The function of human white cells is dependent on a complex machinery involving a network of proteins. Their identification has posed a puzzle for scientists for many years and this book comprises the proceedings of the latest in a series of international meetings that have identified many of these entities and studied their function and clinical importance. Leucocyte Typing VII provides the definitive reference for all those working with antibodies recognising marker molecules on white blood cells. Sorting and tracing white blood cells is important in a range of clinical settings, but especially in the diagnosis of leukaemias. There is a concerted action by regulatory bodies looking for a standard against which these 'biologicals' can be assessed. The book contains the assembled work of many laboratories worldwide which jointly evaluated many hundered different monoclonal antibodies. The results of the collaborative effort reported at the meeting are published in Leucocyte Typing VII. A unique feature of this book is the complete guide to all available CD- antigens. This book is the standard reference for immunologists, cell and molecular biologists, haematologists, and pathologists working on white cell differentiation. It provides immunologists and biochemists with an up to date summary of the current knowledge of molecular aspects of different categories of human white cells (and endothelial and red cells) and provides hematologists and oncologists with information relevant to their clinical practice and research.

The Computational Biomechanics for Medicine titles provide an opportunity for specialists in computational biomechanics to present their latest methodologiesand advancements. Thisvolumecomprises twelve of the newest approaches and applications of computational biomechanics, from researchers in Australia, New Zealand, USA, France, Spain and Switzerland. Some of the interesting topics discussed are:real-time simulations; growth and remodelling of soft tissues; inverse and meshless solutions; medical image analysis; and patient-specific solid mechanics simulations. One of the greatest challenges facing the computational engineering community is to extend the success of computational mechanics to fields outside traditional engineering, in particular to biology, the biomedical sciences, and medicine. We hope the research presented within this book series will contribute to overcoming this grand challenge.

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on hormone and transport systems.

The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on "Sex and gender factors affecting metabolic homeostasis, diabetes and obesity" to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases. There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men.

This book focuses on the nutrients and nutraceuticals that promote active and healthy ageing - recently defined by the WHO as the process of development and maintenance of functional capacity that allows well-being at an advanced stage of life. There has been a rapid rise in the use of nutritional interventions as well as specific nutraceuticals in the management of multifactorial aspects of clinical health outcomes. Written by leading experts this book comprehensively discusses the various ageing phenotypes and age-related diseases. It also assesses the nutritional status of the elderly and the various epidemiological factors that influence it. It reviews the role of dietary fiber in disease-free and fully functional ageing. Further, the book explores the benefits of polyphenols, which are secondary plant metabolites, in protecting against cancer, cardiovascular diseases, and various neurodegenerative diseases.

Soft biological tissues often undergo large (nearly) elastic deformations that can be modeled using the nonlinear theory of elasticity. Because of the varied approaches to nonlinear elasticity in the literature, some aspects of the subject may be difficult to appreciate.This volume clarifies and unifies those treatments, illustrating the advantages and disadvantages of each through various examples in biomechanics. Applications include muscle, arteries, the heart, and embryonic tissues.The revised edition includes new end-of-chapter problems, including answers and detailed solutions to most. The useful reference can be a good textbook for self-study, as well as senior- and graduate-level courses in biomechanics and nonlinear elasticity.

Many neurological conditions are caused by damage to neurons and glial cells. For most of these diseases there are at present no effective treatments to minimize the extent of neuronal and glial loss, and no effective way of replacing what has been lost. This picture is rapidly changing. Developments in basic neuroscience have produced various potential therapies that can protect neurons and glia following traumatic, anoxic, infectious and immunological damage. The old doctrine that axons cannot be made to regenerate, and dead neurons cannot be replaced is no longer tenable, and a wide variety of reconstructive techniques for the nervous system are under development. These and other basic science discoveries will progress into clinical practice, and lead to a revolution in neurology and neurosurgery. This book describes the various conditions that lead to damage to the nervous system, and the ways in which they may be ameliorated. It covers the burgeoning science of reconstruction of the nervous system, through neuronal, glial and stem cell transplantation, axon regeneration, remyelination, plasticity and pharmacological interventions.

Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.

Respiratory diseases are leading causes of death and disability globally, with about 65 million people suffering from COPD, and 334 million from asthma, the most common chronic disease. Each year, tens of millions of people develop and can die from from respiratory infections such as pneumonia and TB. Systemic inflammation may induce and exacerbate local inflammatory diseases in the lungs, and local inflammation can in turn cause systemic inflammation. There is increasing evidence of the coexistence of systemic and local inflammation in patients suffering from asthma, COPD, and other lung diseases, and the co-morbidity of two or more local inflammatory diseases often occurs. For example, rheumatoid arthritis frequently occurs together with, and promotes the development of, pulmonary hypertension. This co-morbidity significantly impacts quality of life, and can result in death for those affected. Current treatment options for lung disease are neither effective, nor condition-specific; there is a desperate need for novel therapeutics in the field. Additionally, the molecular and physiological significance of most major lung diseases is not well understood, which further impedes development of new treatments, especially in the case of coexistent lung diseases with other inflammatory diseases. Great progress has been made in recent years in many areas of the field, particularly in understanding the molecular geneses, regulatory mechanisms, signalling pathways, and cellular processes within lung disease, as well as basic and clinical technology, drug discovery, diagnoses, treatment options, and predictive prognoses. This is the first text to aggregate these developments. In two comprehensive volumes, experts from all over the world present state-of-the-art advances in the study of lung inflammation in health and disease. Contributing authors cover well-known as well as emerging topics in basic, translational, and clinical research, with the aim of providing researchers, clinicians, professionals, and students with new perspectives and concepts. The editors hope these books will also help to direct future research in lung disease and other inflammatory diseases, and result in the development of novel therapeutics.

There are many modes of communication that neurons use to transmit information besides what has come to be called neurotransmission. Many of these other types of communication can be classified as neuromodulatory, where instead of conveying excitation or inhibition, the signal from one neuron changes the properties of other neurons or synapses. This form of neuronal communication is often overlooked by systems physiologists, but it is extremely prevalent in the nervous system and needs to be included in any description of how the nervous system processes information. This book provides the foundations for understanding the cellular and molecular basis for neuromodulatory effects. It illustrates some key examples of the roles played by neuromodulation in sensory processing, neuromuscular transmission, generation of motor behaviours, and learning. Finally, the book seeks to point out areas that are likely to be of importance in the future study of information processing by the nervous system. For neurobiology students and researchers, the book summarizes a vast amount of research, and puts it into the context of how these cellular mechanisms are used in systems of neurons. By spanning the levels of analysis from sub-cellular mechanisms through cellular properties and neuronal systems to behaviour, the book provides a framework for understanding this currently exploding field of research. It is accessible to anyone with a basic understanding of neurobiology, but is in depth enough to satisfy readers who are very familiar with the field.

Angiogenesis and Cardiovascular Disease provides a comprehensive review of the basic scientific and clinical advances in the field of angiogenesis, and its role in the human cardiovascular system. The material presented draws from multiple disciplines, integrating information in a single source. Topics addressed focus first on aspects of development and normal biology of the vasculature, and then on angiogenesis and how it is involved in the pathophysiology and therapy of ischemic cardiovascular disease. Vascular development, endothelial cell biology, the vascular matrix, and growth factors are discussed. Up to date information on current clinical trials, and practical advice concerning application to cardiovascular therapeutic options, are also stressed.

The volume specificity and practicality examines techniques that are commonly used, often without merit, and provides useful information for practitioners, trainers, coaches, clinicians and other readers The book examines a wide range of physiological topics progressing through many of the key issues. Provides a healthy balance between health and wellbeing and elite performance

Over the past three decades the study of pediatric physical inactivity has become a public health concern. The decreases in physical activity have been associated with obesity and numerous hypokinetic diseases. In accordance with this public health concern, the study of pediatric physical activity has become a central part of research in the health and exercise science fields. The Routledge Handbook of Youth Physical Activity is the first book to survey the full depth and breadth of the issues facing this field. Bringing together many of the world's experts and practitioners, the book helps to develop an understanding of the underlying issues related to pediatric physical activity as well as the role physical activity plays on cognitive, psychomotor, and social aspects of childhood. The book addresses issues with physical activity measurement and discuss wide-ranging aspects of physical activity interventions. With more emphasis than ever on physical activity, this book makes an important contribution to the scholars and practitioners working in the field of youth physical activity. This is the first single text on the state of current knowledge related to pediatric physical activity which offers a comprehensive guide to students and academics on these subjects The Routledge Handbook of Youth Physical Activity is key reading for all advanced students, researchers, practitioners, and policy-makers with an interest in physical activity, youth sport, public health matters, sport studies, or physical education.

Reinforce your understanding of pathophysiology with a practical workbook! Corresponding to the chapters in Gould's Pathophysiology for the Health Professions, 7th Edition, this study guide uses a variety of exercises, activities, and review questions to help you master concepts relating to disorders and disease processes. It lets you practice skills and apply concepts to clinical practice. To make review easier, an answer key is included in the back of the book. Learning activities provide a variety of ways to assess your knowledge or identify areas for further study, including labeling exercises, matching exercises on important terminology, crossword puzzles, questions that apply knowledge to more complex situations, and compare/contrast completion charts. Answer key for all of the activities is provided at the back of the book, providing immediate feedback. The same authors as the Pathophysiology textbook - Karin VanMeter and Robert Hubert - ensure that content in the study guide is consistent and accurate. NEW! Updated content and learning activities reflect the revisions in Gould's Pathophysiology for the Health Professions, 7th Edition.

This book summarizes the most recent data on the molecular and cellular mechanisms which determine the unique properties of nerve cells - their ability to differentiate, establish connections to each other, and to form the nervous system with its immense capability for receiving, analysing, and storing information about our external and internal world. The key role of calcium ions in this process is particularly explored, along with nervous system function in aging and neural pathology. The author, based at a high-profile research unit in the Ukraine, is able to draw on significant new research which has not been widely published. Plasticity in nerve cell function will be of interest to researchers and research students in the fields of neurophysiology, cellular physiology, biophysics, and neurochemistry in particular. It will also be of relevance to researchers and medical doctors interested in neuropathology and aging.

This is the first volume in a series on membrane protein transfer. Membrane protein transport underlies the topological disposition of many proteins within cells and it is this disposition that allows for the co-ordination of the central cellular processes, such as metabolism.

Despite extensive physiological, biochemical, and structural studies, the mechanisms of muscle contraction operating in living muscle fibres are still not clearly understood. This book aims to describe and assess various experimental methods currently used in the field of muscle research. For
each method discussed, there is a comprehensive description of its advantages, problems, and limitations. Each chapter also contains a summary of the central results to have been obtained using each method. Comprehensively written by experts in their respective fields, this book will be of interest
to all investigators in muscle physiology.

How can we optimize a bedridden patient s mattress? How can we make a passenger seat on a long distance flight or ride more comfortable? What qualities should a runner s shoes have? To objectively address such questions using engineering and scientific methods, adequate virtual human body models for use in computer simulation of loading scenarios are required. The authors have developed a novel method incorporating subject studies, magnetic resonance imaging, 3D-CAD-reconstruction, continuum mechanics, material theory and the finite element method. The focus is laid upon the mechanical "in vivo"-characterization of human soft tissue, which is indispensable for simulating its mechanical interaction with, for example, medical bedding or automotive and airplane seating systems. Using the examples of arbitrary body support systems, the presented approach provides visual insight into simulated internal mechanical body tissue stress and strain, with the goal of biomechanical optimization of body support systems. This book is intended for engineers, manufacturers and physicians and also provides students with guidance in solving problems related to support system optimization.

"

The first step on your path to success... Foundation in Kinesiology and Biomechanics and Kinesiology in Action work together to create a complete learning experience that builds the foundational knowledge you need to take the next step in your education. A reader friendly text, full-color videos and interactive exercises guide you every step of the way, making an often complex subject easier to understand and apply. Text Foundation in Kinesiology and Biomechanics Develop the must-have knowledge you need of basic joint structure and muscle action and their normal and pathologic functions. You'll focus on the science behind muscle function and movement and how groups of muscle together can contribute to function or dysfunction. This evidence-based approach prepares you to explore the principles of rehabilitation that facilitate movement, strength, and mobility. KinesiologyinAction.com This interactive online program guides you step by step through an immersive multimedia experience that tracks your progress until you've mastered the concepts and are ready to apply them in practice. An access code inside new, printed texts unlocks Kinesiology in Action. Learn more. Visit www.KinesiologyinAction.com

An NRC Handelsblad Book of the Year "Offers rich discussions of olfactory perception, the conscious and subconscious impacts of smell on behavior and emotion." -Science Decades of cognition research have shown that external stimuli "spark" neural patterns in particular regions of the brain. We think of the brain as a space we can map: here it responds to faces, there it perceives a sensation. But the sense of smell-only recently attracting broader attention in neuroscience-doesn't work this way. So what does the nose tell the brain, and how does the brain understand it? A. S. Barwich turned to experts in neuroscience, psychology, chemistry, and perfumery in an effort to understand the mechanics and meaning of odors. She discovered that scents are often fickle, and do not line up with well-defined neural regions. Upending existing theories of perception, Smellosophy offers a new model for understanding how the brain senses and processes odors. "A beguiling analysis of olfactory experience that is fast becoming a core reference work in the field." -Irish Times "Lively, authoritative...Aims to rehabilitate smell's neglected and marginalized status." -Wall Street Journal "This is a special book...It teaches readers a lot about olfaction. It teaches us even more about what philosophy can be." -Times Literary Supplement