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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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Structure and Function of the Neural Cell Adhesion Molecule NCAM (Hardcover, 2010 Ed.)
Loot Price: R5,797
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Structure and Function of the Neural Cell Adhesion Molecule NCAM (Hardcover, 2010 Ed.)
Series: Advances in Experimental Medicine and Biology, 663
Expected to ship within 10 - 15 working days
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Dr. Elisabeth Bock (Photo Keenpress) This book contains review
articles that produce a snapshot of recent developments in the
field of the neural cell adhesion molecule NCAM. The chapters are
grouped into sections reflecting various aspects of NCAM structure
and function. The themes cover the structural basis of cell
adhesion mediated by NCAM and NCAM interaction partners,
NCAM-mediated signaling determinants of NCAM function under
physiological conditions and in disease, and the therapeutic
potential of NCAM mimetics. Section 1, "Structure and Ligands of
NCAM," introduces the reader to the str- tural basis of
NCAM-mediated cell adhesion, discussing the current knowledge of
extracellular and intracellular NCAM ligands and the structural
basis of NCAM int- actions with the fibroblast growth factor (FGF)
receptor. Section 2, "NCAM and Polysialic Acid," focuses on NCAM
polysialylation, discussing the structural and functional aspects
of the most important posttranslational modifications of NCAM by
the addition of a long linear homopolymer of sialic acid to the
fifth Ig-like NCAM module. Section 3, "NCAM-mediated Signal
Transduction," is devoted to signal v BookID 187530_ChapID
FM1_Proof# 1 - 01/03/2011 BookID 187530_ChapID FM1_Proof# 1 -
01/03/2011 vi Preface transduction mechanisms associated with
NCAM-mediated adhesion, with a focus on signaling pathways involved
in NCAM-mediated neurite outgrowth, the role of growth-associated
proteins, signaling through lipid microdomains, and signaling
crosstalk with the epidermal growth factor (EGF) receptor. Section
4, "NCAM Metabolism," focuses on current knowledge about NCAM
biosynthesis and the g- eration and role of soluble NCAM.
General
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