While the health consequences and mechanisms by which visceral fat causes disease are well-studied, relatively less is known about ectopic fat, its patterns of deposition and its effects on the pathoetiology of type 2 diabetes, atherosclerosis, and cardiovascular disease. Visceral and Ectopic Fat: Risk Factors for Type 2 Diabetes, Atherosclerosis, and Cardiovascular Disease covers the wealth of literature that has been amassed over the past decade on this topic. This reference brings all the research and clinical data together in one volume and helps clinicians and academic researchers understand more thoroughly the underlying mechanisms and interrelation between fat depots and ectopic fat stores in relation to health and disease. It showcases some of the recent developments in adipose tissue biology, particularly on the impact of interventional strategies - bariatric surgery, liposuction, physical and dietary intervention - of which information is desired among health specialists and policy makers.

In this issue of Endocrinology and Metabolism Clinics, guest editor Eliza B. Geer brings her considerable expertise to the topic of Patient-Reported Outcomes in Endocrine Diseases. Provides in-depth reviews on the latest updates in Patient-Reported Outcomes in Endocrine Diseases, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Inflammation and Obesity: A New and Novel Approach to Manage Obesity and its Consequences is a comprehensive and up-to-date exploration of the correlation between obesity and inflammation. From the pathophysiology of obesity and inflammation, to the molecular mechanisms of obesity induced chronic inflammation, the book discusses how obesity and inflammation interact with other diseases. It highlights the hidden risk factors of obesity induced chronic inflammation, provides specific patient management guidelines regarding the higher inflammatory response in patients, and concludes with new therapeutic strategies to address inflammation in obese patients.

In this issue of Endocrinology and Metabolism Clinics of North America, guest editors Drs. Connie B. Newman and Alan Chait bring their considerable expertise to the topic of Lipids: Update on Diagnosis and Management of Dyslipidemia. When untreated, dyslipidemia may have serious comorbidities; in this issue, top experts cover the evaluation and management of LDL cholesterol and high triglicerides in adults and children, providing practical information that will help physicians and other health care professionals treat their patients and improve outcomes. Contains 13 practice-oriented topics including lipid and lipoprotein metabolism; measurement of lipids and advanced lipid testing; assessment of CVD risk; inherited forms of hypercholesterolemia; new and emerging therapies for dyslipidemia; and more. Provides in-depth clinical reviews on diagnosis and management of dyslipidemia, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Medicinal Spices and Vegetables from Africa: Therapeutic Potential against Metabolic, Inflammatory, Infectious and Systemic Diseases provides a detailed look at medicinal spices and vegetables that have proven safe-and-effective for consumption and the treatment of diseases, including infectious diseases, cardiovascular disease, and cancer. It provides pharmacological evidence, such as the latest information related to efficacy and safety data, in vitro and in vivo studies, clinical trials, and more, to illustrate the use of these spices and vegetables as both palliative and alternative treatments with the goal of furthering research in this area to produce safer and more effective drugs.

Biomechanics of Tendons and Ligaments: Tissue Reconstruction looks at the structure and function of tendons and ligaments. Biological and synthetic biomaterials for their reconstruction and regeneration are reviewed, and their biomechanical performance is discussed. Regeneration tendons and ligaments are soft connective tissues which are essential for the biomechanical function of the skeletal system. These tissues are often prone to injuries which can range from repetition and overuse, to tears and ruptures. Understanding the biomechanical properties of ligaments and tendons is essential for their repair and regeneration.

Students entering advanced study of environmental physiology may have little experience in researching environmental physiology or may not realize the depth and breadth of the field. "Advanced Environmental Exercise Physiology "offers the first complete look at the scope and major ideas of environmental exercise physiology. It provides students with a solid grounding in prominent research topics and a thorough understanding of the key concepts and current debates in the field. Using an integrative approach, " Advanced Environmental Exercise Physiology," the first book in Human Kinetics' Advanced Exercise Physiology series, considers the human capacity to exercise in and tolerate various environments. Readers will examine the major impact of each environment explored, and they will discover areas of current debate to stimulate further research. The text also helps students directly link the research to athletic and occupational situations in various environments. Through "Advanced Environmental Exercise Physiology, " students will learn the following: - The initial physiological responses upon exposure to an environment that a person is not adapted to - How the body adapts to repeated exposure to an environment - How various environments affect the ability to exercise and work - Individual variability in response to stressful environments Readers will also gain a firm knowledge of the application of basic exercise physiology to specific environmental stressors by looking at the countermeasures that people can take to minimize the impact of environmental stressors. Among the issues explored in this text are the effects of heat, hydration, and cold in the thermal environment; diving, altitude training, and other pressure effects on the human system; and the influences that pollution and air quality have on exercise. The text also explores the microgravity (space) environment and chronobiological rhythms and their effects on exercise performance. "Advanced Environmental Exercise Physiology" addresses the primary environmental factors affecting people when they are exercising and competing in sport, and it provides evidence-based information with numerous references. By linking research with recommendations for real-world situations, this text serves as an invaluable resource for students and professionals alike. Human Kinetics' Advanced Exercise Physiology series offers books for advanced undergraduate and graduate students as well as professionals in exercise science and kinesiology. These books highlight the complex interaction of the various systems both at rest and during exercise. Each text in this series offers a clear and concise explanation of the system and details how each is affected by acute exercise and chronic exercise training.

Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies. The book provides comprehensive, foundational knowledge on the mechanisms of aging and current anti-aging strategies and approaches developed. Aging research has experienced an unprecedented advance over recent years with the discovery that the rate of aging is determined, at least to some extent, mainly by our genetics and modulated by environmental factors. The hallmarks of aging describe the molecular and cellular processes that govern biological aging and their variation in individuals.

Experimental Methods in Orthopaedic Biomechanics is the first book in the field that focuses on the practicalities of performing a large variety of in-vitro laboratory experiments. Explanations are thorough, informative, and feature standard lab equipment to enable biomedical engineers to advance from a 'trial and error' approach to an efficient system recommended by experienced leaders. This is an ideal tool for biomedical engineers or biomechanics professors in their teaching, as well as for those studying and carrying out lab assignments and projects in the field. The experienced authors have established a standard that researchers can test against in order to explain the strengths and weaknesses of testing approaches.

Na Channels from Phyla to Function, the latest volume in the Current Topics in Membranes series, is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume offers an up-to-date presentation of the current knowledge in the field of Na Channels.

Mesenchymal Stromal Cells: Translational Pathways to Clinical Adoption provides the latest information on the necessary steps for successful production of stem cells for a clinical trial. Written by professionals with hands-on experience in bringing MSC therapies to the clinic, and building on the biology and mechanisms of action, this unique book covers the development and production of clinical-grade products that are suitable for use in humans. From design of a cell production facility, to obtaining regulatory approval and reimbursement issues, it is a useful guide for researchers and administrators across biomedical research.

Enzymes of Epigenetics, one of two new volumes in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods that are employed to study epigenetic regulation and includes structural, biochemical, molecular, biological, cellular, computational, and systems approaches. Topics include chromatin structure and histones, posttranslational histone modification enzymes and complexes, histone modification binders, DNA modifications and nucleic acid regulators, epigenetic technologies and small molecule epigenetic regulators, and biological connections

Enzymes of Epigenetics: Part B, one of two new volumes in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods that are employed in the study of epigenetic regulation, including structural, biochemical, molecular, biological, cellular, computational, and systems approaches. Topics include chromatin structure and histones, posttranslational histone modification enzymes and complexes, histone modification binders, DNA modifications and nucleic acid regulators, epigenetic technologies, and small molecule epigenetic regulators and biological connections.

In this issue of Endocrinology and Metabolism Clinics of North America, guest editors Drs. Megan R. Haymart and Maria Papaleontiou bring their considerable expertise to the topic of Thyroidology. Top experts in the field cover recent advances in the diagnosis and management of thyroid conditions, providing a contemporary view of updates in this challenging field. Contains 12 relevant, practice-oriented topics including disparities in thyroid care; the use of LT4/LT3 combinations in treating hypothyroidism; minimally invasive procedures for thyroid nodules; less intensive management options for low-risk thyroid cancer; and more. Provides in-depth clinical reviews on thyroidology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Arrestins: Structure and Function in Vision and Beyond examines the structural basis of the function of arrestin proteins in the brain. Linking basic, translational and clinical research, this volume begins with history and basic signaling principles and then expands to the use of proteins as potential therapeutic targets. Multiple cellular activities are detailed, including activation, signaling, GPCR endocytosis, and ERK signaling, with chapters examining both visual and non-visual arrestins. Experts in their respective fields are featured throughout, making this book essential reading for anyone who wants to explore the basic science underlying these signaling proteins.

Metabolic Analysis Using Stable Isotopes, the newest volume in Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in metabolic analysis using stable isotopes.

The critically acclaimed laboratory standard for almost 50 years, "Methods in Enzymology" is one of the most highly respected publications in the field of biochemistry. Each volume is eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 520 volumes and 40,000 chapters in the collection, much of the material is still relevant today and is truly an essential publication for researchers in all fields of life sciences, including microbiology, biochemistry, cancer research, and genetics, just to name a few.

In this volume, number 545, we have brought together a number of core protocols concentrating on protein, carefully written and edited by experts.
Indispensable tool for the researcher Carefully written and edited by experts to contain step-by-step protocolsBrings together a number of core protocols concentrating on protein

Back to Basics in Physiology: O2 and CO2 in the Respiratory and Cardiovascular Systems exploits the gap that exists in current physiology books, tackling specific problems and evaluating their repercussions on systemic physiology. It is part of a group of books that seek to provide a bridge for the basic understanding of science and its direct translation to the clinical setting, with a final aim of helping readers further comprehend the basic science behind clinical observations. The book is interspersed with clinical correlates and key facts, as the authors believe that highlighting direct patient care issues leads to improved understanding and retention. Physiology students, including graduate and undergraduate students, nursing students, physician associate students, and medical students will find this to be a great reference tool as part of an introductory course, or as review material.