Theory of Endobiogeny, Volume 3: Advanced Concepts for Treatment of Complex Clinical Conditions explains complex and multi-factorial disorders and diseases using the theory of endobiogeny. It provides detailed applications of biological modeling, in-depth assessment into common disorders, an endobiogenic analysis, guidance on using biological modeling tools, and suggestions for treatment using standard of care treatments that also take into account diet, lifestyle and medicinal plants. This approach is an evolution in thinking from reductionism to holism, offering advice for symptomatic treatments that can be used in conjunction with a new way of thinking about diseases and disease management.

Now in its second edition, this comprehensive handbook provides a state-of-the-art overview of recent advances in drug and non-drug therapies for obesity and diabetes. It also addresses major comorbidities, covering topics such as, cardiovascular diseases, renal and neuropsychiatric disorders, appetite control and micro RNAs. Special attention is also devoted to pediatric care, including the latest recommendations for therapy and prevention. Obesity and type 2 diabetes are among the top global health-care budget concerns worldwide and impact professional practice at all levels: in hospitals, clinics and physicians' offices alike. They prominently feature in headlines, and virtually no family, community or country is exempt from their protean, deleterious consequences. Furthermore, given the multiple intersections in their pathways, they often go hand in hand. The good news is that scientific advances in all fields, including genomics, metabolomics, lipidomics and microbiomics, are increasing our understanding of these two disease areas. At the same time, artificial intelligence, machine learning, mobile health and advanced implantable and external devices are rendering prevention and management more available, safe and cost-effective. In addition, bariatric and metabolic surgery has evolved from a niche specialty to an officially endorsed option for several modalities of obesity and diabetes. This book presents the latest lifestyle, pharmacological, surgical and non-surgical treatment options, including endoscopic intervention and cell therapy. Objectively reviewing natural and artificial sweeteners and critically examining issues such as public health initiatives, government mandated taxes for unhealthy foods and environmental planning, no stone is left unturned in gathering the latest practical information. As such, the book will appeal to seasoned specialists, as well as students and healthcare professionals in training.

Saliva as a unique sample for health assessment is gaining attention among researchers of different fields in the last 20 years; being reflected in an impressive increase in the number of papers published studying saliva from different biological aspects in human and veterinary species. Once deemed merely a digestive juice is now considered a biological fluid capable of communicating information about physiopathological processes occurring in organisms, since saliva has been shown to contain molecular and bacterial compounds that can change in response to local and systemic pathologies. Furthermore, the interest of saliva as a diagnostic, prognostic and monitoring biofluid is forced by its non-invasive nature being of easy and inexpensive sampling, involving only minimal discomfort and allowing the collection of multiple/repeated specimens at anytime, anywhere and without need for specialized staff. In this contributed volume, the authors bring together, summarize and reflect the generated knowledge about saliva as a source of biomarkers for health and welfare evaluation in humans and animal models. This volume also highlights the importance of confounding factors, such as sampling methods, flow, total protein content, contamination, or storage. This book will serve as a manual for graduates, practitioners and researchers by providing general ideas about the possibilities and utilities of saliva in clinical practice or investigation, and indicating the main cautions each should have in mind before saliva usage.

This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models. Dysregulation of brain iron homeostasis can lead to severe pathological changes in the neural system. Iron deficiency can slow down the development of the neural system and cause language and motion disorders, while iron overload is closely related to neurodegenerative diseases. Although some current books include chapters on iron metabolism and certain neurodegenerative diseases, this is the first systematic summary of the latest discoveries regarding brain iron metabolism and CNS diseases. By providing novel and thought-provoking insights into the mechanisms and physiological significance of brain iron metabolism and related diseases, the book stimulates further new research directions. It helps graduate students and researchers gain an overall picture of brain iron metabolism and the pathogenesis of neurodegenerative diseases, and also offers pharmaceutical companies inspiration for new treatment strategies for CNS diseases.

The Theory of Endobiogeny Volume 1: Global Systems Thinking and Biological Modeling for Clinical Medicine offers researchers and clinicians a detailed introduction to the theory of Endobiogeny. The book presents a new approach to medicine that is at once scientific and humanistic, quantitative, and qualitative. The philosophical and experimental basis of a global complex systems approach to physiology is presented along with a mathematical approach to modeling the dynamism of the terrain. The importance of the history and physical examination are renewed as a source of "big data" readily available to clinicians for greater insight into the patient's state. Expansion of the therapeutic compendium is proposed based on a rational, clinical approach correlated to mathematical indicators of the physiologic state. What is proposed in this work is a fundamental shift in scientific thinking with a resulting expansion of the boundaries of clinical medicine for the 21st century and beyond.

Handbook of Nutrition, Diet, and the Eye, Second Edition, thoroughly addresses common features and etiological factors on how dietary and nutritional factors affect the eye. The ocular system is perhaps one of the least studied organs in diet and nutrition, yet the consequences of vision loss are devastating. There are a range of ocular defects that have either their origin in nutritional deficiencies/excess or have been shown to respond favorably to nutritional components. Featuring a new section on animal model studies where both the ocular problem and dietary remedies can be varied, there are also new chapters on dietary supplements.

This book provides a comprehensive, organized, and concise overview of xenobiotic metabolic enzymes and their health implications. The subjects addressed are broad in scope with an emphasis on recent advances in research on biochemical and biomedical aspects of these enzymes. The xenobiotics discussed include not just drugs, but also food, smoke, and other environmental chemicals. The subjects covered in this work include: metabolic enzymes and their catalyzed reactions, reactive intermediates generated from metabolic activation, oxidative stress mediated by electrophilic reactive intermediates, bioactivation - mediated cellular and functional damages, activation of Nrf2 - ARE pathway, genetic variations affecting metabolic enzyme expression, enzyme polymorphisms affecting xenobiotic - mediated toxicity, induction of metabolic enzymes for health benefits, and a diversity of metabolic enzyme modulators.

This comprehensive Monograph examines all peripheral and central mechanisms of regulating the secretion of milk from the lactating breast. The author reviews the complete female breast development, starting with the early childhood, up to pregnancy and lactation. Structural and ultrastructural data on the alveolar-ductal system, together with details of breast innervation, are used to investigate the physiological process of lactation. Readers will appreciate the special focus on reflexes, both in the child and the mother, that help to regulate maternal milk production and secretion. Following this, the author sheds a light on the composition and dynamics of milk components during the different periods of lactation. The final section of this volume focusses on practical aspects of modern breastfeeding, like the use of breast pumps or galactogogues, to influence the productivity of milk production. These fundamental principles and structural details will be particularly useful for physiologists and clinicians working in gynecology and pediatrics.

This volume of the series Cardiac and Vascular Biology presents the most relevant aspects of vascular mechanobiology along with many more facets of this fascinating, timely and clinically highly relevant field. Mechanotransduction, mechanosensing, fluid shear stress, hameodynamics and cell fate, are just a few topics to name. All important aspects of vascular mechanobiology in health and disease are reviewed by some of the top experts in the field. This volume, together with a second title on cardiac mechanobiology featured in this series, will be of high relevance to scientists and clinical researchers in the area of vascular biology, cardiology and biomedical engineering.

This book consists of 3 volumes: Basic Science (Volume 1), Clinical Science (Volume 2) and Technology and Methodology (Volume 3). Volume 2 focuses on the clinical aspects of autophagy research, discussing the role of autophagy in neuropsychiatric disorders, the cardiovascular, immune, digestive and endocrine systems, as well as tumors, infection, the kidney, and the respiratory and hematological systems. It also addresses autophagy-related drug development. Written and edited by a team of 90 experts, and presenting the state of the art in autophagy research, this book is a valuable reference resource for researchers and clinicians alike. It can also be used as supplementary material for graduate students majoring in biology and medicine

The principal objective of this book is to provide information needed to define human thermal behavior quantitatively. Human thermal physiology is defined using mathematical methods routinely employed by physicists and engineers, but seldom used by physiologists. Major sections of the book are devoted to blood flow, sweating, shivering, heat transfer within the body, and heat and mass transfer from skin and clothing to the environment. Simple algebraic models based on experimental data from a century of physiological investigation are developed for bodily processes. The book offers an invaluable source of information for physiologists and physical scientists interested in quantitative approaches to the fascinating field of human thermoregulation.

The Science of Hormesis in Health and Longevity provides a comprehensive review of mild stress-induced physiological hormesis and its role in the maintenance and promotion of health. Coverage includes the underlying mechanisms of hormesis, including details of stress-response signaling, an enriched environment, positive challenges and dose-response mechanisms, amongst others. Research from top experts is presented to provide suggestions for developing novel therapeutic strategies, along with lifestyle interventions to promote health and homoeostasis. Researchers in aging and physiology, gerontologists, clinicians and medical students will find this a valuable addition for their work.

Now in its fourteenth edition, this best-selling textbook has been honed over many years to provide a clear, straightforward introduction to the human body for students of nursing, allied health or biomedical and paramedical science. The book covers the core essentials of anatomy and physiology, including basic pathology and pathophysiology of important diseases and disorders. This new edition presents additional illustrations to enhance understanding of key concepts, including pathophysiology and diagnostics. Included for the first time is an introduction to surface anatomy, while other updating reflects current scientific knowledge and developments, including coronavirus. Enhanced learning features and an extensive online resource help you grasp all the important areas. Like millions of readers before you, you will treasure Ross & Wilson as a go-to resource that you will refer to time and again to support this critical aspect of your healthcare education. Clear and easy to read - suitable for students new to the area and anyone whose first language is not English Hundreds of stunning illustrations and images to make learning easy Helpful learning features such as Learning Outcomes boxes, colour coding and orientation icons to facilitate navigation Definitions of common prefixes, suffixes and roots, examples, glossary and an appendix of normal biological values Self-assessment activities in each chapter, including 'spot check' questions for each section and case studies with answers to develop understanding of key principles Accompanying website with animations, videos, audio-glossary and other self-assessment material Evolve Study Resources Online content offered with Ross & Wilson Anatomy and Physiology in Health and Illness 14th edition includes: New for this edition - a set of expert-narrated 3D videos summarizing key topics in the book, powered by Complete Anatomy: the world's most advanced 3D anatomy platform Over 120 animations clarifying underlying principles and make learning fun More than 1700 audio glossary entries Body Spectrum (c) online colouring and self-test software Self-assessment questions to help students test their knowledge

La Terapia del Momento Motivacional de Vida (Temomvi) se formulo para el manejo de disfunciones conductuales que amenazan con alterar o, en efecto, estan alterando el equilibrio vida-momento de la Persona, el grupo o la organizacion. En el mismo su autor hace acopio de ideas innovadoras incorporando conceptos nunca antes contemplados como parte de la terapia psicologica. Ademas, redefine y reconceptualiza los conceptos de normalidad, disfuncion y personalidad integrandolos en un paradigma en el cual se fusionan de forma sistematica y practica aspectos fenomenologicos, existenciales, psicodinamicos, cognitivos y de aprendizaje social. En Temomvi los conceptos de vida, mito de la felicidad, confusion vida-momento, movimiento rotacional-traslacional del ser y la existencia, sufrimiento en lay away, entre otros representan nuevas aportaciones a la prevencion y remision de las disfunciones conductuales y al desarrollo de un estilo de vida.

Protein degradation has been identified as a major mechanism for the regulation of cellular functions. Not surprisingly, its deregulation is implied in almost any pathological condition. This book describes how aged proteins are eliminated during cell metabolism, how cell proliferation is regulated by protein degradation and how its deregulation can contribute to the development of cancer, how protein degradation is modified during normal and abnormal aging, in particular with regard to Alzheimer's disease and other degenerative diseases of the brain and central nervous system. Attempts aiming at correcting these pathologies by interfering with deviations of the normal pathway of protein degradation are also treated.

Measurement and Evaluation in Physical Activity Applications offers the most accessible, student-friendly introduction to the principles and practice of measurement in physical activity available. Fully revised and updated, the second edition provides students with a clear guide to the obstacles to good measurement, and how to apply the principles of good measurement to a range of physical activity disciplines. Spanning applications in exercise science, sports performance, physical education, sports coaching, athletic training, and physical activity and health, the book also includes chapters on the key principles underlying good measurement practice-validity, reliability, and objectivity-as well as an introduction to using statistics and qualitative measurement. Structured to reflect single-semester classes, and involving students at every stage through its rich pedagogy and accessibility, this is a crucial resource for introducing students to the principles of best practice in measurement and evaluation. It is the ideal learning aid for any students studying measurement, evaluation, or assessment in kinesiology, exercise science, sports coaching, physical education, athletic training, and health and fitness.

A new work on the history of vitamins and the brilliant men and women who discovered the existence and nature of these small molecules so vital to our health. Vitamin Discoveries and Disasters: History, Science, and Controversies describes the emergence of nutritional science and its contributions to our understanding of how the body functions. It is an absorbing look at the men and women, many little known in their lifetimes, whose medical detective work helped us conquer a number of devastating health conditions, including some forms of mental illness. Each chapter of Vitamin Discoveries and Disasters focuses on a specific vitamin, describing the researchers, the research, and the historic and scientific contexts for its discovery. Together, these chapters chart the ongoing conflict between physicians who saw illness as caused by organisms and those who saw illness as a result of dietary deficiency. A concluding chapter shows how our stronger grasp of the effects of vitamin deficiencies on large populations can be used to the utmost benefit of society.