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Books > Medicine > Pre-clinical medicine: basic sciences > Physiology

Role of the Choroid Plexus in Health and Disease (Hardcover, 1st ed. 2020): Jeppe Praetorius, Bonnie Blazer-Yost, Helle Damkier Role of the Choroid Plexus in Health and Disease (Hardcover, 1st ed. 2020)
Jeppe Praetorius, Bonnie Blazer-Yost, Helle Damkier
R3,051 Discovery Miles 30 510 Ships in 10 - 15 working days

This book highlights the importance of the choroid plexus, which forms the blood-cerebrospinal fluid barrier and is the site of the major production of the cerebrospinal fluid (CSF). The authors show that this barrier is crucial for maintaining important compositional differences between the blood plasma and the CSF. The choroid plexus epithelial cells also prevent the spread of infectious agents and other blood-borne entities to the brain tissue. Chapter topics range from the production of CSF by electrolyte regulation in the choroid plexus, to details on the selectively transporting nature of this barrier. Further, the authors elaborate on the important roles of CSF in sustaining brain health by providing hydration, solutes, and nutrients to the brain tissue. Readers will also learn how CSF circulates signaling molecules within the compartments of the brain and removes waste products from the brain tissue. Elucidating the regulation of these processes in the choroid plexus is not only important for the readers' understanding of normal brain development and function, but is also crucial for resolving a variety of cerebral challenges that lead to brain edema, as well as developing treatments for diseases. The book discusses disease models like hydrocephalus, sleep disorders, and age-related dementia. Its comprehensive coverage makes this volume a valuable resource for researchers in cell and neurophysiology, as well as graduate students of the neurosciences.

Autophagy in Health and Disease - Potential Therapeutic Approaches (Hardcover, 1st ed. 2018): Kursad Turksen Autophagy in Health and Disease - Potential Therapeutic Approaches (Hardcover, 1st ed. 2018)
Kursad Turksen
R4,574 Discovery Miles 45 740 Ships in 10 - 15 working days

This timely volume explores the impact of autophagy in various human diseases, emphasizing the cell biological aspects and focusing on therapeutic approaches to these diseases. The chapters cover autophagy and its potential applications on diseases ranging from obesity, osteoarthritis, pulmonary fibrosis, and inflammation, through ALS, Parkinson's, retinal degeneration, breast cancer, alcoholic liver disease and more. The final chapters round out the book with a discussion of autophagy in drug discovery and 'bench to bedside'. Chapters are contributed by leading authorities and describe the general concepts of autophagy in health and disease, marrying cell biology and pharmacology and covering: studies derived from preclinical experiments, manufacturing considerations,and regulatory requirements pertaining to drug discovery and manufacturing and production. This volume will be useful for basic scientists as well as already practicing clinicians and advanced graduate students.

Analytical and Quantitative Cardiology - Proceedings of the 10th Goldberg Workshop Held in Haifa, Israel, December 2-5, 1996... Analytical and Quantitative Cardiology - Proceedings of the 10th Goldberg Workshop Held in Haifa, Israel, December 2-5, 1996 (Hardcover)
Samuel Sideman, Rafael Beyer
R2,669 Discovery Miles 26 690 Ships in 12 - 17 working days

Molecular Signalling: Ca2+-Signaling in Cardiac Myocytes: Evidence from Evolutionary and Transgenic Models; M. Morad, Y.J. Suzuki. Diastolic Viscoelastic Properties of Rat Cardiac Muscle; Involvement of Ca2+; B.D.M.Y. Stuyvers, et al. The Contractile Mechanism and Energetics: Molecular Control of Myocardial Mechanics and Energetics: The Chemo-Mechanical Conversion; A. Landesberg. Myocardial Cell Energetics; H. Kammermeier. Cardiac Mechanics and Flow Dynamics: How Cardiac Contraction Affects the Coronary Vasculature; N. Westerhof, et al. Dynamic Interaction between Myocardial Contracton and Coronary Flow; R. Beyar, S. Sideman. Vascular Structure and Remodeling: Endothelial Gene Regulation by Laminar Shear Stress; N. Resnick, et al. Myocardial Structure and Function. Tissue Remodeling with Micro-Structurally Based Material Laws; P. Hunter, T. Arts. Electrical Activation and Propagation: Cardiac Excitation: An Interactive Process of Ion Channels and Gap Junctions; Y. Rudy, R.M. Shaw. The Cardionome: Concepts in Modeling: Design and Strategy for the Cardionome Project; J.B. Bassingthwaighte. 20 Additional Chapters. Index.

Diabetes Mellitus - Insights and Perspectives (Hardcover): Oluwafemi Oguntibeju Diabetes Mellitus - Insights and Perspectives (Hardcover)
Oluwafemi Oguntibeju
R4,097 Discovery Miles 40 970 Ships in 10 - 15 working days
Selected Topics in Neuroendocrinology (Hardcover): Joy Foster Selected Topics in Neuroendocrinology (Hardcover)
Joy Foster
R1,949 Discovery Miles 19 490 Ships in 12 - 17 working days
Targeting Cellular Signalling Pathways in Lung Diseases (Hardcover, 1st ed. 2021): Kamal Dua, Raimar Loebenberg, Angela... Targeting Cellular Signalling Pathways in Lung Diseases (Hardcover, 1st ed. 2021)
Kamal Dua, Raimar Loebenberg, Angela Cristina Malheiros Luzo, Shakti Shukla, Saurabh Satija
R5,580 Discovery Miles 55 800 Ships in 10 - 15 working days

The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the management and treatment of lung disease. It also covers promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing the disease features including novel strategies for targeting chronic lung diseases using advanced drug delivery systems. Importantly, the book examines the significance and relevance of the plant extracts and their constituents with therapeutic efficiencies against lung diseases. As such, the book offers a blend of translational, biological, chemical, and drug delivery aspects relevant to respiratory diseases, thus, offering a valuable resource for pulmonologists and translational researchers working in the field of pulmonary biology and respiratory medicine.

Human - The Science Behind What Makes Your Brain Unique (Paperback): Michael S Gazzaniga Human - The Science Behind What Makes Your Brain Unique (Paperback)
Michael S Gazzaniga
R447 Discovery Miles 4 470 Ships in 10 - 15 working days

What happened along the evolutionary trail that made humans so unique? In his accessible style, Michael Gazzaniga pinpoints the change that made us thinking, sentient humans different from our predecessors. He explores what makes human brains special, the importance of language and art in defining the human condition, the nature of human consciousness, and even artificial intelligence.

Proteinuria: Basic Mechanisms, Pathophysiology and Clinical Relevance (Hardcover, 1st ed. 2016): Judith Blaine Proteinuria: Basic Mechanisms, Pathophysiology and Clinical Relevance (Hardcover, 1st ed. 2016)
Judith Blaine
R3,805 R3,516 Discovery Miles 35 160 Save R289 (8%) Ships in 12 - 17 working days

Recent work has begun to elucidate at the molecular level how albumin is handled by the kidney and how albuminuria develops in various proteinuric diseases including minimal change disease and focal segmental glomerulosclerosis. This volume provides a comprehensive overview of the renal handling of albumin - from basic mechanisms to the pathophysiology of proteinuric diseases. In describing the basic mechanisms of albuminuria, a particular highlight will be the focus on advanced imaging techniques such as intravital microscopy that have allowed a detailed "window" into albumin transit through the kidney. The volume will cover the epidemiological studies which show that albuminuria is a strong and independent marker of kidney disease progression and cardiovascular events, the molecular details of albumin handling in the kidney at the level of the glomerulus and the proximal tubule and the pathophysiology of proteinuric diseases including minimal change disease, membranous nephropathy, focal segmental glomerulosclerosis and diabetic nephropathy.

Advances in Bioactivation Research (Hardcover, 2008): Adnan Elfarra Advances in Bioactivation Research (Hardcover, 2008)
Adnan Elfarra
R6,015 Discovery Miles 60 150 Ships in 10 - 15 working days

This volume provides researchers with recent information on bioactivation reactions of drugs and toxicants. It also provides examples of how molecular and genomic biology, proteomics, mass spectrometry, and computational modeling are used in bioactivation research. In other sections, focus is on recent applications of bioactivation research in pharmacology, toxicology, and environmental health sciences, where contributors demonstrate the integration of bioactivation research.

The Gastrointestinal System - Gastrointestinal, Nutritional and Hepatobiliary Physiology (Hardcover, 2014 ed.): Po Sing Leung The Gastrointestinal System - Gastrointestinal, Nutritional and Hepatobiliary Physiology (Hardcover, 2014 ed.)
Po Sing Leung
R1,643 Discovery Miles 16 430 Ships in 10 - 15 working days

Gastrointestinal (GI) physiology is a fundamental subject that is indispensable not only for undergraduate but also for graduate courses. The audience include, but are not limited to, medical, pharmacy, nursing, human biology, Chinese medicine, and science students, as well as other health-related subject students.The overall objectives of this textbook are to present basic concepts and principles of GI physiology and, more importantly, to convey an understanding of how to apply this knowledge to abnormal GI physiology in the clinical context. As such, the basic knowledge of GI physiology and its application in the form of clinical case studies should be grasped, which are critical for professional examinations and bedside, as well as for general practice in the future. In this handbook, we aim to achieve these elements by covering the breadth of GI, pancreatic, hepatobiliary, and nutritional physiology. Moreover, we include relevant scenario-based clinical case in each chapter so as to evaluate whether the students can apply the basic GI they learn to the clinical setting."

Cell Polarity 2 - Role in Development and Disease (Hardcover, 2015 ed.): Klaus Ebnet Cell Polarity 2 - Role in Development and Disease (Hardcover, 2015 ed.)
Klaus Ebnet
R4,192 R3,610 Discovery Miles 36 100 Save R582 (14%) Ships in 12 - 17 working days

This work provides a state-of-the art overview on the most relevant aspects of cell polarity. Volume 2 discusses the physiological and pathophysiological relevance of cell polarity. It especially focuses on pathophysiological conditions in which one or several aspects of cell polarity are impaired, and in which a loss of cell polarity possibly contributes to disease (e.g. epithelial-to-mesenchymal transition in cancer, role of polarity proteins in cancer). Both volumes are intended for professors, group leaders and researchers in cell biology as well as for medical professionals working in anatomy, cell biology, physiology, pathology and tumor biology.

Insights Into Glucose Tolerance (Hardcover): Vanessa Artiga Insights Into Glucose Tolerance (Hardcover)
Vanessa Artiga
R2,571 Discovery Miles 25 710 Ships in 12 - 17 working days
Extracellular Matrix Omics (Hardcover, 1st ed. 2020): Sylvie Ricard-Blum Extracellular Matrix Omics (Hardcover, 1st ed. 2020)
Sylvie Ricard-Blum
R4,846 Discovery Miles 48 460 Ships in 10 - 15 working days

This book covers different omics aspects related to the extracellular matrix (ECM), namely specific omics resources focused on the extracellular matrix (e.g., databases, repositories and atlases), quantitative proteomics applied to specific extracellular matrices (e.g. basement membranes), biological processes such as ECM degradation (degradomics), cell-matrix interactions (adhesomes), signaling pathways, biomarker discovery and diseases, and interactomics (extracellular matrix interaction networks including not only protein-protein but also protein-glycosaminoglycan interactions). The volume also includes recent advances in glycomics and glycobioinformatics applied to proteoglycans and glycosaminoglycans, which are key biological players. The use of omics data to build dynamic models of ECM-regulated biological pathways is addressed, together with the requirement to standardize omic data, which is a prerequisite for the FAIR (Findability, Accessibility, Interoperability, and Reusability) guiding principles for scientific data management. This book will be of great interest to a broad readership from beginners to advanced researchers, who are interested in extracellular matrix omics and will inspire future research topics.

Basic and Clinical Endocrinology Up-to-Date (Hardcover): Fulya Akin Basic and Clinical Endocrinology Up-to-Date (Hardcover)
Fulya Akin
R4,101 Discovery Miles 41 010 Ships in 10 - 15 working days
High Density Lipoproteins - From Biological Understanding to Clinical Exploitation (Hardcover, 2015 ed.): Arnold Von... High Density Lipoproteins - From Biological Understanding to Clinical Exploitation (Hardcover, 2015 ed.)
Arnold Von Eckardstein, Dimitris Kardassis
R1,744 Discovery Miles 17 440 Ships in 12 - 17 working days

In this Handbook of Experimental Pharmacology on "High Density Lipoproteins - from biological understanding to clinical exploitation" contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation. The book is of interest to researchers in academia and industry focusing on lipoprotein metabolism, cardiovascular diseases and immunology as well as clinical pharmacologists, cardiologists, diabetologists, nephrologists and other clinicians interested in metabolic or inflammatory diseases.

Radiation and Health (Hardcover): Neli Melman Radiation and Health (Hardcover)
Neli Melman
R912 Discovery Miles 9 120 Ships in 12 - 17 working days
Reviews of Physiology, Biochemistry and Pharmacology 159 (Hardcover, 2007 ed.): S.G. Amara, E. Bamberg, B. Fleischmann, T.... Reviews of Physiology, Biochemistry and Pharmacology 159 (Hardcover, 2007 ed.)
S.G. Amara, E. Bamberg, B. Fleischmann, T. Gudermann, S.C. Hebert, …
R5,857 Discovery Miles 58 570 Ships in 10 - 15 working days

Contents

Philip C. Sharpe, Rosemary S. Harrison, and David P. Fairlie: Amyloid Peptides and Proteins in Review. - Marilena Kampa, Artemissia-Phoebe Nifli, George Notas, Elias Castanas: Polyphenols and Cancer Cell Growth. - Michal Janitz: Assigning Functions to Genes The Main Challenge of the Post-Genomic Era. - Brigittte M. Jockusch, Kai Murk and Martin Rothkegel: The Profile of Profilins.

Proceedings of the 14th International Conference on Man-Machine-Environment System Engineering (Hardcover, 2015 ed.): Shengzhao... Proceedings of the 14th International Conference on Man-Machine-Environment System Engineering (Hardcover, 2015 ed.)
Shengzhao Long, Balbir S Dhillon
R6,954 R5,281 Discovery Miles 52 810 Save R1,673 (24%) Ships in 12 - 17 working days

The integrated and advanced science research topic man-machine-environment system engineering (MMESE) was first established in China by Professor Shengzhao Long in 1981, with direct support from one of the greatest modern Chinese scientists, Xuesen Qian. In a letter to Shengzhao Long from October 22nd, 1993, Xuesen Qian wrote: "You have created a very important modern science and technology in China!" MMESE primarily focuses on the relationship between man, machines and the environment, studying the optimum combination of man-machine-environment systems. In this system, "man" refers to people in the workplace (e.g. operators, decision-makers); " machine" is the general name for any object controlled by man (including tools, machinery, computers, systems and technologies), and "environment" describes the specific working conditions under which man and machine interact (e.g. temperature, noise, vibration, hazardous gases etc.). The three goals of optimization of man-machine-environment systems are to ensure safety, efficiency and economy. Proceedings of the 14th International Conference on Man-Machine-Environment System Engineering are an academic showcase of the best papers selected from more than 400 submissions, introducing readers to the top research topics and the latest developmental trends in the theory and application of MMESE. These proceedings are interdisciplinary studies on the concepts and methods of physiology, psychology, system engineering, computer science, environment science, management, education, and other related disciplines. Researchers and professionals working in these interdisciplinary fields and researchers on MMESE related topics will benefit from these proceedings.

Cell Polarity 1 - Biological Role and Basic Mechanisms (Hardcover): Klaus Ebnet Cell Polarity 1 - Biological Role and Basic Mechanisms (Hardcover)
Klaus Ebnet
R4,100 R3,811 Discovery Miles 38 110 Save R289 (7%) Ships in 12 - 17 working days

This work provides a state-of-the art overview on the most relevant aspects of cell polarity. Volume 1 addresses cell polarity and cell migration (front-rear polarity), cell polarity and barrier formation (apico-basal polarity) and neuronal polarity. It particularly focuses on cell polarity at the molecular level and the underlying molecular mechanisms. It also elaborates the common principles and mechanisms that regulate cellular polarization in different cell types and contexts. Both volumes are intended for professors, group leaders and researchers in cell biology as well as medical professionals in the fields of anatomy, cell biology, physiology, pathology and tumor biology.

Exercise Physiology (Hardcover): Pablo De Souza Exercise Physiology (Hardcover)
Pablo De Souza
R3,204 R2,904 Discovery Miles 29 040 Save R300 (9%) Ships in 10 - 15 working days
Applied Physiology Of Exercise Laboratory Manual (Paperback): G Balasekaran, Visvasuresh Victor Govindaswamy, Jolene Ziyuan... Applied Physiology Of Exercise Laboratory Manual (Paperback)
G Balasekaran, Visvasuresh Victor Govindaswamy, Jolene Ziyuan Lim, Peggy Peck Kay Boey, Yew Cheo Ng
R1,416 Discovery Miles 14 160 Ships in 10 - 15 working days

Practical applications of physiology of exercise factual materials found in the Applied Physiology of Exercise textbook are of paramount importance to understand the principles of training. The Applied Physiology of Exercise Laboratory Manual complements the Applied Physiology of Exercise textbook where practical applications in both laboratory and field settings are shared. These practical applications are mostly through personal research at the Nanyang Technological University, National Institute of Education, and Human Bioenergetics Laboratory of Singapore. The uniqueness of the laboratory sessions found in the manual was attested to the many hours of hard laboratory research work. For example, the Running Energy Research Index (RERI) Laboratory was born as a result of a 10-year long research. This laboratory research work, like the other researched laboratory sessions in the manual, is then used in practical sessions in physiology of exercise classes to fine-tune the best possible learning experiences for students. After a long process of fine tuning and constructive feasibility, the laboratory sessions became concrete and designed specifically for this manual.

Advanced Topics in Morphometrics (Hardcover): Phyllis Bates Advanced Topics in Morphometrics (Hardcover)
Phyllis Bates
R1,909 R1,759 Discovery Miles 17 590 Save R150 (8%) Ships in 10 - 15 working days
Loose Leaf for Human Biology (Loose-leaf, 17th ed.): Sylvia Mader, Michael Windelspecht Loose Leaf for Human Biology (Loose-leaf, 17th ed.)
Sylvia Mader, Michael Windelspecht
R4,290 Discovery Miles 42 900 Ships in 10 - 15 working days
Treatment of Type 2 Diabetes (Hardcover): Colleen Croniger Treatment of Type 2 Diabetes (Hardcover)
Colleen Croniger
R4,088 Discovery Miles 40 880 Ships in 10 - 15 working days
Phagocytosis of Dying Cells - From Molecular Mechanisms to Human Diseases (Hardcover, 2009 ed.): Dmitri V. Krysko, Peter... Phagocytosis of Dying Cells - From Molecular Mechanisms to Human Diseases (Hardcover, 2009 ed.)
Dmitri V. Krysko, Peter Vandenabeele
R4,655 Discovery Miles 46 550 Ships in 10 - 15 working days

This book deals with many recent advances made in uncovering the molecular and cellular basis of phagocytosis of apoptotic and necrotic dying cells as well as with the methods used for studying their clearance. There are important practical and clinical reasons for attempting to understand the molecular mechanisms of phagocytosis of dying cells, because inadequate clearance of dying cells may contribute to the development of autoimmune diseases (e.g. systemic lupus erythematosus), as well as atherosclerosis and chronic lung diseases (e.g. chronic obstructive pulmonary disease, asthma and cystic fibrosis). Furthermore, in this book we examine the possibility of using apoptotic cells in the prevention and treatment of graft rejection and in the rational design of immunotherapy and vaccines for cancer treatment. The role of environmental factors in phagocytosis of dying cells is also addressed.

This comprehensive volume integrates the most innovative and current findings from several related disciplines of scientific research, including pathology, immunology, genetics, and cellular and molecular biology. It is divided into two sections: "Molecular mechanisms of phagocytosis of dying cells" and "Impairment of phagocytosis of dying cells and its role in the development of diseases." No other recent books devoted to this subject are available.

All of the contributors are experts working at the forefront of scientific discovery, and the reviews they present systematically examine the most exciting and innovative aspects of their particular areas of expertise. Both researchers and physicians will find this volume of major benefit because it covers the immunological and molecular biological aspects of phagocytosis of dying cells as well as its clinical relevance.

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