This monograph is dedicated to the lives and scientific achievements of the physiology pioneers Warren and Margaret Lewis. Their story spans the first half of the 20th century, from their respective educations through early, independent research to joint research from 1910 to 1955. Among the numerous developments they initiated, were the discovery of pinocytosis, the beginnings of video microscopy and the development of the first mammalian tissue cultures. Their research expanded the theoretical knowledge of cell structure and function. On a more practical level, they advanced many laboratory methods, like the first recipes for culture media. The text is beautifully enriched with personal anecdotes about their lives. This is the story of two scientific pioneers in the context of early 20th century biology and physiology. It is an inspiration for senior and aspiring researchers.

This book offers an ecological conceptualisation of physical literacy. Re-embracing our ancestry as hunter gatherers we gain a new appreciation and understanding of the importance of play, not only in terms of how children learn, but also in showing us as educators how we can lay the foundations for lifelong physical activity. The concept of physical literacy has been recognised and understood throughout history by different communities across the globe. Today, as governments grapple with the multiple challenges of urban life in the 21st century, we can learn from our forebears how to put play at the centre of children's learning in order to build a more enduring physically active society. This book examines contemporary pedagogical approaches, such as constraints-led teaching, nonlinear pedagogy and the athletic skills model, which are underpinned by the theoretical framework of Ecological Dynamics. It is suggested that through careful design, these models, aimed at children, as well as young athletes, can (i) encourage play and facilitate physical activity and motor learning in children of different ages, providing them with the foundational skills needed for leading active lives; and (ii), develop young athletes in elite sports programmes in an ethical, enriching and supportive manner. Through this text, scientists, academics and practitioners in the sub-disciplines of motor learning and motor development, physical education, sports pedagogy and physical activity and exercise domains will better understand how to design programmes that encourage play and thereby develop the movement skills, self-regulating capacities, motivation and proficiency of people, so that they can move skilfully, effectively and efficiently while negotiating changes throughout the human lifespan.

During field and court-based sports, players are continually required to perceive their environment within a match and select and perform the most appropriate action to achieve their immediate goal within that match instance. This ability is commonly known as agility, considered a vital quality in such sports and may incorporate a variety of locomotion and instantaneous actions. Multidirectional speed is a global term to describe the competency and capacity to perform such actions, to accelerate, decelerate, change direction and ultimately maintain speed in multiple directions and movements within the context of sports specific scenarios, encompassing many of these agility, speed, and related qualities. Multidirectional speed in sport depends on a multitude of factors including perceptual-cognitive abilities, physical qualities, and the technical ability to perform the abovementioned actions. Multidirectional Speed in Sport: Research to Application reviews the science of multidirectional speed and translates this information into real-world application in order to provide a resource for practitioners to develop multidirectional speed with athletes, bringing together knowledge from a wealth of world-leading researchers and applied practitioners in the area of 'speed and agility' to provide a complete resource to assist practitioners in designing effective multidirectional speed development programmes. This text is critical reading for undergraduate and graduate sports science students, all individuals involved in training athletes (e.g., coaches, physiotherapists, athletic trainers) along with researchers in the field of sports science and sports medicine.

Essentials of Neuromodulation describes the application of neuromodulation for aesthetic purposes. Detailed for readers are all essential aspects of neuromodulation treatment, including how to best safeguard patients. This volume provides an increased anatomical understanding of the injection anatomy within the face in an effort to focus on standard of care and set an industry standard in cosmetic injectables. Given the highly specialized training required for this skill, it details the history as well as the mechanism of action for each FDA-approved neuromodulating drug on the market. Unique anatomical renderings by medical artist Kevin Cease provide accurate and detailed anatomy to correlate beautifully with the content. With before, during, and after photos of more than 20 models and written detailed descriptions, diagrams, tables, and charts, all types of learners with every style of learning will benefit from this one-of-a-kind book. This book is a stepping stone for in-depth knowledge into this specialty field and begin to set the standard for entrance into the practice of aesthetics.

Science and technology has been used more and more in the last few decades to gain advantage over competitors. Quite often, however, the actual science involved is not published because a suitable journal cannot be found. The Engineering of Sport brings together work from a very diverse range of subjects including Engineering, Physics, Materials and Biomechanics.

The Engineering of Sport represent work which was represented at the 1st International Conference on the Engineering of Sport held in Sheffield, UK in July 1996. Many sports were represented and the material covered split into nine topics covering aerodynamics, biomechanics, design, dynamics, instrumentation, materials, mechanics, modelling, motion analysis, and vibrations. It should be of interest to specialists in all areas of sports research.

This work offers succinct, medically-oriented coverage of biochemistry, examining biologically important materials and presenting the properties of nucleic acids as well as nucleic acid metabolism. Each metabolic process is integrated in a review of overall energy metabolism, diabetes and starvation. A solutions manual is available to instructors only.

The maintenance of arterial blood pressure and the distribution of blood flow to the various organs of the body depends on the control of the pumping action of the heart and of the resistance of the vascular beds in the individual organs in accordance with their metabolic needs. These controls are achieved through the integrated actions of circulat ing hormones, humoral factors that are synthesized and released in the heart and blood vessels, and the autonomic nervous system. The heart, however, is not only the target for the direct and indirect actions of a number of hormones and humoral factors, it is also an endocrine organ in the traditional sense, synthesizing and secreting into the circulation chemical factors that act at distant sites. In this treatise, Hormones and the Heart in Health and Disease, we interpret "endocrinology" broadly and consider traditional hormones as well as autocoids that are secreted by the heart or that act on it. In this overview, the relevant chapters are indicated in parentheses. The discovery of atrial natriuretic peptide (ANP; atrial natriuretic factor, ANF) in the 1980s indicated that the heart does indeed function as an endocrine organ in the classic sense. ANP (Chapter I) is synthesized in the heart and secreted into the circulation for actions on the kidney, where it is a potent natriuretic agent, and on the vasculature, where it causes vasodilation. ANP can also affect myocardial contractility."

Quantitative ultrasound (QUS) of bone is a relatively recent research field. The research community is steadily growing, with interdisciplinary branches in acoustics, medical imaging, biomechanics, biomedical engineering, applied mathematics, bone biology and clinical sciences, resulting in significant achievements in new ultrasound technologies to measure bone, as well as models to elucidate the interaction and the propagation of ultrasonic wave in complex bone structures. Hundreds of articles published in specialists journals are accessible from the Web and from electronic libraries. However, no compilation and synthesis of the most recent and significant research exist. The only book on QUS of bone has been published in 1999 at a time when the propagation mechanisms of ultrasound in bone were still largely unknown and the technology was immature. The research community has now reached a critical size, special sessions are organized in major international meetings (e.g., at the World Congress of Biomechanics, the annual meetings of the Acoustical Society of America, International Bone Densitometry Workshop, etc...). Consequently, the time has come for a completely up to date, comprehensive review of the topic. The book will offer the most recent experimental results and theoretical concepts developed so far and is intended for researchers, graduate or undergraduate students, engineers, and clinicians who are involved in the field. The central part of the book covers the physics of ultrasound propagation in bone. Our goal is to give the reader an extensive view of the mathematical and numerical models as an aid to understand the QUS potential and the types of variables that can be determined by QUS in order to characterize bone strength. The propagation of sound in bone is still subject of intensive research. Different models have been proposed (for example, the Biot theory of poroealasticity and the theory of scattering have been used to describe wave propagation in cancellous bone, whereas propagation in cortical bone falls in the scope of guided waves theories). An extensive review of the models has not been published so far. We intend in this book to present in details the models that are used to solve the direct problem and strategies that are currently developed to address the inverse problem. This will include analytical theories and numerical approaches that have grown exponentially in recent years. Most recent experimental findings and technological developments will also be comprehensively reviewed.

The volume Appetite Control provides a comprehensive description of the mechanisms controlling food intake, and thereby energy balance, in the mammalian organism. During the last decade, research in this area has produced a remarkable wealth of information and has characterized the function of numerous peptides, transmitters, and receptors in appetite control. Dysfunction of these circuits leads to obesity, a growing health concern. However, the plethora of mechanistic information is in marked contrasts to an almost complete lack of anti-obesity drugs that meet the safety standards required for the chronic therapy of morbid obesity. Consequently, ongoing research aims to identify additional targets and agents for a pharmacological intervention. Thus, the mechanisms of appetite control as well as all agents interfering with its control are of considerable practical interest.

The authors of the volume are distinguished scientists who are leading experts in the field, and who have contributed important, original data to our understanding of the mechanisms of appetite control. They have quite different scientific backgrounds and, together, they represent all relevant disciplines. Thereby, the topics are presented from different points of view, not exclusively from that of pharmacology and neuroendocrinology. Thus, the volume addresses all scientists who are interested in the field of obesity research and the pathophysiology of appetite control."

This important monograph summarizes a comprehensive study on the maturation of walking in normal children. Research, undertaken at one of the world's leading gait analysis centers, involved over 400 studies on a total of nearly 300 children in ten age-groups from one to seven years. Data are presented on anthropometric measurements; tests of developmental progress; time/distance parameters such as stride length and walking velocity; twelve joint angles on each side measured throughout the gait cycle; dynamic electromyography of phasic activity in seven lower-extremity muscle groups; and force measurements including vertical force, fore/aft shear, medial/lateral shear and torque. At each age, composite joint-angle graphs and time/distance parameters are brought together with film tracings of a representative child in that age group. In addition, advanced methods of statistical analysis have been applied to the joint-angle data to define prediction regions within which ninety-five percent of normal children should lie throughout the gait cycle. Finally, a 'decision tree' is presented from which a fitted age can be inferred for a subject based on non-age-specific data gathered in a motion analysis lab. Practical applications are demonstrated in a chapter devoted to two case studies.

Every football training session and match should begin with a warm-up in order to improve performance and reduce the risk of injuries. Warm-up in Football provides scientific evidence for the effect of warming up and describes how performance is closely related to muscle temperature. Furthermore, the book explains how the right warm-up prior to a match and at halftime improves the outcome in football. This book provides a basic understanding of the value of warming up and presents a significant number of warm-up programs that can be used whether you are training professional, amateur or youth players. The warm-up programs and exercises are tailored to different training and match situations both on and off the pitch. Highlights from the book include: * New, inspiring and effective ways of warm-up for training. * Warm-up programs before matches. * Warm-up programs to improve performance at the start of the second half. Warm-up in Football is critical reading for all who have an interest in the coaching and physiology of football.

Studies over the past decade have continued to bring tremendous advances to our understanding of bone biology. New pathways have been discovered and expanded our knowledge of the ways in which genes and gene products affect bone cells and thereby bone mass and bone strength. In Bone Research Protocols, Second Edition, expert researchers in the field detail many methods commonly used to study bone biology. Focusing mainly on in vitro methods, this volume gives techniques for isolation, culture and functional analysis of all bone cell types and details a range of imaging methods, including light and ultrastructural microscopy and live cell imaging. Some important in vivo techniques are included, such as analysis of bone resorption and imaging using X rays, fluorescent or luminescent techniques. Methods for study of proteins and nucleic acid are included and methods for analysis of bone composition, measurement of bone strength, and response to mechanical stimulation are described. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Bone Research Protocols, Second Edition seeks to aid scientists in the bone field to establish new techniques in their laboratories.

This accessible work is the first in more than seventy-five years to discuss the many roles of adrenaline in regulating the "inner world" of the body. David S. Goldstein, an international authority and award-winning teacher, introduces new concepts concerning the nature of stress and distress across the body's regulatory systems. Discussing how the body's stress systems are coordinated, and how stress, by means of adrenaline, may affect the development, manifestations, and outcomes of chronic diseases, Goldstein challenges researchers and clinicians to use scientific integrative medicine to develop new ways to treat, prevent, and palliate disease.

Goldstein explains why a former attorney general with Parkinson disease has a tendency to faint, why young astronauts in excellent physical shape cannot stand up when reexposed to Earth's gravity, why professional football players can collapse and die of heat shock during summer training camp, and why baseball players spit so much.

Adrenaline and the Inner World is designed to supplement academic coursework in psychology, psychiatry, endocrinology, cardiology, complementary and alternative medicine, physiology, and biochemistry. It includes an extensive glossary.

Explore the science behind over 50 pilates exercises to master each movement with confidence and control. DK brings you a ground-breaking health book that will help you revitalise your workouts and perfect your Pilates practice, by understanding the muscle action, breathwork and techniques required, every step of the way. Did you know that performing Pilates can strengthen your core, improve flexibility and posture, and help to reduce stress and anxiety at the same time? Backed by scientific research, learn how Pilates exercises benefit every system in the body. Science of Pilates reveals the facts with annotated artworks that show the mechanics, the angles, how your blood flow and respiration are affected, the key muscle and joint actions working below the surface of each exercise, safe alignment, and much more! Go on a journey of self-discovery to explore: - Specially commissioned CGI artworks depict all the main Pilates exercises with variations that add or reduce challenge. - Artworks detail the mechanics of each exercise, correct body posture, the muscles involved and how they engage to perform movements. - Illustrations featuring colour-coding to highlight how the muscles, ligaments, and joints engage, stretch, and relax to perform each exercise. - Pilates programmes tailored to different abilities and aims. - Suggested practices with a progressive increase in challenge over weeks and months. - Easy-to-follow infographics help explain the hard science behind why Pilates training is so effective and what beneficial physical adaptations it can bring. Set out to unearth the facts behind the pseudo-science fads, The Science of Pilates is an approachable, entertaining and easy-to read fitness guide for those seeking self-development backed up by solid scientific evidence. The popular question and answer format brings an immediacy to the information provided, and the highly visually illustrations truly bring the science to life in a contemporary and accessible way. At DK, we believe in the power of discovery. So why stop there? If you like Science of Pilates, then why not try Science of Yoga to help you better understand yoga anatomy in order to perfect your practice and poses, or Science of Strength Training to support you in your journey to build you strongest body. Complete the collection today!

Employing a multidisciplinary approach to phospholipid research, this work catalogues the current knowledge of this class of molecules and details the general, chemical, physical and structural properties of phospholipid monolayers and bilayers. Phospholipid applications are also covered.

This volume is a record of the proceedings of a festspiel held to honor Jozef F. Zwislocki for his outstanding contributions to science and to Syracuse University. His contributions to the knowledge of the hydromechanical, neurophysiological, and perceptual mechanisms of the auditory system are truly monumental. In addition, his contributions to the comprehension of the mammalian auditory system include not only landmark ideas, but also many of the experimental findings in psychoacoustics and peripheral auditory physiology that constitute the database which has provided a springboard for research in laboratories throughout the world. His efforts to link physics, biology, and psychophysics to create a basis for our understanding of the nervous system have had an influence that extends far beyond the science of acoustics.
Although the purpose of this conference was to recognize the many achievements of Professor Zwislocki, the spirit of the participants was to honor him in a manner that best characterized his lifetime dedication to research, that is, to report the results of their own work. Consequently, this volume is first and foremost a compilation of scientific papers in the area of sensory research. Some are reports of recent experiments and some present an overview of research efforts extending from the past up to ongoing work. His influence can be recognized in all of the contributions and some explicitly describe the ties between their own work and the germinal ideas planted by him. This volume, in reflecting the rapid progress being made in sensory science and written by those who are making it, is a fitting tribute to Zwislocki, who always stood at the forefront of his science.

The International Society for the Advancement of Kinanthropometry holds a major conference every four years. This volume contains a selection of papers presented at the fourth such event, held at the World Congress on Youth, Leisure and Physical Activity in Brussels. It represents state-of-the-art research in the field of physical development and physical performance with contributions from the UK, Europe, South America, USA and Canada. The papers are divided into four sections covering body composition and growth; physical activity, health and fitness; performance and anthropometry; and growth and performance.

The result of the first Appalachian Conference on neurodynamics, this volume focuses on processing in biological neural networks. How do brain processes become organized during decision making? That is, what are the neural antecedents that determine which course of action is to be pursued? Half of the contributions deal with modelling synapto-dendritic and neural ultrastructural processes; the remainder, with laboratory research findings, often cast in terms of the models. The interchanges at the conference and the ensuing publication also provide a foundation for further meetings. These will address how processes in different brain systems, coactive with the neural residues of experience and with sensory input, determine decisions.

A presentation of the most elementary form of pulsatile flow as an important prerequisite for the study of other flow applications in biological systems. The book provides in a single source a complete treatment of the fluid dynamics of flow with the required mathematics and emphasis on the basis mechanics. The style and level of this book make it accessible to students and researchers in biophysics, biology, medicine, bioengineering and applied mathematics working in theoretical and clinical work on the cardiovascular system, as well as in the design of new instrumentation, medical imaging systems, and artificial organs. With problems and exercises.

This second book of the three-volume collection "Ion Transport in Tumor Biology" helps readers gain comprehensive knowledge of the pathophysiology of cancer. The authors highlight that ion transport proteins, channels and transporters - collectively referred to as the transportome - are significantly involved in the development and progression of cancer. Nearly 90% of malignant tumor diseases originate from epithelial cells, the function of which, for the most part, is based on the transportome. This volume focuses on molecular principles by showing that dysregulated expression and/or function of ion transporters have been correlated with malignancy in the vast majority of tumor diseases. Within the story of the various chapters, the authors line out various malfunctions of the transportome and where they can be found at different stages of the metastatic cascade. The authors describe how the interactions between the tumor cells' transportome and the environment reinforce mesenchymal behaviour of cancer cells and contribute to their uncontrolled proliferation, migration, invasion, intra- and extravasation up to the formation of metastases. As part of a three-volume collection, this book will fascinate members of the active research community, as well as clinicians from the cancer field.

This book provides a state-of-the-art update, as well as perspectives on future directions of research and clinical applications in the implementation of biomechanical and biophysical experimental, theoretical and computational models which are relevant to military medicine. Such experimental and modeling efforts are helpful, on the one hand, in understanding the aetiology, pathophysiology and dynamics of injury development and on the other hand in guiding the development of better equipment and protective gear or devices that should ultimately reduce the prevalence and incidence of injuries or lessen their hazardous effects. The book is useful for military-oriented biomedical engineers and medical physicists, as well as for military physiologists and other medical specialists who are interested in the science and technology implemented in modern investigations of military related injuries.

Probes developments and trends in research and clinical applications of vitamin E, discussing its chemistry and biochemistry and natural occurence in nuts, seeds, whole grains and vegetable and fish-liver oils. The book covers new findings on the role of vitamin E as a biological response modifier.