For courses in 1- and 2-semester Anatomy & Physiology Simplify your Study of Anatomy & Physiology. Combining a wide range and variety of engaging colouring activities, exercises, and self-assessments into an all-in-one Study Guide, the Anatomy and Physiology Coloring Workbook helps students simplify their study of A&P. Featuring contributions from new co-author Simone Brito, the 12th Edition of this best-selling guide continues to reinforce the fundamentals of anatomy and physiology through a variety of unique, interactive activities. New crossword puzzles have been added for each chapter, along with dozens of strengthened and expanded exercises, illustrations, and over 100 colouring exercises. Additional self-assessments, "At The Clinic" short answer questions, and unique "Incredible Journey" visualisation exercises further reinforce basic concepts that are relevant to health care careers.

Physiology of Sport and Exercise, Eighth Edition With HKPropel Access, continues its legacy as a top physiology textbook and favorite of instructors and students alike. Combining research with extensive visual aids, this resource offers a simple way for students to explore the body’s response to various types and intensities of exercise and sports. Written by a team of distinguished researchers, all past presidents of the American College of Sports Medicine, this eighth edition has been updated based on the most recent standards and guidelines in the field of exercise physiology. The text builds upon the previous edition’s high standards for illustrations, photos, and medical artwork with a refreshed, more sophisticated look to encourage a deep understanding of complex topics. Multimedia components delivered through HKPropel include 26 animations that offer a dynamic way to experience physiological concepts and 66 audio clips that offer explanations of elaborate physiological processes. Leaders in the field help students connect theoretical and practical concepts in 27 video clips. Learning assessments and key term flash cards offer additional interactive opportunities to explore the content, and QR codes throughout the text notify students when complementary digital components are available. Physiology of Sport and Exercise, Eighth Edition, features the following enhancements based on the latest research in the field: Additional information on cellular signaling and molecular adaptations Expanded content on obesity and sports nutrition Reorganized and expanded chapters on energy expenditure and exercise prescription that make the content more accessible to students Extensive updates on important topics, including bioinformatics and big data, reading research articles, molecular mechanisms of increased protein synthesis, muscle cramps, and mitochondrial oxidation Updated Research Perspective sidebars that emphasize emerging findings in the field and a Research Perspectives Finder to help students locate key content quickly As in previous editions, readability and ease of understanding make Physiology of Sport and Exercise different from other physiology resources. Unique learning aids, including chapter-opening outlines and review boxes throughout each chapter, will help students focus on the major concepts addressed. Study questions and a list of key terms at the end of each chapter provide opportunities for recall and self-assessment. A comprehensive glossary and lists of common abbreviations and conversions provide easy reference for students. Physiology of Sport and Exercise has been a pivotal textbook in the field of exercise physiology. Through this edition’s dynamic and interactive learning activities, easy-to-follow layouts, and research-oriented content enriched with visual supplements, students and instructors will find this an invaluable resource for their continued education. Note: A code for accessing HKPropel is included with this ebook.

The Human Hypothalamus: Neuropsychiatric Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume identifies the neurobiology and neurophysiology of disorders relating to the hypothalamus and provides treatment information for these disorders. Disorders covered include neuropsychiatric, neurodegenerative, periodic, and autoimmune disorders. Coverage includes Alzheimer's, Parkinson's, epilepsy, sleep, pain, depression, anxiety, OCD, PTSD, schizophrenia, autism, aggressions, addiction, and more.

Intended for any healthcare professional working with surgical patients, including medical students, residents, surgeons and internists, nurses, dieticians, pharmacists, and physical therapists, The Practical Handbook of Perioperative Metabolic and Nutritional Care focuses on topics from the history of surgery and metabolism, to organic response to stress. Based on clinical processes, the author explores screening, assessment, and the impact of nutritional status on outcomes, in addition to investigating nutritional requirements, including macronutrients and micronutrients. Chapters examine wound healing as well as metabolic and nutritional surgical preconditioning, including coverage of preoperative counseling, preoperative nutrition, and preoperative fasting. Physical exercise is addressed, as well as nutritional therapy in the form of oral supplements, and enteral and parenteral approaches. Additional topics explored include nutrition therapy complications and immunomodulatory nutrients, pro, pre and symbiotics, postoperative oral, enteral and parenteral nutrition, enteral access, vascular access, fluid therapy, and more. With up-to-date information, practical and cost-effective data, this resource is critical for translating theory to practice.

Scientists are deciphering the biology of the tumor cell at a level of detail that would have been hard to imagine just a decade or so ago. The development of high-throughput DNA sequencing and genomics technologies have allowed an understanding of the development, growth, survival, and spread of cancer cells in the body. From this information, we now have a basic blueprint or roadmap of how a single damaged cell can develop into a pre-malignant lesion, a primary tumor, and finally, a lethal tumor that may spread throughout the body and resist both medical therapy and host immune responses. In this book, we provide an overview of our current understanding of this cancer blueprint, which has been aided both by the study of familial cancer syndromes, in vitro studies of cancer cells, and animal models. Three classes of genes have emerged from these studies: tumor suppressor genes needed for normal growth control and DNA repair; oncogenes that regulate cell growth and survival, and epigenetic modifiers, enzymes that regulate the modification of DNA and the proteins that form chromatin. Each of these three classes of genes is mutated or altered at least once in virtually all malignant cancer cells. Current technologies permit the DNA sequencing of cancer exomes (coding gene sequencing), whole genomes, transcriptome (all expressed genes), and DNA methylation profiling. These studies show that all tumors have unique constellations of mutated, rearranged, amplified, and deleted genes. Single-cell sequencing further shows that there is extensive variation in individual cells in the tumor; that cancers evolve, and have many of the properties of a multi-cellular entity. Lastly, cancer cells, through mutations in epigenetic modifiers, can reprogram the genome and unlock entire developmental and gene expression pathways to adapt and survive in changing conditions. This reprogramming allows the tumor to elude the host body's defenses, radiotherapy, chemotherapy, and targeted therapy that we use in cancer treatment. Understanding this cancer blueprint paves the way for the development of future therapies to treat and eliminate cancer.

The Theory of Endobiogeny Volume 2: Foundational Concepts for Treatments of Common Clinical Conditions addresses the core elements of the adaptation response to stressors: autonomic nervous system (ANS), corticotropic axis, immunity and digestive tract function. The volume is oriented for clinical practice, offering clear discussions on treating the root cause of numerous common disorders, and symptomatically addressing the destabilizing factor in a vast number of disorders ranging from depression to irritable bowel, and from migraines to insomnia called spasmophilia.

The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction, Second Edition provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols. This revised edition will allow researchers in the field to gain a thorough understanding of the field from first principles, allowing them to understand, design, develop and improve inhaled pharmaceutical aerosol devices and therapies. Chapters consider mechanics and deposition, specifically in the respiratory tract, while others discuss the mechanics associated with the three existing types of pharmaceutical inhalation devices. This text will be very useful for academics and for courses taught at both undergraduate and graduate levels. Because of the interdisciplinary nature of this book, it will also serve a wide audience that includes engineers and scientists involved with inhaled aerosol therapies.

Pathophysiology of Ischemia-Reperfusion Injury and Use of Fingolimod in Cardioprotection is a deep examination into the mechanisms of myocardial ischemiareperfusion injury and role of fingolimod as a cardioprotective agent through its antioxidant, anti-apoptotic and anti-inflammatory effects. Dr. Ahmed explore the physiology and pathophysiology of myocardial metabolism under normal and ischemic conditions and focused on pharmacological cardioprotection. They provide a concise, yet rigorous discussion of Ischemia-Reperfusion Injury, Myocardial Ischemia during Circulatory Arrest, Myocardial Reperfusion, Myocardial Protection related to Ischemia-Reperfusion Injury and Role of Fingolimod in Cardioprotection. Pathophysiology of Ischemia-Reperfusion Injury and Use of Fingolimod in Cardioprotection is ideal for researchers, cardiovascular scientists, and clinical pharmacologists to further work in this challenging area and apply this knowledge to clinical trials for cardioprotection.

First developed as an accessible abridgement of the successful "Handbook of Stem Cells," "Essentials of Stem Cell Biology" serves the needs of the evolving population of scientists, researchers, practitioners, and students embracing the latest advances in stem cells. Representing the combined effort of 7 editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, and methods to theapplication of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered.
Contributions by Nobel Laureates and leading international investigatorsIncludes two entirely new chapters devoted exclusively to induced pluripotent stem (iPS) cells written by the scientists who made the breakthroughEdited by a world-renowned author and researcher to present a complete story of stem cells in research, in application, and as the subject of political debatePresented in full color with a glossary, highlighted terms, and bibliographic entries replacing references"

Genetic Steroid Disorders, Second Edition targets adult and pediatric endocrinologists, clinical geneticists, genetic counselors, reproductive endocrinologists, neonatologists, urologists, and psychoendocrinologists. It is designed to assist these specialists in the diagnosis and treatment of steroid disorders. This revision includes a new chapter on "Gonadotropins, Obesity and Bone" and new research on non-invasive prenatal diagnosis with cell-free DNA. Chapters are thoroughly updated covering steroid disorders, the genetic bases for the disorder and case presentations, This definitive reference belongs in every medical library!

The lymphatic system develops and functions in parallel with the blood circulatory system (termed the "hemovasculature") and accomplishes transport of interstitial fluids, dietary lipids, and reverse transport of cholesterol, immune cells, and antigens-providing a critical homeostatic fluid balance and transmission of immune cells and mediators back to the cardiovascular system. Although the daily flow of lymph (normally 1-2 L/day under unstressed conditions) is far lower than that of daily blood flow (which is 7,500 L/day), without the adequate functioning of the lymphatics, virtually all organs and tissues would acutely suffer many different physical and inflammatory stresses ranging from edema to organ system failure. Although blood and lymphatic vessels often form in anatomic parallels to one another, our knowledge of the workings of the lymphatic system, the fine structure of lymphatic networks, how they function in different organs, and how they are regulated physiologically and immunologically are far from parallel; our knowledge of the lymphatic system still remains at only a tiny fraction of what is understood about the cardiovascular system. Although both the cardiovascular and lymphatic systems are important transport systems, what they transport and how they transport and propel these very different cargoes could not be more dissimilar. This book provides an overview of the history of the discovery (and re-discovery) of the components of the lymphatic system, lymphatic anatomy, physiological functions of lymphatics, molecular features of the lymphatic system, and clinical perspectives involving lymphatics which may be of interest to scientists, clinicians, patients, and the lay public. We provide a current understanding of some of the more important structural similarities and differences between lymphatics and the blood vascular system, their coordinated control by angiogenic and hemangiogenic growth factors and other modulators, the fate and lineage determinants which control lymphatic development, and the roles that lymphatics may play in several different diseases.

For courses in Human Physiology Don't just study-visualize, explore, and solve problems in human physiology with Principles of Human Physiology! Principles of Human Physiology, Sixth Edition uses a precise and clear-cut writing style to offer lasting comprehension for Human Physiology students, extending to real-life application in the field. The Sixth Edition provides essential digital resources to foster critical thinking and problem-solving skills. The exceptional art program is consistent, scientifically accurate, and visually appealing. Stanfield's renowned flexible pedagogy allows instructors to choose what is essential to students when mapping out their course. MasteringA&P provides a framework for students to practice solving clinical problems, think conceptually, and apply new knowledge. Assigning interactive tutorials and coaching activities in MasteringA&P directs student learning on the toughest topics and provides a comprehensive and engaging learning environment. Also available as a Pearson eText or packaged with Mastering A&P Pearson eText is a simple-to-use, mobile-optimized, personalized reading experience that can be adopted on its own as the main course material. It lets students highlight, take notes, and review key vocabulary all in one place, even when offline. Seamlessly integrated videos and other rich media engage students and give them access to the help they need, when they need it. Educators can easily share their own notes with students so they see the connection between their eText and what they learn in class - motivating them to keep reading, and keep learning. Mastering A&P is an online homework, tutorial, and assessment program designed to work with Principles of Human Physiology to engage students and improve results. Instructors ensure students arrive ready to learn by assigning educationally effective content before class, and encourage critical thinking and retention with in-class resources such as Learning Catalytics (TM). Students can further master concepts after class through traditional and adaptive homework assignments that provide hints and answer-specific feedback. With a wide range of activities available, students can actively learn, understand, and retain even the most difficult concepts. Note: You are purchasing a standalone book; Pearson eText and Mastering A&P do not come packaged with this content. Students, ask your instructor for the correct package ISBN and Course ID. Instructors, contact your Pearson representative for more information. If your instructor has assigned Pearson eText as your main course material, search for: * 0135212995 / 9780135212998 Pearson eText Principles of Human Physiology, 6/e -- Access Card OR * 0135213002 / 9780135213001 Pearson eText Principles of Human Physiology, 6/e -- Instant Access If you would like to purchase both the physical text and Mastering A&P, search for: 0134169042 / 9780134169040 Principles of Human Physiology Plus Mastering A&P with eText -- Access Card Package, 6/E Package consists of: 013429890X / 9780134298900 MasteringA&P with Pearson eText -- ValuePack Access Card -- for Principles of Human Physiology, 6/e 0134169808 / 9780134169804 Principles of Human Physiology, 6/e

This collaboration of two physiologists and a gastroenterologist provides medical and graduate students, medical and surgical residents, and subspecialty fellows a comprehensive summary of digestive system physiology and addresses the pathophysiological processes that underlie some GI diseases. The textual approach proceeds by organ instead of the traditional organization followed by other GI textbooks. This approach lets the reader track the food bolus as it courses through the GI tract, learning on the way each organ's physiologic functions as the bolus directly or indirectly contacts it. The book is divided into three parts: (1) Chapters 1-3 include coverage of basic concepts that pertain to all (or most) organs of the digestive system, salivation, chewing, swallowing, and esophageal function, (2) Chapters 4-6 are focused on the major secretory organs (stomach, pancreas, liver) that assist in the assimilation of a meal, and (3) Chapters 7 and 8 address the motor, transport, and digestive functions of the small and large intestines. Each chapter includes its own pathophysiology and clinical correlation section that underscores the importance of the organ's normal function.

Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery focuses on the emerging hypothesis of a dysfunctional microbiome metabolome vagus nerve brain circuit in Alzheimer's disease and associated diseases and medical conditions, including dementia, aging, COVID-19, autoimmune conditions, and inflammatory skin condition rosacea, which may increase the risk of other conditions. This book also discusses the vagus nerve-related conditions, including Arnold's reflex, laryngopharyngeal reflux, duodenogastric reflux, gastroesophageal reflux, and related pulmonary diseases. The subjects covered in the book also address an important question of which one is more important for human health and intellectual abilities: the human genome or the human microbiome? The conceptual model of food and gut microbial tryptamine vagus nerve circuit is also presented in this book.

A must-have book for understanding one of the most fundamental areas of physical therapy: the nervous system and its relationship to musculoskeletal pain. Osteopath, lecturer and author John Gibbons offers an accessible introduction to the peripheral nervous system (PNS). Alongside real case studies and guidelines for hands-on work with clients and patients, The Vital Nerves demystifies and makes accessible everything from how to diagnose nerve conditions to understanding how our cells communicate. Gibbons provides critical insights into the structure and functions of the PNS; the body's response to stimuli and how it knows what to do; the sympathetic and parasympathetic nervous systems; understanding the stress response; and how reflex testing can aid in diagnosing conditions like Multiple Sclerosis, Parkinson's Disease, and paresthesias. The Vital Nerves addresses practical, common considerations like how to: Assess the nervous system using a patella (reflex) hammer, myotome (muscle) testing and dermatome (sensory) testing Determine whether pain in the posterior part of the thigh is caused by the sciatic nerve, piriformis or simply a hamstring strain Decide at what level a disc may have herniated Differentiate between upper and lower motor neurone disorders Know what to do with the findings of your neurological assessment and the circumstances under which to refer patients for more specialist care. The Vital Nerves is a comprehensive, must-have roadmap to the functional anatomy of the nervous system. Enriched with anatomical drawings and detailed explanations, it explains neurological testing, common neuropathies, and differential diagnoses, and is an indispensable resource for physical therapists and bodyworkers.

In Functional Anatomy of the Pelvis and the Sacroiliac Joint author and respected bodywork specialist John Gibbons looks at one of the most important areas of the body: the pelvis and the sacroiliac joint. He takes readers on a fascinating journey of enlightenment, teaching us to recognize pain and dysfunctional patterns that arise from the pelvic girdle. Gibbons addresses key issues such as: * The walking/gait cycle and its relationship to the pelvis * Leg length discrepancy and its relationship to the kinetic chain and the pelvis * The laws of spinal mechanics * The relationship of the hip joint, gluteal muscles, lumbar spine to the pelvis * Sacroiliac joint screening In addition, he provides step-by-step techniques to identify and correct a number of impaired patterns as well as functional exercises for the pelvis that promote recovery.

Handbook of Animal Models in Neurological Disorders will better readers' understanding of a large variety of animal models and their applicability in studying a number of neurological disorders. Featuring sections on brain injury, stroke and neuroinflammation, this volume discusses in detail the utility, success and pitfalls of multiple models for each condition. Multiple disorders are covered, ranging from neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS, to multiple sclerosis, headache, migraine, and others. With expert authors, this book has applicability for anyone pursuing neuroscience or biomedical research working to better understand, study and ultimately treat neurological dysfunction.

While the health consequences and mechanisms by which visceral fat causes disease are well-studied, relatively less is known about ectopic fat, its patterns of deposition and its effects on the pathoetiology of type 2 diabetes, atherosclerosis, and cardiovascular disease. Visceral and Ectopic Fat: Risk Factors for Type 2 Diabetes, Atherosclerosis, and Cardiovascular Disease covers the wealth of literature that has been amassed over the past decade on this topic. This reference brings all the research and clinical data together in one volume and helps clinicians and academic researchers understand more thoroughly the underlying mechanisms and interrelation between fat depots and ectopic fat stores in relation to health and disease. It showcases some of the recent developments in adipose tissue biology, particularly on the impact of interventional strategies - bariatric surgery, liposuction, physical and dietary intervention - of which information is desired among health specialists and policy makers.