogene Zysten.- 6.6.8 Zysten im Rahmen von Fehlbildungssyndromen.- 6.7 Nicht odontogene Kieferzysten.- 7 Odontogene Tumoren.- 7.1 Gutartige odontogene Tumoren.- 7.1.1 Ameloblastom.- 7.1.2 Odontogener plattenepithelialer Tumor.- 7.1.3 Kalzifizierender epithelialer odontogener Tumor (Pindborg-Tumor).- 7.1.4 Odontogener Klarzelltumor.- 7.1.5 Ameloblastisches Fibrom.- 7.1.6 Ameloblastisches Fibrodentinom (Dentinom und amelo-blastisches Fibroodontom).- 7.1.7 Odontoameloblastom.- 7.1.8 Adenomatoider odontogener Tumor.- 7.1.9 Kalzifizierende odontogene Zyste.- 7.1.10 Komplexes Odontom.- 7.1.11 Zusammengesetztes Odontom (Compound odontoma).- 7.1.12 Odontogenes Fibrom (Fibrom des Kiefers).- 7.1.13 Myxom (odontogenes Myxom, Myxofibrom).- 7.1.14 Gutartiges Zementoblastom (Zementoblastom, echtes Zementom).- 7.1.14.1 Echtes Zementom.- 7.1.14.2 Zemento-ossifizierendes Fibrom.- 7.2 Boesartige odontogene Tumoren.- 7.2.1 Odontogene Karzinome.- 7.2.1.1 Boesartiges Ameloblastom.- 7.2.1.2 Primares intraossares Karzinom.- 7.2.1.3 Boesartige Varianten anderer odontogener epithelialer Tumoren.- 7.2.1.4 Boesartige Tumoren in odontogenen Zysten.- 7.2.2 Odontogenes Sarkom.- 7.2.2.1 Ameloblastisches Fibrosarkom (Ameloblastisches Sarkom).- 7.2.2.2 Ameloblastisches Fibrodentinosarkom (Ameloblastisches Fibroodontosarkom).- 7.2.2.3 Odontogenes Karzinosarkom.- 8 Erkrankungen des Kieferknochens.- 8.1 Osteomyelitis.- 8.1.1 Akute, eitrige Osteomyelitis.- 8.1.2 Chronische, eitrige Osteomyelitis.- 8.1.3 Chronische, fokal-sklerosierende Osteomyelitis.- 8.1.4 Chronische, diffus-sklerosierende Osteomyelitis.- 8.1.5 Chronische Osteomyelitis mit proliferativer Periostitis.- 8.1.6 Sonderformen der Osteomyelitis.- 8.1.6.1 Mykobakterielle Osteomyelitis.- 8.1.6.2 Aktinomykotische Osteomyelitis.- 8.1.6.3 Bruchspaltosteomyelitis.- 8.1.6.4 Radioosteomyelitis.- 8.2 Osteosklerose.- 8.3 Osteomalazie.- 8.4 Hypoparathyreoidismus.- 8.5 Primarer Hyperparathyreoidismus.-

"...excellent, well-organized, and timely." -Lester Packer and Enrique Cardenas, University of Southern California, Los Angeles, from the Series Preface The liver is a vital organ that is responsible for a wide range of functions, most of which are essential for survival. The multitude of functions the liver performs makes it vulnerable to a wide range of diseases. Mitochondrial dysfunction plays an important role in many liver diseases including drug-induced liver injury, alcoholic liver disease, and nonalcoholic fatty liver disease. Mitochondria in Liver Disease gathers the most current research regarding the role of mitochondria in the liver and various diseases to which it is susceptible. The book is separated into two sections, the first of which highlights the latest developments in mitochondrial research. It includes cutting-edge topics such as the regulation of mitochondrial respiration using hydrogen sulfide and the regulation of mitochondrial fusion-fission via the endoplasmic reticulum. The second section reviews the most current research on the role of mitochondria in a wide range of liver diseases. It also addresses novel topics such as the importance of liver mitochondrial constituents as biomarkers of liver injury in plasma and as regulators of the immune system. Mitochondria in Liver Disease represents the current state of knowledge and research on mitochondrial roles in liver diseases. Written by a group of global experts, it provides an authoritative and comprehensive overview of the latest advances and methods that mark key starting points for future research.

The Advances in Microbiology, Infectious Diseases and Public Health Series will provide microbiologists, hygienists, epidemiologists and infectious diseases specialists with well-chosen contributed volumes containing updated information in the areas of basic and applied microbiology involving relevant issues for public health, including bacterial, fungal and parasitic infections, zoonoses and anthropozoonoses, environmental and food microbiology. The increasing threat of the multidrug-resistant microorganisms and the related host immune response, the new strategies for the treatment of biofilm-based, acute and chronic microbial infections, as well as the development of new vaccines and more efficacious antimicrobial drugs to prevent and treat human and animal infections will be also reviewed in this series in the light of the most recent achievements in these fields. Special attention will be devoted to the fast diffusion worldwide of the new findings of the most advanced translational researches carried out in the different fields of microbiological sciences, with the aim to promote a prompt validation and transfer at clinical level of the most promising experimental results.

The Atlas of Adult Autopsy Pathology is a full-color atlas for those performing, or learning to perform, adult autopsies. It is arranged by organ systems and also includes chapters on external examination findings, the effect of decomposition, and histopathological findings, as well as procedures and devices one may encounter during autopsy. The book includes a series of more than 700 color clinical images of adult autopsy pathology. It covers both diseases that are commonly seen as well as less common, or even rare, diseases. In some instances, a diagnosis may be made on the basis of the macroscopic appearance alone, while in others further investigation is required and appropriate guidance is provided. Unlike other atlases, this book goes beyond simply providing a collection of images. It features concise guidance on how to interpret macroscopic findings and prompts when further considerations are useful. This atlas is designed to be a visual reference that can assist with rapid diagnosis of autopsy findings. Comprehensive in its coverage with high-quality illustrations, this definitive atlas is an invaluable resource to trainees and consultant pathologists performing non-forensic autopsies. The book is also an important reference for anatomical pathology technicians, medico-legal specialists, and their officers.

For pre-nursing and allied health students (including mixed-majors courses). Encourage your students to explore the invisible Robert Bauman's Microbiology with Diseases by Body System, Fourth Edition retains the hallmark art program and clear writing style that have made his books so successful. The Fourth Edition encourages students to visualize the invisible with new QR codes linking to 18 Video Tutors and 6 Disease in Depth features that motivate students to interact with microbiology content and explore microbiology further. The continued focus on real-world clinical situations prepares students for future opportunities in applied practice and healthcare careers. A more robust optional MasteringMicrobiology(r)program works with the text to provide an interactive and personalized learning experience that ensures students learn microbiology both in and out of the classroom. Microbiology with Diseases by Body System Plus MasteringMicrobiology (optional) provides an enhanced teaching and learning experience for instructors and students.This program provides the ability to: *Personalize learning with MasteringMicrobiology: MasteringMicrobiology coaches students through the toughest microbiology topics. Engaging tools help students visualize, practice, and understand crucial content. *Think outside the classroom: QR codes in the textbook enable students to use their smartphone or tablet to instantly interact with Dr. Bauman in step-by-step tutorials and explore important developments in microbiology news and research. *Focus on critical thinking: Case studies and engaging activities improve students' ability to solve problems by keeping them interested. *Teach tough topics with superior art: Outstanding art integration through video tutorials, illustrations, and micrographs enables students to absorb and retain difficult microbiology concepts. Note: You are purchasing a standalone product; MasteringMicrobiology does not come packaged with this content. MasteringMicrobiology is not a self-paced technology and should only be purchased when required by an instructor.

Written and edited by an international team of renowned authorities, MacSween's Pathology of the Liver, 8th Edition, remains the field's definitive reference on liver pathology. This must-have text is ideal for surgical pathologists in practice and in training who examine liver specimens on a day-to-day basis. It provides invaluable assistance in recognizing the huge variety of appearances of the liver that result from infections, tumors, and tumor-like lesions, as well as organ damage caused by drugs and toxins. With expert, comprehensive coverage of all malignant and benign hepatobiliary disorders, MacSween's is a convenient, one-stop resource for use in the reporting room as well as in personal study. Shares the knowledge and experience of a "who's who" list of experts in the field of hepatobiliary pathology, led by editors Alastair D. Burt, Linda D. Ferrell, and Stefan G. Hubscher. Features more than 1,000 high-quality, full color illustrations, providing a complete visual guide to each tumor or tumor-like lesion. Discusses advances in molecular diagnostic testing, its capabilities, and its limitations, including targeted/personalized medicine. Incorporates the latest TNM staging and WHO classification systems, as well as new diagnostic biomarkers and their utility in differential diagnosis, newly described variants, and new histologic entities. Includes relevant data from ancillary techniques (immunohistochemistry, cytogenetics, and molecular genetics), giving you the necessary tools required to master the latest breakthroughs in diagnostic technology. Provides you with all of the necessary diagnostic tools to make a complete and accurate pathologic report, including clinicopathologic background throughout. Directs you to the most recent and authoritative sources for further reading with a comprehensive reference list that highlights key articles and up-to-date citations. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

Presenting an area of research that intersects with and integrates diverse disciplines, including genomics, epigenetics, proteomics, and cellular biology, among others, Formalin-Fixed Paraffin-Embedded Tissues: Methods and Protocols collects contributions from expert researchers in order to provide practical guidelines to this complex study. Compiled in order to provide researchers with up-to-date methodological information pertaining to the utilization of genomic, transcriptomic, and proteomic data in diagnosis, prognosis, and tailored therapy, the ultimate aim of this volume is to decipher diseases at a molecular level. Divided into multiple convenient chapters, this detailed book covers various techniques to construct and utilize tissue arrays, it also provides detailed protocols in immunohistochemistry, immunofluorescence, fluorescent and chromogenic in situ hybridization, and ultimately introduces protocols for FFPET microdissection and nucleic acids extraction for their utilization in advanced techniques such as microarray CGH, DNA methylation and pyrosequencing. The volume also discusses FFPET research from an ethical standpoint and concludes with a chapter on novel tissue fixative. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Formalin-Fixed Paraffin-Embedded Tissues: Methods and Protocols serves as a practical guide for scientists of all backgrounds and aims to convey the appropriate sense of fascination associated with this vital field of research.