Channels and transporters are multi-functional proteins that mediate substrate transport and signal transmission and simultaneously act as regulators for other proteins and biosensors for environmental materials. Patch clamping is an epoch-making technique that allows researchers to perform real-time measurements of electrogenic channel/transporter functions at the single/multiple molecular level. This book describes not only the conventional patch clamp techniques but also their newly developed variations or applications, such as perforated patch, slice patch, blind patch, in vivo patch, imaging patch, smart patch, and automated patch clamping. These patch clamp techniques are now essential and are extensively used across the life sciences and in related industries. With plain and practical descriptions of patch clamping and how to carry it out, especially for beginners, the book also shows how widely and exquisitely the patch clamp techniques can be applied by expert electrophysiologists. This work serves as a useful guide for young researchers and students in training and laboratory courses as well as for senior researchers who wish to extend their repertoire of techniques.

In the historical record there is abundant evidence that obesity was a medical and health concern as long as medicine has been practiced. The idea of diet and exercise are bulwarks in the fight against obesity in history from the time of Hippocrates to the 16th century--a span of 2,000 years. However, our scientific understanding of this problem is only a little over 200 years old. An examination of the root cause of what many consider the obesity epidemic, A Guide to Obesity and the Metabolic Syndrome traces the origins and types of obesity and its treatment. Examining in detail the developing treatment for obesity, this book provides: * A history of obesity, including treatment, proposed causes, and perceptions * An examination of the causes and problems associated with obesity * A discussion of lifestyle, diet, exercise, and treatment strategies * A detailed look at the medications and surgeries available for obesity The fact that we have an epidemic of obesity today that is covering the globe suggests that the strategically simple ideas of eating less and exercising more, ideas that require commitment and personal involvement by the individual, have not been very successful. As we move forward in trying to understand this problem, we need to be alert to strategies and tactics that may not require individual motivation and commitment--history has shown that they do not work well. This book supplies guidance on developing and designing novel strategic interventions against obesity and metabolic disorders.

This volume of the Keio University International Symposia for Life Sciences and Medicine contains the proceedings of the 14th symposium held under the sponsorship of the Keio University Medical Science Fund.The fund was established by the generous donation of the late Dr. Mitsunada Sakaguchi. The Keio University International Symposia for Life Sciences and Medicine constitute one of the core activities sponsored by the fund, of which the objective is to contribute to the international community by developing human resources, promoting scienti?c knowledge, and encouraging mutual exchange. Each year, the Committee of the International Symposia for Life Sciences and Medicine selects the most signi?cant symposium topics from applications received from the Keio medical community. The publication of the proceedings is intended to publicize and distribute the information arising from the lively discussions of the most exciting and current issues p- sented during the symposium.On behalf of the Committee,I am most gra- ful to the late Dr. Sakaguchi, who made the series of the symposia possible. We are also grateful to the prominent speakers for their contributions to this volume.In addition,we would like to acknowledge the ef? cient organizational work performed by the members of the program committee and the staff of the fund. Naoki Aikawa, M.D., D.M.Sc., F.A.C.S.

Humans possess a remarkable ability to extract rich three-dimensional information about sound environments simply by analyzing the acoustic signals they receive at their two ears. Research in spatial hearing has evolved from a theoretical discipline studying the basic mechanisms of hearing to a technical discipline focused on designing and implementing increasingly sophisticated spatial auditory display systems. This book contains 39 chapters representing the current state-of-the-art in spatial audio research selected from papers presented in Sendai, Japan, at the First International Workshop on the Principles and Applications of Spatial Hearing.

Students trained in traditional exercise physiology have learned the basic concepts of energy but often don't fully understand human energy consumption at the molecular level." Biochemistry Primer for Exercise Science, Fourth Edition," provides an introduction to biochemistry that will give readers greater insight into the molecular aspects of human physical activity.

Reflecting the rapid development of the field, this classic text continues to present the essentials of biochemistry--molecular biology, basic chemistry, metabolism, and transcription regulation--in an easy-to-understand format. The fourth edition features the most recent research in exercise biochemistry plus new and revised content, including the following:

- All-new coverage of the control of biochemistry and biochemical and muscular adaptations to exercise and training via signaling pathways, an area of study that has received much attention in recent years

- Added information on the regulation of gene expression, which highlights the need for students to comprehend the basics of molecular biology

- Next Stage sections in each chapter, which lead students toward emerging areas of knowledge in the field by examining new or controversial areas of research

- An integration of the chapters on DNA, RNA, and the regulation of protein synthesis to provide a more focused and effective presentation of these key concepts

"Biochemistry Primer for Exercise Science, Fourth Edition," combines information from nutrition, physiology, and biochemistry to provide a clear explanation of the working of metabolism and the human body's response to physical activity. Special elements throughout the text help to demystify this complex and dynamic field of study. Key points reinforce essential concepts and aid readers in relating them to sport and exercise. Chapter summaries outline important information to take away, and review questions with answers allow readers to test their knowledge of each chapter's content. A comprehensive glossary and the list of abbreviations found on the inside front and back covers help readers become familiar with commonly used biochemistry terms, and a reference list provides a starting point for exploring areas of interest in more detail.

With its combination of essential topics, new findings, and future directions in research, "Biochemistry Primer for Exercise Science, Fourth Edition," is a perfect resource for anyone looking to build an understanding of exercise biochemistry. Both students and professionals alike will find the information they need to begin their exploration of this fascinating field of study.

Edited by physiology instructors who are also active clinicians, Integrated Physiology and Pathophysiology is a one-stop guide to key information you need for early clinical and medical training and practice. This unique, integrated textbook unites these two essential disciplines and focuses on the most relevant aspects for clinical application. A concise, review-like format, tables and diagrams, spaced repetition for effective learning, and self-assessment features help you gain and retain a firm understanding of basic physiology and pathophysiology. Integrated Physiology and Pathophysiology works equally well as a great starting point in your studies and as a review for boards. Shares the knowledge and expertise of an outstanding editorial team consisting of two practicing clinicians who also teach physiology and pathophysiology at Harvard Medical School, plus a top Harvard medical student. Provides an integrated approach to physiology and pathophysiology in a concise, bulleted format. Chapters are short and focus on clinically relevant, foundational concepts in clear, simple language. Employs focused repetition of key points, helping you quickly recall core concepts such as pressure-flow-resistance relationships, ion gradients and action potentials, and mass balance. You'll revisit these concepts in a variety of meaningful clinical contexts in different chapters; this "spaced learning" method of reinforcement promotes deeper and more flexible understanding and application. Includes Fast Facts boxes that emphasize take-home messages or definitions. Contains Integration boxes that link physiology and pathophysiology to pharmacology, genetics, and other related sciences. Presents clinical cases and with signs and symptoms, history, and laboratory data that bring pathophysiology to life. Features end-of-chapter board-type questions, complete with clear explanations of the answers, to help prepare you for standardized exams. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

The number of elderly patients with diabetes is increasing at a significant rate. Responding to this growth, this source serves as a solid arsenal of information on the varying presentations and challenges associated with diabetes in the geriatric patient, and supplies clearly written sections on the screening, diagnosis, and treatment of diabetes in elderly populations. With contributions from renowned authorities from the national and international institutions, this reference will depict the role of specific co-morbidities, socioeconomic aspects, and caregiver issues on the effective management of diabetes in the older adult.

While nutrition is central to the management of diabetes, there is no one "diabetic diet". Nutritional prescriptions depend on the type of diabetes, food preferences, lifestyle, treatment regimen, comorbidities, state of health, and the route of caloric administration. Nutritional Strategies for the Diabetic/Prediabetic Patient is a comprehensive reference aimed at advancing physicians' knowledge of nutrition in relation to diabetes, allowing them to provide evidence-based recommendations for their diabetic patients. It also provides dietitians and diabetic educators with an in-depth understanding of the pathophysiology and medical treatment of diabetes. Written by scientists, clinicians, registered dietitians, and certified diabetes educators, this book reviews the molecular mechanisms of disease and drug therapy. It also provides recommendations for management with the level of evidence indicated where appropriate. In areas where little research data is available, the editors present recommendations based on extensive clinical experience. The book places particular focus on the synchronization of nutrient intake with medications, and provides unique clinical management tools, along with details of their ability to be replicated for patient use. To facilitate accessibility, it features evidence-based technical reviews of clinical literature and includes numerous tables and figures, with color photos of wound healing stages. Addressing all aspects of nutrition in adult diabetic and prediabetic patients, Nutritional Strategies for the Diabetic/Prediabetic Patient is an important referencefor those concerned with the dietary management of this disease.

DHEA and the Brain reviews a range of existing studies regarding DHEA administration to animals and humans. Chapter authors evaluate DHEA metabolism in tissues and organs, explore DHEA effects in the liver that may be of importance to the brain, and discuss recent findings regarding how DHEA is made in the brain. New perspectives about the neuroprotective effects of DHEA are presented, as well as insight related to DHEA metabolism in the brain. A number of health benefits have been associated with dehydroepiandrosterone (DHEA), including anti-cancer, anti-osteoporosis, anti-atherosclerosis, anti-diabetes, immuno-stimulating, and memory-enhancing effects. This has prompted millions of people to take this hormone as a daily nutritional supplement. However, there is some concern that prolonged self-administration may result in future health problems, as well as unease about potential side effects due to the production of steroid derivatives in the tissues. Featuring an esteemed panel of contributors, this volume provides an authoritative overview of the research concerning DHEA and the brain. It presents a variety of innovative approaches and ideas for future investigations into the physiological actions of this hormone.

As nutrition research is shifting its focus from epidemiology and physiology to effects of nutrients at the molecular level, a uniquely tailored diet that corresponds to the demands of our genetic signature is emerging as an indispensable need. Using high-throughput genomic tools, nutrigenomics unravels the influence of micro- and macronutrients as potent dietary signals regulating metabolic pathways and unmasks how susceptible genotypes are predisposed to diet-related diseases. Selected topics from this field have been covered in some books, but no other comprehensive text on epigenetics, nutrition, and human health and disease is available, until now. This book illustrates nutrition's influence on epigenetic inheritance and the mechanisms underlying the modification of the metabolic imprint of an individual. This enriched understanding of nutrigenomics can be applied to master a tailored diet that can alleviate imprinted metabolic syndromes. Specifically, the book focuses on: * Maternal, perinatal, and neonatal nutrition * Epigenetic mechanisms and cancer * Impacts of dietary factors, folate deficiency and DNA methylation * Nutrition's influence on genetic imprinting * The basics of nutrigenomics and epigenetic regulation

This important monograph summarizes a comprehensive study on the maturation of walking in normal children. Research, undertaken at one of the world's leading gait analysis centers, involved over 400 studies on a total of nearly 300 children in ten age-groups from one to seven years. Data are presented on anthropometric measurements; tests of developmental progress; time/distance parameters such as stride length and walking velocity; twelve joint angles on each side measured throughout the gait cycle; dynamic electromyography of phasic activity in seven lower-extremity muscle groups; and force measurements including vertical force, fore/aft shear, medial/lateral shear and torque. At each age, composite joint-angle graphs and time/distance parameters are brought together with film tracings of a representative child in that age group. In addition, advanced methods of statistical analysis have been applied to the joint-angle data to define prediction regions within which ninety-five percent of normal children should lie throughout the gait cycle. Finally, a 'decision tree' is presented from which a fitted age can be inferred for a subject based on non-age-specific data gathered in a motion analysis lab. Practical applications are demonstrated in a chapter devoted to two case studies.

Swallowing difficulty or dysphagia is a common disorder and affects all age groups from the newborn to the elderly. Several medical conditions like lack of dentition, gastroesophageal reflux disease, eosinophilic esophagitis, cardiomegaly and strokes can cause dysphagia. It can also follow head -neck surgeries. It is important to diagnose and treat dysphagia, otherwise it can lead to malnutrition and dehydration. Improved understanding of the physiology of swallowing, advances in endoscopic and radiological techniques along with an increasing elderly population has resulted in development of a separate swallowing disorders discipline. This book would be an aid for clinicians, educators and trainees from the fields of speech language pathology, pediatrics, otolaryngology, gastroenterology, oncology, neurology, geriatrics and rehabilitation, all of who form a part of the multidisciplinary swallowing team.

Over the past 10 years, researchers have been investigating the expression, regulation, and protective nature of stress proteins (SPs) during and following exercise. Since the expression of SPs have been shown to provide protection to cells and tissues, the importance of understanding their role during exercise cannot be understated. However the terminology, the myriad of stress proteins, and their complex regulation creates a confusing arena in which to enter. Exercise and Stress Response: The Role of Stress Proteins provides an up-to-date review on topics related to exercise and health, giving investigators the necessary background to pursue stress proteins.

ABOUT THE EDITORS:


Marius Locke, Ph.D. is an Assistant Professor in the Faculty of Physical Education and Health at the University of Toronto in Ontario, Canada. Dr. Locke received a B.A. with honors in Physical Education (1984), a B.Sc. in Biology (1987), and a Ph.D. in Kinesiology from the University of Western Ontario (1992), where he also played varsity football. Dr. Locke was awarded a Natural Science and Engineering Research Council of Canada Post Doctoral Fellowship and studied at the Deborah Research Institute in Browns Mills, New Jersey from 1993-1996. In 1999, Dr. Locke received the American College of Sports Medicine's new investigator award. Dr. Locke is a member of American College of Sports Medicine, the Canadian Society for Exercise Physiology and the Cell Stress Society International.

Earl G. Noble, Ph.D. is an Associate Professor in the School of Kinesiology at the University of Western Ontario in London, Ontario, Canada. He received his B.Sc. (1973) and M.Sc. (1975) in Kinesiology from the University of Waterloo and his Ph.D. from Washington State University (1980). Dr. Noble is a member of the Canadian Society for Exercise Physiology, the American College of Sports Medicine and the Cell Stress Society International and the Research Group on Biochemistry of Exercise of the International Council of Sport Science and Physical Education (UNESCO). The overriding theme of his research is to examine muscle plasticity and the manner in which muscle adapts to novel or stressful conditions, especially exercise.

• How can we predict the trajectory of a baseball from bat to outfield?
• How do the dimples in a golf ball influence its flight from tee to pin?
• What forces determine the path of a soccer ball steered over a defensive wall by an elite player?

An understanding of the physical processes involved in throwing, hitting, firing and releasing sporting projectiles is essential for a full understanding of the science that underpins sport. This is the first book to comprehensively examine those processes and to explain the factors governing the trajectories of sporting projectiles once they are set in motion.

From a serve in tennis to the flight of a ?human projectile? over a high jump bar, this book explains the universal physical and mathematical principles governing movement in sport, and then shows how those principles are applied in specific sporting contexts. Divided into two sections, addressing theory and application respectively, the book explores key concepts such as:

• friction, spin, drag, impact and bounce
• computer and mathematical modelling
• variable sensitivity
• the design of sports equipment
• materials science.

Richly illustrated throughout, and containing a wealth of research data as well as worked equations and examples, this book is essential reading for all serious students of sports biomechanics, sports engineering, sports technology, sports equipment design and sports performance analysis.

Ion channels play a vital role in basic physiological functions such as generation of electrical activity in nerves and muscle, control of cardiac excitability, intracellular signaling, hormone secretion, cell proliferation and many other biological processes. Because of their prevalence and the critical role they play in virtually all tissue types and organs, ion channels are also involved in a number of pathophysiological conditions. The aim of this volume is to review recent advances in the field of ion channel related diseases. Following an overview chapter summarizing the current state of ion channel screening technologies, five topics covering areas such as cancer, cardiac arrhythmias, cystic fibrosis, and pain have been selected, and the current state of knowledge is presented by leading experts in their field. Each chapter is structured to cover the biological rationale for the target, the current status in the development of agents to treat the disease, and future prospects and challenges facing each therapeutic area. The reader will receive a critical overview covering the progress made in the rapidly developing and complex field of ion channels and diseases.

The human brain represents about 2% of the body weight, yet it accounts for approximately 20% of aerobic metabolism. This high dependency on energy-consuming processes is mainly caused by the active transport of ions, which is necessary to compensate for the transmembrane ion currents that are part ofthe complex signaling processes in the brain. Ninety-five percent ofthe brain's ATP is derived from mitochondrial oxidative phosphorylation. Since that organ' s storage capacity for oxygen is minimal, any interruption of oxygen delivery to brain cells willlead to changes in membrane excitability and, there fore, to disruption of neuronal signaling within seconds. It seems that mamma lian brain is especially vulnerable to such an interruption, since oxygen deprivation leads to activation of ion channel mechanisms in neurons that impair their communications. Thus, the function of the brain as a coordinator of vital homeostatic reflexes, and complex body reactions to external challenges, depends critically on the rate of oxygen delivery and oxygen consumption. Oxygen delivery depends on two variables described in the Fick relation ship: volume flow rate ofblood and the arterial oxygen content. A reduction in either of these two variables will have serious effects on vital brain func tions. Reduction of arterial blood flow to the brain can be caused by cardiac arrest, shock, carotid occlusion, Of hypotension (global ischemia). Oxygen content is progressively decreased in asphyxia (including drowning)."

The Physiology of the Joints, conceived and written more than forty years ago by Dr. A. I. Kapandji, deals with biomechanics, a subject until then mentioned only incidentally in textbooks of anatomy. Following his lead, every anatomy textbook nowadays has a large component devoted to the functional aspect of the locomotor system, which has become an essential scientific subject. The seventh edition of this volume deals with the head and the spinal column and has been expanded with the inclusion of new diagrams and text dealing in particular with: The role of the femurs during the different stages of labour The concepts of mass, weight and barycentre How to localise the barycentres Joint hypermobility The law of parsimony and the law of universal profusion This book is intended for medical and physical therapy students; and for practising physicians and surgeons wishing to increase their knowledge of the functional anatomy of the locomotor system.

Integrates Student Knowledge of Nutrition Science with Physiology Today's knowledge of human health demands a multidisciplinary understanding of medically related sciences, and Case Studies in the Physiology of Nutrition answers the call. Dedicated to the integration of nutrition science with physiology, this text cohesively incorporates descriptions of human problems in order to stimulate students' critical thinking about how the body integrates various physiological factors to maintain homeostasis. Contains Key Points, Vocabulary Exercises, and Critical Thinking Problems This textbook uses short story-type case studies about fictional individuals who have health problems in order to address a range of issues in an approachable manner. The studies vary in difficulty, with some being straightforward with very simple answers, while others require in-depth thinking and literature research to solve. Each study presents patient background, symptoms, clinical finding, and questions to ponder. Upon qualifying course adoption, this book also includes a valuable instructor's manual, which provides solutions to exercises, problem analysis, and resolution to each case study. This ready-to-implement resource addresses: Homeostasis Obesity and malnutrition Anemia and diabetes Nutrient-gene expression Immune system Food safety Aging and nutrition Muscle and bone studies Case Studies in the Physiology of Nutrition provides an understanding of nutritional components by defining biochemical, mechanical, and physical functions. Its unique approach will aid students in relating functionality to system failure as well as understanding the role of environment in health and nutrition.

In every sport, there are athletes who represent true technical excellence. Their movement seems effortless and efficient: they create and control forces in the most effective way. Functional force management, the foundation for effective sporting movement and injury resistance, results from the integration of stability, mobility, coordination and balance. These elements combine to prevent the physical restrictions, imbalances and inefficient muscle recruitment patterns which can block athletes from meeting their movement goals. The right muscles firing at the right time and in the right sequence can enable athletes to achieve their full physical potential. Full of colour photographs and images to illustrate the techniques and theories involved, Stability, Sport, and Performance Movement introduces functional stability principles as they apply to sporting movement. A comprehensive chapter on movement testing is followed with four chapters of integrated exercise techniques, which clearly demonstrate form and progression from early activation through to higher-level neuromuscular drills.Programmes and clinical examples help the reader to appreciate the application of this approach across a variety of sports. It is an approach that has been used with international-level athletes in disciplines as diverse as swimming, badminton, gymnastics, karate, cycling, weight lifting, basketball, athletics, snow sports, football, golf, equestrian sports, and tennis. Effective movement starts with great foundations, and these are applicable and relevant across all age groups and ability levels, from beginners through to veterans.

Vasopressin is a hormone which has an increasingly important profile. Not only does it play a physiologically significant role in renal water regulation but it also has other renal actions and plays a role in overall cardiovascular control. Even more interesting is the recent growing interest in its potential effects on the brain, notably its influence on specific behaviours. This monograph about the polypeptide vasopressin covers all aspects relating to the production, control of release, and actions of this molecule within the body, including its roles as a hormone and as a central neurotransmitter. A consideration of the evolution of the molecule across the species and a brief historical perspective are also included. Clinical conditions associated with hypo- and hyper-production states are considered together with aspects of treatment, in addition to other clinical correlates.

When human muscle fatigues, athletic performance becomes impaired. For those individuals suffering muscle or metabolic diseases the effects of muscle fatigue can make everyday tasks difficult. Understanding the scientific processes responsible for skeletal muscle fatigue is therefore central to the study of the physiology of sport, exercise and health.

Written by a team of leading international exercise scientists, this book explores the mechanisms of muscle fatigue and presents a comprehensive survey of current research on this important topic. Examining the wide variety of protocols, assessment methods and exercise models used to study muscle fatigue, the book explores the differential effects of fatigue as influenced by:

• age
• gender
• fitness and training
• the use of ergogenic aids
• medical conditions including cerebral palsy, muscular dystrophy and glycogenosis.

Human Muscle Fatigue covers both clinical and applied approaches in sport and exercise physiology and devotes an entire section to the conceptual framework underpinning research in this area, helping readers from a wide range of backgrounds to engage with the topic. Accessible and detailed, this book is a key text for students and practitioners working in exercise and sports science, medicine, physical therapy and health.

Cannabis Use, Neurobiology, Psychology, and Treatment offers readers a comprehensive reference on neurological changes, both transient and long-term, and other factors surrounding the use of these compounds and extracts. With coverage of both natural and synthetic cannabinoids, this broad coverage allows readers to learn about both adverse and non-adverse effects, including reactivity to pain, changes in behavior, and neuroactivity. This volume provides a platform for research on the effects of these compounds in brain function and neurological dysfunction. Extracts from the Cannabis sativa plant contain scores of psychoactive compounds in addition to the principal agent tetrahydrocannabinol, many of which are neuroactive.

Netter's Integrated Musculoskeletal System is an innovative new text that brings together basic science material from several domains, providing a solid foundation prior to delving into topics of increasing complexity and clinical importance -all highlighted by superb Netter illustrations throughout. Initial chapters give a general overview of the human body, while the remaining chapters examine all facets of the musculoskeletal system, the injuries that affect it at the macroscopic and microscopic levels, and the process of development. As the scientific content becomes more complex, the clinical correlations become more specific. This progressively constructed narrative guides readers efficiently and effectively through the intricacies of the musculoskeletal system in a way that is easy to understand and remember-all in a single, time-saving resource for busy students. Takes an integrated approach including gross anatomy, physiology, biochemistry, neuroscience, histology, and other relevant sciences to better help readers understand the musculoskeletal system. Presents essential content in an easy-to-understand manner, puts it in context, and then elaborates on it with more detail-making connections between content areas and reducing the need for multiple study resources. Features clinical correlations boxes throughout; includes an appendix of commonly-used eponyms to help readers communicate across disciplines and an appendix of Latin/Greek/Arabic roots for anatomical terms. Designed to be used effectively in longitudinally-designed, integrated curricula-for a wide range of health-science students-with carefully organized, concise reading assignments and discrete areas of study for each lesson. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Understanding the 'human operator' is a central concern of both ergonomists and sport and exercise scientists. This cutting-edge collection of international research papers explores the interface between physical, cognitive and occupational ergonomics and sport and exercise science, illuminating our understanding of 'human factors' at work and at play. Drawing on a wide diversity of disciplines, including applied anatomy, biomechanics, physiology, engineering, psychology and design, the book explores themes of central importance within contemporary ergonomics and sport and exercise science, such as performance, health, environment, technology and special populations. Contemporary Sport, Leisure and Ergonomics establishes important methodological connections between the disciplines, advancing the research agenda within each. It is essential reading for all serious ergonomists and human scientists.

An understanding of the scientific principles underpinning the learning and execution of fundamental and skilled movements is of central importance in disciplines across the sport and exercise sciences. The second edition of Motor Control, Learning and Development: Instant Notes offers students an accessible, clear and concise introduction to the core concepts of motor behavior, from learning through to developing expertise. Including two brand new chapters on implicit versus explicit learning and motor control and aging, this new edition is fully revised and updated, and covers: definitions, theories and measurements of motor control; information processing, neurological issues and sensory factors in control; theories and stages of motor learning; memory and feedback; the development of fundamental movement skills; and the application of theory to coaching and rehabilitation practice. Highly illustrated and well-formatted, the book allows readers to grasp complex ideas quickly, through learning objectives, research highlights, review questions and activities, and encourages students to deepen their understanding through further reading suggestions. This is important foundational reading for any student taking classes in motor control, learning or behavior or skill acquisition, or a clear and concise reference for any practicing sports coach, physical education teacher or rehabilitation specialist.