0
Your cart

Your cart is empty

Browse All Departments
Price
  • R0 - R50 (1)
  • R100 - R250 (39)
  • R250 - R500 (232)
  • R500+ (4,371)
  • -
Status
Format
Author / Contributor
Publisher

Books > Medicine > Pre-clinical medicine: basic sciences > Physiology

Innovative Approaches to Cell Biomechanics - From Cell Migration to On-Chip Manipulation (Hardcover, 2015 ed.): Kennedy Omondi... Innovative Approaches to Cell Biomechanics - From Cell Migration to On-Chip Manipulation (Hardcover, 2015 ed.)
Kennedy Omondi Okeyo, Hiromi Miyoshi, Taiji Adachi
R3,891 R3,602 Discovery Miles 36 020 Save R289 (7%) Ships in 12 - 17 working days

This book covers topics on mechanosensing, mechanotransduction, and actin cytoskeletal dynamics in cell motility. It will contribute to a better understanding of how cells functionally adapt to their mechanical environment as well as highlighting fundamental concepts for designing material niches for cell manipulation. With topics from multidisciplinary fields of the life sciences, medicine and engineering, the book is the first of its kind, providing comprehensive, integrated coverage of innovative approaches to cell biomechanics. It provides a valuable resource for seniors and graduate students studying cell biomechanics and is also suitable for researchers interested in the application of methods and strategies in connection with the innovative approaches discussed. Each section of the book has been supplemented with concrete examples and illustrations to facilitate understanding even for readers unfamiliar with cell biomechanics.

Disabling Obesity - From Determinants to Health Care Models (Hardcover, 2013 ed.): Paolo Capodaglio, Joel Faintuch, Antonio... Disabling Obesity - From Determinants to Health Care Models (Hardcover, 2013 ed.)
Paolo Capodaglio, Joel Faintuch, Antonio Liuzzi
R5,454 R5,098 Discovery Miles 50 980 Save R356 (7%) Ships in 12 - 17 working days

Obesity is currently regarded as one of the major health challenges of the developed world. Excess body weight is an important risk factor for morbidity and mortality from cardiovascular diseases, diabetes, cancer, musculoskeletal disorders and even psychiatric problems and is estimated to cause nearly 3 million deaths per year worldwide. Obesity is not necessarily associated with comorbidities: there are indeed metabolically healthy obese individuals. Thus, we need to consider individuals presenting simple with obesity separately from those at risk of developing or who have already developed complex clinical states potentially leading to disability. Comorbidities can tip the balance of independence in patients who already have functional limitations mainly due to the excess of mass itself or who develop conditions such as diabetes, cardiovascular conditions, non-alcoholic fatty liver disease, where an abnormal metabolism of adipose tissue prevails. Morbid obesity with comorbidities leading to disability represents a real social and economic burden for National Health Systems worldwide. The presence of multiple and associated comorbidities often represents an obstacle to being admitted to hospitals for the treatment of metabolic diseases. On the other hand, clinical units with optimal standards for the treatment of pathological conditions in normal-weight patients are often structurally and technologically inadequate for the care of patients with extreme obesity. The aim of this book is to focus on the pathophysiological and rehabilitative aspects of disabling obesity, highlighting multidisciplinary rehabilitation interventions as key to counteracting the disabling aspects of complicated obesity.

Molecular Mechanisms of Angiogenesis - From Ontogenesis to Oncogenesis (Hardcover, 2014 ed.): Jean-Jacques Feige, Gilles Pages,... Molecular Mechanisms of Angiogenesis - From Ontogenesis to Oncogenesis (Hardcover, 2014 ed.)
Jean-Jacques Feige, Gilles Pages, Fabrice Soncin
R5,341 Discovery Miles 53 410 Ships in 12 - 17 working days

Angiogenesis is a multi-stage process that drives the generation of new blood and lymphatic vessels from pre-existing ones. It is highly active during embryogenesis, largely inactive during adulthood but reactivated during wound healing and under a number of pathological conditions including cancer and ocular diseases. In addition to endothelial cells, which line the walls of the vessels, several other cell types (pericytes, macrophages, progenitor cells ) also contribute to angiogenesis. A number of signaling pathways are activated and very finely tune the delicate morphogenetic events that ultimately lead to the formation of stable blood proof neovessels.

This book reviews recent advances in our understanding of the molecular and cellular mechanisms of angiogenesis, with a focus on how to integrate these observations into the context of developmental, post-natal and pathological neovascularization.

The book was published under the auspices of the French Angiogenesis Society. Most contributors are prominent members of this Society or international researchers who have actively contributed to the Annual Meetings of the Society."

Essays on the History of Respiratory Physiology (Hardcover, 2015 ed.): John B West Essays on the History of Respiratory Physiology (Hardcover, 2015 ed.)
John B West
R5,150 Discovery Miles 51 500 Ships in 12 - 17 working days

This book consists of 23 essays about prominent people and events in the history of respiratory physiology. It provides a first-hand chronicle of the advancements made in respiratory physiology starting with Galen and the beginnings of Western physiology. The volume covers every aspect of the evolution of this important area of knowledge: pulmonary circulation, Boyle's Law, pulmonary capillaries and alveoli, morphology, gas exchange and blood flow, mechanics, control of ventilation, and comparative physiology. The book emphasizes societal and philosophical aspects of the history of science. Although it concentrates on physiology, it also describes how cultural movements, such as The Enlightenment, shaped the researchers discussed. This book is published on behalf of the American Physiological Society by Springer. Access to APS books published with Springer is free to APS members.

Memories: Molecules and Circuits (Hardcover, 2007 ed.): B Bontempi, Alcino J. Silva Memories: Molecules and Circuits (Hardcover, 2007 ed.)
B Bontempi, Alcino J. Silva
R4,576 Discovery Miles 45 760 Ships in 10 - 15 working days

This volume surveys the recent advances and provide an integrative view of molecular, cellular, and systems level mechanisms underlying cognitive processes in both animals and humans. Current state of the art and future avenues are discussed by distinguished scientists who provide not only an overview of the underlying neurobiology of cognitive processes from a basic science standpoint, but who also focus on clinical and therapeutic aspects surrounding impairments associated with disorders that affect cognition.

Mesenchymal Stem Cells - Basics and Clinical Application I (Hardcover, 2013 ed.): Birgit Weyand, Massimo Dominici, Ralf Hass,... Mesenchymal Stem Cells - Basics and Clinical Application I (Hardcover, 2013 ed.)
Birgit Weyand, Massimo Dominici, Ralf Hass, Roland Jacobs, Cornelia Kasper
R6,667 Discovery Miles 66 670 Ships in 10 - 15 working days

Prospective Isolation and Characterization of Human Bone Marrow-Derived MSCs, by A. Harichandan, K. Sivasubramaniyan, H.-J. Buhring Urine as a Source of Stem Cells, by Christina Benda, Ting Zhou, Xianming Wang, Weihua Tian, Johannes Grillari, Hung-Fat Tse, Regina Grillari-Voglauer, Duanqing Pei, Miguel A. Esteban Expansion of Mesenchymal Stem/Stromal Cells under Xenogenic-Free Culture Conditions, by Sven Kinzebach, Karen Bieback Adipose-Derived Mesenchymal Stem Cells: Biology and Potential Applications, by Danielle Minteer, Kacey G Marra, J Peter Rubin Potential for Osteogenic and Chondrogenic Differentiation of MSC, by Antonina Lavrentieva, Tim Hatlapatka, Anne Neumann, Birgit Weyand, Cornelia Kasper Potential for Neural Differentiation of Mesenchymal Stem Cells, by Letizia Ferroni, Chiara Gardin, Ilaria Tocco, Roberta Epis, Alessandro Casadei, Vincenzo Vindigni, Giuseppe Mucci, Barbara Zavan Migratory Properties of Mesenchymal Stem Cells, by Thomas Dittmar, Frank Entschladen Dissecting Paracrine Effectors for Mesenchymal Stem Cells, by Stefania Bruno, Federica Collino, Ciro Tetta, Giovanni Camussi Proteomics Approaches in the Identification of Molecular Signatures of Mesenchymal Stem Cells, by Yin Xiao, Jiezhong Chen Does the Adult Stroma Contain Stem Cells?, by Richard Schafer

The Role of Platelets in Blood-Biomaterial Interactions (Hardcover): Y.F. Missirlis, J.-L. Wautier The Role of Platelets in Blood-Biomaterial Interactions (Hardcover)
Y.F. Missirlis, J.-L. Wautier
R3,300 Discovery Miles 33 000 Ships in 10 - 15 working days

Medicine and engineering work together towards solutions for biomedical problems. The interactions of blood elements with artificial materials (bags, tubes, artificial organs, etc.) require many disciplines for its understanding. Thus the effort presented in this book is the culmination of a genuine discussion on the problems arising in blood banks, in hospitals, in biomaterials development, in experimental haemocompatibility testing when platelets interact with biomaterials. Haematologists, chemists, biologists and engineers have tried to put their own point of view and to understand the point of view of the other disciplines. The main themes that are presented in the discussion are: platelet collection, storage and transfusion; haemostasis and anticoagulation; platelet and biomaterials, extracorporeal circulation and implanted materials; haemorheological parameters; modulation of platelet function; biological tests for evaluating platelet biomaterial interactions.

Proceedings of the 13th International Conference on Man-Machine-Environment System Engineering (Hardcover, 2014 ed.): Shengzhao... Proceedings of the 13th International Conference on Man-Machine-Environment System Engineering (Hardcover, 2014 ed.)
Shengzhao Long, Balbir S Dhillon
R6,008 Discovery Miles 60 080 Ships in 10 - 15 working days

The integrated and advanced science research topic Man-Machine-Environment system engineering (MMESE) was first established in China by Professor Shengzhao Long in 1981, with direct support from one of the greatest modern Chinese scientists, Xuesen Qian. In a letter to Shengzhao Long from October 22nd, 1993, Xuesen Qian wrote: You have created a very important modern science and technology in China
MMESE primarily focuses on the relationship between man, machines and the environment, studying the optimum combination of man-machine-environment systems. In this system, man refers to people in the workplace (e.g. operators, decision-makers); machine is the general name for any object controlled by man (including tools, machinery, computers, systems and technologies), and environment describes the specific working conditions under which man and machine interact (e.g. temperature, noise, vibration, hazardous gases etc.). The three goals of optimization of Man-Machine-Environment systems are to ensure safety, efficiency and economy.
"Proceedings of the 13th International Conference on Man-Machine-Environment System Engineering" are an academic showcase of the best papers selected from more than 400 submissions, introducing readers to the top research topics and the latest developmental trends in the theory and application of MMESE.
These proceedings are interdisciplinary studies on the concepts and methods of physiology, psychology, system engineering, computer science, environment science, management, education, and other related disciplines. Researchers and professionals working in these interdisciplinary fields and researchers on MMESE related topics will benefit from these proceedings."

Vascular Morphogenesis - Methods and Protocols (Hardcover, 2015 ed.): Domenico Ribatti Vascular Morphogenesis - Methods and Protocols (Hardcover, 2015 ed.)
Domenico Ribatti
R3,820 Discovery Miles 38 200 Ships in 12 - 17 working days

"Vascular Morphogenesis: Methods and Protocols" provides a range of techniques for studying vascular morphogenesis in vivo and in vitro, reflecting advances in the field. Endothelial cell signaling is currently believed to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation and postnatal tissue remodeling. Understanding the concept of vascular bed specificity represents a major challenge for future investigations. Indeed, one of the most interesting theoretical perspectives and practical applications of endothelial cell signaling is the possibility for these cells to maintain their inductive potential during adult life. Written in the highly successful "Methods in Molecular Biology" series format, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.

Practical and authoritative, "Vascular Morphogenesis: Methods and Protocols" will serve as a instructive and useful reference for cell biologists, anatomists, pathologists and physiologists, as well as all those interested in this area of biological study.

Prevention and Management of Dyslipidemia (Hardcover): Donna Thompson Prevention and Management of Dyslipidemia (Hardcover)
Donna Thompson
R2,413 Discovery Miles 24 130 Ships in 12 - 17 working days
Mechanosensitivity and Mechanotransduction (Hardcover, 2011 Ed.): Irina Kiseleva, Andre Kamkin Mechanosensitivity and Mechanotransduction (Hardcover, 2011 Ed.)
Irina Kiseleva, Andre Kamkin
R6,108 Discovery Miles 61 080 Ships in 10 - 15 working days

This book presents the latest findings in the field of research of mechanosensitivity and mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It contains a detailed description of several stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii cations via intracellular cytoskeletal reorganization and extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K+ channels functioning in mouse B lymphocytes. This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. Currently, investigations of the molecular mechanisms of mechanosensitivity and mechanotransduction are focused on several issues. The majority of studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies. This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.

Muscarinic Receptors (Hardcover, 2012): Allison D. Fryer, Arthur Christopoulos, Neil M. Nathanson Muscarinic Receptors (Hardcover, 2012)
Allison D. Fryer, Arthur Christopoulos, Neil M. Nathanson
R8,812 Discovery Miles 88 120 Ships in 10 - 15 working days

Muscarinic acetylcholine receptors have played a key role in the advancement of knowledge of pharmacology and neurotransmission since the inception of studies in these fields, and the effects of naturally occurring drugs acting on muscarinic receptors were known and exploited for both therapeutic and non-therapeutic purposes for hundreds of years before the existence of the receptors themselves was recognized. This volume presents a broad yet detailed review of current knowledge of muscarinic receptors that will be valuable both to long-time muscarinic investigators and to those new to the field. It describes the detailed insights that have been obtained on the structure, function, and cell biology of muscarinic receptors. This volume also describes physiological analyses of muscarinic receptors and their roles in regulating the function of the brain and of a variety of peripheral tissues. This volume shows how the study of muscarinic receptors continues to provide new and surprising insights not just to the cholinergic system but to the broad areas of neurobiology, cell biology, pharmacology, and therapeutics.

Stem Cells: Current Challenges and New Directions (Hardcover, 2013 ed.): Kursad Turksen Stem Cells: Current Challenges and New Directions (Hardcover, 2013 ed.)
Kursad Turksen
R5,593 R5,238 Discovery Miles 52 380 Save R355 (6%) Ships in 12 - 17 working days

This volume looks at the state-of-the-science in stem cells, discusses the current challenges, and examines the new directions the field is taking. Dr. Turksen, editor-in-chief of the journal "Stem Cell Reviews and Reports," has assembled a volume of internationally-known scientists who cover topics that are both clinically and research-oriented. The contents range from sources of stem cells through their physiological role in health and disease, therapeutic applications in regenerative medicine, and ethics and society. An initial overview and a final summary bookend the contents into a cohesive and invaluable volume.

Histone Deacetylases - Transcriptional Regulation and Other Cellular Functions (Hardcover, 2006 ed.): Eric Verdin Histone Deacetylases - Transcriptional Regulation and Other Cellular Functions (Hardcover, 2006 ed.)
Eric Verdin
R5,932 Discovery Miles 59 320 Ships in 10 - 15 working days

A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small molecule inhibitors-and the biological roles of the several histone deacetylases (HDAC) genes that have been knocked out in mice.

Light and Specular Microscopy of the Cornea (Hardcover, 1st ed. 2017): Katerina Jirsova Light and Specular Microscopy of the Cornea (Hardcover, 1st ed. 2017)
Katerina Jirsova
R6,675 Discovery Miles 66 750 Ships in 10 - 15 working days

The atlas of the Light and Specular Microscopy of the Cornea, particularly of the corneal endothelium presents photographs of healthy and pathological corneas, as well as corneas prepared for grafting. Photographs are taken from donor or patient's corneas. The first part section of the atlas shows healthy corneas and its particular layers: the epithelium (superficial and basal cells, subepithelial nerve plexus), stroma and keratocytes, and the endothelium. Blood vessels or palisades of Vogt in limbus are shown as well. The second part section that shows corneas processed for grafting is focused focuses on the endothelial layer. Main causes of exclusion of corneas from grafting, such as the presence of dead cells, polymeghatism, pleomorphism, cornea guttata or stromal scars have been shown. The third part section of the atlas shows corneas before and after storage in tissue cultures or hypothermic conditions with the aim to assess its suitability of for tissue for grafting. The last final section contains photographs of pathological corneal explants

Back Rehabilitation - Core Stability Re-examined (Paperback): Christopher Norris Back Rehabilitation - Core Stability Re-examined (Paperback)
Christopher Norris
R1,380 Discovery Miles 13 800 Ships in 9 - 15 working days

Low back pain affects most of us at some time, and exercise is key to both its prevention and treatment. Critically appraising work from several approaches to produce an integrated, practical approach suitable for day-to-day clinicians and personal trainers, this essential guide looks at the science and practice of designing and teaching the best exercise programmes for this common condition. Learn: vital client assessment skills, which exercises to use and why, the most effective teaching methods, how to structure and progress a full backpain management programme. Aimed at student therapists and clinical exercise teachers, as well as trainers planning exercise programmes for subjects recovering from low back pain, Back Rehabilitation is essential reading for Therapists and Exercise academics and professionals of all types.

Integrated Metabolomics (Hardcover): Josh Connolly Integrated Metabolomics (Hardcover)
Josh Connolly
R3,196 Discovery Miles 31 960 Ships in 12 - 17 working days
Biomedical Imaging and Computational Modeling in Biomechanics (Hardcover, 2013 ed.): Ugo Andreaus, Daniela Iacoviello Biomedical Imaging and Computational Modeling in Biomechanics (Hardcover, 2013 ed.)
Ugo Andreaus, Daniela Iacoviello
R4,488 R3,612 Discovery Miles 36 120 Save R876 (20%) Ships in 12 - 17 working days

This book collects the state-of-art and new trends in image analysis and biomechanics. It covers a wide field of scientific and cultural topics, ranging from remodeling of bone tissue under the mechanical stimulus up to optimizing the performance of sports equipment, through the patient-specific modeling in orthopedics, microtomography and its application in oral and implant research, computational modeling in the field of hip prostheses, image based model development and analysis of the human knee joint, kinematics of the hip joint, micro-scale analysis of compositional and mechanical properties of dentin, automated techniques for cervical cell image analysis, and biomedical imaging and computational modeling in cardiovascular disease.

The book will be of interest to researchers, Ph.D students, and graduate students with multidisciplinary interests related to image analysis and understanding, medical imaging, biomechanics, simulation and modeling, experimental analysis

Inhibitory Synaptic Plasticity (Hardcover, 2011 ed.): Melanie A. Woodin, Arianna Maffei Inhibitory Synaptic Plasticity (Hardcover, 2011 ed.)
Melanie A. Woodin, Arianna Maffei
R4,576 Discovery Miles 45 760 Ships in 10 - 15 working days

This volume will explore the most recent findings on cellular mechanisms of inhibitory plasticity and its functional role in shaping neuronal circuits, their rewiring in response to experience, drug addiction and in neuropathology. Inhibitory Synaptic Plasticity will be of particular interest to neuroscientists and neurophysiologists.

Reconstructing Mobility - Environmental, Behavioral, and Morphological Determinants (Hardcover, 2014 ed.): Kristian J Carlson,... Reconstructing Mobility - Environmental, Behavioral, and Morphological Determinants (Hardcover, 2014 ed.)
Kristian J Carlson, Damiano Marchi
R5,493 R5,138 Discovery Miles 51 380 Save R355 (6%) Ships in 12 - 17 working days

Assembles a collection of experts to provide a current account of different approaches (e.g., traditional, comparative and experimental) being applied to study mobility. Moreover, the book aims to stimulate new theoretical perspectives that adopt a holistic view of the interaction among intrinsic (i.e. skeletal) and extrinsic (i.e. environmental) factors that influence differential expression of mobility. Since the environment undoubtedly impacts mobility of a wide variety of animals, insights into human mobility, as a concept, can be improved by extending approaches to investigating comparable environmental influences on mobility in animals in general. The book teases apart environmental effects that transcend typical categories (e.g., coastal versus inland, mountainous versus level, arboreal versus terrestrial). Such an approach, when coupled with a new emphasis on mobility as types of activities rather than activity levels, offers a fresh, insightful perspective on mobility and how it might affect the musculoskeletal system.

Aquaporins (Hardcover, 2009 ed.): Eric Beitz Aquaporins (Hardcover, 2009 ed.)
Eric Beitz
R8,790 Discovery Miles 87 900 Ships in 10 - 15 working days

The aquaporin field has matured at an exceptionally fast pace and we are at the verge to develop serious strategies to therapeutically modulate aquaporin function directly or via regulatory networks. Key prerequisites are available today: i. a considerable (and growing) number of aquaporin crystal structures for the rational design of inhibitory molecules, ii. elaborate molecular dynamics simulation techniques for theoretical analyses of selectivity mechanisms and docking experiments, iii. comprehensive data on aquaporin immunohistochemistry, iv. aquaporin knockout animals for physiological studies, and v. assay systems for compound library screenings. The structure of this volume on aquaporins follows the points laid out above and thus covers the developments from basic research to potential pharmacological use. Situated between pharmacology textbooks and recent scientific papers this book provides a timely overview for readers from the fundamental as well as the applied disciplines.

Applied Physiology Of Exercise (Paperback): G Balasekaran, Visvasuresh Victor Govindaswamy, Jolene Ziyuan Lim, Peggy Peck Kay... Applied Physiology Of Exercise (Paperback)
G Balasekaran, Visvasuresh Victor Govindaswamy, Jolene Ziyuan Lim, Peggy Peck Kay Boey, Yew Cheo Ng
R858 Discovery Miles 8 580 Ships in 10 - 15 working days

This book is suitable for anyone interested in training with the use of science. Training has to be science-based and science is the only way forward, thus the book title indicates Applied Physiology of Exercise. Any training can be answered with physiological rationale. If it cannot be answered, people are moving away from specific intelligent training and into erroneous combination high-load training (for example, combining aerobic and anaerobic interval training in a single training session) that may not elicit a higher percentage of physiological adaptations but may induce injuries as the body is not conditioned properly. Combination high-level training may be introduced at a later stage once an individual goes through specific conditioning following a general conditioning of building the 'base' or 'foundation' period for at least six months. Factual training with science takes time to attain superior performance without performance-enhancing drugs or supplements such as growth hormones and testosterone. Gathering the 'right' knowledge is important and hopefully readers will be better equipped after reading this book. There are questions in each chapter to enhance learning and comprehension. It requires readers to think, rationalize, answer, and apply the facts to training or weight loss programs. These questions aim to ignite the critical component of learning as readers critique and re-analyze their training program. Even though each training could be different with everyone holding on to a different training philosophy, facts through science are universal for all.

Heart Rate and Rhythm - Molecular Basis, Pharmacological Modulation and Clinical Implications (Hardcover, 2011 Ed.): Onkar N.... Heart Rate and Rhythm - Molecular Basis, Pharmacological Modulation and Clinical Implications (Hardcover, 2011 Ed.)
Onkar N. Tripathi, Ursula Ravens, Michael C. Sanguinetti
R6,023 Discovery Miles 60 230 Ships in 10 - 15 working days

Pathological heart rhythms are a major health issue. In this book experts from various fields provide an important context for understanding the complicated molecular and cellular mechanisms that underlie normal and pathophysiological cardiac rhythms.

Individual chapters cover a full range of topics, including the ionic basis of pacemaking, the role of specific channels and transporters in sinoatrial node pacemaking, altered intracellular Ca2+ handling in response to disease, computer modeling of the action potentials of pacemaker and working cardiomyocytes, genetic and molecular basis of inherited arrhythmias and a review of established and novel antiarrhythmic agents. Due to the key importance of the specialized pacemaker cells and tissue (sinoatrial and atrioventricular nodes) in maintaining heart rate and rhythm, special emphasis is placed on the peculiar electrophysiology of these cells.

Growth of the Pediatric Skeleton - A Primer for Radiologists (Hardcover, 2008 ed.): Alan Emil Oestreich Growth of the Pediatric Skeleton - A Primer for Radiologists (Hardcover, 2008 ed.)
Alan Emil Oestreich
R1,574 Discovery Miles 15 740 Ships in 10 - 15 working days

This book is an organized approach to understanding bone growth and disease. It integrates anatomic and radiologic knowledge of enchondral and membranous bone growth and emphasizes the similarities of the physis and acrophysis in development. The artwork, jointly produced by artist and author, illustrates the concepts described. The identification of abnormality is aided by the explanations of the causes in terms of pattern recognition.

The Fungal Cell Wall - An Armour and a Weapon for Human Fungal Pathogens (Hardcover, 1st ed. 2020): Jean-Paul Latge The Fungal Cell Wall - An Armour and a Weapon for Human Fungal Pathogens (Hardcover, 1st ed. 2020)
Jean-Paul Latge
R5,738 Discovery Miles 57 380 Ships in 12 - 17 working days

This book illustrates, that the fungal cell wall is critical for the biology and ecology of all fungi and especially for human fungal pathogens. Readers will learn, that the composition of the fungal cell wall is a unique structure, which cannot be found in the human host. Consequently, the chapters outline, how the immune systems of both animals and humans have evolved to recognize conserved and unique elements of the fungal cell wall. As an application example, the authors also show, that the three-dimensional structures of the cell wall are excellent targets for the development of antifungal agents and chemotherapeutic strategies. With the combination of biological findings and medical outlooks, this volume is a fascinating read for scientists, clinicians and biomedical students.

Free Delivery
Pinterest Twitter Facebook Google+
You may like...
Beyond Neurotransmission…
Paul Katz Hardcover R8,020 Discovery Miles 80 200
Current Methods in Muscle Physiology…
Haruo Sugi Hardcover R6,541 Discovery Miles 65 410
The Works of William Harvey
William Harvey Paperback R844 Discovery Miles 8 440
Plasticity in Nerve Cell Function
Platon Kostyuk Hardcover R5,524 Discovery Miles 55 240
Eureka: Biochemistry & Metabolism
Andrew Davison, Anna Milan, … Paperback R1,007 R917 Discovery Miles 9 170
Productivity with Health, Safety, and…
Lakhwinder Pal Singh, Arvind Bhardwaj, … Hardcover R5,743 Discovery Miles 57 430
The Physiology of Marriage
William Andrus Alcott Paperback R535 Discovery Miles 5 350
Synergy
Mark L. Latash Hardcover R3,562 Discovery Miles 35 620
Super Gut - A Four-Week Plan to…
William Davis Paperback R603 R526 Discovery Miles 5 260
Loose Leaf for Human Physiology
Stuart Fox, Krista Rompolski Loose-leaf R4,382 Discovery Miles 43 820

 

Partners