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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Adhesion Molecules (Hardcover)
Loot Price: R3,420
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Adhesion Molecules (Hardcover)
Series: Handbook of Immunopharmacology
Expected to ship within 12 - 19 working days
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The consequences of diseases involving the immune system such as
AIDS, and chronic inflammatory diseases such as bronchial-asthma,
rheumatoid arthritis and atherosclerosis, now account for a
considerable economic burden to governments worldwide. In response
there has been an enormous research effort investigating the basic
mechanisms underlying such diseases, and a tremendous drive to
identify novel therapeutic applications for their prevention and
treatment. Though a plethora of immunological studies have been
published in recent years, little has been written about the
implications of such research for drugs development. As a
consequence, this area has not gained the prominence of other
fields such as molecular pharmacology or neuropharmacology, and a
focul information source for the many pharmacologists interested in
diseases of the immune system remains unpublished.
The Handbook of Immunopharmacology series provides such a source
through the commissioning of a comprehensive collection of volumes
on all aspects of immunopharmacology. Editors have been sought
after for each volume who are not only active in their respective
areas of expertise, but who also have a distinctly pharmacological
bias to their research.
The series follows three main themes, each represented by volumes
on individual component topics. The first covers each of the major
cell types and classes of inflammatory mediators ("cells and
mediators"). The second covers each of the major organ systems and
the diseases involving the immune and inflammatory responses that
can effect them ("systems"). The third covers different classes of
drugs currently used to treat these diseases as well as those under
development ("drugs").
This volume provides a comprehensive overview of the adhsion
molecules, processes and concepts that govern both inflammatory and
infectious diseases, and also deals in detail with the specific in
vivo pathways involved.
The first chapter introduces some of the molecules that mediate
leukocyte adhesion and ranges from their discovery using monoclonal
antibodies and a congenital adhesion deficiency, to their
antagonism in preliminary clinical trials as novel therapeutics. An
in-depth analysis of the structure, distribution and function of
the cell surface glycoproteins that regulates lymphocyte (specific
immune response), granulocyte (acute inflammatory response) and
metastatic cell (malignant processes) adhesions respectively is
provided by the next three chapters. Chapters 5 and 7 detail the
molecular structure, intracellular pathways, specificty of
carbohydrate interactions, and signalling of the molecules that
regulate leukocyte-leukocyte and leukocyte-mesenchymal cell
interactions.
There follows an exploration into the contributions of specific
molecules in inflammatory diseases in various organs from chapters
8-11. The concluding part is unique to this volume by reviewing the
comparable, and in some cases same, cell surface molecules that
mediate virus, bacteria and parasite interactions with host
cells.
The research is far from complete, but Adhesion Molecules is
extremely comprehensive and will be a valuable resource for many a
year to come.
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