There is a critical need for iron intake during the first period of life. The growing infant requires iron to synthesize hemoglobin and to supply expanding tissues with iron-containing enzymes. A lack of iron will eventually lead to iron deficiency anemia, one of the most common single nutrient deficiencies in the world. Today, detailed information has increased our understanding of iron bioavailability from different dietary sources, uptake mechanisms of iron into the small intestinal mucosa for transport to hepatocytes and erythropoietic cells and subsequent receptor mediated cellular acquisition. Metabolic effects of iron deficiency have also been investigated in several tissues. This comprehensive text integrates recent information and address it from a nutritional perspective. It takes this focus because of the increased knowledge on the interrelationship between iron and other essential nutrients. Specific problems of iron nutriture and oxidant stress in prematurely born infants are also addressed in this informative new text

From women's medicine and the writings of Christine de Pizan to the lives of market and tradeswomen and the idealization of virginity, gender and social status dictated all aspects of women's lives during the middle ages. A cross-disciplinary resource, Women andGender in Medieval Europe examines the daily reality of medieval women from all walks of life in Europe between 450 CE and 1500 CE, i.e., from the fall of the Roman Empire to the discovery of the Americas. Moving beyond biographies of famous noble women of the middles ages, the scope of this important reference work is vast and provides a comprehensive understanding of medieval women's lives and experiences. Masculinity in the middle ages is also addressed to provide important context for understanding women's roles. Entries that range from 250 words to 4,500 words in length thoroughly explore topics in the following areas: * Art and Architecture * Countries, Realms, and Regions * Daily Life * Documentary Sources * Economics * Education and Learning * Gender and Sexuality * Historiography * Law * Literature * Medicine and Science * Music and Dance * Persons * Philosophy * Politics * Political Figures * Religion and Theology * Religious Figures * Social Organization and Status Written by renowned international scholars, Women and Gender in MedievalEurope is the latest in the Routledge Encyclopedias of the Middle Ages. Easily accessible in an A-to-Z format, students, researchers, and scholars will find this outstanding reference work to be an invaluable resource on women in Medieval Europe.

The area of polyamines is presented in this useful, two-volume publication. Basic information describing the role of polyamines in the processes of growth and differentiation is given. Also included are data on the regulation of polyamine biosynthesis and metabolism and their interactions with nucleic acids. Several chapters are devoted to the role of polyamines in various aspects of plant biology, with a special emphasis on their participation in the response of plants to extreme environments. Special attention is given to the use of inhibitors of polyamine biosynthesis as potential antitumor and antiproliferative agents. Additionally, progress in the molecular biology and genetic engineering of genes coding for polyamine biosynthetic enzymes is described. Cancer researchers, biologists, geneticists, biochemists, physiologists, and clinicians will find this volume indispensable.

Gain the hands-on practice needed to understand anatomical structure and function! Anatomy & Physiology Laboratory Manual and eLabs, 11th Edition provides a clear, step-by-step guide to dissection, anatomy identification, and laboratory procedures. The illustrated, print manual contains 55 A&P exercises to be completed in the lab, with guidance including instructions, safety tips, and tear-out worksheets. Online, eight eLab modules enhance your skills with simulated lab experiences in an interactive 3-D environment. From noted educators Kevin Patton and Frank Bell, this laboratory manual provides you with a better understanding of the human body and how it works. Labeling exercises and coloring exercises make it easier to identify and remember critical structures examined in the lab and in lectures. Step-by-step "check-box" dissection instructions with accompanying illustrations and photos cover anatomical models and fresh or preserved specimens - and provide helpful guidance during dissection labs. Tear-out Lab Reports contain checklists, drawing exercises, and questions that help demonstrate your understanding of the labs you have participated in, and also allow instructors to check your progress. 250 illustrations include photos of cat, pig, and mink dissections, photos of various bones, microscopic and common histology slides, and depictions of proper procedures. Complete lists of materials for each exercise provide handy checklists for planning and setting up laboratory activities, allowing for easy and efficient preparation. Modern anatomical imaging techniques, such as computed tomography (CT), magnetic resonance imaging (MRI), and ultrasonography, are introduced to demonstrate how new technologies are changing and shaping health care. Review questions throughout the manual provide tools to reinforce and apply your knowledge of anatomy and function concepts. Eight eLabs improve the laboratory experience in an interactive digital environment. Convenient spiral binding allows for hands-free viewing in the lab setting. Hint boxes provide special tips on handling specimens, using equipment, and managing lab activities. Learning objectives at the beginning of each exercise offer a clear framework for learning. NEW! More photos of various types of bones help you learn skeletal anatomy. NEW! More microscope slide images, including "zooming in" at high-power magnification, help you learn microscopic anatomy. NEW! Updated lab tests align with what is currently in use in today's lab environment. NEW! Thorough revision of all chapters covers the latest anatomy and physiology lab exercises.

In a normal physiological state, several bacteria are present in the human gut that is essential to maintain the normal to healthy gastrointestinal function. Disturbances in this "normal flora" lead to gut inflammation and infection. This volume explores the potential of probiotics, the healthy bacteria, to manage gut-related diseases including gastrointestinal cancers, ulcerative colitis, H. pylori infections, and diarrhea; vaginosis; oral health; airway inflammation; and atopic dermatitis. The concept of designer probiotics, edible vaccines and future scope of research in the field is also presented. The animal models used for studying the benefits of probiotics in gut inflammation are described for beginners.

Introduction to Sports Biomechanics: Analysing Human Movement Patterns is a genuinely accessible and comprehensive guide to all of the biomechanics topics covered in an undergraduate sports and exercise science degree. Now in a fully revised and updated third edition, the book explores both the qualitative and quantitative analysis of human movement, covering the following key topics: Movement patterns - the essence and purpose of sports biomechanics Qualitative analysis of sports movements Sports movement patterns and the geometry of motion Quantitative motion analysis in sports biomechanics What causes sports movements? Forces and moments of force The anatomy of human movement Every chapter contains cross references to key terms and definitions, learning objectives and summaries, study tasks to confirm and extend understanding, and suggestions for further reading. In addition to the printed textbook, readers of this new edition will also have access to an Interactive eTextbook version, a new kind of e-book that can be used on both mobile and desktop devices offering students an unparalleled level of interactivity. Featuring video, data files, pop-up definitions, hyperlinks, self-test quizzes and interactive labelling and sorting tasks, this new electronic edition brings the subject of sports biomechanics to life like no other textbook. This remains an essential course text for students of sport and exercise, human movement sciences, ergonomics, biomechanics, physical education, and sports performance and coaching.

This book provides readers with an anaesthesia-focused alternative to general physiology textbooks. The new edition has been reorganised with the trainee anaesthesist in mind, into shorter bite-sized chapters ideal for exam revision. The content includes the physiology of all major organ systems, with specific emphasis on the nervous, respiratory, and cardiovascular systems as well as special sections on pain, aging, specific environments and obesity. Alongside the learning objectives, reflection points and a handy summary of physiological equations and tables, there is greater emphasis on clinical application in this fourth edition, with applied physiology included in almost every section.

The endothelium is an excellent example of where biology meets physics and engineering. It must convert mechanical forces into chemical signals to maintain homeostasis. It also controls the immune response, drug delivery through the vasculature, and cancer metastasis. Basic understanding of these processes is starting to emerge and the knowledge gained from research is now being used in applications from drug delivery to imaging modalities. This book reviews current knowledge in mechanobiology of the endothelium and its implications for the development of theranostic devices.

Addresses the Aging Process and Its Effect on Sports Performance Age-related changes influence all physiological systems, including those used during exercise and sport. Highlighting masters athletes-older adults who train and compete in organized sports-Nutrition and Performance in Masters Athletes examines the extent to which regular physical training can impact these changes. This book bridges the gap between theory and practice, addressing nutritional, exercise and sport sciences, and the actual performance of masters athletes and older exercisers. It reviews in detail many age-related changes that occur in the physiological systems, provides implications of these changes for masters athletes, coaches and clinicians, explores scientifically-based methods to maximize sprint, strength and power, team sport players, endurance and ultra-endurance performance, and focuses on the unique nutritional needs of master athletes. Examines the Growing Body of Knowledge on Masters Athletes Each chapter has been written by a world-leading authority in their field. Contributors focus on a specific topic and discuss available research. Incorporating information from studies on younger and older athletes and healthy older non-athletes, they help determine the training and nutrition implications for sports medicine professionals and clinicians, masters athletes and coaches, and future research directions for academic and postgraduate students. The book includes material on endurance, ultra-endurance, speed, strength and power, and team sports athletes. Sections cover macronutrients (carbohydrate, fat and protein needs), micronutrients (vitamin and mineral needs), fluids and hydration; supplements and ergogenic aids, nutrition for chronic disease, and the training/nutrition needs of every type of masters athletes. Nutrition and Performance in Masters Athletes is highly recommended for medical and health professionals, fellow academics, postgraduates with an interest in masters athletes, as well as masters athlete coaches and masters athletes, and administrators wanting to assist their members.

First published in 1986. Routledge is an imprint of Taylor & Francis, an informa company.

This book promotes an evidence-based paradigm of fetal heart rate monitoring during labour, with a move away from the traditional 'pattern-based' interpretation to physiology-based interpretation. Chapters are presented in a systematic and accessible format, covering topics such as non-hypoxic causes of fetal brain injury, pre-existing hypoxia, types of intrapartum hypoxia, erroneous monitoring of maternal heart rate, fetal scalp blood sampling and fetal ECG (STAN), intermittent auscultation and medico-legal issues. Sections on 'pearls' and 'pitfalls' highlight good practice and common errors to promote best practice. End-of-chapter exercises allow the reader to engage with the theory and test their knowledge of key areas. This is a highly practical manual aimed at obstetricians and midwives, particularly those undergoing CTG training. The book will also be very useful to midwifery and medical students and to all those involved in multiprofessional intrapartum care.

Many fields have explored the nature of mental life from psychology to psychiatry, literature to linguistics. Yet no common "framework" where each of these important perspectives can be honored and integrated with one another has been created in which a person seeking their collective wisdom can find answers to some basic questions, such as, What is the purpose of life? Why are we here? How do we know things, how are we conscious of ourselves? What is the mind? What makes a mind healthy or unwell? And, perhaps most importantly: What is the connection among the mind, the brain, and our relationships with one another? Our mental lives are profoundly relational. The interactions we have with one another shape our mental world. Yet as any neuroscientist will tell you, the mind is shaped by the firing patterns in the brain. And so how can we reconcile this tension-that the mind is both embodied and relational? Interpersonal Neurobiology is a way of thinking across this apparent conceptual divide. This Pocket Guide to Interpersonal Neurobiology is designed to aid in your personal and professional application of the interpersonal neurobiology approach to developing a healthy mind, an integrated brain, and empathic relationships. It is also designed to assist you in seeing the intricate foundations of interpersonal neurobiology as you read other books in the Norton Series on Interpersonal Neurobiology. Praise for Daniel J. Siegel's books: "Siegel is a must-read author for anyone interested in the science of the mind." -Daniel Goleman, author of Social Intelligence: The New Science of Human Relationships "[S]tands out for its skillful weaving together of the interpersonal, the inner world, the latest science, and practical applications." -Jack Kornfield, PhD, founding teacher of the Insight Meditation Society and Spirit Rock Center, and author of A Path With Heart "Siegel has both a meticulous understanding of the roles of different parts of the brain and an intimate relationship with mindfulness . . . [A]n exciting glimpse of an uncharted territory of neuroscience." -Scientific American Mind "Dr. Daniel Siegel is one of the most thoughtful, eloquent, scientifically solid and reputable exponents of mind/body/brain integration in the world today." -Jon Kabat-Zinn, PhD, author of Wherever You Go, There You Are, Full Catastrophe Living, and Coming to Our Senses

Almost all bodily functions are dependent on activity of the autonomic nervous system - from the cardiovascular system, the gastrointestinal tract, the evacuative and sexual organs, to the regulation of temperature, metabolism and tissue defence. Balanced functioning of each aspect of this system is an important basis of our life and well-being. In this long-awaited second edition, the author, a leading figure in this field, provides an up-to-date and detailed description of the cellular and integrative organization of the autonomic nervous system, covering both peripheral and central aspects. The book exposes modern neurobiological concepts that allow us to understand why this system normally runs so smoothly and why its deterioration has such disastrous consequences. This broad overview will appeal to researchers and advanced undergraduate students of the various biological and medical sciences studying how the autonomic nervous system works and to clinicians and physical therapists whose practice involves systems dependent on autonomic functions.

Carnitine Metabolism and Human Nutrition offers a contemporary and in-depth look at the biological effects of carnitine metabolism and its application to clinical and sports nutrition, based on decades of robust scientific enquiry. It gathers and distills key results of the last 20 years of carnitine research to provide an invaluable reference tool for students, researchers, and clinicians. This book addresses the importance of carnitine in skeletal muscle fuel metabolism, the complexities and importance of muscle carnitine transport, and the metabolic insight that has been gained from experiments manipulating muscle carnitine stores. The authors cover the potential application of carnitine supplementation in specific clinical populations and the role of carnitine as an ergogenic aid for athletes. They also provide a comprehensive mechanistic overview of skeletal muscle insulin resistance, including the role of carnitine shuttle systems in the metabolic abnormalities associated with obesity and the metabolic syndrome. Carnitine Metabolism and Human Nutrition provides you with a comprehensive and up-to-date look at the properties and underlying metabolic biochemistry of carnitine. The book provides contributions from leading international scientists, each a pioneer in their chosen study of carnitine metabolism or its application to human nutrition.

Modern Intervention Tools for Rehabilitation addresses current advancements in rehabilitation to better equip clinicians and researchers in the field. This resource will equip professionals for better patient outcomes and improve future rehabilitation research quality. An interdisciplinary understanding of the rehabilitation field is crucial for improved patient care and outcomes, with relevance to patient care in other disciplines as well. With chapters dedicated to diagnostics, choosing appropriate techniques, managing medical treatment, and proper equipment care, readers will be well-equipped to decide on protocols, increase patient outcomes, and improve quality of life.

Excitable media comprise a class of models for a wide range of physical, chemical, and biological systems that exhibit spontaneous formation of spatial patterns. Patterns in Excitable Media: Genesis, Dynamics, and Control explores several aspects of the dynamics of such patterns-in particular their evolution upon interaction with structural and functional heterogeneities in the system. The book provides readers with an introduction to recent developments in the interdisciplinary field of dynamics and control of patterns in nonlinear biological systems described by excitable media models. It also discusses low-amplitude control schemes for eliminating such patterns from an excitable medium which has direct clinical relevance in view of the close connection to life-threatening cardiac arrhythmia.

The first comprehensive overview of an emerging field, Metabolic Medicine and Surgery introduces a new paradigm in patient management that crosses existing subspecialty boundaries. This approach is necessitated by the challenges of treating patients with obesity, metabolic syndrome, cardiovascular disease and prediabetes, as well as those with maldigestion, malabsorption, malnutrition and nutritional deficiencies. This book teaches physicians and surgeons what they need to know about clinical nutrition, metabolism and the metabolic effects of bariatric surgery. It is also applicable to those in primary care, including physicians, residents, medical students, nurses and nurse practitioners, physician assistants and dietitians who are on the front lines of treating patients with obesity, diabetes and cardiovascular disease. The book is presented in four sections: 1. An Overview of Metabolic Medicine and Surgery; 2. Metabolic Syndrome, Insulin Resistance and Obesity; 3. Diseases of Undernutrition and Absorption; 4. A Nutritional Relationship to Neurological Diseases. It contains chapters from world-renowned experts who are widely published in major medical journals. The book also benefits from the contributions of clinicians with extensive experience and perspective in the field, including many who have been witness to its major developments. This book's strength lies in the cross-specialty consensus created by the collaboration of the editors and further developed by their renowned contributors. It demonstrates how medicine, surgery, therapeutics, and nutrition can be combined synergistically to impact patient outcomes. It crystallizes the efforts of a multitude of physicians and scientists trying to control the linked pandemics of obesity, type-2 diabetes and cardiovascular disease. This book helps you develop comprehensive solutions to diseases afflicting vast numbers of patients worldwide.

Over one million readers have turned to "Strength Training Anatomy" for strength training's most effective exercises. Now put those exercises to work for you with "The Strength Training Anatomy Workout."

"The Strength Training Anatomy Workout "is your guide to creating the body and the results you want. Strengthen arms and legs; increase muscle mass; sculpt chest, back, and core; firm glutes; increase hip flexibility . . . it's all here, and all in the stunning detail that only Frederic Delavier can provide

Over 150 full-color illustrations allow you to get inside more than 200 exercises and 50 workouts to see how muscles interact with surrounding joints and skeletal structures. You'll also discover how variations, progressions, and sequencing can affect muscle recruitment, the underlying structures, and ultimately the results.

The "Strength Training Anatomy Workout" includes proven programming for strength, power, bodybuilding, and toning that can be used in a gym or at home. You'll find targeted conditioning routines for optimal performance in more than 30 sports, including basketball, football, soccer, track and field, and golf.

Former editor in chief of "PowerMag" in France, author and illustrator Frederic Delavier is a journalist for "Le Monde du" "Muscle" and a contributor to "Men's Health Germany "and several other strength publications. His previous publication, "Strength Training Anatomy," has sold more than one million copies.

First published in 1982. Routledge is an imprint of Taylor & Francis, an informa company.

A timely symposium entitled Body-Fluid Homeostasis: Transduction and Integration was held at Araraquara, Sao Paulo, Brazil in 2011. This meeting was convened as an official satellite of a joint gathering of the International Society for Autonomic Neuroscience (ISAN) and the American Autonomic Society (AAS) held in Buzios, Rio de Janeiro. Broad international participation at this event generated stimulating discussion among the invited speakers, leading to the publication of Neurobiology of Body Fluid Homeostasis: Transduction and Integration. Drawn from the proceedings and filled with rich examples of integrative neurobiology and regulatory physiology, this volume: Provides updated research using human and animal models for the control of bodily fluids, thirst, and salt appetite Explores neural and endocrine control of body fluid balance, arterial pressure, thermoregulation, and ingestive behavior Discusses recent developments in molecular genetics, cell biology, and behavioral plasticity Reviews key aspects of brain serotonin and steroid and peptide control of fluid consumption and arterial pressure The book highlights research conducted by leading scientists on signal transduction and sensory afferent mechanisms, molecular genetics, perinatal and adult long-term influences on regulation, central neural integrative circuitry, and autonomic/neuroendocrine effector systems. The findings discussed by the learned contributors are relevant for a basic understanding of disorders such as heat injury, hypertension, and excess salt intake. A unique reference on the neurobiology of body fluid homeostasis, this volume is certain to fuel additional research and stimulate further debate on the topic.

Make difficult pathophysiology concepts come to life! Filled with vibrant illustrations, simplified language, and detailed online content Understanding Pathophysiology, 7th Edition delivers the most accurate information on treatments, manifestations, and mechanisms of disease across the lifespan. This new edition is fully revised and includes coverage of rare diseases and epigenetics to you with a thorough understanding of conditions affecting the human body. Plus, with over 30 new 3D animations on the companion Evolve site, quick check boxes at the end of each chapter, and disease progression algorithms, this text helps you engage with the fundamental knowledge you need to succeed in nursing school and in practice. Student resources include animations, review questions, answers to the Quick Check boxes (featured in the text), chapter summary reviews, and case study with answers for select chapters. Algorithms throughout the text clarify disease progression. Did You Know boxes highlight new developments in biologic research, diagnostic studies, preventive care, treatments, and more. Quick Check boxes tests your retention of important chapter concepts. Risk Factor boxes alert you to important safety considerations associated with specific diseases. Summary Review sections provide fast, efficient review of chapter content. Geriatric Considerations boxes and Pediatric Considerations boxes highlight key considerations for these demographics in relevant chapters. Consistent presentation helps you to better distinguish pathophysiology, clinical manifestations, and evaluation and treatment for each disease. Glossary of approximately 1,000 terms familiarizes you with the most difficult or important terminology related to pathophysiology. NEW! Chapters on Alterations in Immunity and Obesity and Disorders of Nutrition feature the latest coverage of these hot topics. NEW! Additional coverage of rare diseases and epigenetics gives you a comprehensive understanding of conditions and cell growths that affect the human body. NEW! Streamlined content and illustrations ensures content is at an appropriate level for undergraduate students. NEW! More than 1000 illustrations in the text and 30+ new 3D animations on companion Evolve site bring difficult concepts to life for a new perspective on disease processes.

Interest in the role of extracellular vesicles (microvesicles and exosomes) is expanding rapidly. It is now apparent that far from being merely cellular debris, these vesicles play a key role in cell-to-cell communication and signaling. Moreover, they are significantly elevated in a number of diseases. This raises the question of their direct role in pathogenesis as well as their possible use as biomarkers.

This book stems from the first international meeting on "Microvesicles and Nanovesicles in Health and Disease" held at Magdalen College, Oxford, in 2010. The purpose of the meeting was to bring together, for the first time, a range of experts from around the world to discuss the latest advances in this field. Key to the study of these vesicles is the availability of methodologies for their measurement in biological fluids. A major section of the meeting focused on a range of exciting new technologies which have been developed for this purpose. The presentations at this meeting form the basis of this book, which will appeal to basic scientists, clinicians, and those developing technology for the measurement of extracellular vesicles.

Pathophysiology and Pharmacology in Nursing has been carefully designed to provide an integrated introduction to both the biology of disease and the therapeutic agents that are used to manage them. It covers the basics of pharmacology, the core pathological concepts of inflammation, infection and cancer, as well as a systems based consideration of the pathophysiology and relevant pharmacology of common disorders. New to the second edition: All content updated and mapped to the 2018 NMC standards Two new chapters on 'Mental health conditions' and 'Renal conditions. The ideal starting point for student nurses to develop a robust, integrated knowledge of human disease and pharmacology, enabling them to provide care that is based on up-to-date knowledge of this important subject.

Gain a complete understanding of the aspects of pulmonary physiology essential to clinical medicine For more than 35 years, this trusted review has provided students, residents, and fellows with a solid background in the aspects of pulmonary physiology that are essential for an understanding of clinical medicine. Pulmonary Physiology clearly describes how and why the human respiratory system works in a style that is easy to absorb and integrate with your existing knowledge of other body systems. Features: Thoroughly updated with new figures, tables, and end-of-chapter references and clinical correlations Each chapter includes clearly stated learning objectives, summaries of key concepts, illustrations of essential concepts, clinical correlations, problems, and pulmonary function test data to interpret, and suggested readings Enables you to understand the basic concepts of pulmonary physiology well enough to apply them with confidence in future practice Provides detailed explanations of physiologic mechanisms and demonstrates how they apply to pathologic states If you're in need of a concise, time-tested, basic review of pulmonary physiology-one that encourages comprehension rather than memorization, your search ends here.

Origins and Principles of Clinical Biomechanics in Human Locomotion discusses key concepts of how biomechanics links to the development of pathology through mechanical laws, anatomy, physiology and health. It provides fundamental principles and practical data, and guidance of how to apply these in the clinical biomechanics field. Coverage includes: major joint movement, muscle action around joints, physiology and patho-physiology of bone, muscle and neurologic disorders. This reference is ideal for teaching students in biomechanics, orthopedics and physiotherapy. It should also be of interest to product development engineers, rehabilitation engineers, those working in prosthetics and orthotics, physiotherapists and occupational therapists. The authors explore the simple laws of motion as applied to anatomy and physiology, in order to help readers understand human pathology within the human lower limb and mobility. They then go on to look at materials science concerns within this field, such as engineering stresses and strains, principles and types of material properties and the shaping of structural properties. Readers will also find within this book information on tissue science, force generation, biological sciences, evolution in biomechanics, human gait, functional units of the lower limb and foot, and finally pathomechanical principles; all as applied to clinical biomechanics.