Cell adhesion is a fundamental determinant of embryonic development and organogenesis. Cellular Adhesion in Development and Disease, volume 112 in Current Topics in Developmental Biology, comprehensively surveys current developments in understanding how adhesion systems affect organismal development. Topics covered include nectins, nectin-like molecules, and afadin in development; cadherin adhesion, signaling, and morphogenesis; endothelial cell junctions; epidermal development and barrier formation; and more.

These new volumes of Methods in Enzymology (554 and 555) on Hydrogen Sulfide Signaling continue the legacy established by previous volumes on another gasotransmitter, nitric oxide (Methods in Enzymology volumes 359, 396, 440, and 441), with quality chapters authored by leaders in the field of hydrogen sulfide research. These volumes of Methods in Enzymology were designed as a compendium for hydrogen sulfide detection methods, the pharmacological activity of hydrogen sulfide donors, the redox biochemistry of hydrogen sulfide and its metabolism in mammalian tissues, the mechanisms inherent in hydrogen sulfide cell signaling and transcriptional pathways, and cell signaling in specific systems, such as cardiovascular and nervous system as well as its function in inflammatory responses. Two chapters are also devoted to hydrogen sulfide in plants and a newcomer, molecular hydrogen, its function as a novel antioxidant.

These new volumes of Methods in Enzymology (554 and 555) on Hydrogen Sulfide Signaling continue the legacy established by previous volumes on another gasotransmitter, nitric oxide (Methods in Enzymology volumes 359, 396, 440, and 441), with quality chapters authored by leaders in the field of hydrogen sulfide research. These volumes of Methods in Enzymology were designed as a compendium for hydrogen sulfide detection methods, the pharmacological activity of hydrogen sulfide donors, the redox biochemistry of hydrogen sulfide and its metabolism in mammalian tissues, the mechanisms inherent in hydrogen sulfide cell signaling and transcriptional pathways, and cell signaling in specific systems, such as cardiovascular and nervous system as well as its function in inflammatory responses. Two chapters are also devoted to hydrogen sulfide in plants and a newcomer, molecular hydrogen, its function as a novel antioxidant.

Endocrine Board Review (EBR) 11th Edition, Reference Edition 2019 is a board examination preparation book designed for endocrine fellows who have completed or are nearing completion of their fellowship and are preparing to sit for the board certification exam, and for practicing endocrinologists in search of a comprehensive self-assessment of endocrinology, either to prepare for recertification or to update their practice. EBR consists of approximately 240 case-based, American Board of Internal Medicine (ABIM) style, multiple-choice questions. Each section follows the ABIM Endocrinology, Diabetes, and Metabolism Certification Examination blueprint, covering the breadth and depth of the certification and recertification examinations. Each case is discussed in detail with detailed answer explanations and references provided. EBR is updated annually with new questions. Customers are advised that this book is a reference edition and the questions in it are designed for self-study and reference. The content is the same as the non-reference edition, but CME and MOC credits are not available upon completion of the material. Anyone with questions about CME and/or MOC credits should consult www.endocrine.org/store for further information.

Pediatric Endocrine Self-Assessment Program (Pediatric ESAP (TM)), Reference Edition, 2019-2020 is a self-study curriculum specifically designed for endocrinologists seeking initial certification or recertification in pediatric endocrinology, program directors interested in a training instrument, and clinicians and health professionals seeking a self-assessment and a broad review of pediatric endocrinology. Pediatric ESAP (TM) consists of 100 multiple-choice questions in all areas of pediatric endocrinology, diabetes, growth, and metabolism. There is extensive discussion of each correct answer and references. Pediatric ESAP (TM) is updated every two years with new questions. Customers are advised that this book is a reference edition and the questions in it are designed for self-study and reference. The content is the same as the non-reference edition, but CME and MOC credits are not available upon completion of the material. Anyone with questions about CME and/or MOC credits should consult www.endocrine.org/store for further information.

Clinics Clinics

This book addresses instruments, methodologies and diagnostic methods used to evaluate and diagnose human movement, locomotion and physical status in general. Starting from historical perspective, the idea of understanding human locomotion by applying technical measurement devices and incorporating measurement data into physical representation of gross body movement is presented and explained, an approach known as inverse dynamics. With this approach as a kind of umbrella concept, components of measurement systems including relevant signal and data processing methods are described. Modern instruments to capture body movement by measuring its kinematics, kinetics and surface electromyography (sEMG) are thus described; all systems being used dominantly-if not exclusively-in a movement analysis laboratory setting. Focusing mainly on human posture and gait, but including also examples of movement patterns from selected kinesiological and sports activities, the book attempts to present essentials of biomechanics and biomedical engineering approach to this subject matter. It illustrates how data collected and elaborated by modern engineering technology can complement traditional expert knowledge of a kinesiologist or a medical doctor. The book is applicable in the fields of sports, physical activities, as well as in medical diagnostics and rehabilitation. The examples of this book's practical application might be in evaluation of efficiency of human gait, in evaluation of skeletal muscle fatigue in physical exercise, in biomechanical diagnostics of traumatological conditions requiring orthopaedic treatment and the like. This book can also be used in planning and executing research endeavours, particularly in a clinical context as a reference for various diagnostics procedures. It presents the lecture notes of a course carrying the same name within Medical Studies in English at the University of Zagreb for more than a decade.

Methodological Approaches for Sleep and Vigilance Research examines experimental procedures used to study the sleep-wake cycle, with topics covered by world leaders in the field. The book focuses on techniques commonly used in the sleep field, including polysomnography, electrophysiology, single- and multi-unit spiking activity recording, brain stimulation, EEG power spectra, optogenetics, telemetry, and wearable and non-wearable tracking devices. Further chapters on imaging techniques, questionnaires for sleep assessment, genome-wide association studies, artificial intelligence and big data are also featured. This discussion of significant conceptual advances into experimental procedures is suitable for anyone interested in the neurobiology of sleep.

Endocrine Self-Assessment Program (ESAP (TM)), Reference Edition 2019 is a self-study curriculum for physicians and health professionals wanting a self assessment and a broad review of endocrinology. It consists of 120 brand-new multiple choice questions in all areas of endocrinology, diabetes, and metabolism. There is extensive discussion of each correct answer, a comprehensive syllabus, and references. ESAP is updated annually with new questions. Customers are advised that this book is a reference edition and the questions in it are designed for self-study and reference. The content is the same as the non-reference edition, but CME and MOC credits are not available upon completion of the material. Anyone with questions about CME and/or MOC credits should consult www.endocrine.org/store for further information.

"The Path from Biomarker Discovery to Regulatory Qualification "is a unique guide that focuses on biomarker qualification, its history and current regulatory settings in both the US and abroad. This multi-contributed book provides a detailed look at the next step to developing biomarkers for clinical use and covers overall concepts, challenges, strategies and solutions based on the experiences of regulatory authorities and scientists. Members of the regulatory, pharmaceutical and biomarker development communities will benefit the most from using this book-it is a complete and practical guide to biomarker qualification, providing valuable insight to an ever-evolving and important area of regulatory science.

For complimentary access to chapter 13, "'""Classic' Biomarkers of Liver Injury, " by John R. Senior, Associate Director for Science, Food and Drug Administration, Silver Spring, Maryland, USA, please visit the following site: http: //tinyurl.com/ClassicBiomarkers
Contains a collection of experiences of different groups taking different types of biomarkers to different levels of qualification and provides insightful case studies of an important area of regulatory science

Focuses on practical advice, concepts, strategies and overall outcomes to support those working toward biomarker qualification for clinical use

Offers a valuable resource for members of the regulatory, pharmaceutical and biomarker development communities. "

Effectively manage parathyroid and bone metabolism disorders with The Parathyroid Gland and Bone Metabolism! Brought to you by the same leading endocrinologists responsible for the highly acclaimed two-volume textbook, Endocrinology: Adult and Pediatric, this derivative book presents a compilation of chapters covering all endocrinology material related to parathyroid and bone metabolism. Never before available as a stand-alone offering, this content will enable you to give your patients the benefit of today's best know-how on parathyroid and bone metabolism from the leading resource in endocrinology. Stay abreast of the newest knowledge and advances on parathyroid and bone metabolism, including. pediatric parathyroid disorders and bone metabolism disorders major diseases common to the aging population such as osteoporosis advances in the genetics of disorders involving calciotropic hormones newer diagnostic approaches and therapies for bone diseases, from osteoporosis to Paget's disease and much more. Count on all the authority that has made Endocrinology, 6th Edition, edited by Drs. Jameson and De Groot, the go-to clinical medical reference for endocrinologists worldwide. Make the best clinical decisions with an enhanced emphasis on evidence-based practice in conjunction with expert opinion.

Pulmonary hypertension is a life-threatening disease with no known cure. Here we provide a concise yet comprehensive review of the current knowledge about the pathophysiology of pulmonary hypertension (PH). The underlying signaling mechanisms involved in pulmonary vascular remodeling and the exaggerated vascular contractility, two characteristic features of pulmonary hypertension, are discussed in depth. The roles of inflammation, immunity, and right ventricular function in the pathobiology of pulmonary hypertension are discussed. The epidemiology of the five groups of pulmonary hypertension (World Health Organization classification; Nice, 2013) is also briefly described. A clear understanding of our current knowledge about the pathogenesis of PH is essential for further exploration of the underlying mechanisms involved in this disease and for the development of new therapeutic modalities. This book should be of interest to researchers and graduate students, both in basic research and in clinical settings, in the fields of pulmonary vascular biology and pulmonary hypertension.

This book is about the theory of Hot and Cold, a mutual fundamental base of traditional medicines all around the world. The theory describes the dynamic balance state of the body on the axis of hot and cold for each individual and proposes the fact that deviation from this equilibrium is a predisposing factor for diseases. Such an approach helps practitioners to provide treatments tailored to the patient's condition, not the disease. This book, for the first time, has gathered native descriptions of Hot and Cold theory in different traditional medicines, including traditional Chinese medicine, Persian (Humoral, Unani) medicine, Ayurvedic medicine and Latin American and Caribbean medicines. After defining the common ground, contemporary research - in nutrition, pharmacology, physiology and systems biology - has been explored using scientific methodology. This work is the result of an international collaboration of more than 30 scientists and scholars with high reputations in their fields. Hot and Cold theory, as a holistic individualized approach in prevention, diagnosis and treatment, can be merged into the novel fast-paced concepts in systems biology and precision medicine. Through this bridge, the authors propose that the Hot and Cold theory should be revisited more deeply by medical scientists, who are the main audience of this book, to pave the way towards integrated holistic personalized medicine.

Provides in-depth, clinical reviews on diabetes and prediabetes prevention and control, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. In this issue of Endocrinology and Metabolism Clinics, guest editor K M Venkat Narayan brings considerable expertise to the topic of diabetes and prediabetes.

This book focuses on the role of the endocannabinoid system in local and systemic inflammation, with individual chapters written by experts in the field of cannabinoid research and medicine. The topics explore the actions of the endocannabinoid system on the immune system, including neuroinflammation in autoimmune disorders such as multiple sclerosis, and in neurodegenerative disorders such as Huntington's and Alzheimer's, as well as local and systemic inflammatory conditions affecting organs including the eye (uveitis and corneal inflammation), the bladder (interstitial cystitis), pancreas (diabetes), cardiovascular system (stroke), joints (arthritis), and sepsis. The objective of this book is to provide knowledge transfer on the use of cannabinoids in inflammatory disease by critically examining preclinical and clinical research on the immunomodulatory actions of the endocannabinoid system, with specific emphasis on the actions of cannabinoids in diseases where inflammation is a prominent component. By drawing these results together, we seek to provide further understanding of the complexities of endocannabinoid system modulation of immune function and identify potential uses and limitations for cannabinoid-based therapeutics.

Once thought uncommon, cases of Hashimoto's thyroiditis are becoming much more commonplace through the increasing use of needle biopsy and serologic tests for antibodies that have led to much more frequent recognition. It is currently one of the most common thyroid disorders with the possibility that it may be increasing in frequency. As diagnostic methods improve, it is imperative that quick treatments are administered to improve the quality of life of patients. Diagnosing and Managing Hashimoto's Disease: Emerging Research and Opportunities is an essential publication that provides critical reference material for diagnosing and treating Hashimoto's Disease in a clinical environment. Featuring research on topics such as spontaneous hypothyroidism, papillary thyroid carcinoma, and differential diagnosis, this publication is ideally designed for clinicians, therapists, doctors, nurses, hospital administrators, researchers, educators, academicians, and students looking for the most up-to-date research on treating Hashimoto's Disease.

This original six chapter book will briefly review and integrate the basic concepts behind water distribution and movement in the body. This fills a knowledge gap that most medical and undergraduate physiology students acquire when these topics are studied separately. As of now, there is no textbook that fully integrates renal, cardiovascular and water physiology in a clear understandable manner. The book is intended primarily for medical students and undergraduate physiology students. Chapters include: 1) Water and its Distribution; 2) Water Dynamics; 3) Fluid Handling by the Heart and Blood Vessels; 4) Fluid Handling by the Kidneys; 5) Water and Oxygen Delivery; 6) Integration in the Response to Hemorrhage, Volume Depletion, and Water Redistribution.
An easy-to-read, step by step explanation of how water is distributed, how it moves, how this aides in oxygen delivery and how this is regulated in the human body.

Presentsa complex and detailed topicin an original way that will allow students to understand more complex textbooks and explanations"

In this issue of Endocrinology and Metabolism Clinics, Guest Editor Pauline Camacho brings her considerable expertise to the topic of Osteoporosis. Provides concise and comprehensive coverage of the issues physicians face every day. Presents the latest information on a timely, focused topic under the leadership of experienced editors in the field.

Food and water are necessary for survival, but can only be obtained via ingestive behavior (feeding, drinking, and moving). Survival thus depends on the ability of the brain to coordinate the need for water and energy with appropriate behaviors to modify their intake as necessary for homeostasis. However, the balance of these behaviors also inherently determines body weight, and imbalances contribute to the development of weight disorders, such as obesity and anorexia nervosa. The lateral hypothalamic area (LHA) of the brain is anatomically positioned to coordinate the sensation of osmotic and energy status with goal-directed ingestive behaviors necessary to maintain homeostasis and body weight, and, hence, may hold insight into the potential treatment for energy balance disorders. This volume reviews the essential role of the LHA for the control of body weight, from its historical description as a ""feeding center"" to the current view of this LHA as a cellularly heterogeneous hub that regulates multiple aspects of physiology to influence body weight. Furthermore, we evaluate how specific LHA populations coordinate certain metabolic cues and behaviors, which may guide the development of pathway-specific interventions to improve the treatment of energy balance disorders.

Since the publication of the first edition of this book in 2010, an explosion of spectacular discoveries in the field of regeneration has compelled the current revisit of the field of Regenerative Nephrology. This second edition features subjects as diverse as age and gender influencing regenerative processes; mechanisms and pathways of premature cell senescence affecting kidney regeneration; the ways intrinsic regenerative processes can become subverted by noxious stressors eventuating in disease progression; novel mechanistic and engineering efforts to recreate functional kidney or its component parts; cell reprogramming and reconditioning as emerging tools of future regenerative efforts; and effects of various biologicals on kidney regeneration. These newer additions to the armamentarium of Regenerative Medicine and Nephrology have become an integral part of the second edition of the book. Cutting-edge investigations are summarized by the constellation of the most experienced contributing authors coming together from around the world under the umbrella of the second edition.

This book aims at providing insights into the collagen superfamily and the remarkable diversity of collagen function within the extracellular matrix. Additionally, the mechanisms underlying collagen-related diseases such as dystrophic epidermolysis bullosa, osteogenesis imperfecta, as well as collagen-related myopathies and neurological disorders are discussed. Collagens are the most abundant extracellular matrix proteins in organisms. Their primary function is to provide structural support and strength to cells and to maintain biomechanical integrity of tissues. However, collagens can no longer be considered just as structural proteins. They can act as extracellular modulators of signaling events and serve critical regulatory roles in various cell functions during embryonic development and adult homeostasis. Furthermore, collagens are associated with a broad spectrum of heritability-related diseases known as "collagenopathies" that affect a multitude of organs and tissues including sensorial organs. The book is a useful introduction to the field for junior scientists, interested in extracellular matrix research. It is also an interesting read for advanced scientists and clinicians working on collagens and collagenopathies, giving them a broader view of the field beyond their area of specialization.

Global Emergency of Mental Disorders is a comprehensive, yet easy-to-read overview of the neurodevelopmental basis of multiple mental disorders and their accompanying consequences, including addiction, suicide and homelessness. Compared to other references that examine the treatment of psychiatric disorders, this book uniquely focuses on their neurodevelopment. It is designed for neuroscience, psychiatry, psychology students, and various other clinical professions. With chapters on anxiety, depression, schizophrenia and others, this volume provides information about incidence, prevalence and mortality rates in addition to developmental origins. With millions worldwide affected, this book will be an invaluable resource.