Using a unique outline format, Anatomic and Clinical Pathology Review is both a concise guide for board preparation and a practical quick reference for both residents and practitioners. It covers the major organ systems and subspecialty areas you'll encounter on the certification and recertification exam, including well-established correlations with contemporary molecular and genomic medicine. This comprehensive, easy-to-use review by Dr. Meghan M. Hupp provides the information you need to confidently recognize and accurately diagnose diseases and interpret what you see under the microscope and in the laboratory. Distills the essential information needed to prepare for both the Anatomic and Clinical Pathology board exams in an easy-to-read outline format. Provides high-yield, at-a-glance summaries in quick reference format for all topics that are encountered by pathology residents and practitioners in the boards. Uses brief, to-the-point explanatory text to make key facts easier to memorize. Incorporates current molecular and serologic tumor markers, techniques, and findings as appropriate. Features numerous high-quality illustrations that provide a visual guide to histologic appearance of key entities. Ideal for junior residents as a framework for rotations through the subspecialties, for senior residents and fellows to prepare for boards and their future practice, and for newly practicing pathologists. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Foodborne pathogens continue to cause major public health problems worldwide. These organisms are the leading causes of illness and death in less developed countries, killing approximately 1.8 million people annually. In developed countries, foodborne pathogens are responsible for millions of cases of infectious gastrointestinal diseases each year, costing billions of dollars in medical care and lost productivity. In addition, new foodborne diseases are likely to emerge driven by factors such as pathogen evolution, changes in agricultural and food manufacturing practices, and changes to the human host status. A third problem is that there are growing concerns that terrorists could use pathogens to contaminate food and water supplies in attempts to incapacitate thousands of people and disrupt economic growth. Fuelled by these concerns, research into the genomics, molecular biology, and microbiology of the most important foodborne pathogens has escalated to unprecedented levels in recent

A benchmark survey of current clinical findings on the complex interactions between diet, stress, and mental health, and their impact on disease states. The authors give special attention to the influence of stress on physical health, mental health, and cognitive function, including the critical effects of maternal nutritional status and stress levels on fetal physical and mental development, the role of lipids in the development and treatment of depression, the role of fish oil in the development of aggressive behaviors, and the consequences of obesity on stress and the development of eating disorders. Additional chapters examine the effects of stress on chronic disorders, women, and cardiac function, and the influence of inflammation on diet, neurological functions, disease incidence, and cognitive functions.

The scope of Neuromuscular Pathology continuous to expand, as evidenced by the numerous multivolume and speciality texts published in recent years. This short textbook provides a complete overview of both clinical and histological aspects of common and rare neuromuscular diseases. The objective is twofold: to provide information about neuromuscular diseases in a simplified, integrated, and rapidly accessible format suited to those initially encountering the discipline, and also to provide a clear approach using simple pictures, tables and algorithms to illustrate histological features in muscle and nerve biopsy. This volume is conveniently divided into three sections with a total of 30 chapters. The first section deals with basic principles of neuromuscular histology and physiology, processing technique, histochemistry, and laboratory management. The second and third sections deal with neuromuscular diseases that are summarized in a stepwise approach, complemented by algorithms and organized tables. A simplified, integrated, and rapidly accessible format covering both common and rare neuromuscular diseases Clear simple illustrations, organized tables and algorithms to aid the reader in finding an easy approach to accurate diagnosis Practical tips to facilitate histopathological diagnosis. Clinical scenarios discussing common neuromuscular conditions Neurologists, neuropathologists, trainees and medical students involved in clinical neuroscience and pathology will find this guide of practical benefit in both education and practice.

Over the last ten years, much effort has been devoted to improving the biophysical techniques used in the study of viruses. This has resulted in the visualization of these large macromolecular assemblages at atomic level, thus providing the platform for functional interpretation and therapeutic design. Structural Virology covers a wide range of topics and is split into three sections. The first discusses the vast biophysical methodologies used in structural virology, including sample production and purification, confocal microscopy, mass spectrometry, negative-stain and cryo-electron microscopy, X-ray crystallography and nuclear magnetic resonance spectroscopy. The second discusses the role of virus capsid protein structures in determining the functional roles required for receptor recognition, cellular entry, capsid assembly, genome packaging and mechanisms of host immune system evasion. The last section discusses therapeutic strategies based on virus protein structures, including the design of antiviral drugs and the development of viral capsids as vehicles for foreign gene delivery. Each topic covered will begin with a review of the current literature followed by a more detailed discussion of experimental procedures, a step in the viral life cycle, or strategies for therapeutic development. With contributions from experts in the field of structural biology and virology this exceptional monograph will appeal to biomedical scientists involved in basic and /or applied research on viruses. It also provides up-to-date reference material for students entering the field of structural virology as well as scientists already familiar with the area.

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of thoracic pathology, it incorporates the most recent clinical, pathological, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, Diagnostic Pathology: Thoracic, 3rd Edition, is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource. Provides a clear framework for a better understanding of the clinical and histopathologic appearances of pulmonary, pleural, and mediastinal entities Features an updated chapter on severe acute respiratory syndrome (SARS) pneumonia with current knowledge, statistics, and pathophysiology on COVID-19, including new images that encompass the radiology, gross pathology, and histopathology of the disease Includes updated criteria, terminology, and classifications for a wide range of tumors from the 2021 World Health Organization Classification of Tumors of the Lung, Pleura, Thymus and Heart, reflecting changes to currently used terminologies for adenocarcinoma, squamous cell carcinoma, neuroendocrine tumors, mesothelioma, soft tissue tumors, benign tumors, and more Covers the recent explosion of molecular genetic information, including new Molecular Pathology sections with new information on the genetic underpinnings of diseases Specifies genetic mutation types associated with each tumor and covers numerous types of molecular tests, including next-generation sequencing studies and how the specific genetic alterations are used to differentiate disease and aid in diagnosis Features over 3,900 high-quality images, including histologic images, gross pathology images, radiologic images, and full-color illustrations as well as more than 750 additional online-only images to help practicing and in-training pathologists reach a confident diagnosis Contains multiple recent consensus clinical practice guidelines for thoracic disease diagnosis, including those for molecular genetic testing and predictive biomarker testing from the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices

There are three major types of human retroviruses, namely HIV, HTLV, and endogenous human retroviruses. This book presents the latest findings on the replication of these human retroviruses. This book is unique in that there has been no comparable book that integrates the findings from the three known classes of human retroviruses. Other books have focused on one of the three classes of human retroviruses individually.

An accomplished international team of contributing authors have combined their expertise to provide cutting-edge findings in this important field. The book will be a valuable reference for students, researchers and medical professionals.

The book begins with a review of zoonotic pandemics of the past: the "Black Death" or bubonic plague of the Middle Ages, the Spanish Influenza pandemic (derived from avian influenza) of the early 20th century, to the more modern pandemic of AIDS/HIV infection, which originated in Africa from primates. However, the majority of chapters focus on more recent zoonoses, which have been recognized since the late 20th century to the present: * SARS and MERS coronaviruses* New avian influenza viruses * The tick-borne Henan fever virus from China* The tick-borne Heartland virus from the United States * Recently recognized bacterial pathogens, such as Streptococcus suis from pigs. In addition, reemergence of established zoonoses that have expanded their niche are reviewed, such as the spread of Zika virus and Chikungunya virus to the Western Hemisphere, and the emergence and spread of Ebola virus infection in Africa. A chapter is also devoted to an overview of the mechanisms and various types of animals involved in the transmission of diseases to humans, and the potential means of control and prevention. Many endemic and sporadic diseases are still transmitted by animals, through either direct or indirect contact, and zoonoses are estimated to account for about 75% of all new and emerging infectious diseases. It is predicted by public health experts that the next major pandemic of infectious disease will be of animal origin, making Emerging Zoonoses: A Worldwide Perspective a crucial resource to all health care specialists by providing them with much needed information on these zoonotic diseases.iv>

Prepare for your future nursing career with Essentials of Pathophysiology: Concepts of Altered Health States . This clear, readable, and student-friendly text delivers "need to know" disease content along with the essential foundation in science that students need to succeed in their future careers. Approaching the topic as an exploration of pathophysiology, the book relates normal body functioning to the physiologic changes that occur as a result of disease and provides concise yet complete coverage of how the body works. The Fifth Edition, which is based on the comprehensive Porth's Pathophysiology , 10th edition, includes a dynamic art program, unit-opening case studies, and lifespan content threaded throughout. 3D animations online and a brilliant art program enhance the learning experience. Key benefits of Essentials of Pathophysiology include: Unit Opening Case Studies prepare students for clinical practice and put a real face on pathophysiology and help relate the clinical presentation to the underlying pathophysiology. "Chunked" content, including learning outcomes and summary statements, encourages students to pause to review salient points. Full-color Art increases understanding of key concepts showing the clinical manifestations of diseases and disease processes. Lab References are easily accessible with lists of common suffixes and prefixes, normal laboratory values in both conventional and SI units, and a comprehensive glossary. Narrated Animations , available on thePoint, bring to life the most clinically relevant and difficult to understand disorders. The leading content is also incorporated into Lippincott CoursePoint, a dynamic learning solution that integrates this book's curriculum, adaptive learning tools, and real-time data reporting into one powerful student learning experience. Learn more at www.NursingEducationSuccess.com/CoursePoint.

Anatomy and pathology are key areas in medical training, but the amount medical students have to learn within them can seem overwhelming. This book helps students gain a firm grasp of the facts they must know before they enter their clinical years. It encompasses the core basics of the major organ systems in the body and presents them in a memorable, easy-to-read form. The book covers the background and knowledge that are clinically relevant to, and commonly encountered in, end-of-semester exams and provides a solid preparation for clinical years. It is an excellent resource for all medical students wishing to gain and retain anatomy and pathology knowledge in a time-effective manner.

Viruses are the causes of approximately 25% of human cancers. Due to their importance in carcinogenesis, there is a desperate need for a book that discusses these viruses. This book is therefore timely, providing a comprehensive review of the molecular biology of oncogenic viruses and the cancers they cause. Viruses that are discussed in the individual chapters include hepatitis B virus, hepatitis C virus, human papilloma viruses, Epstein????????????Barr virus, Kaposi's sarcoma virus and human T-cell leukemia virus type 1. This book provides up-to-date information for graduate students, postdoctoral fellows, medical students, physicians and non-experts who are interested in learning more about the oncogenic viruses and how they cause human cancers.

Microbial infections have been and continue to be a major threat to public health. China has a huge population, among which, microbial infections are of great concern. The Journal of Microbes and Infection, a nationwide journal in China with over 4000 subscriptions, publishes original research articles on microbes and infections in the Chinese language. This book contains selected research articles published in this journal from 2006 to 2007 that have been translated into English, and offers a glimpse of a broad range of microbial infections including the clinical and epidemiological aspects of various viral infections, current status of bacterial infections in hospitals, and severe cases of fungal infections. This book provides a rare opportunity for scientists and physicians abroad to see the completely original research data, rather than just the abstract, based on studies conducted in modern China. Articles on molecular biological and bioinformatic studies are also included. An overview of the recent research trend in medical microbiology and infectious diseases in China will be presented as well. Scientists and physicians working in the fields of virology, microbiology, immunology, epidemiology, vaccinology, and infectious diseases will find the articles in this book fascinating and relevant to their own research and practice.

Pocket Guide to Gene Level Diagnostics in Clinical Practice is an abbreviated, pocket-size, quick-reference guide that provides a point-by-point synopsis of the vast wealth of information contained in CRC Handbook of Gene Level Diagnostics in Clinical Practice. All sections and subsections in the Pocket Guide are cross-referenced to corresponding pages in the Handbook. The book works well on its own as a quick reference, but also can be used in conjunction with the larger Handbook for detailed coverage and references to specific information. Pocket Guide to Gene Level Diagnostics in Clinical Practice also includes extensive supplements featuring material not included in the Handbook. These are intended to provide an up-dated, practical source of information useful to anyone involved in molecular diagnostic research and/or service. Supplements are cross-referenced to the main text of the Pocket Guide, that complement and enhance the material covered. Pocket Guide to Gene Level Diagnostics in Clinical Practice will be a handy reference for professionals and students in pathology, biotechnology, biology, and medicine.

The scope of Neuromuscular Pathology continuous to expand, as evidenced by the numerous multivolume and speciality texts published in recent years. This short textbook provides a complete overview of both clinical and histological aspects of common and rare neuromuscular diseases. The objective is twofold: to provide information about neuromuscular diseases in a simplified, integrated, and rapidly accessible format suited to those initially encountering the discipline, and also to provide a clear approach using simple pictures, tables and algorithms to illustrate histological features in muscle and nerve biopsy. This volume is conveniently divided into three sections with a total of 30 chapters. The first section deals with basic principles of neuromuscular histology and physiology, processing technique, histochemistry, and laboratory management. The second and third sections deal with neuromuscular diseases that are summarized in a stepwise approach, complemented by algorithms and organized tables. A simplified, integrated, and rapidly accessible format covering both common and rare neuromuscular diseases Clear simple illustrations, organized tables and algorithms to aid the reader in finding an easy approach to accurate diagnosis Practical tips to facilitate histopathological diagnosis. Clinical scenarios discussing common neuromuscular conditions Neurologists, neuropathologists, trainees and medical students involved in clinical neuroscience and pathology will find this guide of practical benefit in both education and practice.

This is the first comprehensive book on human/animal gene responses to RNA viral infections, including prevalent, emerging and re-emerging RNA viruses such as HIV, SARS-CoV, West Nile virus, influenza virus and many others. Human gene responses are reviewed by leading virologists worldwide in the following aspects: (i) the altered gene expression profiles at the transcriptional and translational levels detected with cutting-edge technologies such as cDNA microarray and proteomics; (ii) host innate and adapted immune responses to viral replication in target organs; (iii) virus-activated signal transduction pathways in cell survival, apoptosis and autophagosomal pathways; and (iv) the small interfering RNA/microRNA-mediated gene silencing pathway, a recently characterized new host defense mechanism against viral infection. Organized into 27 highly accessible and well-illustrated chapters, this volume explores state-of-the-art knowledge of the molecular mechanisms of RNA virus infection and host virus interactions. This comprehensive compilation of the altered gene expression profiles and signal transduction pathways in host cells in response to the majority of human/animal RNA viruses opens new directions for basic and clinical research on viral pathogenesis, and also provides valuable biomarkers for researchers to select gene targets in the development of diagnostic tests and antiviral therapeutics for a number of infectious diseases.

Apart from malaria, schistosomiasis is the most prevalent parasitic infection in the world. It affects more than 200 million people in 76 tropical and subtropical countries, causing great suffering and resulting in thousands of deaths. Written by world authorities, this book examines many aspects of the biology, pathology, and control of the schistosoma parasite. Ranging in topic from infection in Pharaonic Egypt, through DNA relationships and biological systems, to advances in development of vaccines against the parasite, this book is a comprehensive text written for researchers and medical professionals alike.

Comprehensive, concise, and superbly illustrated, Weedon's Skin Pathology Essentials, 3rd Edition, provides expert, easy-to-read guidance on key diagnoses in dermatopathology for pathologists and dermatologists in practice and training. This clearly written, well-structured text/atlas is ideal for quickly looking up practical problems in the recognition and diagnosis of skin lesions both clinically and histologically. Cross-referenced to the encyclopedic and authoritative Weedon's Skin Pathology, 5th Edition, it enables you to avoid pitfalls and make the most accurate diagnoses with confidence. Covers more than 1,300 dermatopathological entities, both common and rare, including additional entries in every section of the text. Provides more than 3,000 color histopathologic and clinical images for complete visual coverage of key diagnostic points for any given entity, and features new illustrations of rare conditions and unusual manifestations. Includes numerous summary tables and diagnostic algorithms that guide you to the most likely diagnosis and set of differential diagnoses for numerous inflammatory and neoplastic skin conditions. Discusses the latest immunohistochemical staining techniques and molecular genetic techniques. Uses a highly templated, bulleted, outline format throughout, facilitating quick and easy retrieval of key information. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

A short, highly readable and well illustrated book on general and systematic pathology, approached from the point of view of what medical students need to know in order to understand the clinical work they will eventually be doing. Includes a great variety of self-assessment, to reinforce the messages and to test understanding - and to help students prepare for exams. Concise synoptic (not telegraphic text). Appropriate self-assessment material. Only covers core, so student knows the whole book is essential. Includes key objectives. Contains simple and memorable diagrams for reproduction in exams. Ideal for learning as well as examination review, specifically trying to stimulate the student into assessing his/her own knowledge. The books in the series both complement other available major texts, but also contain enough material to stand in the own right. Provides examination practice. Part of co-ordinated series. Now general and systematic pathology combined in one volume. Further refinement to contents to reflect evolution of what is regarded as core knowledge. Major revision of self-assessment material to match change in style of examination (mainly more EMQ- and OSCE-style questions). New cover design.

Combining theory and practice, this book is a comprehensive analysis of suffocation, asphyxiation, and neck pressure deaths. It includes important developments in the field such as lung histomorphology in fatal strangulation, systematic dissection of the larynx, biochemical findings, and postmortem imaging. Significant challenges arise in accurately diagnosing these deaths when compared to other forms of external violence. International experts explain the pitfalls and subtleties of identifying such cases making this an important resource for readers involved in such investigations. Tables, statistics, scientific and historical evidence throughout further validate the value of this book. Provides a comprehensive introduction to every major topic of asphyxia and neck pressure death Features more than 300 figures to aid understanding and facilitate accurate diagnosis of these death types Includes the important topic of postmortem radiology findings Navigates the reader through the potential pitfalls and misdiagnoses of asphyxia and neck pressure deaths with expert guidance About the Editor Professor Burkhard Madea MD, Director, Instiute of Forensic Medicine, University of Bonn, Germany, is a world-renowned forensic pathologist and the author of more than a dozen books and 600 papers.

To celebrate the 40th anniversary of the discovery of Natural Killer (NK) cells, this volume focuses on the recent advances in our understanding of NK cell development and differentiation and their acquisition of functional properties, as well as the latest models for NK-cell analysis in mice and applications in clinical medicine. NK cells have travelled a circuitous path from their initial description as 'spontaneous killers' (for some simply an experimental artifact) to being a bona fide subset of innate lymphoid cells with a complementary mode of action in immune defense and an important mediator of immune reactivity in health and disease. Together, these reviews provide a timely and concise picture of the evolution of NK cells as essential agents in immunity and as potent weapons against disease. This book offers an appealing and insightful resource for scientists and clinicians.

This volume provides a modern look on the age-old influenza infection and the preventive role of anti-influenza shots. Influenza pandemic outbreaks are unrelenting despite the growing understanding of the molecular basis of viral infection and its spreads. A leap in medical technologies has revolutionized the design of new influenza vaccines. The chapters cover vaccination strategies in various age-groups of people and provide the extensive amount of knowledge on the immune response to influenza vaccination in a spectrum of disease conditions.

This book offers an analytical look at the much debated risks and benefits of the newly developed COVID-19 mRNA-vaccines. As such, it is one of the first books to give a comprehensive overview of mRNA vaccines against COVID-19 and the only one that addresses this topic from a broad multidisciplinary background. It brings together insights from various underlying disciplines on the challenges of developing and evaluating the most suitable vaccines for mass vaccination programs enrolled throughout the world - focusing on safety and efficacy. This book should not be missing on the shelf of any biomedical researcher, epidemiologist, public health professional or clinical researcher interested in SARS-CoV2 or virology and vaccine development in general.

Sudden cardiac death represents a highly heterogeneous group of cardiovascular disorders. While some may initially think of sudden death as primarily an arrhythmogenic event, this actually represents the minority of cases of sudden cardiac death. In the vast majority of cases, there is an underlying anatomic disorder of the cardiovascular system responsible for the ultimate hemodynamic collapse known as sudden cardiac death. This book will provide an atlas type review of ischemic and non-ischemic etiologies of sudden cardiac death. Beyond the atlas, however, will be a "clinical pathologic correlation" for each described disorder providing practicing clinicians with practical information to facilitate proper diagnosis and treatment. While an increasing array of noninvasive diagnostic tools continue to develop, the sad fact remains that many of the physicians and operators of these new diagnostic modalities have never actually seen specimens which demonstrate the fundamental pathologic abnormalities. This ability to see first hand the underlying pathology creates an opportunity to advance the science and enhance ones understanding of these disease processes. There is not a comprehensive text on this subject on the market today which provides clinical and patholigical material in such a comprehensive manner.

Microbiology for the Healthcare Professional, 3rd Edition offers an excellent foundation for understanding the spread, treatment, and prevention of infectious disease - critical knowledge for today's healthcare professional. This straightforward introductory text makes microbiology approachable and easy to learn, presenting just the right level of information and detail to help you comprehend future course material and apply concepts to your new career. UNIQUE! Why You Need to Know and Life Application boxes make the content more relevant by putting material in a real-world context, helping you understand how concepts apply to everyday situations. UNIQUE! Medical Highlights boxes in each chapter provide anecdotal information about a pathological condition mentioned in the chapter, with illustrations and updates on new trends and information specific to the healthcare industry. UNIQUE! Health Care Application tables in each chapter provide quick access to focused information on pathogens as they relate to the subject matter of the chapter, including symptoms, causes, and treatments for a given condition/pathogen when applicable. Timesaving focus on just the necessary information provides the ideal level of introductory microbiology coverage. Chapter outlines and key terms for every chapter enable more efficient learning. Learning objectives clarify chapter goals and guide you through the content. Twenty review questions at the end of each chapter test your retention and help you identify areas requiring further study. NEW! The Bigger Picture section in each body system chapter identifies other body systems that might be affected by a particular microbial infection. NEW! Technology Boxes highlight new technology, such as artificial intelligence, that is becoming more essential to diagnosis and treatment in the healthcare field.

This book provides a concise but comprehensive description of human infectious diseases due to microbial pathogens, from a physician's and a microbiologist's point of view, as well as providing an understanding of the use of microbial pathogens as biological weapons. It is indispensable for students, physicians, medical and nursing staff, and infectious disease specialists. All topics are covered in a concise fashion, which also are useful for self-study and life-long learning (applicable for part-time students).