This work is recognised as the standard textbook for professionals involved in the diagnosis and management of inborn errors of metabolism (IEM) and an essential resource in this multidisciplinary field. For the 6th edition all 43 chapters have been newly written or revised by authors with particular expertise in their subject areas. Contents: A clinical and biochemical approach to the recognition and diagnosis of IEM with algorithms to symptoms, signs, and syndromes in patients of all ages; Emergency treatments; Medications - Separate comprehensive sections on IEM of: Carbohydrates; Mitochondrial Energy; Amino and organic acids; Vitamin-responsive defects; Neurotransmitter and Small peptides, Lipid and Bile Acids; Nucleic Acid and Heme; Organelles - Disorders affecting the synthesis and remodelling of complex lipids and fatty acid homeostasis are now included.

This fully updated and extended second edition provides a comprehensive overview on the basic concepts of the rapidly developing field of osteoimmunology and also offers in-depth insights into the molecular mechanisms of bone diseases. Clinical data is presented and put into context with the latest research findings. This second edition in addition discusses the latest topics in transplantation immunology. The book addresses scientists and physicians working in immunology, pathophysiology and osteology.

This textbook is a comprehensive guide to physiology for undergraduate and postgraduate medical students. Divided into seven sections, the book covers haematology, physiological testing, clinical examination, and experimental physiology. The final sections provide charts and key questions, calculations, and sample problem solving. Each section is further subdivided into several chapters providing extensive detail on each topic. This ninth edition has been fully revised to provide students with the latest information and advances in the field. The book is highly illustrated with photographs, diagrams and flowcharts, and will assist students in preparation for examinations. Key points Comprehensive guide to physiology for medical students Fully revised, new edition providing latest information in the field Highly illustrated with photographs, diagrams and flowcharts Previous edition (9789350259320) published in 2012

Functional Anatomy for Sport and Exercise: A Quick A-to-Z Reference is the most user-friendly and accessible available reference to human musculoskeletal anatomy in its moving, active context. Fully updated and revised, the second edition features more illustrations to enhance student learning and an expanded hot topics section to highlight key areas of research in sport and exercise. An accessible format makes it easy for students to locate clear, concise explanations and descriptions of anatomical structures, human movement terms and key concepts. Covering all major anatomical areas, the book includes: an A-to-Z guide to anatomical terms and concepts, from the head to the foot clear and detailed colour illustrations cross-referenced entries throughout hot topics discussed in more detail in sports examples discussed in more detail full references and suggested further reading This book is an essential quick reference for undergraduate students in applied anatomy, functional anatomy, kinesiology, sport and exercise science, physical education, strength and conditioning, biomechanics and athletic training.

Zinc is one of the most abundant transition metals in the human body, and it has various benefits as an essential trace element in the regulation of the living body. Nutritional deficiency of zinc is known to induce many chronic diseases such as immune system disorders, rheumatoid arthritis, diabetes, obesity, atherosclerosis, cancers, bone growth retardation, osteoporosis and others. This book introduces the recent topics concerning the characteristics, uses and benefits of zinc. This book will be helpful in research development and also in the understanding of the various physiological-pathophysiological roles of zinc.

White blood cells, or leukocytes are cells of the immune system involved in defending the body against both infectious disease and foreign materials. Five different and diverse types of leukocytes exist, but they are all produced and derived from a multipotent cell in the bone marrow known as a hematopoietic stem cell. They live for about 3 to 4 days in the average human body. In this book, the authors present current research in the study of the biology, classification and role in disease of leukocytes. Topics include an analysis of peptides and proteins isolated from alligator leukocytes; modification of immune cell activity by neuroendocrine mediators and development of disease; congenital defects of phagocytes; leukocyte mitochondrial membrane potential in type 1 diabetes; biology of human myeloid dendritic cells; and the leukocyte expression of CD36 as a biomarker for Alzheimer's disease.

With detailed contributions from more than 40 leading authorities, this edition comprehensively explores the immunobiology, pathophysiology, and clinicial manifestations of graft-versus-host disease (GvHD), offering sections revealing the most up-to-date research on immune activation and dysregulation, the pathophysiology of target organ damage, and GvHD prevention and treatment. 53 illustrations.

Presenting a comprehensive overview of the multifaceted field of proteases in the extracellular matrix environment, this reference focuses on the recently elucidated functions of complex proteolytic systems in physiological and pathological tissue remodeling. The proteases treated include both serine proteases such as plasminogen activators and TTSPs, metalloproteases such as MMPs and ADAMS and cysteine protease cathepsins. The text specifically addresses the role of extracellular proteases in cancer cell invasion, stroke and infectious diseases, describing the basic biochemistry behind these disease states, as well as therapeutic strategies based on protease inhibition. With its trans-disciplinary scope, this reference bridges the gap between fundamental research and biomedical and pharmaceutical application, making this required reading for basic and applied scientists in the molecular life sciences.

How does the brain regulate sexual behavior, or control our body weight? How do we cope with stress? Addressing these questions and many more besides, this thoroughly revised new edition reflects the significant advances that have been made in the study of neuroendocrinology over the last twenty years. The text examines the importance of the hypothalamus in regulating hormone secretion from the endocrine glands, describing novel sites of hormone release including bone, heart, skeletal muscle and liver. The role of steroid hormone, neurotransmitter and peptide receptors, and the molecular responses of target tissues, is integrated into the discussion of the neuroendocrine brain, especially through changes in gene expression. Particular attention is attached to neuropeptides, including their profound influence on behavior. Complete with new full-color figures throughout, along with review and essay questions for each chapter, this is an ideal resource for undergraduate and graduate students of neuroscience, psychology, biology and physiology.

Human intelligence isn't just located in the brain. Our bodies are marvelously sophisticated and complex, with a variety of autonomic systems that help maintain our health without us ever having to think about them. But how exactly do all these physiological structures actually work? In Our Intelligent Bodies, physiology professor Gary F. Merrill takes you on a guided tour through the human body. You'll learn how our eyes are designed to detect unimaginably small bursts of light and how our ears contain bundles of tiny hairs, each one attuned to different sound frequencies. You'll also discover how our hearts are smart enough to compensate for skipped beats and irregular rhythms and how our pulmonary system adjusts for low oxygen levels. You'll even find out why the gut is sometimes called the 'second brain,' its reflexes controlled by millions of neurons. Written in a fun, easy-to-comprehend style and filled with illuminating analogies, Our Intelligent Bodies also brings readers up to date on cutting-edge research into the wonders of human physiology. It will give you a new appreciation for the smart decisions our bodies are making when our brains aren't paying attention.

How the Endocrine System Works is not another standard introduction to endocrinology, but an innovative and fun way to learn about the importance of the key glands in the human body and the hormones they control. It is explained in 9 easy-to-understand lectures, with additional material on the treatment and management of endocrine disorders. How the Endocrine System Works: Is designed for those in need of a concise introduction to this fascinating area of medicine Has been rigorously updated to reflect today s endocrinology teaching Includes more focus on the treatment and management of endocrine disorders Features more on evidence-based medicine, obesity, epidemiology, and biostatistics Includes summaries of key research which affects diagnostic criteria Includes brand new case-based review questions at the end of each chapter Features full-color diagrams throughout How the Endocrine System Works is the perfect introduction for all medical students, as well as for students of bioscience, and other healthcare disciplines.

This concise, user-oriented and up-to-date desk reference offers a broad introduction to the fascinating world of medical technology, fully considering today 's progress and further development in all relevant fields. The "Springer Handbook of Medical Technology" is a systemized and well-structured guideline which distinguishes itself through simplification and condensation of complex facts. This book is an indispensable resource for professionals working directly or indirectly with medical systems and appliances every day. It is also meant for graduate and post graduate students in hospital management, medical engineering, and medical physics.

Skin physiology assessment is moving from a descriptive approach to a deeper understanding of biophysical and biochemical processes in the stratum corneum, such as epidermal barrier function and stratum corneum hydration. New, non-invasive approaches offer reliable and reproducible methods for product testing in the pharmaceutical and cosmetic industry, as well as in basic research. While standard instruments focus on functional aspects, innovative devices offer a deeper understanding of underlying mechanisms. This book discusses the assessment of skin physiology and of skin functions in clinical studies using non-invasive biophysical instruments, offering readers a comprehensive guide to planning, performing and evaluating the results of scientific studies in skin measurement and the legal framework for these studies. Written by leading experts in the field, it focuses on practical aspects of non-invasive measurements. After introducing the legal aspects of the current framework for clinical cosmetic studies and basic research in cosmetology, it explores the technical practicalities of organizing a testing lab and the pre-requirements for planning a study. The third and main section addresses specific topics in cosmetic testing e.g. skin hydration, and also includes chapters on sensory aspects and in vivo skin structure vizualization. This new, updated edition of Practical Aspects of Cosmetic Testing is a valuable tool for researchers, students, and medical staff wanting to gain insights into how best to assess skin functions in controlled studies using non-invasive biophysical instruments.

Signal transduction pathways are at the core of most biological processes and are critical regulators of heart physiology and pathophysiology. The heart is both a transmitter and dynamic receptor of a variety of intracellular and extracellular stimuli, playing a critical role of an integrator of diverse signaling mechanisms. Alterations in signaling pathways are contributing factors in the development and progression of a broad spectrum of diseases, ranging from dysrhythmias and atherosclerosis to hypertension and the metabolic syndrome. Targeting specific components of these signaling pathways has been shown to be effective in preclinical studies with significant therapeutic impact. This book brings together current knowledge in cardiovascular cell signal transduction mechanisms, advances in novel therapeutic approaches to improve cardiac function, and discussion of future directions. Presented from a post-genomic perspective, this exciting book introduces important new ideas in cardiovascular systems biology. It is an invaluable reference for cardiology researchers and practitioners.

Orthopaedic procedures in elderly patients are challenging and costly. As the population ages these costs will continue to escalate. ORTHOPAEDIC ISSUES IN OSTEOPOROSIS weaves together theory and applications to provide the first reference available on the orthopaedic aspects of osteoporosis.

The focus on the management of patients who have had a fracture sets this book apart. Featuring extensive coverage of surgical management of osteoporotic fractures, it highlights the challenges of internal repair in osteoporotic bone. The chapters combine the basic and clinical essentials of osteoporosis with the latest orthopaedic findings in applied research and surgical treatment.

Fractures associated with osteoporosis account for the majority of the money spent on this condition. However, the orthpaedic treatment of osteoporotic bone is a formidable surgical problem, and one not covered explicitly in any book - until now. With over 300 tables, line drawings, equations, and macro or X-ray photographs, ORTHOPAEDIC ISSUES IN OSTEOPOROSIS is a long overdue resource.

About the Editor: Yuehuei H. (Huey) An, MD, graduated from the Harbin Medical University, Harbin, Northeast China in 1983 and was trained in orthopaedic surgery at the Beijing Ji Shui Tan Hospital (Residency), and in hand surgery at Sydney Hospital (Clinical Fellow), Australia. In 1991, Dr. An joined with Dr. Richard J. Friedman in the Department of Orthopaedic Surgery at the Medical University of South Carolina to establish the MUSC Orthopaedic Research Laboratory, which is now a multifunctional orthopaedic research center. Dr. An has published more than 100 scientific papers and book chapters and more than 100 abstracts and edited 6 books, including Animal Models in Orthopaedic Research (CRC Press 1999) and Mechanical Testing of Bone and the Bone-Implant Interface (CRC Press 2000). He is an active member of eight academic societies in the fields of orthopaedics, biomaterials, biomechanics, and tissue engineering.

This fascinating volume applies the concept of chronomics to the medical treatment of hypertension. It starts with the recent updates on chronomics, the analytic techniques, and their application to community-based assessments. The authors advocate the use of 7-day/24-h records of blood pressure, which is effective for finding masked hypertension, masked morning surge, and other rhythm abnormalities. Most organisms, from cyanobacteria to mammals, are known to use the circadian mechanism. However, our body systems also demonstrate circaseptan (roughly weekly), circannual (roughly yearly), and even longer rhythms. Chronomics monitors the physiological data and then analyzes the superimposed rhythms, isolating the cycles mathematically to determine how organisms and their environment interact. It is the study of interactions among time structures (chronomes) in and around us.

Proteins of Iron Metabolism presents a clear picture of the structure and function of the main proteins involved in iron metabolism. The book gives you a detailed description of the structure and function of each protein, and discusses the structure and regulation of the corresponding genes in parallel. It supplies an analysis of the differential expression and regulation of these proteins.

Numerous figures offer an integrated view of iron metabolism at the level of various tissues. The book delineates the mechanisms controlling cellular iron metabolism and shows how these mechanisms adapt to the differential and peculiar iron need of different cell types. Each chapter contains extensive bibliographical information providing a wide reference to the literature.

The comprehensive coverage of the advances in understanding the mechanisms controlling cellular iron metabolism, especially at the molecular level, found in this book will give you insight into the regulation of iron metabolism. Proteins of Iron Metabolism fills the need for a clearly written, comprehensive review of the latest research, putting every thing you need in one easy-to-use resource.

This second edition of the Bone Mechanics Handbook summarizes the current understanding of bone mechanics with comprehensive coverage of the histology, physiology, and the cell and molecular biology of the bone. It is updated with the most recent advances on mechanical properties of the bone, most notably of cancellous bone, and the streaming potentials in the bone, which reflect the realization of the importance of fluid movement in bone tissue.

This book is a concise, easy-to read guide to a selection of the most important contemporary electrophysiological techniques, their implementation, applications, and ways in which they can be combined and integrated with related neuroscience techniques. It is intended for students, postdocs and faculty with a basic neuroscience background, so does not obscure the relevant technical details with textbook neuroscience tutorials as many other books do. Each chapter provides a concise overview of the underlying theory, a comprehensive description of equipment, materials, methods, data management and analysis, a troubleshooting guide, and a list of frequently asked questions. No book or online resource can function as a strictly DIY set of instructions on how to implement a complex technique. However, this book provides a fundamental and accessible set of information intended to form a foundation prior to, during, and after hands-on experience and training, greatly facilitating the initial learning process and subsequent fine-tuning of technical details.

Because of developments in powerful computer technology, computational techniques, advances in a wide spectrum of diverse technologies, and other advances coupled with cross disciplinary pursuits between techno logy and its greatly significant applied implications in human body pr ocesses, the field of biomechanics is evolving as a broadly significan t area. Now in four volumes, Biomechanical Systems, Techniques, and Ap plications explores the many areas of significant advances, including dynamics of musculo-skeletal systems; mechanics of hard and soft tissu es, muscles, bone remodeling, hard and soft tissue interfaces, blood f low, air flow, flow-prosthesis interfaces, and impact; cardiovascular and respiratory biomechanics; and dynamics of many machine interaction s.

Biomechanics is the application of mechanical principles to living organisms, and it is one of the most exciting and fastest growing research areas. In forensic science, it is biomechanics that explains trauma to the body at a crime scene or the fracture of fibers and textiles, and helps interpret blood spatter. "Forensic Biomechanics" is a comprehensive overview of the role of biomechanics in forensics. Well-illustrated with real-life case studies, and using a multidisciplinary approach, this unique book is an invaluable reference for practicing forensic scientists, lawyers, and researchers.

Anyone planning on a career in the therapeutic sciences requires a unique foundation in the basic sciences of the human body. This new book offers detailed content on the muscles, skeleton, and nervous system, but also provides the necessary information on other systems. Specially written applications with a focus on massage and physical therapy are included. An outstanding illustration program is also integrated to highlight important concepts and special diagrams are presented that point to origin, insertion, and innervation of muscles. This is crucial knowledge for massage therapists, physical therapists, and occupational therapists

The Guyton and Hall Physiology Review is the ideal way to prepare for class exams as well as the physiology portion of the USMLE Step 1. More than 1,000 board-style questions and answers allow you to test your knowledge of the most essential, need-to-know concepts in physiology. Includes thorough reviews of all major body systems, with an emphasis on system interaction, homeostasis, and pathophysiology. Designed as a companion to the 13th edition of Guyton and Hall Textbook of Medical Physiology, highlighting essential key concepts and featuring direct page references to specific questions. Provides essential information needed to prepare for the physiology portion of the USMLE Step 1. Student Consult eBook version included with purchase. This enhanced eBook experience includes the full text plus an interactive assessment section.

Threonine, one of proteinogenic as well as essential amino acids, is classified as polar and uncharged residue, which may play an important role in intermolecular interactions between protein molecules and small ligand molecules. This book includes chapters on the lysozyme of egg white, which contains seven threonine residues in the primary structure; the requirements of threonine for laying hens fed diets with increasing levels of threonine at variable and constant ratios; the role threonine may potentially play in intermolecular interactions towards ligands of small molecules and the highly mutated threonine-producer strains, and ways of optimisation and intensification of its biosynthesis.

Proper nutrition is the single most important component of preventative health care. Heart disease, diabetes, and other ailments are all linked to dietary habits. Accurate nutritional assessment can be a matter of life or death.
Laboratory Tests for the Assessment of Nutritional Status explores the expanded number of nutrients that can now be evaluated. The author makes a compelling case for the practice and advancement of this critical health care tool. Nutritional assessment identifies undernutrition, overnutrition, specific nutrition deficiencies, and imbalances. Diligent assessment determines the appropriate nutrition intervention and monitors its effects.
This book is a total revision of the 1974 version of the same title co -authored by Sauberlich. Since then, remarkable progress has been made on the methodologies applicable to nutrition status assessment and to the expanded number of nutrients that can be evaluated, especially trace elements. The introduction of high-performance liquid chromatography, amperometric detectors, and other technologies has advanced nutritional assessment by leaps and bounds. Today, nutritionists can gauge the value of microminerals, trace elements, and ultratrace elements. Sauberlich's revision updates the reader to the latest and most important trends in nutrition. These laboratory methods for the assessment of nutritional status are vital for identifying individuals as well as populations with nutritional risks.