Structure and Function of the Neural Cell Adhesion Molecule NCAM (Hardcover, 2010 Ed.)

Dr. Elisabeth Bock (Photo Keenpress) This book contains review articles that produce a snapshot of recent developments in the field of the neural cell adhesion molecule NCAM. The chapters are grouped into sections reflecting various aspects of NCAM structure and function. The themes cover the structural basis of cell adhesion mediated by NCAM and NCAM interaction partners, NCAM-mediated signaling determinants of NCAM function under physiological conditions and in disease, and the therapeutic potential of NCAM mimetics. Section 1, "Structure and Ligands of NCAM," introduces the reader to the str- tural basis of NCAM-mediated cell adhesion, discussing the current knowledge of extracellular and intracellular NCAM ligands and the structural basis of NCAM int- actions with the fibroblast growth factor (FGF) receptor. Section 2, "NCAM and Polysialic Acid," focuses on NCAM polysialylation, discussing the structural and functional aspects of the most important posttranslational modifications of NCAM by the addition of a long linear homopolymer of sialic acid to the fifth Ig-like NCAM module. Section 3, "NCAM-mediated Signal Transduction," is devoted to signal v BookID 187530_ChapID FM1_Proof# 1 - 01/03/2011 BookID 187530_ChapID FM1_Proof# 1 - 01/03/2011 vi Preface transduction mechanisms associated with NCAM-mediated adhesion, with a focus on signaling pathways involved in NCAM-mediated neurite outgrowth, the role of growth-associated proteins, signaling through lipid microdomains, and signaling crosstalk with the epidermal growth factor (EGF) receptor. Section 4, "NCAM Metabolism," focuses on current knowledge about NCAM biosynthesis and the g- eration and role of soluble NCAM.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Series:	Advances in Experimental Medicine and Biology, 663
Release date:	December 2009
First published:	2010
Editors:	Vladimir Berezin
Dimensions:	235 x 155 x 25mm (L x W x T)
Format:	Hardcover
Pages:	434
Edition:	2010 Ed.
ISBN-13:	978-1-4419-1169-8
Categories:	Books > Medicine > Clinical & internal medicine > Neurology & clinical neurophysiology Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > General Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences Promotions
LSN:	1-4419-1169-3
Barcode:	9781441911698

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