Focuses on Biology, Pharmacology, and Therapeutic Applications The study and diverse applications of bioactive peptides traverse many sub-disciplines within chemistry, biology, physics, and medicine. Answering a long-standing need, Bioactive Peptides focuses on the biology, pharmacology, and therapeutic applications of endogenous peptide mediators and their analogues. Moving peptide science beyond chemical synthesis strategies and into the realms of peptide biology and therapeutics, it presents the overall contribution that peptide science has made to molecular, cellular, and whole organism biology, while also discussing future targets and therapeutic applications. Beneficial for Experts and Novices Alike Part I provides details of bioactive peptides that interact with common drug targets and analyzes some of the most competitive areas of current research worldwide. While it is widely known that mammalian physiological systems utilize bioactive peptides that have yet to be discovered, other animals provide a rich and valuable source of bioactive peptides. This fascinating area of science is the theme of Part II. Parts III and IV investigate the unique bioactivities of various peptides that are ripe for further exploration. This definitive reference also includes: A detailed description and analysis of a broad range of peptides that interact with G protein-coupled receptors, the quantitatively dominant drug target A discussion of non-ribosomal peptides, which hold promise as sources of endogenous mediators Important examples of common methodologies employed to identify, characterize, and further develop bioactive peptides from a range of natural sources With mounting worldwide interest in their therapeutic potential, bioactive peptides-includ

An understanding of the scientific principles underpinning the learning and execution of fundamental and skilled movements is of central importance in disciplines across the sport and exercise sciences. The second edition of Motor Control, Learning and Development: Instant Notes offers students an accessible, clear and concise introduction to the core concepts of motor behavior, from learning through to developing expertise. Including two brand new chapters on implicit versus explicit learning and motor control and aging, this new edition is fully revised and updated, and covers: definitions, theories and measurements of motor control; information processing, neurological issues and sensory factors in control; theories and stages of motor learning; memory and feedback; the development of fundamental movement skills; and the application of theory to coaching and rehabilitation practice. Highly illustrated and well-formatted, the book allows readers to grasp complex ideas quickly, through learning objectives, research highlights, review questions and activities, and encourages students to deepen their understanding through further reading suggestions. This is important foundational reading for any student taking classes in motor control, learning or behavior or skill acquisition, or a clear and concise reference for any practicing sports coach, physical education teacher or rehabilitation specialist.

This book focuses on the systems biomechanics of bone remodeling that provide a multiscale platform for bone adaptation, spanning the cellular, tissue, and organ levels. The mathematical model explained in each section provides concrete examples of in silico approaches for bone adaptation. It will be immensely useful for readers interested in bone morphology and metabolism and will serve as an effective bridge connecting mechanics, cellular and molecular biology, and medical sciences. These in silico approaches towards exploring the mechanisms by which the functioning of dynamic living systems is established and maintained have potential for facilitating the efforts of graduate students and young researchers pioneering new frontiers of biomechanics.

The groundbreaking science behind the surprising source of good health Stanford University's Justin and Erica Sonnenburg are pioneers in the most exciting and potentially transformative field of human health and wellness, the study of the relationship between our bodies and the trillions of organisms representing thousands of species to which our bodies play host, the microbes we call the microbiota. The Sonnenburgs argue that the microbiota determines in no small part whether we're sick or healthy, fit or obese, sunny or moody-and that the microbiota has always been with us, coevolving with humans and entwining its functions with ours. They show us that humans are really composite organisms with microbial and human parts. But now, because of changes to diet, antibiotic over-use, and over-sterilization, our gut microbiota is facing a "mass extinction event," which may explain the mysterious spike in some of our most troubling modern afflictions, from food allergies to autism, cancer to depression. It doesn't have to be this way. The Good Gut is a groundbreaking work that offers a new plan for health that focuses on how to nourish your microbiota, including recipes and a menu plan. The Sonnenburgs show how we can keep our microbiota off the endangered species list and strengthen the community that inhabits our gut and thereby improve our own health. In this important and timely investigation, they look at safe alternatives to antibiotics; dietary and lifestyle choices to encourage microbial health; the management of the aging microbiota; and the nourishment of your own individual microbiome. Caring for our gut microbes may be the most important health choice we can make.

This is the clearest and most straightforward biomechanics textbook currently available. By breaking down the challenging subject of sport and exercise biomechanics into short thematic sections, it enables students to grasp each topic quickly and easily, and provides lecturers with a flexible resource that they can use to support any introductory course on biomechanics. The book contains a wealth of useful features for teaching and learning, including clear definitions of key terms, lots of applied examples, guides to further reading, and revision questions with worked solutions. It has been significantly expanded to encompass rapidly developing areas, such as sports equipment design and modern optoelectronic motion analysis systems, and it includes a number of new sections that further develop the application of biomechanics in sports performance and injury prevention. A new companion website includes a test bank, downloadable illustrations and, where appropriate, suggestions for learning outcomes and/or lab-based sessions for lecturers. Instant Notes in Sport and Exercise Biomechanics has been an invaluable course companion for thousands of students and lecturers over the last decade. Engaging, direct, and now fully refreshed, it is the only biomechanics textbook you'll ever need.

This well-established and acclaimed textbook introducing the rapidly growing field of nerve and muscle function has been completely revised and updated. Written with undergraduate students in mind, it begins with the fundamental principles demonstrated by the pioneering electrophysiological experiments on cell excitability. This leads to more challenging material recounting recent discoveries from applying modern biochemical, genetic, physiological and biophysical, experimental and mathematical analysis. The resulting interdisciplinary approach conveys a unified contemporary understanding of nerve and skeletal, cardiac and smooth muscle function at the molecular, cellular and systems levels. Emphasis on important strategic experiments throughout clarifies the basis for our current scientific views, highlights the excitement and challenge of biomedical discovery, and suggests directions for future advances. These fundamental ideas are then translated into discussions of related disease conditions and their clinical management. Now including colour illustrations, it is an invaluable text for students of physiology, neuroscience, cell biology and biophysics.

The leading text on human physiology for more than four decades-enhanced by all new video tutorials For more than four decades, Ganong's Review of Medical Physiology has been helping those in the medical field understand human and mammalian physiology. Applauded for its interesting and engagingly written style, Ganong's concisely covers every important topic without sacrificing depth or readability, and delivers more detailed, high-yield information per page than any other similar text or review. Thoroughly updated to reflect the latest research and developments in important areas such as chronic pain, reproductive physiology, and acid-base homeostasis, Ganong's Review of Medical Physiology, Twenty-Sixth Edition incorporates examples from clinical medicine to illustrate important physiologic concepts. Ganong's will prove valuable to students who need a concise review for the USMLE, or physicians who want to keep pace with the ever-changing world of medical physiology. *More than 600 full-color illustrations*Two types of review questions: end-of-chapter and board-style*NEW! Increased number of clinical cases and flow charts*NEW! Video tutorials from the author; high-yield Frequently Asked Question feature with detailed explanations; improved legends that eliminate the need to refer back to the text

Multiscale Biomechanics provides new insights on multiscale static and dynamic behavior of both soft and hard biological tissues, including bone, the intervertebral disk, biological membranes and tendons. The physiological aspects of bones and biological membranes are introduced, along with micromechanical models used to compute mechanical response. A modern account of continuum mechanics of growth and remodeling, generalized continuum models to capture internal lengths scales, and dedicated homogenization methods are provided to help the reader with the necessary theoretical foundations. Topics discussed include multiscale methods for fibrous media based on discrete homogenization, generalized continua constitutive models for bone, and a presentation of recent theoretical and numerical advances. In addition, a refresher on continuum mechanics and more advanced background related to differential geometry, configurational mechanics, mechanics of growth, thermodynamics of open systems and homogenization methods is given in separate chapters. Numerical aspects are treated in detail, and simulations are presented to illustrate models. This book is intended for graduate students and researchers in biomechanics interested in the latest research developments, as well as those who wish to gain insight into the field of biomechanics.

With life expectancy increasing globally, older adults around the world want to live active lifestyles with improved health and higher quality of life. Physiology of Exercise and Healthy Aging, Second Edition, examines the effects of the aging process on the major physiological systems and identifies the positive impacts of physical activity and regular exercise for older adults, including delaying specific diseases and increasing quality of life. Students will be presented with foundational concepts of physiology to understand the structural and functional changes on the major physiological systems throughout the aging process. Physiological responses to acute and chronic exercise are examined, with comprehensive coverage of studies on age-related diseases and other common issues for older adults, including cardiovascular disease, cardiorespiratory fitness, type 2 diabetes, muscle metabolism and strength, osteoporosis, neurophysiology, and arthritis, plus content new to this edition that addresses mental health, pelvic floor issues and incontinence, and sexual activity. Programming recommendations in each chapter translate exercise science into practice, examining the benefits of exercise, contraindicated exercises, and other forms of physical activity beneficial to the aging population. Exercise considerations address the training needs of older adults in three unique groups: average aging adults, frail elderly with special needs, and masters athletes, with expanded content more reflective of today's active seniors. With an emphasis on screening and assessment, coupled with basic principles of exercise and training programs, students will learn to safely administer exercise programs that meet the needs of older adults-in any stage of aging and at various levels of physical activity-to contribute to increased health and quality of life for all. Chapter-opening quotes bring content to life with insights from scientists, fitness professionals, and other experts. Chapter objectives, new to this edition, help readers to understand and apply key concepts. Questions to Consider at the end of each chapter provide tools for reflection, while references direct students to additional reading and opportunities for further learning. An appendix offers easy access to assessments and forms, including a Three-Day Nutritional Assessment form and a Client Report form, preparing readers for professional use in their careers with older adult clients. Physiology of Exercise and Healthy Aging, Second Edition, delivers a thorough discussion of the physiological effects of aging and illustrates the power of exercise as a tool to reduce or offset the effects of aging in order to improve the quality of life enjoyed by our aging population.

Sport, Recovery and Performance is a unique multi-disciplinary collection which examines both the psychological and physiological dimensions to recovery from sport. Including contributions from medicine, neuroscience, psychology and sport science, the book expertly explores the implications for applied and strategic interventions to both retain and stabilize performance, and promote health and well-being. Including chapters written by its leading experts, the book represents an important milestone in this evolving field of study. It covers issues around measuring recovery, the impact of overtraining on sleep and mental health, and addresses topics such as the impact of travel on performance. The book informs not only how managing recovery can improve performance, but also offers insights in how recovery can sustain athletes' physical and mental health. Citing research from a range of individual and team sports, as well as extreme situations and the workplace, this is an important book that will be widely read across the sport sciences.

Enhanced by a new chapter, new illustrations, and new Q&As, Lippincott (R) Illustrated Reviews: Physiology, Second Edition brings physiology clearly into focus, telling the story of who we are; how we live; and, ultimately, how we die. By first identifying organ function and then showing how cells and tissues are designed to fulfill that function, this resource decodes physiology like no other text or review book. Tailored for ease of use and fast content absorption, the book's outline format, visionary artwork, clinical applications, and unit review questions help students master the most essential concepts in physiology, making it perfect for classroom learning and test and boards preparation. A new chapter on erythropoiesis and blood gas transport provides critical information on this key topic. New content on the impact of normal aging on organ function brings the book thoroughly up to date. Review questions with explanations for each system help prepare students for course and board examinations. More than 600 annotated, full-color illustrations-including more than 20 new to this edition-guide readers step by step through complex processes. Overviews and Chapter Summaries set clear goals for topic mastery and reemphasize essential concepts in a coherent framework. Clinical Applications boxes and clinical images encourage readers to apply their knowledge, taking them from the classroom to the bedside. Margin Example Equation boxes and in-text boxes highlight memorable information and keep physiology in a real-world context. Five online animations explain complex concepts in a memorable way. A consistent outline format makes critical information easy to access and assimilate. Cross references and Infolinks to topics are keyed to page headers to expedite location and are also provided for topics in other books in the Lippincott (R) Illustrated Reviews series to help students develop an interdisciplinary grasp of key concepts. Unit-review questions in board-review style test understanding of fundamental concepts as well as the students' ability to draw connections among multiple organ systems. eBook available for purchase. Fast, smart, and convenient, today's eBooks can transform learning. These interactive, fully searchable tools offer 24/7 access on multiple devices, the ability to highlight and share notes, and more

This important new book is the first text on motor learning and control to focus exclusively on the development of movement coordination in children. It is also the first book to bring together in one volume both cognitive and ecological-psychological approaches to the subject. Based on cutting-edge theory and research, the book explores how children develop coordination within three real-world settings:
* everyday behaviour, including studies on spoon use, handwriting and posture
* movement disorder, including studies of perceptual motor behaviour of children with Down's Syndrome and Cerebral Palsy
* sporting activity, including studies of catching and throwing behaviour.
The book therefore makes a unique contribution to our understanding of the development of children. It will be essential reading for all those with a particular interest in movement coordination within the fields of sport science, health science and ergonomics, as well as all psychologists, developmentalists, educators and clinicians working with children.

Why do we eat? Is it instinct, or some other impetus? Despite the necessity of food, anxieties about what and how to eat are widespread in our culture, and scientists and physicians continue to have shifting theories about the phenomenon of appetite and its causes and norms. In Appetite and Its Discontents, Elizabeth A. Williams charts the history of inquiry into appetite between 1750 and 1950, as scientific and medical concepts of appetite shifted alongside developments in physiology, natural history, psychology, and ethology. Williams argues that trust in appetite was undermined in the mid-eighteenth century, when researchers who investigated ingestion and digestion began claiming that science alone could say which ways of eating were healthy and which were not. Tracing nineteenth- and twentieth-century conflicts over the nature of appetite, Williams explores contemporary worries about eating through the lens of science and medicine to show us how appetite--once a matter of personal inclination--became an object of science.

In this issue of Endocrinology and Metabolism Clinics, guest editor Eliza B. Geer brings her considerable expertise to the topic of Patient-Reported Outcomes in Endocrine Diseases. Provides in-depth reviews on the latest updates in Patient-Reported Outcomes in Endocrine Diseases, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

In this forgotten treatise, preserved largely in medieval translations into Arabic and Latin, the greatest medical scientist of antiquity investigates the relationship between conscious and unconscious movements. He looks at the structure of the tongue and the oesophagus, and asks why mental perceptions can have physical effects on the body. Some of his questions still trouble modern scientists, although they would not accept most of his answers. The extensive Introduction and Commentary explain the medical background for non-medical specialists, and discuss the place of this treatise and of anatomy in medieval medicine down to Leonardo da Vinci. As well as being the first English translation of this important work, this is also the first comparative study of medieval translations of the same ancient text, and is based on new editions and collations of all three. The Commentary pays special attention to the linguistic elements involved in making these translations.

First published in 1936, as the second edition of 1933 original, this book was written to provide a radiological study of the digestive tract's anatomy, physiology and pathology. Illustrative figures, detailed appendices and a bibliography are also included. This book will be of value to anyone with an interest in anatomy, physiology and the history of medicine.

Football Biomechanics explores the latest knowledge of this core discipline in sport science across all codes of the sport. Encompassing a variety of styles, including original scientific studies, syntheses of the latest research, and position statements, the text offers readers the most up-to-date and comprehensive reference of the underlying mechanics of high-level football performance. The book is divided into five parts, covering fundamental football actions, the biomechanics of direct free kicks, footwear, biomechanical considerations in skill acquisition and training, and artificial turf. It bridges the gap between theory and practice in a variety of key areas such as: ball kicking mechanics (in soccer and other football codes) ball impact dynamics aerodynamics of ball flight special techniques (such as the 'knuckle ball shot') by world-famous players the efficacy and development of footwear biomechanical and motor performance differences between female and male soccer players artificial turf from an injury and a performance perspective. Made up of contributions from leading experts from around the world, Football Biomechanics is a vital resource for researchers and practitioners working in all football codes, and useful applied reading for any sport science student with an interest in football.

This book presents an overview of the latest theories of affect regulation and focuses on how these theories work in clinical settings and how therapists can be taught to implement them. The notion of teaching and learning will be extended by the theories themselves-the author presents methods of education that enact the theories being taught. The book is divided into eight chapters, each one highlighting a particular structure or related structures of the brain. Suggestions for learning how to clinically apply the neurobiological/neuroanatomical information are offered. What is so unique about this book is that the bulk of the chapters are clinical dialogue, accompanied by neurobiological commentary. Thus, readers can see for themselves, during the course of parts of sessions, just how a "neurobiological outlook" can inform therapeutic understandings of what clients are doing and saying. The result is a very user-friendly learning experience for readers, as they are taken along a journey of understanding various brain systems and how they relate to psychotherapeutic principles. Elegantly bridging the gap between the academic and clinical domains, this book is essential for anyone interested in the application of neurobiological principles to psychotherapy and wishes to learn about neurobiology without feeling overwhelmed or intimidated.

Out of the broad arena of sport science and sport psychology, Roland A. Carlstedt presents a comprehensive collection on the neuroscience and associated psychophysiology that underlies and drives sport performance. Featuring sections ranging from the basics and foundations (anatomy and physiology) to the applied (assessment during competition, training, and mental training), Handbook of Sport Neuroscience and Psychophysiology is the first volume to provide students, researchers, practitioners, and coaches the latest knowledge on the brain, mind-body processes, and psychophysiological responding in the context of sport performance.

Dance has always been an important aspect of all human cultures, and the study of human movement and action has become a topic of increasing relevance over the last decade, bringing dance into the focus of the cognitive sciences. Since the first edition of The Neurocognition of Dance was published, research into the cognitive science of dance has expanded extensively, with the number of scientific studies focusing on dance and dance-related topics in cognitive psychology growing significantly. Featuring three new chapters addressing topics that have become highly relevant to the field in recent years - neuroaesthetics, entrainment, and choreographic cognition - as well as progress in teaching based on novel methods, this comprehensively revised and updated new edition of The Neurocognition of Dance is full of cutting-edge insights from scientists, researchers, and professionals from the world of dance. Also now including online material such as links to video clips, colour images and hands-on material for practical application, this book is an essential companion for students and professionals from fields including dance, cognitive psychology, sport psychology and sport science, movement science, and cognitive robotics.

Strength and power are recognised as key components of human health and performance. Therefore, it is vital for exercise scientists and strength and conditioning practitioners to be able to assess these qualities effectively. Testing methods of these components are often presented as standalone chapters in textbooks which provides the reader with an overview of these aspects. Testing and Evaluation of Strength and Power provides a detailed explanation of testing and evaluation methods for strength and power. The book considers the relationship between the methods of assessment, research on the various approaches to evaluation and how practitioners and researchers can use the information in applied settings. The book provides the reader with a comprehensive overview of methods of strength and power assessment protocols and how they can be used to inform programming. This integrated approach to assessment of strength and power is recommended reading for students on strength and conditioning course and of vital reading to those on specialised courses on strength and power as well as coaches in the fitness testing and strength and conditioning disciplines.

Medicinal Spices and Vegetables from Africa: Therapeutic Potential against Metabolic, Inflammatory, Infectious and Systemic Diseases provides a detailed look at medicinal spices and vegetables that have proven safe-and-effective for consumption and the treatment of diseases, including infectious diseases, cardiovascular disease, and cancer. It provides pharmacological evidence, such as the latest information related to efficacy and safety data, in vitro and in vivo studies, clinical trials, and more, to illustrate the use of these spices and vegetables as both palliative and alternative treatments with the goal of furthering research in this area to produce safer and more effective drugs.

Treatments, Nutraceuticals, Supplements and Herbal Medicine in Neurological Disorders offers readers a comprehensive reference on their potential for treatment in a wide variety of neurological diseases. Spanning various types of these compounds, this broad coverage allows readers to learn about the use of nutraceuticals and botanicals alone, or in combination with, other dietary regimes and/or vitamins and minerals. It covers diseases including Alzheimer’s, Parkinson’s, ALS and MS, and severe neurological conditions including brain injury, stroke, headache and migraine. This volume provides a platform for research on nutraceuticals and botanical agents and on future investigations of these compounds. There are over 600 neurological disorders affecting both the central and peripheral nervous systems, some of which have been treated by nutraceuticals and herbal medicine, hence this is a timely resource on the topics covered.

Biomechanics of Tendons and Ligaments: Tissue Reconstruction looks at the structure and function of tendons and ligaments. Biological and synthetic biomaterials for their reconstruction and regeneration are reviewed, and their biomechanical performance is discussed. Regeneration tendons and ligaments are soft connective tissues which are essential for the biomechanical function of the skeletal system. These tissues are often prone to injuries which can range from repetition and overuse, to tears and ruptures. Understanding the biomechanical properties of ligaments and tendons is essential for their repair and regeneration.