Written by an experienced and well-respected physician and professor, this new volume, building on the previous volume, Ultrasonic Topographical and Pathotopographical Anatomy, also available from Wiley-Scrivener, presents the ultrasonic topographical and pathotopographical anatomy of the head and neck, offering further detail into these important areas for use by medical professionals. This atlas of topographic and pathotopographic human anatomy is a fundamental and practically important book designed for doctors of all specializations and students of medical schools. Here you can find almost everything that is connected with the topographic and pathotopographic human anatomy, including original graphs of logical structures of topographic anatomy and development of congenital abnormalities, topography of different areas in layers, pathotopography, computer and magnetic resonance imaging (MRI) of topographic and pathotopographic anatomy. Also you can find here new theoretical and practical sections of topographic anatomy developed by the author himself which are published for the first time. They are practically important for mastering the technique of operative interventions and denying possibility of iatrogenic complications during operations. This important new volume will be valuable to physicians, junior physicians, medical residents, lecturers in medicine, and medical students alike, either as a textbook or as a reference. It is a must-have for any physician's library.

This is the definitive reference book on massage as a remedial therapy for sports training and injuries. It covers all practical and theroretical aspects of the subject, ranging from the basics through to the treatment of soft tissue injuries;and it gives guidance on how to work in a support role with medical practitioners treating more serious injury. It offers innovative new ideas like 'working posture and the psychology of injury of treatment. This book goes beyond the conventional idea that massage is just a pleasant luxury, and shows it as a vital component in an athlete's training. The therapy offers effective relief for muscular problems, with practical advice on how to achieve permanant solutions for better performance in sport.

Fundamentals of Pediatric Imaging, Third Edition presents the foremost techniques of pediatric medical image analysis and processing. It includes advanced imaging techniques, neuro applications, and highlights basic anatomy needed to understand this complex specialty. The book introduces the theory and concepts of pediatric digital image analysis and newly revised information on quality and safety topics, imaging modalities, imaging applications, and new discoveries in diseases and treatments. The newly revised edition provides updates in areas of expertise including neurologic, musculoskeletal, cardiac, chest, and GU imaging. Edited by Lane F. Donnelly, MD, recipient of the Society of Pediatric Radiology's 2009 Singleton-Taybi Award, this book is sure to be a prime reference in pediatric medical imagining.

During the long twentieth century, explorers went in unprecedented numbers to the hottest, coldest, and highest points on the globe. Taking us from the Himalayas to Antarctica and beyond, Higher and Colder presents the first history of extreme physiology, the study of the human body at its physical limits. Each chapter explores a seminal question in the history of science, while also showing how the apparently exotic locations and experiments contributed to broader political and social shifts in twentieth-century scientific thinking. Unlike most books on modern biomedicine, Higher and Colder focuses on fieldwork, expeditions, and exploration, and in doing so provides a welcome alternative to laboratory-dominated accounts of the history of modern life sciences. Although this is a book about two male dominated practices--science and exploration--it recovers the stories of women's contributions, sometimes accidentally, and sometimes deliberately, erased.

Dr. Michael Gershon has devoted his career to understanding the human bowel (the stomach, esophagus, small intestine, and colon). His thirty years of research have led to an extraordinary rediscovery: nerve cells in the gut that act as a brain. This "second brain" can control our gut all by itself. Our two brains -- the one in our head and the one in our bowel -- must cooperate. If they do not, then there is chaos in the gut and misery in the head -- everything from "butterflies" to cramps, from diarrhea to constipation. Dr. Gershon's work has led to radical new understandings about a wide range of gastrointestinal problems including gastroenteritis, nervous stomach, and irritable bowel syndrome. The Second Brain represents a quantum leap in medical knowledge and is already benefiting patients whose symptoms were previously dismissed as neurotic or "it's all in your head."

Second edition of the only comprehensive and student-friendly introduction to molecular exercise physiology available 12 chapter structure around which a complete single-semester course can be built Explains the concepts of exercise physiology at a molecular level in clear, accessible language and relates them to real practical and applied outcomes Covers applications in both sport and health-related physical activity Includes new chapters on the molecular aspects of exercise and cancer, and exercise and metabolic and cardiovascular diseases Every chapter includes useful features such as learning objectives, summaries, structured guides to further reading, review questions, overviews of work by key researchers and box discussions of important contemporary debates

This book provides an innovative and comprehensive overview of the relationship between lung and exercise, both in healthy, active subjects and in subjects with chronic respiratory diseases. It investigates in detail the central role of the lungs during exercise and illustrates the impact of respiratory impairment due to both acute and chronic lung diseases on performance. Further, the book presents the latest evidence-based findings, which confirm that exercise is an effective and safe form of prevention and rehabilitation in respiratory diseases. The first section describes the changes in the respiratory system during exercise and the contribution of respiration to exercise, while readers will learn how to perform a respiratory assessment in the second section. The third section addresses a broad range of chronic respiratory diseases and the (in)ability of those affected to play sports and perform exercise, thus providing a basis for individual assessments. The last two sections focus on respiratory training, rehabilitation and the relationship between respiration and the environment, e.g. in high-altitude and underwater sports. The book will appeal to a wide readership, including pulmonologists, sport medicine physicians, physiotherapists and trainers, as well as instructors and students in exercise science.

This new volume in the Subcellular Biochemistry series will focus on the biochemistry and cellular biology of aging processes in human cells. The chapters will be written by experts in their respective fields and will focus on a number of the current key areas of research in subcellular aging research. Main topics for discussion are mitochondrial aging, protein homeostasis and aging and the genetic processes that are involved in aging. There will also be chapters that are dedicated to the study of the roles of a variety of vitamins and minerals on aging and a number of other external factors (microbiological, ROS, inflammation, nutrition). This book will provide the reader with a state of the art overview of the subcellular aging field. This book will be published in cooperation with a second volume that will discuss the translation of the cell biology of aging to a more clinical setting and it is hoped that the combination of these two volumes will bring a deeper understanding of the links between the cell and the body during aging.

Throughout the world, cardiovascular diseases associated with ischemic and reperfusion organ injuries are among the main factors of human mortality. Hence, the analysis of mechanisms responsible for these injuries and the development of approaches to their prevention and treatment present a pressing problem for specialists in biology and medicine.

This book is based on firsthand experience gained by the author and her research team during many years of experimental studies, supported by the analysis of abundant literature published between 1970 and 1999. It deals with the comparative assessment of ischemic and reperfusion injuries and their mechanisms in vitally important organs differing in their sensitivity to oxygen deficiency, metabolic activity, and provision with radical-generating and antioxidant system. A distinctive feature of the monograph, compared to previous studies in this field, is that attention is focused on the role of free-radical reactions, their place among other damaging factors (disturbances of energy metabolism, intensification of lipolysis and phospholipolysis, etc.), a detailed analysis of mechanisms responsible for the formation of free radicals during ischemia (the roles of electron transport pathways, radical-generating enzymes, macrophages, endothelial cells, etc, ), and a general review of modern methods of antiradical and antiischemic therapy. None of the books published to date is characterized by such an approach to the problem.

Problems of Living: Perspectives from Philosophy, Psychiatry, and Cognitive-Affective Science addresses philosophical questions related to problems of living, including questions about the nature of the brain-mind, reason and emotion, happiness and suffering, goodness and truth, and the meaning of life. It draws on critical, pragmatic, and embodied realism as well as moral naturalism, and brings arguments from metaphysics, epistemology, and ethics together with data from cognitive-affective science. This multidisciplinary integrated approach provides a novel framework for considering not only the nature of mental disorders, but also broader issues in mental health, such as finding pleasure and purpose in life.

This textbook integrates the classic fields of mechanics-statics, dynamics, and strength of materials-using examples from biology and medicine. The book is excellent for teaching either undergraduates in biomedical engineering programs or health care professionals studying biomechanics at the graduate level. Extensively revised from a successful third edition, Fundamentals of Biomechanics features a wealth of clear illustrations, numerous worked examples, and many problem sets. The book provides the quantitative perspective missing from more descriptive texts, without requiring an advanced background in mathematics. It will be welcomed for use in courses such as biomechanics and orthopedics, rehabilitation and industrial engineering, and occupational or sports medicine. This book: Introduces the fundamental concepts, principles, and methods that must be understood to begin the study of biomechanics Reinforces basic principles of biomechanics with repetitive exercises in class and homework assignments given throughout the textbook Includes over 100 new problem sets with solutions and illustrations

Successfully learn to apply dental anatomy to the practice of dentistry with Wheeler's Dental Anatomy, Physiology, and Occlusion, 11th Edition. Updated and visually enhanced, the eleventh edition of this market-leading dental text expands its focus on clinical applications and includes dozens of online 360-degree and 3-D tooth animations to give you an unparalleled view of dentitions, pulp formation, the sequence of eruptions, and countless clinical considerations. Every text purchase also comes with access to the companion ExpertConsult website - where you can reference the entire text electronically as well as engage with a wealth of learning activities, animations, and hands-on resources to better understand and retain the information covered in your text. In all, this proven learning package offers all the up-to-date information, best practices, and tools to prepare you for the dental anatomy and occlusion section of the exams and ensure long-term clinical success. More than 800 full-color images include detailed, well-labeled anatomical illustrations as well as clinical photographs. Bolded key terms draw students' attention to essential terminology. Practical appendices include Review of Tooth Morphology with a concise review of tooth development from in utero to adolescence to adulthood; and Tooth Traits of the Permanent Dentition with tables for each tooth providing detailed information such as tooth notation, dimensions, position of proximal contacts, heights, and curvatures. 360-degree virtual reality and 3-D animations on Expert Consult help students refine their skills in tooth identification and examination. Step-by-step videos on Expert Consult demonstrate occlusal adjustments. Labeling exercises challenge students to identify tooth structures and facial anatomy with drag-and-drop labels. Chapter on clinical applications includes practical applications and case studies to prepare students for exams. Topics include root planing and scaling; extraction techniques and forces; relationship of fillings to pulp form and enamel form; and occlusal adjustment of premature occlusal contacts and arch form in relationship to bite splint designs. NEW! Learning objectives and pre-test questions at the start of every chapter focus students' attention on the knowledge and critical thinking expectations for each chapter. NEW! Full-color images have replaced many of the black and white images to give students a more vivid picture of clinical situations and procedures. NEW! Updated information incorporates new research and visuals to ensure students are equipped with the latest best practices. NEW! Access to the companion Expert Consult website includes hands-on exercises, animations, videos, quizzes, exams, and more to round out students' learning experience and help ensure their ability to apply book content.

The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel "myokines" that might act as new therapeutic agents in the future.

Providing the ocular anatomy and physiology content needed for a thorough comprehension of this complex field, Clinical Anatomy and Physiology of the Visual System, 4th Edition, offers a solid foundation for recognizing and understanding specific clinical situations and how they relate to anatomic structure. This concise, well-referenced resource covers the clinical anatomy of the eye, its adnexa and visual pathways, and histologic information-the information you need for success in coursework, certification exams, and clinical practice. Features vivid, full-color illustrations that help you visualize the clinical anatomy of the eye along with the cellular physiology behind diseases and disorders of the visual system. Emphasizes clinical application throughout, helping you better understand the processes that occur in disease and dysfunction. Clinical Comment sections offer a unique focus on clinical situations, conditions, diseases, and treatments. Contains new OCT, OCTA, MRI, and CT images that demonstrate clinical views of ocular anatomy. OCT technology is incorporated to describe the retinal layers, newly described anatomical components of the vitreous, corneal and anterior chamber angle anatomy, and the choroidal and retinal vasculature. Covers current topics such as genes essential in eye development, scleral and choroidal changes occurring with myopia progression, limbal stem cells, age-related macular degeneration and VEGF therapies, and microinvasive glaucoma surgical procedures. Includes updated concepts and terminology: Edinger Westfall preganglionic cells, sensory innervation to the cornea, knees of Wilbrand, intrinsically photosensitive retinal ganglion cells, and more. Provides expert coverage by a practicing optometrist, giving you a practical framework for recognizing and understanding clinical situations, problems, and treatments. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Air temperature alone is not an adequate indication of environmental warmth. Wind, sunshine and humidity are also important. The notion that all these factors might be combined into a single figure indicating warmth is attractive. In this 1972 monograph, the problem of constructing such an index of heat stress is examined from a theoretical point of view. The approach involves a step-by-step examination of the physical principles which govern heat exchange at the skin surface. Mathematical terms are carefully defined and the physical concepts explained and illustrated. A great deal of information has been culled form specialist reports and is brought together and assessed critically. Although it is an older work, this book will continue to be of interest to all concerned with advancements in thermal physiology.

This 1978 volume contains papers from contributors to the Third International Conference on Comparative physiology. The Conference selected particular areas for examination. In the first section of this volume the problems of how animals can take up water vapour from the atmosphere are considered as well as advances in studies of how water movements across epithelia are generated by solute movements. The second section deals with how a wide variety of animals, both invertebrate and vertebrate, living under stress in ionically unbalanced environments cope with the unusual difficulties of ionic regulation. In the final section biologists and physicists examine the role of fluid mechanics in biology. Both the theoretical basis of the hydrodynamics and aerodynamics and the biological investigations on the variety of fluid flows encountered inside and around organisms are presented.

A classic reborn for its Golden Anniversary.

Now celebrating its 50 years in print, this text has held onto the foundation of its great success, while also being re-invented for today's audience. The focus of this text remains the practical instruction of functional anatomy in order to quickly, and convincingly, guide readers to its use in professional performance. This text is filled with modern applications that will show your students the relevance of foundational material to their future careers.

An all-new author team of expert instructors Peggy Houglum and Dolores Bertoti, a brand-new, full-color design, and new learning and teaching resources online at DavisPlus all make the field's gold standard more valuable than ever as it prepares readers to apply theory to clinical practice.

Since the first gap junction protein (connexin) was cloned over a decade ago, more than a dozen connexin genes have been cloned. Consequently, a wealth of information on the molecular basis of gap junctional communication has been accumulated. This book pays tribute to this exciting era in the history of cell communication research by documenting the great strides made in this field as a result of the merging of biophysics and molecular biology, two of the most powerful approaches to studying the molecular basis of membrane channel behavior. Twenty-eight comprehensive chapters, authored by internationally recognized leaders in the field, discuss the biophysical, physiological, and molecular characteristics of cell-to-cell communication via gap junctions. Key aspects of molecular structure, formation, gating, conductance, and permeability of vertebrate and invertebrate gap junction channels are highlighted. In addition, a number of chapters focus on recent discoveries that implicate connexin mutations and alterations of gap junctional communication in the pathogenesis of several diseases, including the X-linked Charcot-Marie-Tooth demyelinating disease, some forms of inherited sensorineural deafness, malignant transformation, cardiac malformations and arrhythmia, eye lens cataract, and Chagas disease.

Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila's value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases. The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases.

A study of mast cells and basophils, designed for the use of immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.

This book is an essential handbook on bisphosphonates, the most widely used new class of drugs for osteoporosis therapy. It reviews basic physiology in addition to the indications and adverse reactions of these drugs. Bisphosphonates in Bone Disease, 4E, discusses the compounds' chemistry, mechanisms of action, and animal toxicology before presenting a clinical picture of the diseases treated by bisphosphonates. The book provides a table listing the trade names of the commercially available bisphosphonates, registered indications, and the available forms for various countries. The revised Fourth Edition contains approximately 50% new material, including information on all of the latest drugs.
* The revised fourth edition contains approximately 50% new material
* Includes information on all the latest drugs

Contents:
1. Cell Membranes, Epithelial Barriers and Drug Absorption 2. Parenteral Drug Delivery 3. Drug Delivery to the Oral Cavity or Mouth 4. Oesophageal Transit 5. The Stomach 6. Drug Absorption from the Small Intestine 7. Drug Delivery to the Large Intestine and Rectum 8. Transdermal Drug Delivery 9. Nasal Drug Delivery 10. Pulmonary Drug Delivery 11. Ocular Drug Delivery 12. Vaginal and Intrauterine Drug Delivery.

When we walk, drive a car, or fly an airplane, visual motion is used to control and guide our movement. Optic flow describes the characteristic pattern of visual motion that arises in these situations. This book is the first to take an in-depth look at the neuronal processing strategies that underlie the brain's ability to analyze and use optic flow for the control of self-motion. It does so in a variety of species which use optic flow in different behavioral contexts. The spectrum ranges from flying insects to birds, higher mammals and man. The contributions cover physiological and behavioral studies as well as computational models. Neuronal Processing of Optic Flow provides an authoritative and comprehensive overview of the current state of research on this topic written by a group of authors who have made essential contributions to shaping this field of research over the last ten years.
Key Features
* Provides the first detailed overview of the analysis of complex visual motion patterns in the brain
* Includes physiological, behavioral, and computational aspects of optic flow processing
* Highlights similarities and differences between different animal species and behavioral tasks
* Covers human patients with visual motion deficits
* Enhances the reader's understanding with many illustrations

G protein-coupled receptors (GPCRs) are a large protein family of transmembrane receptors vital in dictating cellular responses. GPCRs are involved in many diseases, but are also the target of around half of all modern medicinal drugs. "Shifting Paradigms in G Protein Coupled Receptors" takes a look at the way GPCRs are examined today, how they react, how their mutations lead to disease, and the many ways in which they can be screened for compounds that modulate them. Chemists, pharmacologists, and biologists will find essential information in this comprehensive reference.

With a wealth of sound practical advice, from the authors' years of extensive experience, this book will be invaluable for all those prescribing aerobic exercise programmes for cardiovascular health including: general practitioners, physiotherapists, nurses, exercise instructors and advisors.Covers traditional and contemporary approaches Many easy-to-use charts for the calculation of exercise intensities and aerobic exercise programmes Well referenced and thoroughly tested