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This unique introductory text explains cell functions using the engineering principles of robust devices. Adopting a process-based approach to understanding cell and tissue biology, it describes the molecular and mechanical features that enable the cell to be robust in operating its various components, and explores the ways in which molecular modules respond to environmental signals to execute complex functions. The design and operation of a variety of complex functions are covered, including engineering lipid bilayers to provide fluid boundaries and mechanical controls, adjusting cell shape and forces with dynamic filament networks, and DNA packaging for information retrieval and propagation. Numerous problems, case studies and application examples help readers connect theory with practice, and solutions for instructors and videos of lectures accompany the book online. Assuming only basic mathematical knowledge, this is an invaluable resource for graduate and senior undergraduate students taking single-semester courses in cell mechanics, biophysics and cell biology.
This volumes features contributions on the latest advances in the chemistry, biology and clinical applications of the thymosins from leading scientists and clinicians working in the field. The use of chemically defined and synthesized molecules, rather than crude or partially purified extracts has enabled scientists working in this field to acquire definitive information on the molecular biology, immunology and potential clinical applications of this important class of BRMs.
Paper in this volume cover a wide range of topics including: advances in the structure, design, immunology and molecular biology of thymosin alpha 1 (Tα1), prothymosin alpha (ProTα) and thymosin beta 4 (Tβ4). an exploration of role of the thymosins in cardioprotection, neuroplasticity, stem cells, wound healing, inflammation and angiogenesisclinical applications of Tα1 and other BRMsa look at the current status of translational trials with Tβ4 in areas of wound repair, cardiovascular disease, epidermolysis bullosa and eye injuries.
The availability of synthetic thymosins enables both researchers and clinicians to acquire definitive information on the immunology, pharmacology and emerging clinical applications of Tα1 and Tβ4. Clinicians will be particularly interested in the most recent reports of clinical responses and diagnostic applications.
This volume will also be of keen interest to biochemists, pharmacologists, immunologists and other basic scientists interested in acquiring information on the state of the art of the latest purification procedures, the chemical characterization, pharmacokinetics, immunopharmacology, and molecular biology of the thymosins alone or in combination with other BRMs and standard therapies.
NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.
ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http: //www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
Anatomy & Physiology Made Incredibly Visual is an innovative new reference that brings clinical subjects to life using a vivid, graphic presentation. Like the Incredibly Easy series, the Incredibly Visual series takes difficult clinical topics and presents them in a clear, concise, easy-to-understand manner. The highly visual nature of this book makes anatomy and physiology fundamentals accessible to the reader in a unique and interesting way that enables quick review and comprehension as well as practical application. For each body system, the book logically first presents anatomic fundamentals necessary to understand the complex physiology of the body. Then physiologic processes are presented more visually than ever before. This new approach to clinical content maximizes the power of visual thinking by getting readers as close to the clinical content as they can get without actually being in the room with a patient. Complex ideas are broken down into their component parts, with each component made unmistakably simple in appealingly colorful and graphic ways. Readers will read less, understand more, and see things more clearly than ever before. A companion website is available with fully-searchable text.
This book focuses on sports performance. According to the Longman Dictionary of Contemporary English, "performance" refers to "how well or badly a person, company etc. does a particular job or activity" and "high performance" describes "cars, computers etc. that are able to go faster, do more work etc. than normal ones". In the 100-m dash Usain Bolt is indubitably the fastest person in history and Javier Sotomayor, the world record holder in the high jump, has exhibited the highest level of performance in this event. In these contests, the index of sports performance is unitary; it is simply the time or the jumping/throwing distance. What is it that allows such performers to achieve the fastest running time or the highest jump? One of the topics covered in this book is an attempt to clarify some of the unique motor skills and/or physical abilities that underlie such high performances. This book comprises a compilation of updated reviews on performance in various sports, including both basic and applied research and is divided into three parts. The central theme of Part I is the brain. Basic research on human locomotion, motor imagery, and cognitive function are included in this part. In Part II, the focus is on basic information involving high performance in sports, including the athletes' physiology, genetics, nutrition and biomechanics. In Part III, entitled "Performance and Coaching in Various Sports", the latest findings involving skills and performance in individual sports are presented. These performances are thoroughly described and to the extent possible, explained utilizing observations that involve applied biomechanics, coaching science and information technology. In the e-book version, videos and images are available, which provide valuable information on movement in sports. This book will awaken a deeper and more sophisticated interest in exceptional sports performance, not only in specialists such as researchers, athletes, and coaches, but also in laypeople who enjoy participating in and watching sports.
This is the first book to explore the science underlying the concept of "koku", which is central to an understanding of the palatability of food within Japanese cuisine and is attracting increasing interest among food scientists and professionals worldwide. Koku may be defined as the sensation that results from the complexity of the food (i.e., its richness or body), its lingering aftertaste or persistence, and its heartiness in terms of taste, aroma, and texture. A variety of substances have been found to impact significantly on koku, including umami substances, phytosterols, certain aromatic compounds, and kokumi substances. In Koku - Food Science and Physiology, readers will find full explanation of the conceptual aspects and the latest research results on a wide range of topics, including the relevant flavor chemistry and sensory analysis. Written by leading scientists in the field, the book will be a valuable resource for students and researchers in the fields of food chemistry, nutritional science, taste physiology, and neuroscience, as well as for professionals in the food industry.
Physiology of Sport and Exercise, Seventh Edition With Web Study Guide, continues its legacy as a top physiology textbook and favorite of instructors and students alike. Combining research with extensive visual aids, this resource offers a simple way for students to develop an understanding of the body's abilities to perform various types and intensities of exercise and sport, to adapt to stressful situations, and to improve its physiological capacities. Written by a team of distinguished researchers, all past presidents of the American College of Sports Medicine, this seventh edition has been updated based on the most recent position stands, standards, and guidelines in the field of sport and exercise physiology. Throughout the text, updated photos join with the superb illustrations and medical artwork to clarify difficult concepts and illustrate how the body performs. Digital components found in the web study guide now include 26 animations that offer a dynamic way to experience physiological concepts, and 66 audio clips that provide explanations of complex physiological processes to aid students' understanding of important illustrations in the text. Leaders in the field discuss recent developments and real-world applications in 27 video clips to help students connect theoretical and practical concepts. Corresponding icons throughout the text notify students when digital elements are available to complement the materials. In addition to the expanded digital components, Physiology of Sport and Exercise, Seventh Edition, features new and updated content based on the latest research in the field: Additional information on overtraining and exercise addiction Expanded content on fatigue and mobility in aging New sections on epigenetics, bioinformatics, and neuromuscular function New information on exercise genomics New Research Perspectives emphasizing emerging findings in the field, and a new Research Perspectives Finder to help students locate key content quickly Ease of reading has been the standout feature of this popular text. The seventh edition continues to offer comprehensive coverage of the complex relationship between human physiology and exercise while maintaining an engaging and student-friendly tone. Unique learning features paired with an accessible layout, including chapter-opening outlines and review boxes throughout each chapter, will help students focus on the major concepts addressed. Study questions and a list of key terms at the end of the chapter increase students' opportunities for recall and self-testing. A comprehensive glossary and lists of common abbreviations and conversions provide easy reference for students as they complete labs and assignments. To foster an enriched learning experience, both students and instructors can take advantage of the web-based ancillaries that accompany the text. In addition to animations, videos, and audio clips, the web study guide includes comprehension quizzes to provide immediate feedback to students on their knowledge retention as well as end-of-unit mastery checks that students can use for evaluating their progress. Instructors are provided with access to an instructor guide, test package, ready-to-use chapter quizzes, and a presentation package plus image bank. The presentation package includes PowerPoint slides with key points and content, which can be modified to suit a variety of class structures. An image bank features all of the graphics, artwork, and content photos from the text for easy insertion into tests, quizzes, handouts, and other course materials. Digital extras-composed of the animations, videos, and audio clips that students find in the web study guide-bolster comprehension of challenging concepts. Physiology of Sport and Exercise has been a pivotal textbook of the engaging field of exercise physiology. Through dynamic and interactive learning activities, easy-to-follow layouts, and research-oriented content enriched with visual supplements, students and instructors will find this an invaluable resource for their continued education.
The Organizing Committee of the 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases compiled a group of junior investigators to provide reviews on the topics they presented at the Puerto Vallarta Bioactive Lipids conference, as part of the book series, Advances in Experimental Medicine and Biology (AEMB). The book in this series will be titled Bioactive Lipids in Cancer, Inflammation and Related Diseases. Topics range from all classes of lipids including prostaglandins, resolvins, spingolipids, P450-derived lipids, endocannabanoids and phospholipids. The focus includes physiology, cell biology, and structural studies in organisms from bacteria to humans and how these studies addressed the role of lipids in various disease i.e. cancer, inflammation, diabetes, obesity, cardiovascular disease and others.
Mechanics and biomechanics are essential subjects to a range of health-care professionals such as physiotherapists and sports scientists, medical engineers and occupational therapists. This text presents the core of these subjects within the context of clinical practice. A case-study approach is used throughout to illustrate and explain common problems amenable to biomechanical analysis. The eight chapters cover the basic principles of statics and dynamics, principles of machines, structures and materials, and fluid mechanics, without assuming high levels of prior knowledge of maths. Worked examples, tutorial problems and answers are included in each chapter.
With ACSM's Certification Review as your guide, you can be ready to successfully pass the exam to become a Certified Personal Trainer (CPT), Certified Exercise Physiologist (EP-C), or Certified Clinical Exercise Physiologist (CEP). As a review tool, this text will help you identify your strengths and weaknesses and then eliminate those areas of weakness with further study. Most importantly, this text will help you advance your career in fitness and exercise. Now aligned with the tenth edition of the ACSM's Guidelines for Exercise Testing and Prescription , this text is reflective of the key changes and the only print resource for the current ACSM certification exams. ACSM's Certification Review is organized into three parts by certification level.
Move at your own pace with this kinesiology course guide A required course for majors pursuing sports medicine, exercise science, nursing, or sports therapy degrees, kinesiology is central to a variety of fields. Kinesiology For Dummies tracks an introductory course in the science and imparts the basics of human body movement. With this resource, you will learn how physical activity can alleviate chronic illnesses and disabilities, what factors contribute to musculoskeletal injury, and how to reverse those influences. Complete with a 16-page color insert of medical instructions, this book covers the basics of exercise physiology, exercise and health psychology, introductory biomechanics, motor control, history and philosophy of sport and exercise, and mind-body connections. * Written by experts in exercise science * Addresses a timely subject as exercise science careers and majors are increasingly popular * Runs parallel to a kinesiology course with accessible, concise language Interested learners, kinesiology students, and health or sports therapy professionals will benefit from this refresher course in the basics.
Since the birth of the dietary fibre hypothesis in the early 1970's, research on this topic has been growing rapidly. However, though the remarkable number of experimental works, the role of fibre on human health is still uncompletely understood. The objective of this book is to synthesise the current knowledge on the physiological effects of dietary fibre in man by focusing on the mechanisms of action.
..".the most comprehensive adventure sport physiology book I am aware of; therefore, I recommend it wholeheartedly."" The Sport and Exercise Scientist, March 2009"
This book provides students and professionals with a well-written, accessible introduction to the science underlying a variety of adventure sports. Written specifically for this increasingly popular field of study, the text has been divided into two parts: the first provides the foundations for adventure physiology, the second the specific physiological and environmental demands of a range of adventure sports including kayaking, canoeing, sailing, windsurfing, climbing, mountaineering and skiing.
Written by two adventure sports performers with extensive teaching and coaching experience, this book will prove invaluable to students taking courses in adventure and outdoor education and professional instructors involved in such activities. In addition, students of sport and exercise science and physical education will find this an excellent introduction to the physiological response to exercise.Clearly explains the basic physiological principles and applies them to a variety of land and water-based sports.In full colour throughout, the book includes numerous illustrations, together with key points and chapter summaries to reinforce learning.Contains original pieces from elite and high-level athletes describing the physiological demands of their particular sport in a real-world context. These include London sports personality of the year Anna Hemmings, respected climbers Dave Macleod and Neil Gresham, and Olympic medallists Tim Brabants and Ben Ainslie.Dedicated web site contains an original sample training programme and a set of adventure sport specific exercises.
This textbook provides a unique, pocket-sized, self-directed study guide to fluid, electrolyte and acid base homeostasis for undergraduate biomedical science, pharmacology, medical and allied health students. It details the chemical (mostly ionic) composition of body fluids, explains how abnormalities arise, what laboratory tests can be used to identify and analyze the cause of these disorders and shows how normality can be achieved to maintain health.
This book gathers a selection of original articles and critical reviews presented at the 21st International Taurine Meeting, held in Shenyang, China in May 2018, which discussed and disseminated the latest findings on taurine, especially in human life. The book is divided into eight parts, which respectively address: Taurine and Metabolism, Taurine and Nutrition, Taurine and Organ Dysfunction, Taurine and Heart Health, Taurine and Anti-cancer, Taurine and Anti-oxidation / Anti-microbial, Taurine and Neuroprotection, and Taurine and Anti-inflammatory. These latest discoveries concerning the functions and advantageous effects of taurine on the health of various human body systems will not only advance the treatment of human diseases and the quality of human life, but also promote further research into the applications of taurine in human health.
How does the brain regulate sexual behavior, or control our body weight? How do we cope with stress? Addressing these questions and many more besides, this thoroughly revised new edition reflects the significant advances that have been made in the study of neuroendocrinology over the last twenty years. The text examines the importance of the hypothalamus in regulating hormone secretion from the endocrine glands, describing novel sites of hormone release including bone, heart, skeletal muscle and liver. The role of steroid hormone, neurotransmitter and peptide receptors, and the molecular responses of target tissues, is integrated into the discussion of the neuroendocrine brain, especially through changes in gene expression. Particular attention is attached to neuropeptides, including their profound influence on behavior. Complete with new full-color figures throughout, along with review and essay questions for each chapter, this is an ideal resource for undergraduate and graduate students of neuroscience, psychology, biology and physiology.
Closing a gap in the scientific literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefit approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.
This textbook uses a case-study approach to present the core principles of biochemistry and molecular biology in the context of human disease to students who will be involved in patient care. The 29 clinical cases have been carefully selected to cover key scientific concepts and some common, and other not so common, diseases. While the principal focus is on topics relating to metabolic disease, further subjects such as connective tissue disorders, neurological disorders, auto-inflammatory disorders, infective diseases, and cancer are also addressed. Each chapter provides a specific patient report that includes the natural history, pertinent clinical laboratory data, physical findings, subsequent diagnosis, and therapy. This is followed by a comprehensive discussion of the normal biochemical processes and reactions pertaining to the case, along with the pathophysiological mechanisms of the disease. Graphical diagrams are provided in each chapter for ease of comprehension.
The book is designed to provide a flowing description of the physiology of heat stress, the illnesses associated with heat exposure, recommendations on optimising health and performance, and an examination of Olympic sports played in potentially hot environmental conditions. In the first section the book examines how heat stress effects performance by outlining the basics of thermoregulation and how these responses impact on cardiovascular, central nervous system, and skeletal muscle function. It also outlines the pathophysiology and treatment of exertional heat illness, as well as the role of hydration status during exercise in the heat. Thereafter, countermeasures (e.g. cooling and heat acclimation) are covered and an explanation as to how they may aid in decreasing the incidence of heat illness and minimise the impairment in performance is provided. A novel and particular feature of the book is its inclusion of sport-specific chapters in which the influence of heat stress on performance and health is described, as well as strategies and policies adopted by the governing bodies in trying to offset the deleterious role of thermal strain. Given the breadth and scope of the sections, the book will be a reference guide for clinicians, practitioners, coaches, athletes, researchers, and students.
Kathrin Stauffer a biochemist and seasoned body psychotherapist takes a look at organ systems of the human body to illuminate the connections between body and mind, exploring the body as both the ground of our physical experience and as a metaphor for our emotional life. Beginning with a discussion of the basic building blocks of the body, cells and molecules, Stauffer works through the body system by system, showing through clinical case examples that an understanding of each system can greatly enhance the art of psychotherapy: The Central Nervous System, The Skeletal Musculature, The Respiratory System, The Skin, The Digestive System, Fluids and Connective Tissue, The Endocrine System, The Reproductive System, and The Respiratory System. Throughout, Stauffer presents human anatomy and physiology in clear, simple terms, with facts selected for interest and relevance to psychotherapists. Many links are made between physical and psychological function to give readers a taste of how body psychotherapists work in clinical practice to integrate body and mind, and thus help their clients become more whole. Anatomy & Physiology for Psychotherapists invites psychotherapists, complementary therapists, and anyone else interested in the mind/body connection to engage with the physical body to bring more depth into their therapeutic work."
This book is an accessible collection of case study scenarios ideal for physiology and pharmacology revision for pharmacy, medical, biomedical science, clinical science and healthcare students. Clearly structured and organized by major organ system, the book emphasises ways in which key signs and symptoms of disease inform diagnosis and the choice of treatment, together with the relevant pharmacological mechanisms. Each chapter has a clinical focus and includes clear learning outcomes, key points and model answers with detailed explanations designed to enhance students' understanding of the physiology and pharmacology underpinning each case study scenario. 50 topics are covered and the cases presented include an extensive range of psychological, neurological, endocrine, cardiovascular, respiratory, renal, gastrointestinal and reproductive disorders, their symptoms, complications and usual treatment along with the actions and uses of some widely- used drugs.* An essential revision text designed to help students apply their theoretical knowledge to real-life cases* Realistic case studies focusing on commonly occurring conditions and diseases* Model answers throughout* Learning outcomes provided at the beginning of each chapter* Key learning points presented in the cases follow each model answer* Helps students to understand the relevance and clinical implications of the topics studied in physiology and pharmacology courses* Reinforces major concepts and definitions* Includes a glossary with a full list of drugs and disorders to support the text
With mathematical and computational models furthering our understanding of lung mechanics, function and disease, this book provides an all-inclusive introduction to the topic from a quantitative standpoint. Focusing on inverse modeling, the reader is guided through the theory in a logical progression, from the simplest models up to state-of-the-art models that are both dynamic and nonlinear. Key tools used in biomedical engineering research, such as regression theory, linear and nonlinear systems theory, and the Fourier transform, are explained. Derivations of important physical principles, such as the Poiseuille equation and the wave speed equation, from first principles are also provided. Example applications to experimental data throughout illustrate physiological relevance, whilst problem sets at the end of each chapter provide practice and test reader comprehension. This book is ideal for biomedical engineering and biophysics graduate students and researchers wishing to understand this emerging field.
This book offers a comprehensive overview of toxicology, highlighting the significance of peptide-based toxins from marine environments. It discusses the principles of protein-carbohydrate and domain-domain interactions to increase our understanding of toxicology in zebrafish models, as well as drug interaction mechanisms and target definition in drug discovery. It also reviews the structure of marine peptides/toxins and the toxicology of peptide secreting cells and cells that respond to these enzymes, and describes the normal and abnormal toxicology of marine peptides in zebrafish models. Offering insights into the field of proteomics, particularly current practice and research models for solving its many riddles, the book also explains the analytical principles of marine protein-protein and protein-carbohydrate interaction in the context of teratogenicity in target identification in peptide- based drug discovery. Lastly, the book methodically examines the preclinical research on marine proteins/peptides.
Optimal nutrition is difficult to achieve. Insufficient energy and nutrient intake leads to inadequate growth, whereas too much can result in increased risk of non-communicable diseases (mainly obesity) and may adversely affect children with chronic diseases. Our understanding of the pathophysiology of inappropriate growth and the pathways involved in optimal and catch-up growth is constantly evolving. There is also new data emerging on the role of genes and the interaction between nutrition and epigenetic changes involved in growth, as well as on the interplay between nutrition and growth factors and hormones in health and disease states. In this latest yearbook, noted specialists present leading studies related to various aspects of nutrition and growth published between July 2017 and June 2018. Each study is summarized, with comments, providing additional and helpful views of interpretation. The book will provide useful and valuable information for health care providers, physicians, nurses, dieticians, scientists, and anyone else interested in nutrition.
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