This detailed new edition aims to provide a range of methods and protocols for studying vascular morphogenesis in vivo and in vitro to reflect up-to-date advances in the field. Of note, the book explores endothelial cell signaling is currently understood to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation, and postnatal tissue remodeling. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and timely, Vascular Morphogenesis: Methods and Protocols, Second Edition will serve as an ideal guide to this area of study for a broad audience amongst cell biologists, anatomists, pathologists, and physiologists.

An international team of experts critically review the recent progress in basic and applied research in angiogenesis. Their cutting-edge discussion ranges from the stimulation and repression of angiogenesis to the discovery of novel targets and the use angiotherapy in the clinic. They also detail the fundamental concepts in the physiology and pathophysiology of angiogenesis and evaluate the potential of angiotherapy in the management of angiogenic disease, highlighting some of the angiogenics and antiangiogenics both in development and in clinical trials.

Melatonin is a powerful hormone and antioxidant with numerous effects on the metabolism and the health of humans. Available as a dietary supplement in the United States since 1993, it is one of the most popular over-the-counter alternative remedies available. Comprising contributions from researchers who have studied the role of melatonin in various disease and physiological states, Melatonin in the Promotion of Health, Second Edition provides a wide variety of expert reviews on the biology of melatonin relevant to health. Beginning with a history of melatonin and its relation to circadian rhythms, the book examines its use in a host of applications, including: Gut motility and gastrointestinal diseases Anesthesia and surgery Bone health Breast cancer Cardiovascular diseases Diabetes Age-related macular degeneration and uveitis Melanoma, solar skin damage, and collagen synthesis The prevention of DNA damage Mental disorders, sleep, and issues related to jet lag and shift work The data gathered from a large number of carefully controlled animal and human studies have clearly implicated melatonin in the control mechanisms of a wide variety of physiological and psychological activities, making it a potent candidate for therapeutic use in the treatment of a diverse range of diseases. This volume demonstrates that continued studies of this molecule raise the exciting prospect of providing new avenues of treating numerous diseases more effectively and with less side-effects than those found in conventional treatment modalities.

International Research in Science and Soccer II showcases the very latest research into the world's most widely played sport. With contributions from scientists, researchers and practitioners working at every level of the game, from grassroots to elite level, the book covers every key aspect of preparation and performance, including: * performance and match analysis; * training and testing; * physiotherapy and injury prevention; * biomechanics; * youth development; * women's soccer; * sport science and coaching; * sport psychology. Sports scientists, trainers, coaches, physiotherapists, medical doctors, psychologists, educational officers and professionals working in soccer will find this in-depth, comprehensive volume an essential and up-to-date resource. The chapters contained within this volume were first presented at The Fourth World Conference on Science and Soccer, held in Portland, Oregon, in June 2014 under the auspices of the World Commission of Science and Sports.

Profound mortality rates, due to cardiovascular disease, are a worldwide problem. Cardiovascular disease results from complications of a silent and chronic arterial disease: atherosclerosis. The challenge for the practitioner is adapting diagnostic and therapeutic responses to prevent this common and complex disease. Dyslipidemia, are disorders of the metabolism of soluble transporters of lipids in extracellular spaces of the human body (including blood), called lipoproteins. They are major cardiovascular risk factors, causally related with atherosclerosis and are themselves multifactorial diseases, resulting from interactions between genetic and environmental factors. The study of genetic factors has recently taken a new path with the study of DNA as an experimental object. More than fifty genes of lipoprotein metabolism have been identified in both their physiological actions and their contribution to the pathogenesis of human dyslipidemia. The diversity of observations has refined our current knowledge of the control of lipid metabolism and energy homeostasis in living organisms beyond the limits of the cardiovascular system (e.g., brain, immune system, and development). These studies have given way to a shake-up of former phenotypic classifications, distinguishing new entities, defining targeted therapeutic strategies, providing a basis for different patterns of disease distribution in human populations.

This open access book summarizes the latest scientific findings regarding the biological effects of the Fukushima Daiichi Nuclear Power Plant (FNPP) accident in 2011. Various cases of changes in animals and organisms have been reported since the FNPP accident. However, it is often unknown whether they are actually due to radiation, since the dose or dose-rate are not necessarily associated with the changes observed. This book brings together the works of radiation biologists and ecologists to provide reliable radioecology data and gives insight into future radioprotection. The book examines the environmental pollution and radiation exposure, and contains valuable data from abandoned livestock in the ex-evacuation zone and from wild animals including invertebrates and vertebrates, aqueous and terrestrial animals, and plants that are subjected to long-term exposure in the area still affected by radiation. It also analyzes dose evaluation, and offers new perspectives gained from the accident, as well as an overview for future studies to promote radioprotection of humans and the ecosystem. Since the biological impact of radiation is influenced by various factors, it is difficult to scientifically define the effects of low-dose/low-dose-rate radiation. However, the detailed research data presented can be combined with the latest scientific and technological advances, such as artificial intelligence, to provide new insights in the future. This book is a unique and valuable resource for researchers, professionals and anyone interested in the impact of exposure to radiation or contamination with radioactive materials.

Fluids and Electrolytes: Essentials for Healthcare Practice is designed to give a solid understanding of fluid and electrolyte physiology and its implications for practice, including acid-base balance and intravenous (IV) therapy, in a concise and easily understandable format. Chapters incorporate physiological, developmental and practical aspects, highlighting some of the key issues that arise from childhood to old age. This accessible text is presented with clear graphical representations of key processes, numerous tables and contains interesting facts to explore some common myths about human fluid and electrolyte physiology. A valuable resource for healthcare students, this book also provides a strong comprehensive overview for practitioners, nurses, physiotherapists and paramedics.

This volume presents the state of the art description of the current understanding of the biology of somatostatin including its gene regulation, prosomatostatin processing, cellular effects, somatostatin receptor subtypes, mechanism of action, signal transduction, regulation of cell growth and apoptosis, design and use of receptor subtype-selective somatostatin analogs, derivatives of somatostatin analogs tagged with radionuclides/chemotoxins, and their clinical relevance in the diagnosis and treatment of cancer. Each chapter is written by expert(s) active in somatostatin research (experimental and/or clinical). It will serve as the only single one-stop source of the most up to date information on the basic and clinical aspects of the biology of somatostatin and its receptors.

This volume contains original submissions on the development and application of molecular imaging computing. The editors invited authors to submit high-quality contributions on a wide range of topics including, but not limited to: * Image Synthesis & Reconstruction of Emission Tomography (PET, SPECT) and other Molecular Imaging Modalities * Molecular Imaging Enhancement * Data Analysis of Clinical & Pre-clinical Molecular Imaging * Multi-Modal Image Processing (PET/CT, PET/MR, SPECT/CT, etc.) * Machine Learning and Data Mining in Molecular Imaging. Molecular imaging is an evolving clinical and research discipline enabling the visualization, characterization and quantification of biological processes taking place at the cellular and subcellular levels within intact living subjects. Computational methods play an important role in the development of molecular imaging, from image synthesis to data analysis and from clinical diagnosis to therapy individualization. This work will bring readers from academia and industry up to date on the most recent developments in this field.

Sports surface design is crucial for the successful performance of sports skills and the reduction of injury risk. Surfaces have developed from natural materials such as turf, clay and cinder, to synthetic surfaces such as acrylic tennis courts, artificial turf for soccer and synthetic running tracks, while our understanding of natural turf has developed in terms of properties appropriate for different sports and surface sustainability. This book draws together the very latest research on biomechanical, medical and engineering approaches to the study of sports surfaces. Written by a team of leading international sport scientists, engineers and technologists, the book covers every key aspect of surface development and design, including: surface behaviour surface classification, function, construction and maintenance influence of surfaces on player performance and injury surface test methods and monitoring development of natural turf and synthetic surfaces shoe-turf interaction future developments in sports surface technology. Representing the most comprehensive and up-to-date study of sports surfaces, this book is important reading for all researchers and professionals working in sports technology, sports engineering, biomechanics or sports medicine.

Diagnosis and Treatment of Traumatic Brain Injury will improve readers' understanding of the complexities of diagnosis and management of traumatic brain injuries. Featuring chapters on drug delivery, different treatments, and rehabilitation, this volume discusses in detail the impact early diagnosis and effective management has on the long-term prognosis of these injuries and the lives of those affected. This book will be relevant for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries. Traumatic brain injury has complex etiology and may arise as a consequence of physical abuse, violence, war, vehicle collisions, working in the construction industry, and sports. Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury will improve readers' understanding of the detailed processes arising from traumatic brain injury. Featuring chapters on neuroinflammation, metabolism, and psychology, this volume discusses the impact of these injuries on neurological and body systems to better understand underlying pathways. This book will be relevant for neuroscientists, neurologists, clinicians, and anyone working to better understand traumatic brain injury.

The wealth of primary information provided by genome sequencing projects in various species is of enormous potential value in our efforts to understand biological funtions and molecular interactions not only in normal development and cellular physiology, but also in diseases. However, utili- tion of these resources can come only from the development and application of a fully integrated set of molecular, biochemical, biophysical, and genetic skill bases. As key components of many cell signalling pathways, protein kinases are implicated in a broad variety of diseases, including cancers and neurodegenerative conditions, and offer considerable potential as tractable targets for therapeutic intervention. With these issues in mind, the present vlume has been compiled to provide examples of core skills required for ana- sis of knase-mediated signalling cascades, with particular emphasis on iden- fication of proteins according to interactive relationships and analysis of functional properties of signalling proteins. Compilation of Protein Kinase Protocols has been possible only as a - sult of the effort of all the contributors, and I am grateful to them for taking the time and having the patience to desseminate the detailied information - quired in order that others can succeed in the application of these techniques. Most importantly, I extend my deepest gratitude to Chris, Emma, and Helen for making it all worthwhile Alastair D. Reith v Contents Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . iv ix Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Protein Kinase-Mediated Signaling Networks: Regulation and Functional Characterization Alastair D. Reith. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

This workbook aims to help students build their confidence and consolidate their studies in anatomy and physiology. Fully updated in its sixth edition, the workbook provides full-page colouring exercises for every system of the body, designed to help the reader to test their memory and reinforce their knowledge. Students can label diagrams, answer multiple choice questions and complete a range of exercises that will leave them with a more in-depth understanding of core anatomy and physiology concepts. This is a perfect revision tool for students of nursing and allied health, paramedical science, operating department practice, complementary therapy and massage therapy, as well as trainee healthcare assistants. It is a valuable companion to the 14th edition of Ross & Wilson Anatomy and Physiology in Health and Illness but can also be used in conjunction with any other anatomy and physiology text. Appealing, interactive and engaging way to learn anatomy and physiology Straightforward language and user-friendly approach to help students of all levels master difficult concepts with ease Wide range of exercises suit different learning styles Bespoke website with a unique online colouring and self-test software program - The Body Spectrum (c) and other interactive activities including case studies to support and reinforce learning New layout and additional space for students to make their own notes and construct a personalised revision summary

The must read, fully updated guide to bike fit. Burning thighs and lungs aside, cycling shouldn't be a painful or uncomfortable experience. If you suffer from numb hands, hot-spots on your feet, back pain or saddle discomfort when you're riding, chances are something isn't right with your bike set-up, your body or how they interact. But not all cyclists can afford a professional bike fit. This accessible manual contains all the information you need to find your perfect cycling position, revealed by one of the world's leading authorities on bike fit. This new edition includes brand new material on: - why almost all cyclists would benefit from shorter cranks - an in-depth look at saddle health, with special attention and advice for female cyclists - watt-saving advice for time trialists and triathletes - how to make indoor cycling more tolerable. Let Phil Burt guide you through your own Bike Fit, to ensure your bike and body work in harmony.

Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas. The sigma receptor was originally thought to be a subset of the opioid receptor family, and it is less than 10 years since it was recognized that this receptor represents unique binding sites in mammalian brain and peripheral organs, distinct from any other known neurotransmitter receptor. Since the sigma receptors exhibit high affinity for members of diverse classes of psychotropic drugs, and have been postulated to be involved in various central nervous disorders, neuroscientists have demonstrated a great deal of interest in the elucidation of these receptor sites and their biological relevance. Relatively little is known about the precise role of sigma receptors in normal brain function and in CNS disorders, despite an overwhelming research effort. This research has resulted in many controversies, some of which have been reconciled while others have not. This volume aims to update the reader on the current situation, and deals with the potential functional significance of these receptors in the brain and peripheral organs and, where appropriate, makes reference to the clinical potential of these sites.

The popular narrative of "globesity" posits that the adoption of Western diets is intensifying obesity and diabetes in the Global South and that disordered metabolisms are the embodied consequence of globalization and excess. In Metabolic Living Harris Solomon recasts these narratives by examining how people in Mumbai, India, experience the porosity between food, fat, the body, and the city. Solomon contends that obesity and diabetes pose a problem of absorption between body and environment. Drawing on ethnographic fieldwork carried out in Mumbai's home kitchens, metabolic disorder clinics, food companies, markets, and social services, he details the absorption of everything from snack foods and mangoes to insulin, stress, and pollutants. As these substances pass between the city and the body and blur the two domains, the onset and treatment of metabolic illness raise questions about who has the power to decide what goes into bodies and when food means life. Evoking metabolism as a condition of contemporary urban life and a vital political analytic, Solomon illuminates the lived predicaments of obesity and diabetes, and reorients our understanding of chronic illness in India and beyond.

In September 1991, Victor Zammit and I were in the Department of Biochemistry, the University of Cambridge, discussing ou r collaborative research project when we real ized thepotential value and need fora conference specifically concerned with fatty acid oxidation and ketogenesis. Thei dea, onceseeded, was indulged and flourished into the first "Fatty Acid Oxidation & Ketogenesis (FAOx&K) Conference"t hatwas held in the Department at Eastertime, 1992. Itw as attended byc olleagues mainly from the U. K., France and Spain. From these modest beginnings atradition for holding a conference every second yearh asgrown and this Book results from the 4th International FAOx&K Conference that was held in London at the Institute of Child Health & Great Ormond Street Hospital forChildren NHSTrust, University College London Medical School in the new Conference Suite and was attended by colleagues from over twenty c ountries and five different c ontinents. I would like to thank allm y colleagues who havec ontributed to the conferences and, mos t importantly, to this Book. The first two c onferences were held in the University of Cambridge and were orga nized entirely by me but Simon Eaton, who came to work in London with me in Febru ary 1997, b ecame Conference Secretary andco organized the last two meetings. His contribution tot he conferences has been invaluable and w ithout hisdedicated help and effort neither the latermeetings n ort his Book would haveb een possible.

Written by the authority on hypertrophic cardiomyopathy (HCM) and an HCM patient, and fully endorsed by the Hypertrophic Cardiomyopathy Association (HCMA), the leading advocacy and support organization, the 3rd Edition of this best-selling guide offers unparalleled insight into all aspects of living with and treating HCM.

Accessible and practical, A Guide to Hypertrophic Cardiomyopathy For Patients, Their Families and Interested Physicians 3rd Edition: Answers the most pressing questions posed by patients, their families, and non-specialistshealth professionals involved in their careCovers everything from what is HCM and initial diagnosis of this increasingly prevalentcondition to the latest treatment optionsReflects the first-ever HCM guidelines published by the American Heart Association in 2011

Percutaneous Surgery of the Upper Urinary Tract: Handbook of Endourology contains five focused, review-oriented volumes that are ideal for students and clinicians looking for a comprehensive review rather than a whole course. Each volume is easily accessible through eBook format. Topics covered review both the endourological diagnosis and treatment of prostate, urethral, urinary bladder, upper urinary tract, and renal pathology. All chapters describe the most recent techniques, review the latest results, and analyze the most modern technologies. In the past ten years, the field of endourology has expanded beyond the urinary tract to include all urologic minimally invasive surgical procedures. Recent advancements in robotic and laparoscopic bladder surgery make this one of the fastest moving fields in medicine. As current textbooks are too time-consuming for busy urologists or trainees who also need to learn other areas of urology, this collection provides quick references and over 4000 images that are appropriate for fellows as well as those teaching in the field.

This book reviews the recent advances in the development of proteomics-based biomarkers for the non-invasive diagnosis of altitude sickness and explores the potential of antioxidant therapy for this sickness. The first chapters introduce the associated pathophysiology and provide mechanistic insights into the enhanced generation of reactive oxygen and nitrogen species (RONS), which leads to an increase in oxidative damage to lipids, proteins, and DNA. The book then highlights the current problems relating to the diagnosis and treatment of altitude sickness and summarizes novel approaches for identifying potential biomarkers and therapeutics. Lastly, it explores the therapeutic efficacy of antioxidant agents.

Clinical Exercise Physiology, Fifth Edition With HKPropel Access, is a comprehensive guide to the clinical aspects of exercise physiology, investigating 24 chronic diseases and conditions and addressing a variety of populations. The text has been a mainstay in the field since its inception in 2003 and is an ideal resource for students preparing for clinical exercise certifications, including those offered by the American College of Sports Medicine (ACSM-CEP), American Council on Exercise (Medical Exercise Specialist), Canadian Society for Exercise Physiology (CSEP-CEP), and Exercise & Sports Science Australia (ESSA-AEP). Clinical Exercise Physiology, Fifth Edition, employs a logical progression of content to provide greater coverage and depth of diseases than is typically found in most clinical exercise physiology textbooks. It examines the effects of exercise on 24 chronic conditions, with each chapter covering the epidemiology, pathophysiology, clinical considerations, drug and surgical therapies, and exercise testing and prescription issues for the chronic condition. Other chapters are devoted to examining exercise-related issues for four special populations. Each chapter in this fifth edition is revised and updated to include the latest research, clinical guidelines, and position statements from professional organizations. In addition, it incorporates the following new elements: An upgrade to a full-color layout, for a more engaging learning experience and enhanced presentation of data New Clinical Exercise Bottom Line sidebars that highlight key information a clinical exercise physiologist needs when working with clinical populations A new chapter on clinical exercise programming that offers detailed recommendations for clinical populations A completely rewritten chapter on spinal cord injury and updates throughout each chapter to reflect the most up-to-date guidelines and position statements Expanded coverage of clinical exercise physiology certification options In addition to practical application sidebars throughout the text, the fifth edition also has related online tools to support student learning. Delivered through HKPropel, more than 60 case studies are presented in a SOAP note format so students can explore clinical evaluations, looking closely at subjective and objective data, assessments, and plans. Discussion questions and interactive key term flash cards foster better understanding and retention, while chapter quizzes can be assigned by instructors through the platform to assess student comprehension. Endorsed by the Clinical Exercise Physiology Association (CEPA), the Canadian Society for Exercise Physiology (CSEP), the British Association of Sport and Exercise Sciences (BASES), and Exercise & Sports Science Australia (ESSA), Clinical Exercise Physiology, Fifth Edition, offers a contemporary review of the variety of diseases and conditions that students and professionals may encounter in the field. New and veteran clinical exercise physiologists, as well as those preparing for clinical exercise certification exams, will appreciate the in-depth coverage of the clinical populations that benefit from physical activity. Note: A code for accessing HKPropel is included with this ebook.

This User's Guide describes the nature of thyroid disorders, natural thyroid-replacement hormones, and the important role of supplemental vitamins and minerals for thyroid function.

This book systematically introduces the bionic nature of force sensing and control, the biomechanical principle on mechanism of force generation and control of skeletal muscle, and related applications in robotic exoskeleton. The book focuses on three main aspects: muscle force generation principle and biomechanical model, exoskeleton robot technology based on skeletal muscle biomechanical model, and SMA-based bionic skeletal muscle technology. This comprehensive and in-depth book presents the author's research experience and achievements of many years to readers in an effort to promote academic exchanges in this field. About the Author Yuehong Yin received his B.E. , M.S. and Ph.D. degrees from Nanjing University of Aeronautics and Astronautics, Nanjing, in 1990, 1995 and 1997, respectively, all in mechanical engineering. From December 1997 to December 1999, he was a Postdoctoral Fellow with Zhejiang University, Hangzhou, China, where he became an Associate Professor in July 1999. Since December 1999, he has been with the Robotics Institute, Shanghai Jiao Tong University, Shanghai, China, where he became a Professor and a Tenure Professor in December 2005 and January 2016, respectively. His research interests include robotics, force control, exoskeleton robot, molecular motor, artificial limb, robotic assembly, reconfigurable assembly system, and augmented reality. Dr. Yin is a fellow of the International Academy of Production Engineering (CIRP).

Clinical Exercise Science is an introduction to core principles and best practice in exercise science for students and practitioners working with clinical populations. Combining the latest scientific research with evidence-based, practitioner-led analysis, the book offers integrated coverage of the full clinical exercise curriculum, including: Pathophysiology of exercise and disease Exercise as a clinical intervention Exercise, nutrition, and lifestyle Health behaviour change Clinical skills in exercise science The book covers a wide range of conditions, including cardiovascular disease, pulmonary disease, metabolic disease and mental health problems, and includes an array of useful features to guide student learning, such as case studies, study tasks, definitions of key terms and suggestions for further reading. With contributions from leading researchers and health practitioners, this is an invaluable foundation text for any clinical exercise science course, and useful reading for any student or practitioner working in exercise science, exercise rehabilitation, health science or physical therapy.