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Books > Medicine > Pre-clinical medicine: basic sciences > Physiology

Insights Into Glucose Tolerance (Hardcover): Vanessa Artiga Insights Into Glucose Tolerance (Hardcover)
Vanessa Artiga
R2,522 Discovery Miles 25 220 Ships in 12 - 19 working days
The Gastrointestinal System - Gastrointestinal, Nutritional and Hepatobiliary Physiology (Hardcover, 2014 ed.): Po Sing Leung The Gastrointestinal System - Gastrointestinal, Nutritional and Hepatobiliary Physiology (Hardcover, 2014 ed.)
Po Sing Leung
R1,565 Discovery Miles 15 650 Ships in 10 - 15 working days

Gastrointestinal (GI) physiology is a fundamental subject that is indispensable not only for undergraduate but also for graduate courses. The audience include, but are not limited to, medical, pharmacy, nursing, human biology, Chinese medicine, and science students, as well as other health-related subject students.The overall objectives of this textbook are to present basic concepts and principles of GI physiology and, more importantly, to convey an understanding of how to apply this knowledge to abnormal GI physiology in the clinical context. As such, the basic knowledge of GI physiology and its application in the form of clinical case studies should be grasped, which are critical for professional examinations and bedside, as well as for general practice in the future. In this handbook, we aim to achieve these elements by covering the breadth of GI, pancreatic, hepatobiliary, and nutritional physiology. Moreover, we include relevant scenario-based clinical case in each chapter so as to evaluate whether the students can apply the basic GI they learn to the clinical setting."

Extracellular Matrix Omics (Hardcover, 1st ed. 2020): Sylvie Ricard-Blum Extracellular Matrix Omics (Hardcover, 1st ed. 2020)
Sylvie Ricard-Blum
R4,608 Discovery Miles 46 080 Ships in 10 - 15 working days

This book covers different omics aspects related to the extracellular matrix (ECM), namely specific omics resources focused on the extracellular matrix (e.g., databases, repositories and atlases), quantitative proteomics applied to specific extracellular matrices (e.g. basement membranes), biological processes such as ECM degradation (degradomics), cell-matrix interactions (adhesomes), signaling pathways, biomarker discovery and diseases, and interactomics (extracellular matrix interaction networks including not only protein-protein but also protein-glycosaminoglycan interactions). The volume also includes recent advances in glycomics and glycobioinformatics applied to proteoglycans and glycosaminoglycans, which are key biological players. The use of omics data to build dynamic models of ECM-regulated biological pathways is addressed, together with the requirement to standardize omic data, which is a prerequisite for the FAIR (Findability, Accessibility, Interoperability, and Reusability) guiding principles for scientific data management. This book will be of great interest to a broad readership from beginners to advanced researchers, who are interested in extracellular matrix omics and will inspire future research topics.

Basic and Clinical Endocrinology Up-to-Date (Hardcover): Fulya Akin Basic and Clinical Endocrinology Up-to-Date (Hardcover)
Fulya Akin
R3,900 Discovery Miles 39 000 Ships in 10 - 15 working days
High Density Lipoproteins - From Biological Understanding to Clinical Exploitation (Hardcover, 2015 ed.): Arnold Von... High Density Lipoproteins - From Biological Understanding to Clinical Exploitation (Hardcover, 2015 ed.)
Arnold Von Eckardstein, Dimitris Kardassis
R1,711 Discovery Miles 17 110 Ships in 12 - 19 working days

In this Handbook of Experimental Pharmacology on "High Density Lipoproteins - from biological understanding to clinical exploitation" contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation. The book is of interest to researchers in academia and industry focusing on lipoprotein metabolism, cardiovascular diseases and immunology as well as clinical pharmacologists, cardiologists, diabetologists, nephrologists and other clinicians interested in metabolic or inflammatory diseases.

Proceedings of the 14th International Conference on Man-Machine-Environment System Engineering (Hardcover, 2015 ed.): Shengzhao... Proceedings of the 14th International Conference on Man-Machine-Environment System Engineering (Hardcover, 2015 ed.)
Shengzhao Long, Balbir S Dhillon
R6,818 R5,179 Discovery Miles 51 790 Save R1,639 (24%) Ships in 12 - 19 working days

The integrated and advanced science research topic man-machine-environment system engineering (MMESE) was first established in China by Professor Shengzhao Long in 1981, with direct support from one of the greatest modern Chinese scientists, Xuesen Qian. In a letter to Shengzhao Long from October 22nd, 1993, Xuesen Qian wrote: "You have created a very important modern science and technology in China!" MMESE primarily focuses on the relationship between man, machines and the environment, studying the optimum combination of man-machine-environment systems. In this system, "man" refers to people in the workplace (e.g. operators, decision-makers); " machine" is the general name for any object controlled by man (including tools, machinery, computers, systems and technologies), and "environment" describes the specific working conditions under which man and machine interact (e.g. temperature, noise, vibration, hazardous gases etc.). The three goals of optimization of man-machine-environment systems are to ensure safety, efficiency and economy. Proceedings of the 14th International Conference on Man-Machine-Environment System Engineering are an academic showcase of the best papers selected from more than 400 submissions, introducing readers to the top research topics and the latest developmental trends in the theory and application of MMESE. These proceedings are interdisciplinary studies on the concepts and methods of physiology, psychology, system engineering, computer science, environment science, management, education, and other related disciplines. Researchers and professionals working in these interdisciplinary fields and researchers on MMESE related topics will benefit from these proceedings.

Radiation and Health (Hardcover): Neli Melman Radiation and Health (Hardcover)
Neli Melman
R884 Discovery Miles 8 840 Ships in 10 - 15 working days
Reviews of Physiology, Biochemistry and Pharmacology 159 (Hardcover, 2007 ed.): S.G. Amara, E. Bamberg, B. Fleischmann, T.... Reviews of Physiology, Biochemistry and Pharmacology 159 (Hardcover, 2007 ed.)
S.G. Amara, E. Bamberg, B. Fleischmann, T. Gudermann, S.C. Hebert, …
R5,568 Discovery Miles 55 680 Ships in 10 - 15 working days

Contents

Philip C. Sharpe, Rosemary S. Harrison, and David P. Fairlie: Amyloid Peptides and Proteins in Review. - Marilena Kampa, Artemissia-Phoebe Nifli, George Notas, Elias Castanas: Polyphenols and Cancer Cell Growth. - Michal Janitz: Assigning Functions to Genes The Main Challenge of the Post-Genomic Era. - Brigittte M. Jockusch, Kai Murk and Martin Rothkegel: The Profile of Profilins.

Exercise Physiology (Hardcover): Pablo De Souza Exercise Physiology (Hardcover)
Pablo De Souza
R3,043 R2,763 Discovery Miles 27 630 Save R280 (9%) Ships in 10 - 15 working days
Cell Polarity 1 - Biological Role and Basic Mechanisms (Hardcover): Klaus Ebnet Cell Polarity 1 - Biological Role and Basic Mechanisms (Hardcover)
Klaus Ebnet
R4,019 R3,737 Discovery Miles 37 370 Save R282 (7%) Ships in 12 - 19 working days

This work provides a state-of-the art overview on the most relevant aspects of cell polarity. Volume 1 addresses cell polarity and cell migration (front-rear polarity), cell polarity and barrier formation (apico-basal polarity) and neuronal polarity. It particularly focuses on cell polarity at the molecular level and the underlying molecular mechanisms. It also elaborates the common principles and mechanisms that regulate cellular polarization in different cell types and contexts. Both volumes are intended for professors, group leaders and researchers in cell biology as well as medical professionals in the fields of anatomy, cell biology, physiology, pathology and tumor biology.

Textbook of Nephro-Endocrinology (Hardcover): Ajay K Singh, Gordon H. Williams Textbook of Nephro-Endocrinology (Hardcover)
Ajay K Singh, Gordon H. Williams
R3,744 Discovery Miles 37 440 Ships in 12 - 19 working days

The Textbook of Nephro-Endocrinology is the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers both researchers and clinicians expert, gold-standard analysis of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoprosis, and, hypoparathyroidism.
* Investigates both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems.
* Presents a uniquely comprehensive and cross-disciplinary look at all aspects of nephro-endocrine disorders in one reference work.
* Clear translational presentations by the top endocrinologists and nephrologists in each specific hormone or functional/systems field.

Nathan Zuntz - His Life and Work in the Fields of High Altitude Physiology and Aviation Medicine (Hardcover): Hanns-Christian... Nathan Zuntz - His Life and Work in the Fields of High Altitude Physiology and Aviation Medicine (Hardcover)
Hanns-Christian Gunga
R1,962 Discovery Miles 19 620 Ships in 12 - 19 working days

This book focuses on the life and work of Nathan Zuntz (1847-1920), a German physiologist, who made significant contributions to high altitude physiology and aviation medicine.
He achieved fame for his invention of the Zuntz-Geppert respiratory apparatus in 1886 and the first treadmill (Laufband) in 1889. He also invented an X-ray apparatus to observe cardiac changes during exercise and constructed a climate chamber to study exercise under varying and sometimes extreme climates.
* Focuses on Zuntz's contribution to high altitude physiology and aviation medicine

Advanced Topics in Morphometrics (Hardcover): Phyllis Bates Advanced Topics in Morphometrics (Hardcover)
Phyllis Bates
R1,814 R1,675 Discovery Miles 16 750 Save R139 (8%) Ships in 10 - 15 working days
Angiogenesis: In Vivo Systems, Part B, Volume 445 (Hardcover): David A. Cheresh Angiogenesis: In Vivo Systems, Part B, Volume 445 (Hardcover)
David A. Cheresh
R4,489 Discovery Miles 44 890 Ships in 12 - 19 working days

Understanding how angiogenesis "works" and how to control it will have massive implications on the management, treatments, and ultimately the prevention of many common (and not so common) diseases. Angiogenesis is the growth of new blood vessels and is an important natural process in the body. A healthy body maintains a perfect balance of angiogenesis modulators. In many serious disease states, however, the body loses control over angiogenesis. Diseases that are angiogenesis-dependent result when blood vessels either grow excessively or insufficiently.
* Tried-and-tested techniques written by researchers that developed them, used them, and brought them to fruition
* Provides the "builder's manual" for essential techniques--a one-stop shop that eliminates needless searching among untested techniques
* Includes step-by-step methods for understanding the cell and molecular basis of wound healing, vascular integrin signaling, mechanical signaling in blood vessels, and vascular proteomics

Treatment of Type 2 Diabetes (Hardcover): Colleen Croniger Treatment of Type 2 Diabetes (Hardcover)
Colleen Croniger
R3,888 Discovery Miles 38 880 Ships in 10 - 15 working days
Phagocytosis of Dying Cells - From Molecular Mechanisms to Human Diseases (Hardcover, 2009 ed.): Dmitri V. Krysko, Peter... Phagocytosis of Dying Cells - From Molecular Mechanisms to Human Diseases (Hardcover, 2009 ed.)
Dmitri V. Krysko, Peter Vandenabeele
R4,427 Discovery Miles 44 270 Ships in 10 - 15 working days

This book deals with many recent advances made in uncovering the molecular and cellular basis of phagocytosis of apoptotic and necrotic dying cells as well as with the methods used for studying their clearance. There are important practical and clinical reasons for attempting to understand the molecular mechanisms of phagocytosis of dying cells, because inadequate clearance of dying cells may contribute to the development of autoimmune diseases (e.g. systemic lupus erythematosus), as well as atherosclerosis and chronic lung diseases (e.g. chronic obstructive pulmonary disease, asthma and cystic fibrosis). Furthermore, in this book we examine the possibility of using apoptotic cells in the prevention and treatment of graft rejection and in the rational design of immunotherapy and vaccines for cancer treatment. The role of environmental factors in phagocytosis of dying cells is also addressed.

This comprehensive volume integrates the most innovative and current findings from several related disciplines of scientific research, including pathology, immunology, genetics, and cellular and molecular biology. It is divided into two sections: "Molecular mechanisms of phagocytosis of dying cells" and "Impairment of phagocytosis of dying cells and its role in the development of diseases." No other recent books devoted to this subject are available.

All of the contributors are experts working at the forefront of scientific discovery, and the reviews they present systematically examine the most exciting and innovative aspects of their particular areas of expertise. Both researchers and physicians will find this volume of major benefit because it covers the immunological and molecular biological aspects of phagocytosis of dying cells as well as its clinical relevance.

Innovative Approaches to Cell Biomechanics - From Cell Migration to On-Chip Manipulation (Hardcover, 2015 ed.): Kennedy Omondi... Innovative Approaches to Cell Biomechanics - From Cell Migration to On-Chip Manipulation (Hardcover, 2015 ed.)
Kennedy Omondi Okeyo, Hiromi Miyoshi, Taiji Adachi
R3,814 R3,533 Discovery Miles 35 330 Save R281 (7%) Ships in 12 - 19 working days

This book covers topics on mechanosensing, mechanotransduction, and actin cytoskeletal dynamics in cell motility. It will contribute to a better understanding of how cells functionally adapt to their mechanical environment as well as highlighting fundamental concepts for designing material niches for cell manipulation. With topics from multidisciplinary fields of the life sciences, medicine and engineering, the book is the first of its kind, providing comprehensive, integrated coverage of innovative approaches to cell biomechanics. It provides a valuable resource for seniors and graduate students studying cell biomechanics and is also suitable for researchers interested in the application of methods and strategies in connection with the innovative approaches discussed. Each section of the book has been supplemented with concrete examples and illustrations to facilitate understanding even for readers unfamiliar with cell biomechanics.

Folic Acid and Folates, Volume 79 (Hardcover): Gerald Litwack Folic Acid and Folates, Volume 79 (Hardcover)
Gerald Litwack
R5,479 Discovery Miles 54 790 Ships in 12 - 19 working days

First published in 1943, "Vitamins and Hormones" is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms.
Under the capable and qualified editorial leadership of Dr. Gerald Litwack, "Vitamins and Hormones" continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.
*Includes color illustrations
*Available on ScienceDirect
*Longest running series published by Academic Press
*Contributions by leading international authorities

Angiogenesis: In Vivo Systems, Part A, Volume 444 (Hardcover): David A. Cheresh Angiogenesis: In Vivo Systems, Part A, Volume 444 (Hardcover)
David A. Cheresh
R4,483 Discovery Miles 44 830 Ships in 12 - 19 working days

Angiogenesis is the growth of new blood vessels and is an important natural process in the body. A healthy body maintains a perfect balance of angiogenesis modulators. In many serious disease states, however, the body loses control over angiogenesis. Diseases that are angiogenesis-dependent result when blood vessels either grow excessively or insufficiently. Understanding how angiogenesis "works" and how to control it, will have massive implications on the management, treatments, and ultimately the prevention of many common (and not so common) diseases.
Angiogenesis cuts across virtually every discipline. The Angiogenesis Foundation identified angiogenesis as a "common denominator" in our most serious diseases. Excessive angiogenesis occurs in diseases such as cancer, diabetic blindness, age-related macular degeneration, rheumatoid arthritis, psoriasis, and many other conditions. Insufficient angiogenesis occurs in diseases such as coronary artery disease, stroke, and delayed wound healing.

* Tried-and-tested techniques written by researchers that developed them, used them, and brought them to fruition.
* Provides the "builder's manual" for essential techniques. This is a one-stop shop that eliminates needless searching among untested techniques.
* Includes step-by-step methods for understanding the cell and molecular basis of wound healing, vascular integrin signaling, mechanical signaling in blood vessels, and vascular proteomics

The Eye's Aqueous Humor, Volume 62 (Hardcover, 2nd edition): Dale J. Benos, Sidney A. Simon The Eye's Aqueous Humor, Volume 62 (Hardcover, 2nd edition)
Dale J. Benos, Sidney A. Simon; Volume editing by Mortimer M. Civan
R4,646 Discovery Miles 46 460 Ships in 12 - 19 working days

DESCRIPTION:
Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. Articles in this volume discuss ion transport;
ocular aquaporins and aqueous humor dynamics;
the role of Ggap junction channels in the ciliary body secretory epithelium; regional dependence of inflow; functional modulators linking Iinflow with outflow of aqueous humor; aqueous humor outflow resistance; aqueous humor dynamics; the effects of circulatory events on
aqueous humor inflow and intraocular pressure; retinal ganglion cells and glaucoma; what functional genomics is teaching us about intraocular pressure regulation and glaucoma;
molecular approaches to glaucoma; outflow signaling mechanisms and new therapeutic strategies for the control of intraocular pressure.
*Guest edited by cell membrane experts
*Dynamic and thorough coverage of all aspects of the aqueous humor from inflow to outflow
*Provides the latest teachings on genomics and glaucoma
*Highlights new therapeutic strategies for the control of intraocular pressure

Angiogenesis: In Vitro Systems, Volume 443 (Hardcover): David A. Cheresh Angiogenesis: In Vitro Systems, Volume 443 (Hardcover)
David A. Cheresh
R4,484 Discovery Miles 44 840 Ships in 12 - 19 working days

Angiogenesis is the growth of new blood vessels and is an important natural process in the body. A healthy body maintains a perfect balance of angiogenesis modulators. In many serious disease states, however, the body loses control over antiogenesis. Diseases that are angiogensis-dependent result when blood vessels either grow excessively or insufficiently.
* Tried-and-tested techniques written by researchers that developed them, used them, and brought them to fruition
* Provides the "builder's manual" for essential techniques--a one-stop shop that eliminates needless searching among untested techniques
* Includes step-by-step methods for understanding the cell and molecular basis of wound healing, vascular integrin signaling, mechanical signaling in blood vessels, and vascular proteomics

Disabling Obesity - From Determinants to Health Care Models (Hardcover, 2013 ed.): Paolo Capodaglio, Joel Faintuch, Antonio... Disabling Obesity - From Determinants to Health Care Models (Hardcover, 2013 ed.)
Paolo Capodaglio, Joel Faintuch, Antonio Liuzzi
R5,347 R5,000 Discovery Miles 50 000 Save R347 (6%) Ships in 12 - 19 working days

Obesity is currently regarded as one of the major health challenges of the developed world. Excess body weight is an important risk factor for morbidity and mortality from cardiovascular diseases, diabetes, cancer, musculoskeletal disorders and even psychiatric problems and is estimated to cause nearly 3 million deaths per year worldwide. Obesity is not necessarily associated with comorbidities: there are indeed metabolically healthy obese individuals. Thus, we need to consider individuals presenting simple with obesity separately from those at risk of developing or who have already developed complex clinical states potentially leading to disability. Comorbidities can tip the balance of independence in patients who already have functional limitations mainly due to the excess of mass itself or who develop conditions such as diabetes, cardiovascular conditions, non-alcoholic fatty liver disease, where an abnormal metabolism of adipose tissue prevails. Morbid obesity with comorbidities leading to disability represents a real social and economic burden for National Health Systems worldwide. The presence of multiple and associated comorbidities often represents an obstacle to being admitted to hospitals for the treatment of metabolic diseases. On the other hand, clinical units with optimal standards for the treatment of pathological conditions in normal-weight patients are often structurally and technologically inadequate for the care of patients with extreme obesity. The aim of this book is to focus on the pathophysiological and rehabilitative aspects of disabling obesity, highlighting multidisciplinary rehabilitation interventions as key to counteracting the disabling aspects of complicated obesity.

Principles of Gender-Specific Medicine - Sex and Gender-Specific Biology in the Postgenomic Era (Hardcover, 4th edition):... Principles of Gender-Specific Medicine - Sex and Gender-Specific Biology in the Postgenomic Era (Hardcover, 4th edition)
Marianne Legato J
R4,531 R4,124 Discovery Miles 41 240 Save R407 (9%) Ships in 12 - 19 working days

Awarded with the 2018 Prose Award in Clinical Medicine, the third edition of Principles of Gender-Specific Medicine explored and described exciting new areas in biomedicine that integrated technology into the treatment of disease and the augmentation of human function. Novel topics such as the sex-specific aspects of space medicine, the development and the use of genderized robots and a discussion of cyborgs were included in the third edition, providing a preview of the expanding world of sex-specific physiology and therapeutics. This Fourth Edition is a continuation of the mission to trace the relevance of biological sex to normal function and to the experience of disease in humans. We are now twenty years into the postgenomic era. The investigation of how the genome produces the phenome has led to fascinating insights as well as yet unanswered questions. Principles of Gender-Specific Medicine, Fourth Edition, has a central theme: discuss advances in understanding the role of epigenetics in regulating gene expression in a dynamic, sex-specific way during human life. It explores the protean role of epigenetics in human physiology, the relevance of environmental experience to human function, the therapeutic promise of cutting-edge methodologies like gene manipulation, the preparation of humans for space travel, the use of artificial intelligence in detection and therapeutic decisions concerning disease states, the possibilities for technological support of not only compromised individuals but of the augmentation of human function, and an analysis of the benefits, limitations and issues that surround our current expectations of personalized medicine.

Molecular Mechanisms of Angiogenesis - From Ontogenesis to Oncogenesis (Hardcover, 2014 ed.): Jean-Jacques Feige, Gilles Pages,... Molecular Mechanisms of Angiogenesis - From Ontogenesis to Oncogenesis (Hardcover, 2014 ed.)
Jean-Jacques Feige, Gilles Pages, Fabrice Soncin
R5,238 Discovery Miles 52 380 Ships in 12 - 19 working days

Angiogenesis is a multi-stage process that drives the generation of new blood and lymphatic vessels from pre-existing ones. It is highly active during embryogenesis, largely inactive during adulthood but reactivated during wound healing and under a number of pathological conditions including cancer and ocular diseases. In addition to endothelial cells, which line the walls of the vessels, several other cell types (pericytes, macrophages, progenitor cells ) also contribute to angiogenesis. A number of signaling pathways are activated and very finely tune the delicate morphogenetic events that ultimately lead to the formation of stable blood proof neovessels.

This book reviews recent advances in our understanding of the molecular and cellular mechanisms of angiogenesis, with a focus on how to integrate these observations into the context of developmental, post-natal and pathological neovascularization.

The book was published under the auspices of the French Angiogenesis Society. Most contributors are prominent members of this Society or international researchers who have actively contributed to the Annual Meetings of the Society."

Essays on the History of Respiratory Physiology (Hardcover, 2015 ed.): John B West Essays on the History of Respiratory Physiology (Hardcover, 2015 ed.)
John B West
R5,050 Discovery Miles 50 500 Ships in 12 - 19 working days

This book consists of 23 essays about prominent people and events in the history of respiratory physiology. It provides a first-hand chronicle of the advancements made in respiratory physiology starting with Galen and the beginnings of Western physiology. The volume covers every aspect of the evolution of this important area of knowledge: pulmonary circulation, Boyle's Law, pulmonary capillaries and alveoli, morphology, gas exchange and blood flow, mechanics, control of ventilation, and comparative physiology. The book emphasizes societal and philosophical aspects of the history of science. Although it concentrates on physiology, it also describes how cultural movements, such as The Enlightenment, shaped the researchers discussed. This book is published on behalf of the American Physiological Society by Springer. Access to APS books published with Springer is free to APS members.

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