This timely and compact monograph addresses how to determine drug permeability across the blood-brain barrier more effectively. Focusing on the physiological mechanisms that influence the passage of agents into the brain, the book covers the latest research on the blood-brain barrier, the current problems of and solutions to drug delivery to the central nervous system (CNS), existing strategies, and prospects for future research. Avoid excessive in vivo experimentation and utilize timesaving in vitro techniques. A concise reference with reviews from nearly 40 international specialists in diverse fields, The Blood-Brain Barrier and Drug Delivery to the CNS -assesses the properties of the blood-brain barrier to determine and measure drug permeability in animals and humans -presents techniques to predict successful drug uptake through in vitro systems or by computation of physicochemical parameters -examines the multidrug resistance protein P-glycoprotein as a natural transporter -analyzes current drug designs to known requirements for transport -looks at drug delivery systems for the brain -and much more! Densely packed with over 800 literature references, drawings, photographs, x-rays, tables, and equations, The Blood-Brain Barrier and Drug Delivery to the CNS is a vital addition to the bookshelves of biochemists, pharmacists, clinical and research pharmacologists, neuroscientists and neurologists, and graduate and medical school students in these disciplines.

SUITABLE FOR KINDLE AND OTHER EBOOK DEVICES Switch off the news and mute your tense WhatsApp chats - here are 101 family-friendly, fun, smart, silly, useful, good-to-know things to do and learn that will take your mind off what's going on outside the comfort of your own home, providing you with plenty of much needed moments of positivity and calm. Including (but not limited to!): * Quizzes * Anagrams * Poems * Riddles * Jokes * Word games * Fun facts * And other ways to occupy your time in a fulfilling way. Suitable for those aged 7 to 107, with the quizzes requiring some grown-up knowledge. And whilst you #StayHome, don't miss these other great titles from Sphere Books: ** The Bumper Book of Would You Rather? Over 350 hilarious hypothetical questions for ages 6 to 106 ** ** Home Sweet Home: The Little Book of Natural Cleaning ** ** Shelf Respect: A Book Lovers' Guide to Curating Book Shelves at Home **

The screech of rubber against asphalt. And then the crash: a violent two-car collision resulting in a twisted mass of metal, plastic, and glass-and worse, the deaths of both drivers.

Accident reconstruction is but one phase of road traffic fatality (RTF) cases. Even as police officers draw their last diagram, interview their last witness, and reconstruct their final scenario, a different team of investigators works diligently on solving another puzzle: determining how the victims actually died.

Investigation of Road Traffic Fatalities: An Atlas covers the issues that face medical examiners and coroners in determining the nature and extent of RTF injuries as well as the cause, manner, and circumstances of death. Also ideal for medicolegal death investigators and law enforcement personnel who work with medical examiners and coroners during RTF investigations, this Atlas covers everything from "Typical road traffic fatality injuries" to "Injuries caused by safety/restraint devices" and "Autopsy and toxicology testing."

For anyone involved in RTF probes, Investigation of Road Traffic Fatalities: An Atlas is essential reading.

The Plasmodium spp. parasite was identified as the causative agent of malaria in 1880, and the mosquito was identified as the vector in 1897. Despite subsequent efforts focused on the epidemiology, cell biology, immunology, molecular biology, and clinical manifestations of malaria and the Plasmodium parasite, there is still no licensed vaccine for the prevention of malaria. Physical barriers (bed nets, window screens) and chemical prevention methods (insecticides and mosquito repellents) intended to interfere with the transmission of the disease are not highly effective, and the profile of resistance of the parasite to chemoprophylactic and chemotherapeutic agents is increasing. The dawn of the new millennium has seen a resurgence of interest in the disease by government and philanthropic organizations, but we are still faced with compl- ities of the parasite, the host, and the vector, and the interactions among them. Malaria Methods and Protocols offers a comprehensive collection of protocols describing conventional and state-of-the-art techniques for the study of malaria, as well as associated theory and potential problems, written by experts in the field. The major themes reflected here include assessing the risk of infection and severity of disease, laboratory models, diagnosis and typing, molecular biology techniques, immunological techniques, cell biology techniques, and field applications.

This is the first critical edition and translation of the first Islamic medical work on fevers. Zad almusafir is perhaps the most influential handbook in the history of medical science, and Gerrit Bos's provides invaluable insight into the medical theory of Book Seven.

This is a thoroughly revised edition of a well-received reference work on helminthiases and their impact on worldwide public health. The carefully presented collection covers both common and neglected helminth infections. Readers will discover an up-date overview to helminth epidemiology (including molecular typing), specific biological, immunological and immunopathological aspects, diagnosis and latest perspectives of control. New contributions give particular attention to economic consequences of helminthiases, deworming programs and future public health approaches, as well as most recent findings in host immune responses. Helminths are long-lived multicellular organisms that have co-evolved with humans over many thousands of years. They are responsible for infections which affect around one fourth of the human population, at global level. Despite the huge efforts in research during the last years, effective control of helminth infections is still far from optimal standards and the resulting diseases remain neglected. The highly readable link of parasitological background and clinical application makes this book a valuable read not only for parasitologists but also physicians and medical students, health professionals as well as experts in public health issues. Moreover, all readers concerned with combating neglected parasitoses towards the Sustainable Development Goal SDG 3 (Good Health and Well-being) will understand the significance of this renewed volume.

Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria.

This concise, comprehensive guide is divided into two sections; nails and the skin. Each section includes information on the types of infections, aetiology, diagnostic procedures, such as sampling techniques, and therapy, including topical, systemic and adjunctive.

Neglected tropical diseases (NTDs) are a group of diseases frequently found in impoverished communities in tropical and sub-tropical countries. The risk for many of the NTDs is high in both deprived urban and rural areas of East Asia. Adapted to the endemic settings and characteristics of the diseases, a range of tools and strategies are currently being rolled out for the large-scale control of many NTDs. Both vector control measures and community sensitization programmes have for example been used to control dengue in urbanized settings. Challenges posed by yaws and lymphatic filariasis are being addressed by mass drug administration, while rabies requires the involvement of the veterinary public health sector for disease control. For leprosy, an elimination target has been defined; however, achieving this goal remains a considerable challenge. Food-borne trematodiases, on the other hand, are emerging and require a deeper understanding of its burden in East Asia and how these diseases can be tackled in a cost-effective manner. Finally, factors, such as an increase of non-communicable diseases due to changing lifestyles which accompany economic growth, the spreading HIV epidemic as well as climate change and the occurrence of natural disasters can potentially affect the epidemiology and control of NTDs. This volume discusses the mentioned topics in detail with contributions by experts in the respective research areas from different working environments.

In 2003, the word "coronavirus" spread across the globe, somewhat further than the virus that sparked the panic. In this book, expert researchers examine these devastating viruses through 23 state-of-the-art, widely applicable protocols with minute detail. Comprehensive and cutting-edge, the book serves as an ideal guide for all virologists and especially for those working with coronaviruses. Written by international experts, this book is relevant to a wide array of professions.

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of endocrine pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Endocrine is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource. Provides essential knowledge in all areas of endocrine pathology, including thyroid, parathyroid, pituitary, adrenal, paraganglia, pancreas, skin, neuroendocrine neoplasms, and inherited tumor syndromes-more than 150 diagnoses in all Offers a wealth of new information based on recently recognized and discovered endocrine diseases, as well as tumor types with important implications for patient care Includes new content on thyroid lesions and tumors now associated with DICER1 gene mutations; the correlation of newly characterized genetic abnormalities in endocrine tumors associated with responses to targeted therapies; and newly recognized syndromes, such as multiple endocrine neoplasia type 4 and type 5, glucagon cell hyperplasia and neoplasia, and others Meticulously edited by Dr. Vania Nose with contributions from renowned pathologists to ensure that common/classic endocrine diagnoses as well as newly recognized diseases and unusual cases, are well covered Features nearly 2,200 high-quality images in print and online, including clinical and histologic images, gross pathology images, radiologic images, and full-color illustrations to help practicing and in-training pathologists reach a confident diagnosis Includes updated criteria, terminology, and classifications for a wide range of tumors according to the latest literature, including the 2022 WHO Endocrine and Neuroendocrine Tumors classification Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices

This book shows how the discipline of pathology fits into society and interfaces with science and medicine. It focuses on anatomical pathology and covers the practice of laboratory medicine in the clinical setting. The book is helpful for health professionals, especially anatomical pathologist.

This innovative reference explores a wide selection of topics associated with aging, providing a solid understanding of the significance and molecular basis of the aging process and charting the course of future research in the area. Stresses the interplay of mitochondria, mitochondrial DNA, oxidants, and antioxidants! Featuring the research of over 55 experts in the area, Understanding the Process of Aging -covers the functions of nitric oxide and peroxynitrite in mitochondria -integrates several views on the role of mitochondria in the development of apoptosis -gives a quantitative analysis of mutations of mitochondrial DNA during human aging -highlights mitochondrial free radical production -introduces new roles of ubiquinone in mitochondrial functions -offers new antioxidant-based complementary therapeutic strategies -details aspects of intact cells and whole organisms in health and disease -and more! Featuring over 1800 references, tables, drawings, and photographs, Understanding the Process of Aging benefits nutritionists and dieticians, geriatricians, cell and molecular biologists, chemists and biochemists, pharmacologists, biotechnologists, neurologists, cardiologists, oncologists, dermatologists, and graduate and medical school students in these disciplines.

These practical books written by members of the British Association of Medical Managers (BAMM) help clinical directors tackle their role as medical managers. They provide information and guidance, to enable their readers to benefit from the sharing of learning, good ideas and best practice. 'What is innovative about this series is the focus. Focused training is the norm. Yet the clinician in management makes do with generic management texts which, excellent as they may be, do not recognise the enormous diversity of today's NHS. Managing a pathology service is just not the same as managing a cardiac surgery service. This series is about providing help with the context and practicalities of managing directorates.' Peter Lees and Jenny Simpson in the Series Foreword Clinical Director of Pathology is for consultants considering taking up the role of clinical director, and those actually doing the job. It is also useful for laboratory business managers as an induction to pathology. It summarises the key management issues within pathology and is based on practical case studies rather than theoretical management concepts. It highlights a number of key areas that clinical directors of pathology should be tackling in order to maintain the quality and cost effectiveness of their service.

Guide to Forensic Pathology provides a concise overview of forensic pathology to those who wish to know the basics but lack formal forensic training. Both fascinating and practical, this book explains everything from who the experts are in death investigation and what their roles are to how effective testimonies are presented in court. The importance of forensic DNA testing is emphasized with a separate section in this timely reference guide.

Key features: High quality full color photographs and descriptive texts on the location and removal of the organs from the mouse Instructive methods and clear visuals for trimming and orienting the organs for paraffin histology to obtain the best possible sections for analysis Full color photomicrographs of the resulting section for each organ stained with hematoxylin and eosin demonstrating important features and landmarks for the histologist to ensure the optimal area for analysis is achieved All in one, easy to use guide organized by individual organs of the laboratory mouse Spiralbound for easy reference in the lab This "one-stop" guide offers an essential resource for any academic, research or development operation where mouse necropsy and/or histology are performed. Connecting the reader 'from the mouse to the microscope', it provides a detailed guide for locating, trimming, orientating and embedding of the most frequently investigated tissues collected in the laboratory mouse. It shows where the organs reside in the mouse, how to trim and embed them as well as the resulting optimal sections. This guide brings together the wealth of scattered information into one high-quality text, the emphasis is on providing knowledge that will help histologists and scientists get better results in any downstream assays where ideal sections are needed.

Written by nearly 60 of the world's leading investigators in this rapidly expanding field, this state-of-the-art reference furnishes detailed presentations on the basic science and clinical aspects of cilia, mucus, and mucociliary interactions. Providing stimulating coverage of the latest information in a single source, Cilia, Mucus, and Mucociliary Interactions -discusses the genetic determinants of mucociliary system structure and function -explains ciliary wave activity in cell-cell communication -elucidates many of the key physiological processes in ciliary regulation -reveals possible means of treating irregularities in mucus secretion and clearance -improves understanding of clinical syndromes, including abnormalities pertaining to nasal sinuses, upper and lower airways, and the systemic role of cilia -approaches the clinical management of mucociliary dysfunction logically using currently available diagnostic and therapeutic techniques -and much more! Containing bibliographic citations, tables, equations, drawings, and photographs, this exhaustive guide is essential reading for physiologists, pulmonologists, otolaryngologists, pediatricians, microbiologists, basic scientists, and graduate and medical school students in these disciplines.

Anthropological contributions to the study of infectious disease and to the study of actual infectious disease eradication programmes have rarely been collected in one volume. In the era of AIDS and the global resurgance of infectious diseases such as tuberculosis and malaria, there is widespread interest and concern about the cultural, ecological and political factors that are directly related to the increased prevalence of infectious disease. In this book, the authors have assembled the growing scholarship in one volume. Chapters explore the coevolution of genes and cultural traits; the cultural construction of 'disease' and how these models influence health-seeking behaviour; cultural adaptive strategies to infectious disease problems; the ways in which ethnography sheds light on epidemiological patterns of infectious disease; the practical and ethical dilemmas that anthropologists face by participating in infectious disease programmes; and the political ecology of infectious disease.

Anthropological contributions to the study of infectious disease and to the study of actual infectious disease eradication programmes have rarely been collected in one volume. In the era of AIDS and the global resurgance of infectious diseases such as tuberculosis and malaria, there is widespread interest and concern about the cultural, ecological and political factors that are directly related to the increased prevalence of infectious disease. In this book, the authors have assembled the growing scholarship in one volume. Chapters explore the coevolution of genes and cultural traits; the cultural construction of 'disease' and how these models influence health-seeking behaviour; cultural adaptive strategies to infectious disease problems; the ways in which ethnography sheds light on epidemiological patterns of infectious disease; the practical and ethical dilemmas that anthropologists face by participating in infectious disease programmes; and the political ecology of infectious disease.

Though medically minor and very common, herpes simplex is a condition which is capable of causing considerable distress, for psychological and social as much as physical reasons. Herpes Simplex contrasts the image of the condition presented in the media with the medical and epidemiological evidence, and discusses ways in which the distress associated with the condition can be alleviated.
The first part of the book examines the impact of diagnosis and then explains the roles of accurate information and empathic support, medical treatment and support groups in learning to live with recurrent symptoms. Other chapters use the experiences of people with the condition in different parts of their bodies to illustrate how the meaning of herpes simplex and response to the symptoms alters in association with life changes. The final chapters review psychosocial research, discuss the importance of the Herpes Viruses Association in acquiring a store of knowledge about people's experiences, and highlight the significance of herpes simplex as a public health problem.
Herpes Simplex demonstrates the importance of a biopsychosocial approach. It will be invaluable to doctors, nurses and other health professionals, as well as to people troubled by the condition.

eBook available with sample pages: 0203137132

Discussing the systemic immune response in the contexts of health, disease, and therapy, this unique resource-the only broadly based book of its kind available on the subject-offers comprehensive examinations of the pathways and agents that affect the human immune response and provides state-of-the-art presentations on practical methods of immune modulation. Focuses on the immune response and modulation in infectious diseases, such as HIV, hepatitis, and parasitic infections and highlights immune modulating agents in gastrointestinal diseases, sepsis, cancer, and autoimmunity! Written by over 50 international authorities representing distinguished institutions in nine countries, Immune Modulating Agents -introduces basic immunoregulatory mechanisms as homeostasis -details cytokines, cellular and humoral immune responses, and hematopoiesis -describes neuroendocrine - immune system interactions and the role of psychological stress on immune competence -delineates factors that influence disease susceptibility, including nutrition -covers drug delivery systems, gene therapy, organ transplantation, arthritis treatment, and vaccination strategies -shows how to design clinical trials using immune modulating agents -and more!

The Middle East and North Africa (MENA) is highly endemic for several neglected tropical diseases (NTDs), including viral, bacterial, protozoan and helminth infections. This new volume covers the most prevalent NTDs found in about 22 MENA countries emphasizing the disease burden, clinical manifestations and control approaches. Each individual chapter deals with one specific disease and is written by a group of experts on that topic.

This volume begins with a summary of the classical genetic studies and molecular genetic studies of the most common diseases, and indicates what makes them amenable to analysis and treatment. A range of possible future therapeutic options are discussed, from conventional drug targets through to gene therapy. The final chapters assess the value of diagnosis and prediction of the inheritance of various diseases.

A concise summary of vital information on drug targets and current therapy regimes for all of the major viral infections. The book brings together in a single volume aspects of antiviral therapy from diverse areas of research and practice, providing up-to-date coverage of recent developments. Starting from an overview of the history of antiviral chemotherapy, the book goes on to describe the development of drugs against HIV, herpesvirus, respiratory viruses, papillomaviruses and hepatitis virus infections. The drugs currently available are reviewed and possible therapies and drug targets for future prophylactic and therapeutic use are discussed.

Leading international virologists review the state-of-the-art in the biology, pathogenesis, and epidemiology of the hepatitis viruses. The authorities writing here examine the five well-recognized hepatitis viruses, A through E, and some of the newer agents, the so-called non- A-E hepatitis viruses. They also provide in-depth discussions of the biological nature of the viruses, the pathogenesis of the acute and chronic diseases they cause, the methods and ease with which they are transmitted, and their clinical signs and symptoms. Additional topics include diagnostic tests and routine blood screening, new vaccines, and the use of interferon and antiviral drugs. Viral Hepatitis: Diagnosis, Therapy, and Prevention provides the most comprehensive and up-to-date survey of the hepatitis viruses currently available