The last fifteen years have witnessed the extraordinary evolution of basic and clinical research in the field of lysoso-mal storage diseases (LSDs), transforming many of them from dire, untreatable progressive diseases to conditions that allow for possible cure or mitigation. In addition to the presently employed techniques of haematopoietic stem cell transplantation and enzyme replacement for a number of lysoso-mal storage diseases, other therapeutic approaches are being developed that are based on different principles. The awareness that the efficacy of treatment is greater if adminis-tered at the first signs of disease or, even better, during the pre-symptomatic phase underscores the urgency of early clinical diagnosis. Efforts are being made to improve the clinical acumen of paediatricians, paediatric surgeons and neurologists, rheumatologists, orthopaedists, and other professionals who come into early contact with children with LSDs. The possibility of including some of these disorders in routine neonatal screening is also a matter of discussion. This volume provides an updated overview of epidemiologic, biochemical, genetic, pathogenetic, and clinical aspects of these disorders and outlines the various treatment options currently available for the LSDs. The need for patients with rare diseases like LSDs to be followed-up in a specialised centre is emphasised in view of the many kinds of multidisciplinary treatment that are needed to improve the quality of life and survival of these children.

Learn the what, how, and why of pathophysiology! With easy-to-read, in-depth descriptions of disease, disease etiology, and disease processes, Pathophysiology: The Biologic Basis for Disease in Adults and Children, 8th Edition helps you understand the most important and most complex pathophysiology concepts. This updated text includes more than 1,300 full-color illustrations and photographs to make it easier to identify normal anatomy and physiology, as well as alterations of function. This edition includes a NEW chapter on obesity and nutritional disorders, along with expanded coverage of rare diseases and epigenetics. It's the most comprehensive and authoritative pathophysiology text available! The most comprehensive and authoritative pathophysiology text on the market provides unparalleled coverage of Pathophysiology content. Over 1,300 full-color illustrations and photographs depict the clinical manifestations of disease and disease processes - more than in any other pathophysiology text. Consistent presentation of diseases includes pathophysiology, clinical manifestations, and evaluation and treatment. Lifespan content includes ten separate pediatric chapters and special sections with aging and pediatrics content. Outstanding authors Kathryn McCance and Sue Huether have extensive backgrounds as researchers and instructors, and utilize expert contributors, consultants, and reviewers in developing this edition. Algorithms and flowcharts of diseases and disorders make it easy for you to follow the sequential progression of disease processes. Additional What's New boxes highlight the most current research and clinical development. Nutrition and Disease boxes explain the link between concepts of health promotion and disease. Chapter summary reviews provide concise synopses of the main points of each chapter. NEW! Chapter on obesity and nutritional disorders thoroughly covers these growing global concerns. NEW! Added coverage of rare diseases and epigenetics further explore genetic disease traits. NEW! Over 50 new or heavily revised illustrations visually highlight pathophysiology concepts. NEW! More than 30 new 3D animations on Evolve bring difficult concepts to life for a new perspective on disease processes.

In Everything Moves, Susan Lowell de Solorzano shares her understanding of biotensegrity as developed over years of direct study with the concept's originator, Stephen M. Levin. Biotensegrity becomes accessible experientially, yet without shying away from the complexities involved. The material presented is suitable for coaches and movement teachers new to biotensegrity as well as those with more advanced levels of understanding. Whether their focus is performance, sports, Alexander Technique, Feldenkrais, yoga, Pilates, martial arts, or dance, any arena in which bodies move can be informed by Everything Moves.

A full-color guide to the entire field of clinical endocrinology and its scientific underpinnings - updated with the latest breakthroughs and developments Greenspan's Basic & Clinical Endocrinology delivers a succinct, leading-edge overview of the underlying molecular biology of the endocrine system and the latest perspectives on the diagnosis and treatment of specific diseases and disorders. Featuring an enhanced design that includes hundreds of full-color illustrations and clinical photographs, Greenspan's is a true must-have during traditional or integrated courses in endocrinology, endocrinology rotation, or exam prep in internal medicine and endocrinology and as reference for disease management. Greenspan's provides clinically relevant coverage of metabolic bone disease, pancreatic hormones and diabetes mellitus, hypoglycemia, obesity, geriatric endocrinology, and many other diseases and disorders. Supporting this essential material is a handy appendix of normal hormone reference ranges across the lifespan. Here's why Greenspan's is an essential tool for learning how to manage endocrine patients: * The Tenth Edition is enhanced by updated content throughout each chapter * NEW CHAPTERS on Transgender Endocrinology and Disorders of Sexual Determination and Differentiation * Important chapter on Evidence-Based Endocrinology and Clinical Epidemiology * Concise, balanced coverage of both scientific and clinical principles that guide patient management * The best source for current concepts in endocrine pathophysiology to aid clinical decision making * The most practical, current insights into diagnostic testing * More than 270 full-color illustrations and clinical photographs If you are in need of a well-illustrated, completely up-to-date guide to the entire field of clinical endocrinology, this trusted classic belongs on your desk or computer.

This book presents a comprehensive overview of the roles of D-amino acids and latest research findings, to reveal their fascinating aspects and to facilitate better understanding of their important roles in physiology and diseases. It also provides useful hints for the development of drugs and functional foods. D-Amino acids were once called unnatural amino acids and were considered to be insignificant for eukaryotes especially in mammals. However, different D-amino acids have been revealed to be distributed in various mammalian tissues and to bear important physiological roles. For example, D-serine is implicated in memory formation and learning, and its abnormal concentration in tissues have been reported in neurological diseases such as schizophrenia and amyotrophic lateral sclerosis. D-Aspartate is found in a variety of mammalian tissues, particularly in the central nervous system and the genitals. D-Aspartate facilitates the endocrine secretion of prolactin, inhibits the secretion of melatonin, and plays a peculiar role in the control of reproductive functions in mammals, including the stimulation of testosterone synthesis. Written by the leading scientists in the field, this book is a valuable source of information for researchers in biochemistry, physiology, and neuroscience, as well as in the pharmaceutical and food industries.

The modulation of cellular interactions represents a crucial aspect of many inter and intra-cellular processes, including the regulation of gene expression, cell growth, migration, differentiation and apoptosis. Glycoproteins, which constitutes one of the major groups of adhesion molecules and receptors, plays an important role in such processes and over the last decade, research has highlighted the therapeutic implications this has for many physiological and pathological processes such as inflammation, arthritis and metastasis.;The first part of this book deals with the structure and biosynthesis of glycoconjugates, in addition to reviewing the structure and metabolism of glycosaminoglycans and glycolipids. It also features a general overview of cellular adhesion mechanisms and the extra-cellular matrix.;The second part addresses the pathological roles played by glycoconjugates and their potential therapeutic applications, for example in the progression of cancer, neurophysiopathologies and carbohydrate deficient glycoprotein syndromes.

For one-semester Anatomy & Physiology courses. This package includes Mastering A&P Focus on the essential what, how, & why of human anatomy & physiology With the 12th Edition of Essentials of Human Anatomy & Physiology, science educator Suzanne Keller joins bestselling author Elaine Marieb in helping learners focus on the essential What, How, & Why of A&P, without getting sidetracked in unnecessary details. Thoroughly updated with dozens of new figures, photos, and current information on medical recommendations and terminology, the 12th Edition continues to set the standard for brief, accessible one-semester A&P texts. The authors' hallmark clear and friendly writing style has been strengthened with familiar analogies and abundant mnemonic cues that help students learn and remember concepts. Continuing to offer just the right balance of anatomy, physiology, and clinical coverage, engaging new chapter previews help learners hone in on what structures and functions they are studying, how they function, and why they are important to learn. This package includes Mastering A&P Mastering (TM) A&P is an online homework, tutorial, and assessment program designed to engage students and improve results. Instructors ensure that students arrive ready to learn by assigning educationally effective content before class, and encourage critical thinking and retention with in-class resources such as Learning Catalytics (TM). Students can further master concepts after class through assignments that provide hints and answer-specific feedback. With a wide range of activities available, students can actively learn, understand, and retain even the most difficult concepts. Mastering A&P should only be purchased when required by an instructor. Please be sure you have the correct ISBN and Course ID. Instructors, contact your Pearson rep for more information.

Maia is the story of an idea, and its development into a working hypothesis, that provides a cybernetic interpretation of how growth is controlled. Growth at the lowest level is controlled by regulating the rate of growth. Access to the output of control mechanisms is provided by perturbing the growing organism, and then filtering out the consequences to growth rate. The output of the growth control mechanism is then accessible for interpretation and modelling. Perturbation experiments have been used to provide interpretations of hormesis, the neutralization of inhibitory load and acquired tolerance to toxic inhibition, and catch-up growth. The account begins with an introduction to cybernetics covering the regulation of growth and population increase in animals and man and describes this new approach to access the control of growth processes. This book is suitable for postgraduate students of biological cybernetics and researchers of biological growth, endocrinology, population ecology and toxicology.

"Running Mechanics and Gait Analysis With Online Video" is the premier resource dedicated to running mechanics and injury prevention. Running continues to be one of the most popular sports, despite the fact that up to 70 percent of runners will sustain overuse injuries during any one-year period. Therefore, it is imperative for health care professionals, coaches, and runners themselves to be informed on injury prevention and optimal treatment. Referencing over 250 peer-reviewed scientific manuscripts, this text is a comprehensive review of the most recent research and clinical concepts related to gait and injury analysis.

"Running Mechanics and Gait Analysis With Online Video" supplies professionals with an expansive array of clinical applications. Physical therapists and athletic trainers will come away with an understanding of ways to build on standard practice, while runners, coaches, and personal trainers will gain a new appreciation for the performance benefits that gait analysis can provide. The text has the following features:

- A discussion of the complexities of running biomechanics as they relate to muscular strength, flexibility, and anatomical alignment for the purpose of providing an advanced clinical assessment of gait

- Guidelines for assessing, treating, and preventing a range of common and not-so-common running injuries

- A detailed analysis of running biomechanics to help professionals identify the interactions of the kinetic chain and the causes of overuse injuries

- A video library featuring 33 clips that demonstrate the biomechanical patterns discussed in the text

- Documented clinical examples to help practitioners apply the wealth of information in the book to their own practice

Early chapters introduce readers to the basics of running-related injuries, foot mechanics, and shoe selection before progressing to discussions of knee and hip mechanics, ways to influence gait mechanics, and technical aspects of video gait analysis. Via a detailed joint-by-joint analysis, the book pinpoints common problem areas for runners and describes protocols for treatment. Later chapters present case studies of injured runners to guide professionals through a detailed biomechanical analysis and treatment recommendations, and an overview chapter summarizes the interrelationships of movement patterns at each joint with anatomical, strength, flexibility, and kinetic chain factors.

"Running Mechanics and Gait Analysis With Online Video" is the most comprehensive resource for running-related research. Readers will come away armed with the knowledge and tools to perform an advanced clinical assessment of gait and rehabilitate and prevent running injuries.

A continuing education quiz based on the content of this book is also available for purchase separately.

Dietary anthocyanins and flavonoids in vegetables, fruits and grain corms have their diverse functions to human dietary life. Topics discussed in this book include original findings and reviews such as their distributions, extractions, separations, characterization, stability, functions, biosynthesis pathway, the regulation of the biosynthetic enzymes by anthocyanins and flavonoids, food colours, and molecular biology such as a relationship of biomolecule with anthocyanins or flavonoids in vegetables and fruits. Kiwifruits, muscadine berries, color rices, Justicia species, strawberry, a Brazilian fruit of jabuticaba (Myrciaria cauliflora), jujube berry fruits, grapes, bilberries, taro as a vegetable and corn, and other fruits have been included in this book.

This book summarizes our current understanding about the biology and patho-biology of cardiomyocytes and depicts common techniques for the study of these cells. The book is divided into two parts; the first part provides insight into role and function of cardiomyocytes under normal conditions and describes embryogenesis and differentiation, in the second part the role of cardiomyocytes in aging and disease is discussed and cellular responses under stress conditions illustrated. Cardiomyocytes represent the main mass of the heart, and cellular malfunction directly modifies heart function leading to subsequent heart failure. As such, cardiomyocytes are causative involved in the main reasons of heart failure, such as post-infarct remodeling, hypertensive heart disease, idiopathic heart failure, and interactions with other co-morbidities such as diabetes. On the other hand, cardiomyocytes are necessarily target of therapy. Therefore, a precise understanding of cardiomyocytes biology is a pre-requisite for proper disease treatment and evidence based medicine. The book is written for cell biologists, pharmacologists and biomedical researchers specialized in cardiac and vascular biology.

This book provides a state-of-the-art report on our current understanding of aquaporins and the future direction of the field. Aquaporins (AQPs) are a group of water-channel proteins that are specifically permeable to water and other small molecules, such as glycerol and urea. To date thirteen water-channel proteins (AQP0 - AQP12) have been cloned and the mechanisms and physiological functions of water transport across biological membranes have long been the subject of interest. Recent advances in the molecular biology and physiology of water transport have yielded new insights into how and why water moves across cell membranes, and studies on aquaporin knockout mouse models suggest that aquaporins are involved in the development of some diseases and they may be useful targets of research into selective-inhibitor drugs. By focusing on the advances made over the last 20 years in the biophysics, genetics, protein structure, molecular biology, physiology, pathophysiology and pharmacology of aquaporins in mammalian cell membranes, this book provides novel insights into further mechanisms and the physiological significance of water and some small molecule transport in mammals in order to stimulate further research in new directions.

Somatic growth is a crucial component in the development of an organism. Growth is manifested in many levels during an organisms lifespan; rapid intrauterine growth is followed by extrauterine development that subsides with age. The control of growth is exerted via particularly complex and multifaceted mechanisms that affect every cell of the body, regulating the balance between the anabolic and catabolic processes, and it is intimately entwined with almost every physiological function. The central component of this regulatory system is the hypothalamo-hypophyseal axis that controls not only all of the endocrine organs of the body, but also regulates the growth of every cell via growth hormone (GH) release. It would certainly exceed the scope of the present book to summarize the growth-related complex peripheral actions of the various hormonal systems of the hypothalamo-hypophyseal axis. GH secretion is modulated primarily by the somatotropic axis, which is one of the functional components of the hypothalamo-hypophyseal axis and integrates the stimulatory and inhibitory actions of growth hormone-releasing hormone (GHRH) and somatostatin upon GH release, respectively. Therefore, in the present volume we attempt to give an overview of the regulatory components of a somatotropic axis with a special emphasis on the regulatory input provided by hypothalamic hormonal and neurotransmitter/neuromodulator systems. Since it is particularly complicated to extrapolate animal data to human physiology, the authors focus on human results while animal studies are detailed only if they provide a better understanding to how growth is regulated in humans. This process has proven to be difficult due to the scarcity of human studies in this field.

Because of developments in powerful computer technology, computational techniques, advances in a wide spectrum of diverse technologies, and other advances coupled with cross disciplinary pursuits between technology and its greatly significant applied implications in human body processes, the field of biomechanics is evolving as a broadly significant area. This Third Volume presents the advances in widely diverse areas with significant implications for human betterment that occur continuously at a high rate. These include dynamics of musculo-skeletal systems; mechanics of hard and soft tissues; mechanics of muscle; mechanics of bone remodeling; mechanics of implant-tissue interfaces; cardiovascular and respiratory biomechanics; mechanics of blood flow, air flow, flow-prosthesis interfaces; mechanics of impact; dynamics of man machine interaction; and numerous other areas. The great breadth and depth of the field of biomechanics on the international scene requires at least four volumes for adequate treatment. These four volumes constitute a well integrated set that can be utilized as individual volumes. They provide a substantively significant and rather comprehensive, in-depth treatment of biomechanic systems and techniques that is most surely unique on the international scene.

This book presents an overview of the latest theories of affect regulation and focuses on how these theories work in clinical settings and how therapists can be taught to implement them. The notion of teaching and learning will be extended by the theories themselves-the author presents methods of education that enact the theories being taught. The book is divided into eight chapters, each one highlighting a particular structure or related structures of the brain. Suggestions for learning how to clinically apply the neurobiological/neuroanatomical information are offered. What is so unique about this book is that the bulk of the chapters are clinical dialogue, accompanied by neurobiological commentary. Thus, readers can see for themselves, during the course of parts of sessions, just how a "neurobiological outlook" can inform therapeutic understandings of what clients are doing and saying. The result is a very user-friendly learning experience for readers, as they are taken along a journey of understanding various brain systems and how they relate to psychotherapeutic principles. Elegantly bridging the gap between the academic and clinical domains, this book is essential for anyone interested in the application of neurobiological principles to psychotherapy and wishes to learn about neurobiology without feeling overwhelmed or intimidated.

Metabolism, behaviour, sleep, mood swings, the immune system, fighting, fleeing, puberty and sex: these are just a few of the things our bodies control with hormones. Armed with a healthy dose of wit and curiosity, medical journalist Randi Hutter Epstein takes us on a journey through the unusual history of these potent chemicals from a basement filled with jarred nineteenth-century brains to a twenty-first-century hormone clinic in Los Angeles. Brimming with fascinating anecdotes, illuminating new medical research and humorous details, Aroused introduces the leading scientists who made life-changing discoveries about the hormone imbalances that ail us, as well as the charlatans who used those discoveries to peddle false remedies.

Functional Biochemistry in Health and Disease provides a clear and straightforward account of the biochemistry that is necessary to understand the physiological functions of tissues or organs essential to the life of human beings. Focusing on the dynamic aspects of biochemistry and its application to the basic functions of the body, the book bridges the gap between biochemistry and medical practice.

Carefully structured within five sections, each biochemical, physiological or medical subject that is covered in the book is presented in one complete chapter. Consequently, each subject can be read and studied in isolation although cross-sectional links between the subjects are included where necessary. Background material, both biochemical and medical, that is necessary for an understanding of the subject, is included at the start of each chapter and clear, relevant diagrams enhance students' understanding.Focuses on medically relevant aspects of biochemistry written from a physiological rather than a chemical perspective.Clear presentation that minimises the use of jargon.Each chapter contains boxes on related topics, relevant diagrams and a brief glossary.Coverage includes athletic performance, apoptosis and the immune system.Key historical developments are included to show how modern biochemistry has evolved.

By linking biochemistry, medical education and clinical practice this book will prove invaluable to students in medical and health sciences, biomedical science and human biology taking an introductory biochemistry course. In addition it will appeal to biochemistry and biology students interested in clinical applications of biochemistry.

Axons are nerve fibres that typically conduct electrical impulses away from the neuron's cell body. The function of the axon is to transmit information to different neurons, muscles and glands. In this book, the authors discuss the cell biology, molecular dynamics and role in neural repair and rehabilitation of axons. Topics include the traumatic retraction of living neural processes and their inhibitions; water translocation from the axoplasm into the glioplasm during reactive reorganisation of myelinated nerve fibres; problems and mechanisms in axonal afterdischarges; the putative role of axon cytoskeleton protein in MS repair; microtubules as a potential therapeutic target for the treatment of neurodegenerative diseases; morphometrical and molecular biological analyses of facial nerves in healthy adults and patients with facial nerve palsy; intrinsic axon growth potential; and sensory axonal guidance by chemorepulsive and chemoattractive cues in higher vertebrates.

Recently developed diagnostic and therapeutic technologies such as OCT-angiography and small gauge vitrectomy have influenced the modern treatment of diabetic retinopathy. This volume provides a summary of the state-of-the-art evidence-based approach to managing complications that may occur with diabetic retinopathy. It offers the latest information on pathogenesis and diagnosis, and highly experienced clinicians review the results of relevant randomized clinical trials that serve as the basis of current therapy. The book provides not only a summary of data from randomized trials but also an analysis and interpretation by internationally renowned experts. Ophthalmology residents, fellows, and practicing clinicians will find this book to be a useful reference when seeking evidence-based treatment strategies for various complications of diabetic retinopathy. It is also for researchers identifying new avenues of drug developments and for insurance professionals and health care policy administrators who are establishing evidence-based therapy guidelines for therapeutic intervention.

An astonishing work of cutting-edge science and cultural history from one of our most respected cultural critics and thinkers, Naomi Wolf, author of the modern classic The Beauty Myth

When an unexpected medical crisis sends Naomi Wolf on a journey to tease out the intersections between sexuality and creativity, she discovers--much to her own astonishment--an increasing body of scientific evidence that documents new insights about female sexual response. These breakthrough discoveries show that the vagina, clitoris, and labia--the female sexual centers--are not "merely flesh," but directly affect the female brain, and that the female brain directly affects, in newly documented ways, the vagina and female sexual centers. The vagina thus has a fundamental relationship to female consciousness itself. Utterly enthralling and totally fascinating, Vagina draws on this set of insights about "the mind-vagina connection" to reveal new information about what women really need, on many different levels, and considers what sexual relationships--and a woman's relationship to her self, as well as to her own desire and pleasure--transformed by these insights, may look like.

A brilliant and nuanced synthesis of physiology, history, and cultural criticism, Vagina explores the physical, political, and spiritual implications for women--and for society as a whole--in this startling series of new scientific breakthroughs from a writer whose conviction and keen intelligence have propelled her works to the tops of bestseller lists, and firmly into the realm of modern classics.

Comprehensive, single-source coverage of the entire second year of medical school! First Aid for the Basic Sciences: Organ Systems, Third Edition is a unique single-source review of the entire second year medical school curriculum. This full-color, richly illustrated, and engagingly written resource provides readers with a solid understanding of basic sciences relative to human organ systems which all medical students must be familiar. When used with the companion review First Aid for the Basic Sciences: General Principles, Third Edition, this powerful combination distills must-know course information to help students survive their first two years of medical school and provides an in-depth review for the USMLE Step 1. * An essential companion during your first two years of medical school * Includes important foundational content most other reviews leave out * Focuses on the high-yield topics and facts tested on the USMLE Step 1 * Enhanced by full-color images, learning aids, tables, and concise text to streamline your study and help you excel in coursework and on the USMLE Step 1 * Provides a complete framework for understanding anatomy, embryology, pathology, and pharmacology by organ systems * Mirrors the table of contents of First Aid for the USMLE Step 1 to facilitate side-by-side study * Written by students who aced the USMLE and reviewed by top faculty

This book meets the long-awaited need for a comprehensive overview of the biological role of HDLs. Edited by one of the pioneers in HDL and cholesterol research, this monograph summarizes current knowledge on HDL turnover, regulation and physiology. Clearly structured, the various sections cover HDL structure, formation, secretion and removal, as well as plasma metabolic factors. The biological activities and clinical aspects are equally discussed, as is the impact of HDL on common diseases and their prevention.

REA's Essentials provide quick and easy access to critical information in a variety of different fields, ranging from the most basic to the most advanced. As its name implies, these concise, comprehensive study guides summarize the essentials of the field covered. Essentials are helpful when preparing for exams, doing homework and will remain a lasting reference source for students, teachers, and professionals. Anatomy and Physiology includes an introduction to the human body, the chemistry of life, cells, the skin, the skeletal system, the skeletal muscles, the nervous system, the sense organs, the endocrine system, the circulatory system, the respiratory system, the digestive system, the urinary system, the reproductive system, and human development.