Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants. In this setting, inducible signaling pathways the airway mucosa play a central role in the initiation of airway inflammation through production of antimicrobial peptides (defensins), cytokines, chemokines and arachidonic acid metabolites that coordinate the complex processes of vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial constriction and tissue remodeling. These signals also are responsible for leukocytic infiltration into the submucosa, T helper-lymphocyte skewing, and allergic sensitization. Currently, it is well appreciated that asthma is a heterogeneous in terms of onset, exacerbants, severity, and treatment response. Current asthma classification methods are largely descriptive and focus on a single aspect or dimension of the disease. An active area of investigation on how to collect, use and visualize multidimensional profiling in asthma. This book will overview multidimensional profiling strategies and visualization approaches for phenotyping asthma. As an outcome, this work will facilitate the understanding of disease etiology, prognosis and/or therapeutic intervention. "

Over the past three decades the study of pediatric physical inactivity has become a public health concern. The decreases in physical activity have been associated with obesity and numerous hypokinetic diseases. In accordance with this public health concern, the study of pediatric physical activity has become a central part of research in the health and exercise science fields. The Routledge Handbook of Youth Physical Activity is the first book to survey the full depth and breadth of the issues facing this field. Bringing together many of the world's experts and practitioners, the book helps to develop an understanding of the underlying issues related to pediatric physical activity as well as the role physical activity plays on cognitive, psychomotor, and social aspects of childhood. The book addresses issues with physical activity measurement and discuss wide-ranging aspects of physical activity interventions. With more emphasis than ever on physical activity, this book makes an important contribution to the scholars and practitioners working in the field of youth physical activity. This is the first single text on the state of current knowledge related to pediatric physical activity which offers a comprehensive guide to students and academics on these subjects The Routledge Handbook of Youth Physical Activity is key reading for all advanced students, researchers, practitioners, and policy-makers with an interest in physical activity, youth sport, public health matters, sport studies, or physical education.

This well-established book on injury biomechanics has been extensively revised and expanded for this new edition. It now includes a fundamental treatment of the mechanics at a cellular level, written by the new coauthor Prof. Barclay Morrison III from Columbia University. Furthermore, considerably more attention is paid to computer modeling, and in particular modeling the human body. The book addresses a wide range of topics in injury biomechanics, including anatomy, injury classification, injury mechanisms, and injury criteria. Further, it provides essential information on regional injury reference values, or injury criteria, that are either currently in use or proposed by both US and European communities. Although the book is intended as an introduction for doctors and engineers who are newcomers to the field of injury biomechanics, sufficient references are provided for those who wish to conduct further research, and even established researchers will find it useful as a reference guide to the biomechanical background of each proposed injury mechanism and injury criterion.

The volume specificity and practicality examines techniques that are commonly used, often without merit, and provides useful information for practitioners, trainers, coaches, clinicians and other readers The book examines a wide range of physiological topics progressing through many of the key issues. Provides a healthy balance between health and wellbeing and elite performance

The volume specificity and practicality examines techniques that are commonly used, often without merit, and provides useful information for practitioners, trainers, coaches, clinicians and other readers The book examines a wide range of physiological topics progressing through many of the key issues. Provides a healthy balance between health and wellbeing and elite performance

This book provides a concise yet comprehensive review of the morphological, biochemical, electrical, mechanical, and metabolic properties of vascular smooth muscle, the regulation of vascular activities and the intracellular signaling involved. It particularly focuses on newly identified vasoactive agents, enzymes and transduction mechanisms. It also discusses the latest findings in the regulation of cerebral, coronary and pulmonary circulation as well as vascular activity under hypoxia and ageing. The second edition intends to update the contents of the first edition with the latest achievements in the regulation of vascular activities from biochemical, structural, genetic, physiological, and pharmacological aspects. In addition, two new chapters related to microRNA and extracellular vesicles have been added to reflect their newly discovered important roles in vascular activities. The contraction and dilatation activities of vasculature are of fundamental importance for maintaining circulation homeostasis and adapting to physiological changes. Over the last four decades, there have been significant advances in our understanding of the biochemical, structural, genetic, physiological, and pharmacological aspects of vascular activity regulation, and these insights into the responsiveness of blood vessels under normal and pathophysiological conditions help to provide valuable weapons in the fight vascular diseases. The book is of interest to researchers and graduate students, both in basic research and in clinic settings, in the field of vascular biology.

The first step on your path to success... Foundation in Kinesiology and Biomechanics and Kinesiology in Action work together to create a complete learning experience that builds the foundational knowledge you need to take the next step in your education. A reader friendly text, full-color videos and interactive exercises guide you every step of the way, making an often complex subject easier to understand and apply. Text Foundation in Kinesiology and Biomechanics Develop the must-have knowledge you need of basic joint structure and muscle action and their normal and pathologic functions. You'll focus on the science behind muscle function and movement and how groups of muscle together can contribute to function or dysfunction. This evidence-based approach prepares you to explore the principles of rehabilitation that facilitate movement, strength, and mobility. KinesiologyinAction.com This interactive online program guides you step by step through an immersive multimedia experience that tracks your progress until you've mastered the concepts and are ready to apply them in practice. An access code inside new, printed texts unlocks Kinesiology in Action. Learn more. Visit www.KinesiologyinAction.com

This is the first volume in a series on membrane protein transfer. Membrane protein transport underlies the topological disposition of many proteins within cells and it is this disposition that allows for the co-ordination of the central cellular processes, such as metabolism.

This book describes control of ventilation during sleep in both health and disease states. The topics are presented in a fashion that can be easily comprehended with many figures to illustrate complex concepts. Thus, a wide range of topics, starting from the site of normal respiratory rhythm generation to chemoreceptor control of sleep apnea, description of the apneic threshold, pathophysiology of upper airway closure, novel techniques to measure control of breathing, effect of cerebral blood flow on breathing, effect of opioids on ventilation, effect of heart failure on ventilation, genetic aspects of breathing disorders, age and gender differences, and various therapies are discussed. Key Features * Helps to bridge the gap between straight forward physiology and clinical practice through a range of topics and use of case vignettes * Explores various aspects of clinical management and control which is beneficial to sleep clinicians, respiratory physiologists, intensivists, trainees, and researchers. * Distills complex concepts into understandable language and figures, providing helping resource to the clinicians, that transforms a dry topic vis a viz control of ventilation into an exciting understandable 'clinician' language.

Adenosine Receptors in Neurodegenerative Diseases covers the role of adenosine receptors in brain function, also focusing on related methodologies and perspectives in therapeutics. The book provides an up-to-date overview by the best specialists in the field, helping readers consider the importance of adenosine and expand the global impact and visibility of adenosine research in the CNS field. Chapters include adenosine biology and signaling, gene regulation, control of motor function, and novel adenosine-based therapies in the CNS. It is an ideal resource for researchers, advanced graduate students, clinicians, and industry scientists working in the fields of clinical neuroscience and molecular and cellular neuroscience.

Despite extensive physiological, biochemical, and structural studies, the mechanisms of muscle contraction operating in living muscle fibres are still not clearly understood. This book aims to describe and assess various experimental methods currently used in the field of muscle research. For
each method discussed, there is a comprehensive description of its advantages, problems, and limitations. Each chapter also contains a summary of the central results to have been obtained using each method. Comprehensively written by experts in their respective fields, this book will be of interest
to all investigators in muscle physiology.

This thorough volume explores protocols of proteome- and metabolome-wide strategies for the identification of protein-small molecule complexes in different organisms, in order to shed light on these important regulatory interactions. Experimental and computational strategies to characterize protein-metabolite interactions are discussed, and recent advances in enabling technologies are featured as well. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and expert implementation advice to ensure success in future research. Authoritative and practical, Cell-Wide Identification of Metabolite-Protein Interactions will aid researchers seeking a better understanding of the mechanisms of signal transduction occurring in the cell and assessing the effect of complex formation on cell physiology.

This book provides a clear link between the application of sports science principles and theory to practice. The book allows practitioners to go off and design and defend their own evidence-based training programmes Provides the reader with an appropriate background in physiology, biomechanics and psychology to aid in the development of the training process

Builds on the growing Talent Development literature through application and consideration with the Paralympic context. Provides important translational support to help academics and practitioners bridge the theory to practice divide. Establishes a truly international view through engagement with academic across the globe Provides a holistic consideration of Talent Development - cultural, organisational, physical, psychological, coaching, decision-making It presents a comprehensive scope. Covering courses such as Human Movement, Sports Science, Sports Coaching, Physical Education, Human Kinetics, Kinesiology, Sports Management, Adapted Sports); and covering disciplines such as Sport Psychology, Sport Engineering, Skill Acquisition, Adapted Sport, Motor Learning, and Motor Behaviour. Practical contributions as the chapters will focus on providing practical information to coaches, parents, athletes, students, trainers, and applied sport scientists

How can we optimize a bedridden patient s mattress? How can we make a passenger seat on a long distance flight or ride more comfortable? What qualities should a runner s shoes have? To objectively address such questions using engineering and scientific methods, adequate virtual human body models for use in computer simulation of loading scenarios are required. The authors have developed a novel method incorporating subject studies, magnetic resonance imaging, 3D-CAD-reconstruction, continuum mechanics, material theory and the finite element method. The focus is laid upon the mechanical "in vivo"-characterization of human soft tissue, which is indispensable for simulating its mechanical interaction with, for example, medical bedding or automotive and airplane seating systems. Using the examples of arbitrary body support systems, the presented approach provides visual insight into simulated internal mechanical body tissue stress and strain, with the goal of biomechanical optimization of body support systems. This book is intended for engineers, manufacturers and physicians and also provides students with guidance in solving problems related to support system optimization.

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Electric currents and electromagnetic fields have been applied to biological systems, particularly humans, with both therapeutic and pathological results. Applied Bioelectricity discusses biological responses to electric currents and electromagnetic fields, including medical applications and shock hazards. The book covers fundamental physical and engineering principles of responses to short-term electrical exposure and emphasizes human reactions, although animal responses to electricity are considered as well. The treatment covers reactions from the just-detectable to the clearly detrimental. An important new chapter discusses standards for human exposure to electromagnetic fields and electric current and demonstrates how these standards have been developed based on the principles treated in earlier chapters. J. Patrick Reilly is a member of the principal staff of the Johns Hopkins University Applied Physics Laboratory and is President of Metatec Associates.

Physical Activity and the Aging Brain: Effects of Exercise on Neurological Function is a complete guide to the manifold effects of exercise and physical activity on the aging brain. Cognitive decline and motor impairment, onset of diseases and disorders, and even changes in family structure and social settings that occur as we age can all impact activity levels, yet continued physical activity is crucial for successful neurological functioning. This book examines the role that exercise and physical activity play in halting or modulating the deleterious effects of these numerous aging concerns by first examining the current state of research into how exercise manifests physical changes in the brain. It then discuss how physical activity combines with other lifestyle factors to benefit the aging brain, including nutrition, computerized brain training, and social engagement. Most significantly, it also covers how physical activity can serve as therapy to help alleviate the symptoms of various neurological diseases impacting aging populations, with particular emphasis on Alzheimer's disease and age-related cognitive decline. The book provides broad coverage of the effects of exercise and physical activity on the aging brain, its therapeutic effects, and the many factors that influence the aging process.

Enzymology at the Membrane Interface: Intramembrane Proteases, Volume 584, the latest release in the Methods in Enzymology series, covers a subset of enzymes that work in the environment of the biological cell membrane. This field, called interfacial enzymology, involves a special series of experimental approaches for the isolation and study of these enzymes.

Quantitative Human Physiology: An Introduction, winner of a 2018 Textbook Excellence Award (Texty), is the first text to meet the needs of the undergraduate bioengineering student who is being exposed to physiology for the first time, but requires a more analytical/quantitative approach. This book explores how component behavior produces system behavior in physiological systems. Through text explanation, figures, and equations, it provides the engineering student with a basic understanding of physiological principles with an emphasis on quantitative aspects.

Ghrelin, the endogenous ligand for the growth hormone secretagogue (GHS) receptor, is critical in the control of food intake and energy balance. The ghrelin receptors are now known to have important physiological properties as modulators of growth hormone release, appetite, glucose homeostasis, metabolism, immune function, neurotransmitter activity, cognitive function and neurodegeneration. Bringing all of this information together in the first comprehensive text on the topic, Ghrelin in Health and Disease provides a state-of-the-art synthesis of the latest work in this area for physicians and physician-scientists. This volume addresses the unique property of ghrelin as a modulator of function. Such a property provides potential utility for safe intervention in a wide variety of disease states. Indeed as we learn more about the basic physiology of ghrelin, the potential for treating new disease targets emerge requiring validation in the clinic. Each chapter in this volume is authored by a leading investigator in the field. The introductory chapter sets the background for the book and provides a superb overview of the relevance of ghrelin to physiology, describing how the discovery of ghrelin has prompted us to completely rethink traditional physiology. The authors conclude their chapters by critically addressing the future translational aspects of ghrelin biology and outlining what key basic research and clinical questions remain to be addressed. An invaluable resource, Ghrelin in Health and Disease distinguishes itself as the first comprehensive title covering all of the molecular and clinical issues relating to ghrelin and advancing our clinical understanding of obesity, growth, and reproductive pathogenesis.

After 17 years, the Nutricia Symposium retumed to its horne grounds in The of the 10th Nutricia Netherlands, where the first five Symposia were held. The objective Symposium was to bring together a limited number of opinion leaders and key researchers in selected topics of infant nutrition to discuss the current state of the art based on original contributions and reviews. The discussion sessions after the papers were taped and edited and may give additional information and views. As a result of time constraints, the discussions on a few papers had to be cut short, or, unfortunately, could not take place at all. Nevertheless, we strongly recommend reading the discussion sections, such as the panel discussion on the requirements for LCPUFA for term and/or preterm infants. During the preparation of the Symposium the sad news that Professor J . H. P. Jonxis died prompted the organisers to dedicate one special lecture to the memory of the principal organiser of the first four Nutricia Symposia. This lecture entitled "What determines the production and composition ofbreast milk?" was given by Dr. Kathleen Moti . Acknowledgement should be made to the co-organizers and co-chairmen Professor Sir David HuH, Professor Pieter Sauer and Dr. Terence Stephenson for their contri bution. Finally, without mentioning names, the editors wish to thank a number of persons within the Nutricia organization without whom the Symposium and its Pro ceedings would not have been possible."

This book examines how the growing knowledge of the huge range of protist-, animal-, and plant-bacterial interactions, whether in shared ecosystems or intimate symbioses, is fundamentally altering our understanding of biology. The establishment and maintenance of these interactions and their contributions to the health and survival of all partners relies on continuous cell-to-cell communication between them. This dialogue may be concerned with all aspects of the biology of both partners. The book includes chapters devoted to exploring, explaining, and exposing these dialogues across a broad spectrum of plant and animal eukaryotes to a broad field of biologists. Key Features Explores the nature of the interactions between eukaryotic hosts and their microbial symbionts Examines the links between prostist, animal, and plant evolution and microbial communities Reviews specific taxa and the microbial diversity associated with these taxa Illustrates the role microbes play in the physiology and etiology of several model species Includes chapters by an international team of leading scholars