Advanced Cardiovascular Exercise Physiology, Second Edition, systematically details the effects of acute and chronic exercise training on each component of the cardiovascular system: the heart, the vasculature, and the blood (including blood clotting factors). Students and professionals working within exercise science and related health professions will gain a comprehensive understanding of the cardiovascular system and learn how to apply this knowledge to their work. Advanced Cardiovascular Exercise Physiology, Second Edition, highlights the complex interaction of the components of the cardiovascular system, both at rest and during exercise. Using the latest scientific and medical research, this text presents an engaging discussion of cardiovascular responses and adaptions to both aerobic and resistance exercise training, and it offers readers possible future directions for research. Specific attention is paid to the beneficial effects of exercise and the mechanisms through which regular exercise promotes cardioprotection. The second edition incorporates new topics and expanded information on the following: Ventricular hypertrophy Central blood pressure and its measurement Pathophysiology of arterial stiffness and relevant measurement techniques Blood pressure during exercise and its clinical importance The effects of prolonged acute exercise on cardiac arterial and hemostatic function Endothelial function, including the impact of aging and sex, and potential mechanisms An individual's response and adaptation to both resistance training and aerobic training The second edition of Advanced Cardiovascular Exercise Physiology uses a larger format to showcase its richly illustrated contents. Updated figures and graphics visually elucidate physiological mechanisms to depict exercise responses and training adaptations. Each chapter begins with chapter objectives and ends with a summary to help students retain important content. Fifteen case studies are included in the text to showcase the application of chapter material. Key terms are boldfaced throughout the text and are defined at the end of each chapter. In addition, sidebars describe real-world examples and applications. This text is divided into two sections. The first section offers a concise explanation of the structure and function of each component of the cardiovascular system. In the second section, readers encounter a detailed discussion of the acute and chronic effects of aerobic and resistance exercise on cardiac function, vascular function, and hemostatic variables. Advanced Cardiovascular Exercise Physiology, Second Edition, provides a framework for understanding how the components of the cardiovascular system cooperate to support exercise and how those components adapt to and benefit from a systematic program of exercise training.

Gain a foundational understanding of gastrointestinal physiology and how the GI system functions in health and disease. Gastrointestinal Physiology, a volume in the Mosby Physiology Series, explains the fundamentals of this complex subject in a clear and concise manner, while helping you bridge the gap between normal function and disease with pathophysiology content throughout the book. Helps you easily master the material in a systems-based curriculum with learning objectives, Clinical Concept boxes, highlighted key words and concepts, chapter summaries, self-study questions, and a comprehensive exam. Keeps you current with recent advances in gastrointestinal physiology with coverage of the physiological significance of gastrointestinal peptides; the regulation of mucosal growth and cancer; details surrounding acid secretion and peptic ulcers; and more. Includes clear, 2-color diagrams that simplify complex concepts. Features clinical commentaries that show you how to apply what you've learned to real-life clinical situations. Covers the regulation of pancreatic secretion and gallbladder contraction; the transport processes for the absorption of nutrients; facts about fat absorption; and the regulation of food intake. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. Complete the Mosby Physiology Series! Systems-based and portable, these titles are ideal for integrated programs. Blaustein, Kao, & Matteson: Cellular Physiology and Neurophysiology Cloutier: Respiratory Physiology Koeppen & Stanton: Renal Physiology Pappano & Weir: Cardiovascular Physiology White, Harrison, & Mehlmann: Endocrine and Reproductive Physiology Hudnall: Hematology: A Pathophysiologic Approach

Synthesizing coverage of sensation and reward into a comprehensive systems overview, Neurobiology of Sensation and Reward presents a cutting-edge and multidisciplinary approach to the interplay of sensory and reward processing in the brain. While over the past 70 years these areas have drifted apart, this book makes a case for reuniting sensation and reward by highlighting the important links and interface between the two. Emphasizing the role of reward in reinforcing behaviors, the book begins with an exploration of the history, ecology, and evolution of sensation and reward. Progressing through the five senses, contributors explore how the brain extracts information from sensory cues. The chapter authors examine how different animal species predict rewards, thereby integrating sensation and reward in learning, focusing on effects in anatomy, physiology, and behavior. Drawing on empirical research, contributors build on the themes of the book to present insights into the human sensory rewards of perfume, art, and music, setting the scene for further cross-disciplinary collaborations that bridge the neurobiological interface between sensation and reward.

As humans evolved from primordial organisms they lost the capacity to make certain essential molecules. By their very absence in specific pathologies and diseases, the thirteen human vitamins were discovered and their crucial role in metabolism revealed. This textbook provides a thorough chemocentric view on the key small molecules of life, the human vitamins and their active coenzyme forms. Detailing how their unique chemistries control the interconversion and the flux of hundreds of central human metabolites, The Chemical Biology of Human Vitamins examines the parallel and convergent tracks of the vitamins and their coenzyme forms. Analysing the mode of action of each of the vitamins, the book will illuminate the challenges that face each cell; metabolism could not proceed without the chemical functional groups vitamins provide. Authored by leading educators, this text will serve as an ideal guide and reference point for chemists in both academia and industry, graduates and advanced undergraduate students in biochemistry, chemical biology, metabolism and metabolomics.

This book summarizes experimentally-supported research on the therapeutic efficacy of plant extracts and their constituents on a range of respiratory diseases including infections. It discusses the pharmacological, cellular and molecular factors involved in the pathogenies of respiratory diseases and their modulation by plant-derived compounds. Additionally, it underlines the growing relevance of medicinal plant-based advanced drug delivery systems for treating lung diseases providing maximal therapeutic efficacy with better patient compliance. Overall, this comprehensive book is a blend of translational, biological, chemical and drug delivery aspects of medicinal plants employed in targeting respiratory diseases and attracts a range of audiences including physiochemist, translational and clinical researchers working in the field of respiratory diseases.

Contents include: 'Biochemistry and molecular biology of neural lipids', 'Advances in lipid analysis/lipidomics', 'Metabolism and enzymology of glycerolipids', 'Lipid metabolism in brain development and aging', 'Cellular and subcellular localization of neural lipids', and much more.

The volume raises attention to the need of a completely new approach to breast cancer based on the knowledge collected on early breast cancer in the past two decades. The chapters are contributed by experts of all the fields participating in the clinical research and care of breast cancer. The practical importance of such a book is underlined by the increasing number of breast cancer cases, and also the increasing proportion of early stage-cases. The ultimate goal of the book is to point to the heterogeneous nature of the disease which is more striking and has more importance in care at the very early stages than at the more advanced stages. The book recommends the utilization of all the information provided by multimodality imaging and special pathological methods, a new classification system and therapeutic guidelines since early breast cancers should not be treated based on experience obtained with palpable tumors. No similar book has been yet released to the market. The book is written for all the members of the team participating in the diagnosis and treatment of breast cancer (radiologists, pathologists, surgeons, clinical and radiation oncologists), but may be useful for medical students and residents too. The chapters are illustrated with didactic pictures, and special emphasis is given to provide a peep into the practice of the special procedures for the careful examination and individualized therapy of each case.

This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 3 focuses on the technical aspects of autophagy research. It is comprised of two parts. The first part discusses the basic process of autophagy, including its overall classification and individual stages in the life cycle of autophagosomes. The second part discusses the tools, strategies, and model systems in current autophagy research, including cell and animal models, detection and manipulation methods, as well as screening, genomic, proteomic and bioinformatic approaches. The book is written and edited by a team of active scientists. It is intended as a practical reference resource for interested researchers to get started on autophagy studies.

An Introduction to Cardiovascular Physiology provides the student with the key concepts of cardiovascular physiology, from the fundamentals of how the cardiovascular system works in both health and disease, through to a consideration of more complex physiological mechanisms. This brand new companion work Cardiovascular Physiology: Questions for Self-Assessment allows students to test themselves on all aspects of the topic with over 200 questions and answers, at a pace to suit their learning. Questions follow An Introduction to Cardiovascular Physiology's table of contents, and the author has set at least one question on each chapter's learning objective to help the student to assess their progress against the set objectives. The questions are designed to test basic understanding, fundamental principles and medical relevance, and they avoid excessive detail. Most are in a multiple choice, True/False format, with a sprinkling of other question styles including extended matching questions, where the reader chooses the best answer from a list, and testing little numerical problems. Also included with the answers are 'More information' boxes that include a brief explanation, and links to relevant information and figures from a range of chapters, thus encouraging integration of learning across the subject.

The fifth edition of Introduction to Exercise Science introduces students to every core area of study in the discipline. It comprises concise chapters which introduce the history, key lines of inquiry relating to both health and performance, technology, certifications, professional associations, and career opportunities associated with each area. No other book offers such a wide-ranging, evidence-based introduction to exercise science. Written by leading and experienced experts, chapters include: reading and interpreting literature measurement in exercise science anatomy in exercise science exercise physiology exercise epidemiology athletic training exercise and sport nutrition biomechanics motor control exercise and sport psychology Packed with pedagogical features-from journal abstract examples to study questions and further reading suggestions-and accompanied by a website including practical lab exercises, Introduction to Exercise Science is a complete resource for a hands-on introduction to the core tenets of exercise science. It is an engaging and invaluable textbook for students beginning undergraduate degrees in Kinesiology, Sport & Exercise Science, Sports Coaching, Strength & Conditioning, Athletic Training, Sports Therapy, Sports Medicine, and Health & Fitness.

The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the management and treatment of lung disease. It also covers promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing the disease features including novel strategies for targeting chronic lung diseases using advanced drug delivery systems. Importantly, the book examines the significance and relevance of the plant extracts and their constituents with therapeutic efficiencies against lung diseases. As such, the book offers a blend of translational, biological, chemical, and drug delivery aspects relevant to respiratory diseases, thus, offering a valuable resource for pulmonologists and translational researchers working in the field of pulmonary biology and respiratory medicine.

Chronic obstructive pulmonary disease (COPD) is the most common respiratory disorder of adults in the developed world and is the fourth main cause of death in the USA. It is also associated with high morbidity, and poses an enormous burden of suffering and expense. Despite this, the disease has received little attention compared with other respiratory conditions such as asthma and lung cancer.
Current treatment can offer some marginal symptomatic relief but does not address the underlying disease process. Indeed, smoking cessation is the only intervention known to alter the rate of disease progression. There is clearly great need, and potential, for the development of superior therapies for symptomatic relief and disease modification. This book brings together leading researchers and physicians to discuss the most recent advances in our understanding of COPD, and draws together basic and clinical aspects relevant to the topic. Coverage includes the basic pathology, current and potential therapies, and detailed consideration of the major theories for the pathogenesis of COPD.

Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.

This book presents the latest knowledge on both the physiological and the microbiological aspects of wound healing. Fresh insights into the process of cutaneous wound healing are described, which involves tissue regeneration and repair processes consisting of a sequence of molecular and cellular events. The management of infected wounds is then discussed in detail, covering the roles of traditional medicine practices, novel anti-infective formulations, non-antibiotic approaches, and probiotic bacteria. A section devoted to the interdisciplinary approach to wound care addresses topics including in vitro and in vivo research models, the development of advanced wound dressings, tissue engineering, and the potential applications of bioscaffolds. The authors are all leading researchers in the field. This book is an attempt to showcase current research status and future directions in the area of wound-healing research, which must be of interest to a large group of readers and researchers interested in this field.

This book provides a state-of-the-art compendium on the role of proteoglycans and glycosaminoglycans during development and in cancer. It also suggests directions for novel therapeutic and biotechnological applications in stem cell biology. Proteoglycans and glycosaminoglycans, as part of the extracellular matrix, are multifunctional modulators of growth factor, cytokine, integrin and morphogen signaling, which determine both self-renewal, senescence and/or differentiation of stem cells during development. Since proteoglycans modulate cell adhesion and migration they are important organizers of the extracellular matrix within the proper stem cell niche. A malfunctioning of proteoglycans and glycosaminoglycans contributes to the cancer stem cell phenotype, which is linked to therapeutic resistance and recurrence in malignant disease. This book is essential reading for anyone interested in the extracellular matrix and its role in development. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.

Lung diseases are leading causes of death and disability globally, with about 65 million people suffering from COPD, and 334 million from asthma. Each year, tens of millions of people develop and can die from lung infections such as pneumonia and TB. Systemic inflammation may induce and exacerbate local inflammatory diseases in the lungs, and local inflammation can in turn cause systemic inflammation. There is increasing evidence of the coexistence of systemic and local inflammation in patients suffering from asthma, COPD, and other lung diseases, and the co-morbidity of two or more local inflammatory diseases often occurs. For example, rheumatoid arthritis frequently occurs together with, and promotes the development of, pulmonary hypertension. This co-morbidity significantly impacts quality of life, and can result in death for some patients. Current treatment options for lung disease are neither always effective, nor condition-specific; there is a desperate need for novel therapeutics in the field. Additionally, the molecular and physiological significance of most major lung diseases is not well understood, which further impedes development of new treatments, especially in the case of coexistent lung diseases with other inflammatory diseases. Great progress has been made in recent years in many areas of the field, particularly in understanding the molecular geneses, regulatory mechanisms, signalling pathways, and cellular processes within lung disease, as well as basic and clinical technology, drug discovery, diagnoses, treatment options, and predictive prognoses. This is the first text to aggregate these developments. In two comprehensive volumes, experts from all over the world present state-of-the-art advances in the study of lung inflammation in health and disease. Contributing authors cover well-known as well as emerging topics in basic, translational, and clinical research, with the aim of providing researchers, clinicians, professionals, and students with new perspectives and concepts. The editors hope these books will also help to direct future research in lung disease and other inflammatory diseases, and result in the development of novel therapeutics.

Approx.572 pages

This book aims at providing insights into the collagen superfamily and the remarkable diversity of collagen function within the extracellular matrix. Additionally, the mechanisms underlying collagen-related diseases such as dystrophic epidermolysis bullosa, osteogenesis imperfecta, as well as collagen-related myopathies and neurological disorders are discussed. Collagens are the most abundant extracellular matrix proteins in organisms. Their primary function is to provide structural support and strength to cells and to maintain biomechanical integrity of tissues. However, collagens can no longer be considered just as structural proteins. They can act as extracellular modulators of signaling events and serve critical regulatory roles in various cell functions during embryonic development and adult homeostasis. Furthermore, collagens are associated with a broad spectrum of heritability-related diseases known as "collagenopathies" that affect a multitude of organs and tissues including sensorial organs. The book is a useful introduction to the field for junior scientists, interested in extracellular matrix research. It is also an interesting read for advanced scientists and clinicians working on collagens and collagenopathies, giving them a broader view of the field beyond their area of specialization.

Infants and children spend one- to two-thirds of their life asleep. Despite this, very little attention has been paid to understanding both normal sleep and sleep-related abnormalities during child development. This volume is devoted to breathing during sleep, its changes with development (from the fetus onwards), and the pathophysiology of sleep-related breathing disorders. Sleep and Breathing in Children: investigates breathing during sleep from the fetus onwards examines the effects of sleep on upper airway resistance, ventilatory drive, and respiratory muscle tone compares differences between childhood and adult obstructive sleep apnea, and the profound changes in breathing and sleep during growth and maturation discusses the current research within the field of pediatric sleep disorders reviews the history of childhood obstructive sleep apnea syndrome, and outlines a future framework for the study of childhood sleep-disordered breathing

Discover the fundamental principles of biomedical measurement design and performance evaluation with this hands-on guide. Whether you develop measurement instruments or use them in novel ways, this practical text will prepare you to be an effective generator and consumer of biomedical data. Designed for both classroom instruction and self-study, it explains how information is encoded into recorded data and can be extracted and displayed in an accessible manner. Describes and integrates experimental design, performance assessment, classification, and system modelling. Combines mathematical concepts with computational models, providing the tools needed to answer advanced biomedical questions. Includes MATLAB (R) scripts throughout to help readers model all types of biomedical systems, and contains numerous homework problems, with a solutions manual available online. This is an essential text for advanced undergraduate and graduate students in bioengineering, electrical and computer engineering, computer science, medical physics, and anyone preparing for a career in biomedical sciences and engineering.

Robert Provine boldly goes where other scientists seldom tread-in search of hiccups, coughs, yawns, sneezes, and other lowly, undignified human behaviors. Upon investigation, these instinctive acts bear the imprint of our evolutionary origins and can be uniquely valuable tools for understanding how the human brain works and what makes us different from other species. Many activities showcased in Curious Behavior are contagious, but none surpasses yawning in this regard-just reading the word can make one succumb. Though we often take it as a sign of sleepiness or boredom, yawning holds clues to the development of our sociality and ability to empathize with others. Its inescapable transmission reminds us that we are sometimes unaware, neurologically programmed beasts of the herd. Other neglected behaviors yield similar revelations. Tickling, we learn, may be the key to programming personhood into robots. Coughing comes in musical, medical, and social varieties. Farting and belching have import for the evolution of human speech. And prenatal behavior is offered as the strangest exhibit of all, defying postnatal logic in every way. Our earthiest acts define Homo sapiens as much as language, bipedalism, tool use, and other more studied characteristics. As Provine guides us through peculiarities right under our noses, he beckons us to follow with self-experiments: tickling our own feet, keeping a log of when we laugh, and attempting to suppress yawns and sneezes. Such humble investigations provide fodder for grade school science projects as well as doctoral dissertations. Small Science can yield big rewards.

Prepare for a career as a leading respiratory therapist with the solid foundation in anatomy and physiology found in Des Jardins' best-selling CARDIOPULMONARY ANATOMY & PHYSIOLOGY: ESSENTIALS OF RESPIRATORY CARE, 7E. This extremely reader-friendly presentation delivers the most complete, accurate information about the structure and function of the respiratory system. Clear and concise coverage presents even complicated concepts in an understandable format using full-color design and proven learning features that guide you in applying what you've learned to your professional career. Thirteen new Clinical Connections add to the book's total 141 Clinical Connections that link chapter content to today's clinical setting and highlight actual situations that respiratory therapists encounter every day. These features also direct meaningful discussion and strengthen your critical-thinking skills.