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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Connexin Cell Communication Channels - Roles in the Immune System and Immunopathology (Paperback)
Loot Price: R2,029
Discovery Miles 20 290
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Connexin Cell Communication Channels - Roles in the Immune System and Immunopathology (Paperback)
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Plasma membrane-associated channels known as gap junctions, along
with their protein building blocks-connexins-have an important
functional role in a range of immunological processes, including
heart function, cell growth and specialization, and early
development. Spanning basic science and potential clinical
applications, Connexin Cell Communication Channels: Roles in the
Immune System and Immunopathology assembles and synthesizes four
decades of the most important research carried out in this field.
The book first provides a historical overview of the discovery of
these membrane channels in cells and tissues of the immune system.
It describes their general molecular and biological characteristics
and examines how they participate in the evolution, organization,
function, and regulation of leukocytes, as well as their
interaction with other tissues. The next section examines
immunologically related disease scenarios where gap junctions and
connexins have been shown to play a fundamental role. The
contributors explain how gap junctional communication participates
in the establishment and maintenance of immunological properties
such as antibody and cytokine production, as well as lymphocyte
immune surveillance in both physiological and pathological
conditions. The book explores the most important technical
approaches used and how they have been specially adapted to answer
key biological questions particular to the mobile nature of
leukocytes. It also describes the most recent understanding of how
gap junctions and connexins participate in antigen recognition,
cross-presentation, lymphocyte activation, and in the assembly and
function of the immunological synapse. Finally, the book focuses on
the latest progress made on translating the knowledge gained to
specific treatment modalities. Topics in this section include
approaches for reducing scarring and cardiac arrhythmia, combating
inflammation in the central nervous system, and enhancing
epithelial tissue repair. A comprehensive view of achievements in
this promising field, the book will inform and update specialists,
clinical practitioners, and those studying the potential for
commercial applications.
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