The Handbook of Behavioral Neurobiology series deals with the aspects of neurosciences that have the most direct and immediate bearing on behavior. It presents the most current research available in the specific areas of sensory modalities. This volume explores circadian rhythms.

Describes essential redox biology reactions and concepts in exercise physiology. Defines and critiques how to assess and manipulate key redox parameters in an in vivo human exercise context. Summarizes underlying mechanisms. Provides examples of translationally important research relating to many disease states. Includes an international team of leading experts

The question of ""what is thought"" has intrigued society for ages, yet it is still a puzzle how the human brain can produce a myriad of thoughts and can store seemingly endless memories. All we know is that sensations received from the outside world imprint some sort of "molecular signatures" in neurons - or perhaps synapses - for future retrieval. What are these molecular signatures, and how are they made? How are thoughts generated and stored in neurons? The Biology of Thought explores these issues and proposes a new molecular model that sheds light on the basis of human thought. Step-by-step it describes a new hypothesis for how thought is produced at the micro-level in the brain - right at the neuron.

Despite its many advances, the neurobiology field lacks a comprehensive explanation of the fundamental aspects of thought generation at the neuron level, and its relation to intelligence and memory. Derived from existing research in the field, this book attempts to lay biological foundations for this phenomenon through a novel mechanism termed the ""Molecular-Grid Model"" that may explain how biological electrochemical events occurring at the neuron interact to generate thoughts. The proposed molecular model is a testable hypothesis that hopes to change the way we understand critical brain function, and provides a starting point for major advances in this field that will be of interest to neuroscientists the world over.
*Written to provide a comprehensive coverage of the electro-chemical events that occur at the neuron and how they interact to generate thought
*Provides physiology-based chapters (functional anatomy, neuron physiology, memory) and the molecular mechanisms that may shape thought
*Contains a thorough description of the process by which neurons convert external stimuli to primary thoughts

In this issue of Endocrinology and Metabolism Clinics, guest editors Channa Jayasena and Shalender Bhasin bring their considerable expertise to the topic of Hypogonadism. Provides in-depth reviews on the latest in Hypogonadism. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

A New York Times bestseller and a Book of the Year for the Evening Standard and The Times.

Is getting a little less comfortable the key to living a happier, healthier life?

When journalist Scott Carney came across a picture of a man in his fifties sitting on a glacier in just his underwear, he assumed it must be a hoax. Dutch guru Wim Hof claimed he could control his body temperature using his mind and teach others to do the same. Sceptical, Carney signed up to Hof’s one-week course, not realising that it would be the start of a four-year journey to unlock his own evolutionary potential.

From hyperventilating in a Polish farmhouse to underwater weight training in California, and eventually climbing Mt Kilimanjaro wearing just shorts and running shoes, Carney travelled the world testing out unorthodox methods of body transformation and discovering the science behind them.

In What Doesn’t Kill Us he explains how getting a little less comfortable can help us to unlock our lost evolutionary strength.

Second edition of the only comprehensive and student-friendly introduction to molecular exercise physiology available 12 chapter structure around which a complete single-semester course can be built Explains the concepts of exercise physiology at a molecular level in clear, accessible language and relates them to real practical and applied outcomes Covers applications in both sport and health-related physical activity Includes new chapters on the molecular aspects of exercise and cancer, and exercise and metabolic and cardiovascular diseases Every chapter includes useful features such as learning objectives, summaries, structured guides to further reading, review questions, overviews of work by key researchers and box discussions of important contemporary debates

Second edition of the only comprehensive and student-friendly introduction to molecular exercise physiology available 12 chapter structure around which a complete single-semester course can be built Explains the concepts of exercise physiology at a molecular level in clear, accessible language and relates them to real practical and applied outcomes Covers applications in both sport and health-related physical activity Includes new chapters on the molecular aspects of exercise and cancer, and exercise and metabolic and cardiovascular diseases Every chapter includes useful features such as learning objectives, summaries, structured guides to further reading, review questions, overviews of work by key researchers and box discussions of important contemporary debates

As the worldwide prevalence of morbid obesity among adolescents continues to rise, recent years have seen a large increase in the performance of adolescent bariatric surgery. While surgical intervention often becomes necessary when conservative weight-loss therapies have failed, no standards regarding the post-operative regimen and long-term management of adolescent patients have been established. Thus, the treatment of obesity and its co-morbidities requires a multidisciplinary approach, taking into account epidemiological, clinical, nutritional, and genetic aspects of morbid obesity in the pediatric age group. This volume discusses both conventional therapy and surgical options for morbid obesity in the pediatric age group. In the first part, obesity-related diseases, genetics, and psychological factors are analyzed. The second part focuses on current bariatric surgery procedures, including dietary restrictions and guidelines to prevent nutritional deficiencies common after surgery. Therefore, the book will prove an invaluable resource for pediatricians, surgeons, nutritionists, dieticians, and all other health professionals who treat adolescent obesity.

In sport disciplines such as running, ice skating, bicycling and cross-country skiing the aerodynamic drag force constitutes the major obstacle to overcome. Furthermore, in ski jumping and in various activities involving a ball the aerodynamic lift force comes in addition into action.

This book describes the various sport disciplines on the basis of aerodynamic analysis and also cover the biomechanics part by illustrative performance examples. Such treatment of the underlying physical phenomena of sport activities gives a valuable supplement to existing literature on sport. The reader will also be guided to references which exist for the various topics discussed, so she or he can go into a deeper study of the particular sport activity at wish.

Human footprints provide some of the most emotive and tangible evidence of our ancestors. They provide evidence of stature, presence, behaviour and in the case of early hominin footprints, evidence with respect to the evolution of human gait and foot anatomy. While human footprint sites are rare in the geological record the number of sites around the World has increased in recent years, along with the analytical tools available for their study. The aim of this book is to provide a definitive review of these recent developments with specific reference to the increased availability of three-dimensional digital elevation models of human tracks at many key sites. The book is divided into eight chapters. Following an introduction the second chapter reviews modern field methods in human ichnology focusing on the development of new analytical tools. The third chapter then reviews the major footprint sites around the World including details on several unpublished examples. Chapters then follow on the role of geology in the formation and preservation of tracks, on the inferences that can be made from human tracks and the final chapter explores the application of this work to forensic science. Audience: This volume will be of interest to researchers and students across a wide range of disciplines - sedimentology, archaeology, forensics and palaeoanthropology.

3D Multiscale Physiological Human aims to promote scientific exchange by bringing together overviews and examples of recent scientific and technological advancements across a wide range of research disciplines. As a result, the variety in methodologies and knowledge paradigms are contrasted, revealing potential gaps and opportunities for integration. Chapters have been contributed by selected authors in the relevant domains of tissue engineering, medical image acquisition and processing, visualization, modeling, computer aided diagnosis and knowledge management. The multi-scale and multi-disciplinary research aspects of articulations in humans are highlighted, with a particular emphasis on medical diagnosis and treatment of musculoskeletal diseases and related disorders. The need for multi-scale modalities and multi-disciplinary research is an emerging paradigm in the search for a better biological and medical understanding of the human musculoskeletal system. This is particularly motivated by the increasing socio-economic burden of disability and musculoskeletal diseases, especially in the increasing population of elderly people. Human movement is generated through a complex web of interactions between embedded physiological systems on different spatiotemporal scales, ranging from the molecular to the organ level. Much research is dedicated to the understanding of each of these systems, using methods and modalities tailored for each scale. Nevertheless, combining knowledge from different perspectives opens new venues of scientific thinking and stimulates innovation. Integration of this mosaic of multifaceted data across multiple scales and modalities requires further exploration of methods in simulations and visualization to obtain a comprehensive synthesis. However, this integrative approach cannot be achieved without a broad appreciation for the multiple research disciplines involved.

Subjects in the monograph "Biophysics of the Failing Heart" include state of the art chapters considering major biophysical mechanisms for why hearts responding to acquired or inherited stressors enter into maladaptive processes eventually leading to an inability of the heart to respond efficiently to hemodynamic loads especially during exercise. The chapters describe biophysical techniques that have been applied to determine the triggers for the heart failure process as well as the mechanisms for sustaining the disorders. These techniques include measurements of active and passive mechanical properties and hemodynamics at levels of organization ranging from molecules to hearts beating in situ. Biophysical concepts and approaches are also applied to determination of signaling and signal transduction, energetics, ionic currents, transport processes, electro-chemical and chemo-mechanical coupling. By its emphasis on biophysical aspects of a prevalent clinical condition, the monograph is unique in its perspective and focus. The breadth of information in the chapters all in one place will be of value to clinicians and researchers at all levels. Modern research approaches and clinical understanding of heart failure demands integration of multiple aspects of the disorders. In most cases, combinations of clinician scientists and researchers author the chapters. A main benefit of the book is couched in its didactic approach together with its emphasis on how biophysical concepts and techniques aid in diagnosis and development of new therapies.

"The Biological Action of Physical Medicine: Controlling the Human Body's Information System" challenges the contemporary way of thinking of diagnostics and therapy "from the outside." Drawing on 30 years of independent comprehensive research, this reference provides a universal and scientifically acceptable physiological theory, explaining the mode of action of methods of physical medicine as well as the underlying physiological mechanisms.

Scientific research described in this book explains the universal neurophysiological foundation of all the respective methods, including organ electrodermal diagnostics (OED), thermotherapy (heat, cryostimulation), phototherapy (infrared, ultraviolet, laser), ultrasound therapy, electrotherapy (from transcutaneous electric nerve stimulation to electromagnetic field therapies), magnetotherapy, and mechanical nerve stimulation (acupuncture, reflexive massage, cupping, high-pressure hydrotherapy). A better understanding of physical medicine's modes of action not only insures better clinical results, but also illuminates pain mechanisms and our understanding of the functioning of the nervous system.
Fully explains the important therapeutic modalities of genuine physical medicine as well as the underlying physiological mechanismsShows how to access and control the diagnostic information circulating in the sensory nervous system

This book examines how the growing knowledge of the huge range of protist-, animal-, and plant-bacterial interactions, whether in shared ecosystems or intimate symbioses, is fundamentally altering our understanding of biology. The establishment and maintenance of these interactions and their contributions to the health and survival of all partners relies on continuous cell-to-cell communication between them. This dialogue may be concerned with all aspects of the biology of both partners. The book includes chapters devoted to exploring, explaining, and exposing these dialogues across a broad spectrum of plant and animal eukaryotes to a broad field of biologists. Key Features Explores the nature of the interactions between eukaryotic hosts and their microbial symbionts Examines the links between prostist, animal, and plant evolution and microbial communities Reviews specific taxa and the microbial diversity associated with these taxa Illustrates the role microbes play in the physiology and etiology of several model species Includes chapters by an international team of leading scholars

Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced by the chronic and slow progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently prevalent in the extreme elderly that these disorders can arguably be considered "normal." Aging and Aging-Related Disorders examines the interface between normal and pathological aging, and illustrates how this border can sometimes be diffuse. It explores and illustrates the processes underlying the means by which aging becomes increasingly associated with inappropriate levels of free radical activity and how this can serve as a platform for the progression of age-related diseases. The book provides chapters that examine the interactive relationship between systems in the body that can enhance or sometimes even limit cellular longevity. In addition, specific redox mechanisms in cells are discussed. Another important aspect for aging discussed here is the close relationship between the systems of the body and exposure to environmental influences of oxidative stress that can affect both cellular senescence and a cell's nuclear DNA. What may be even more interesting to note is that these external stressors are not simply confined to illnesses usually associated with aging, but can be evident in maturing and young individuals. A broad range of internationally recognized experts have contributed to this book. Their aim is to successfully highlight emerging knowledge and therapy for the understanding of the basis and development of aging related disorders.

"Modelling Methodology for Physiology and Medicine, Second Edition, "offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modeling methodology that is widely applicable to physiology and medicine. The second edition, which is completely updated and expanded, opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration.

The focus of "Modelling Methodology for Physiology and Medicine, Second Edition, "is the methodology that underpins good modeling practice. It builds upon the idea of an integrated methodology for the development and testing of mathematical models. It covers many specific areas of methodology in which important advances have taken place over recent years and illustrates the application of good methodological practice in key areas of physiology and medicine. It builds on work that the editors have carried out over the past 30 years, working in cooperation with leading practitioners in the field.
Builds upon and enhances the reader's existing knowledge of modeling methodology and practiceEditors are internationally renowned leaders in their respective fieldsProvides an understanding of modeling methodologies that can address real problems in physiology and medicine and achieve results that are beneficial either in advancing research or in providing solutions to clinical problems

'Earthing' introduces readers to the landmark discovery that living in contact with the Earth's natural surface charge - being grounded - naturally discharges and prevents chronic inflammation in the body. This effect has massive health implications because of the well-established link between chronic inflammation and all chronic diseases, including the diseases of ageing and the ageing process itself.

Like many of us, journalist David K. Randall never gave sleep much thought. That is, until he began sleepwalking. One midnight crash into a hallway wall sent him on an investigation into the strange science of sleep. In Dreamland, Randall explores the research that is investigating those dark hours that make up nearly a third of our lives. Taking readers from military battlefields to children s bedrooms, Dreamland shows that sleep isn't as simple as it seems. Why did the results of one sleep study change the bookmakers odds for certain Monday Night Football games? Do women sleep differently than men? And if you happen to kill someone while you are sleepwalking, does that count as murder? This book is a tour of the often odd, sometimes disturbing, and always fascinating things that go on in the peculiar world of sleep. You ll never look at your pillow the same way again."

This new edition now includes case studies. These new examples of the application of the methodologies to the real world of professional sport are invaluable Provides key, comprehensive coverage of physiology testing and guidelines in an area where there are a lot of different protocols used and data interpretation methods employed Presents research and instruction from contributors with a wealth of experience and reputation within the areas

Learn about the human body from the inside out Some people think that knowing about what goes on inside the human body can sap life of its mystery which is too bad for them. Anybody who's ever taken a peak under the hood knows that the human body, and all its various structures and functions, is a realm of awe-inspiring complexity and countless wonders. The dizzying dance of molecule, cell, tissue, organ, muscle, sinew, and bone that we call life can be a thing of breathtaking beauty and humbling perfection. Anatomy & Physiology For Dummies combines anatomical terminology and function so you'll learn not only names and terms but also gain an understanding of how the human body works. Whether you're a student, an aspiring medical, healthcare or fitness professional, or just someone who's curious about the human body and how it works, this book offers you a fun, easy way to get a handle on the basics of anatomy and physiology. * Understand the meaning of terms in anatomy and physiology * Get to know the body's anatomical structures from head to toe * Explore the body's systems and how they interact to keep us alive * Gain insight into how the structures and systems function in sickness and health Written in plain English and packed with beautiful illustrations, Anatomy & Physiology For Dummies is your guide to a fantastic voyage of the human body.

Ecophysiology attempts to clarify the role and importance of physiological processes in the ecological relations of species in their natural habitats. Including blood collection and the measurement of plasma components and hormone levels, the basic principles and methods relevant to any ecophysiological study are covered in this text. Examples are collected from a wide range of vertebrates living in deserts, cold climates and oceans. The book is an introduction to ecophysiology for advanced students, as well as researchers in ecology, biodiversity and conservation.

Our understanding of the genetic and developmental mechanisms underlying scoliosis is rapidly evolving, this timely second edition of The Genetics and Development of Scoliosis is to provide researchers, clinicians, and students with the most current views in this field. This volume brings together leaders in understanding congenital and idiopathic scoliosis to present the current state of research, and to compare the genetic etiology of these conditions, in order to identify potential shared developmental mechanisms. This book will summarize the recent advances in studies of spinal development and how disruptions during embryogenesis in embryonic segmentation can lead to congenital vertebral defects. In addition, recent reports of genetic loci predisposing patients to develop juvenile and adolescent idiopathic scoliosis will be presented, and key clinical features are reviewed. Finally, there will be discussion of how genetic heterogeneity and gene-environment interactions may contribute to congenital scoliosis and isolated vertebral malformations.

Provides students and researchers comprehensive, vital and robust guidelines for clinical sport testing. The new edition provides an increased coverage of special populations compared with the previous edition reflecting the increasing importance of the area Brings together internationally recognised and BASES accredited experts for each section