Fluids and Electrolytes: Essentials for Healthcare Practice is designed to give a solid understanding of fluid and electrolyte physiology and its implications for practice, including acid-base balance and intravenous (IV) therapy, in a concise and easily understandable format. Chapters incorporate physiological, developmental and practical aspects, highlighting some of the key issues that arise from childhood to old age. This accessible text is presented with clear graphical representations of key processes, numerous tables and contains interesting facts to explore some common myths about human fluid and electrolyte physiology. A valuable resource for healthcare students, this book also provides a strong comprehensive overview for practitioners, nurses, physiotherapists and paramedics.

In September 1991, Victor Zammit and I were in the Department of Biochemistry, the University of Cambridge, discussing ou r collaborative research project when we real ized thepotential value and need fora conference specifically concerned with fatty acid oxidation and ketogenesis. Thei dea, onceseeded, was indulged and flourished into the first "Fatty Acid Oxidation & Ketogenesis (FAOx&K) Conference"t hatwas held in the Department at Eastertime, 1992. Itw as attended byc olleagues mainly from the U. K., France and Spain. From these modest beginnings atradition for holding a conference every second yearh asgrown and this Book results from the 4th International FAOx&K Conference that was held in London at the Institute of Child Health & Great Ormond Street Hospital forChildren NHSTrust, University College London Medical School in the new Conference Suite and was attended by colleagues from over twenty c ountries and five different c ontinents. I would like to thank allm y colleagues who havec ontributed to the conferences and, mos t importantly, to this Book. The first two c onferences were held in the University of Cambridge and were orga nized entirely by me but Simon Eaton, who came to work in London with me in Febru ary 1997, b ecame Conference Secretary andco organized the last two meetings. His contribution tot he conferences has been invaluable and w ithout hisdedicated help and effort neither the latermeetings n ort his Book would haveb een possible.

This open access book summarizes the latest scientific findings regarding the biological effects of the Fukushima Daiichi Nuclear Power Plant (FNPP) accident in 2011. Various cases of changes in animals and organisms have been reported since the FNPP accident. However, it is often unknown whether they are actually due to radiation, since the dose or dose-rate are not necessarily associated with the changes observed. This book brings together the works of radiation biologists and ecologists to provide reliable radioecology data and gives insight into future radioprotection. The book examines the environmental pollution and radiation exposure, and contains valuable data from abandoned livestock in the ex-evacuation zone and from wild animals including invertebrates and vertebrates, aqueous and terrestrial animals, and plants that are subjected to long-term exposure in the area still affected by radiation. It also analyzes dose evaluation, and offers new perspectives gained from the accident, as well as an overview for future studies to promote radioprotection of humans and the ecosystem. Since the biological impact of radiation is influenced by various factors, it is difficult to scientifically define the effects of low-dose/low-dose-rate radiation. However, the detailed research data presented can be combined with the latest scientific and technological advances, such as artificial intelligence, to provide new insights in the future. This book is a unique and valuable resource for researchers, professionals and anyone interested in the impact of exposure to radiation or contamination with radioactive materials.

This book discusses the relationship between cellular immunity and tryptophan metabolism, as well as its products, serotonin and melatonin, in the development of several diseases and reappraises the common signal transduction pathways of the neurodegenerative diseases, carcinogenesis, immune tolerance, inflammation, hypersensitivity reactions, neuropsychiatric disorders, in addition to bacterial tryptophan biosynthesis and novel antimicrobials. Tryptophan Metabolism: Implications for Biological Processes, Health and Disease presents fundamental information on tryptophan related metabolic pathways and metabolites, implications of these products for specific biological processes, diseases and conditions. This book focuses on effects of tryptophan metabolites on human health and will appeal to researchers, clinicians and students within this field.

Sports surface design is crucial for the successful performance of sports skills and the reduction of injury risk. Surfaces have developed from natural materials such as turf, clay and cinder, to synthetic surfaces such as acrylic tennis courts, artificial turf for soccer and synthetic running tracks, while our understanding of natural turf has developed in terms of properties appropriate for different sports and surface sustainability. This book draws together the very latest research on biomechanical, medical and engineering approaches to the study of sports surfaces. Written by a team of leading international sport scientists, engineers and technologists, the book covers every key aspect of surface development and design, including: surface behaviour surface classification, function, construction and maintenance influence of surfaces on player performance and injury surface test methods and monitoring development of natural turf and synthetic surfaces shoe-turf interaction future developments in sports surface technology. Representing the most comprehensive and up-to-date study of sports surfaces, this book is important reading for all researchers and professionals working in sports technology, sports engineering, biomechanics or sports medicine.

This edited book focuses on the recent advances in our understanding of age-related macular degeneration (AMD), combining epidemiology and clinical diagnosis, with genetics and immunological aspects as well as the role of proteostasis and mitochondria before diving into new therapies including stem cell based approaches. AMD is a leading cause of largely incurable blindness worldwide and projected to double from 2.07 million to 5.44 million individuals by 2050 in the United States. Globally, 288 million individuals are projected to have AMD by 2040. The disease has enormous socioeconomic impact on the affected individuals, their families and the society. This book will bring together the state of the art basic science knowledge with clinically relevant findings and address the challenges for future research in AMD. The intersection of different disciplines will provide potential areas for further investigations to reduce the burden of blindness from AMD. This book offers an appealing and insightful resource for clinicians, scientists, students and fellows.

This is a self-contained monograph on human voice. It systematically expounds a theory of voice production initiated by Leonhard Euler, through an analysis of large amount of human voice data, especially simultaneously acquired voice signals and electroglottograph signals, as well as temporal variations of pressures directly below and above the vocal folds. Its contents include the physics and physiology of human voice production, parametrical representations of voice signals, and technology applications. Background knowledge on general acoustics and mathematical tools pertinent to quantitative descriptions of human voice are explained in detail.Readers of this monograph include researchers, practitioners and students in the fields of physiology and medicine, acoustics, computer science, telecommunication, acoustic phonetics, and vocal music.

Percutaneous Surgery of the Upper Urinary Tract: Handbook of Endourology contains five focused, review-oriented volumes that are ideal for students and clinicians looking for a comprehensive review rather than a whole course. Each volume is easily accessible through eBook format. Topics covered review both the endourological diagnosis and treatment of prostate, urethral, urinary bladder, upper urinary tract, and renal pathology. All chapters describe the most recent techniques, review the latest results, and analyze the most modern technologies. In the past ten years, the field of endourology has expanded beyond the urinary tract to include all urologic minimally invasive surgical procedures. Recent advancements in robotic and laparoscopic bladder surgery make this one of the fastest moving fields in medicine. As current textbooks are too time-consuming for busy urologists or trainees who also need to learn other areas of urology, this collection provides quick references and over 4000 images that are appropriate for fellows as well as those teaching in the field.

This is an edited collection of peer-reviewed papers presented at the Ninth International Conference of the Society for the Advancement of Kinanthropometry. Defined as the relationship between human body structure and function, kinanthropometry is an area of growing interest, and these proceedings will be of use to students, academics and professionals in the areas of ergonomics, sports science, nutrition, health, and other allied fields. The assembled works represent the latest research findings across kinanthropometry, moving the discipline forward and promoting good practice and the exchange of expertise.

Thebook comprises the contribution of several authors who are among the mostrenowned scientists working in the field of mathematical modeling and numerical simulation of the human cardiocirculatory system. The contributions cover a wide range of topics, from the pre processing of clinical data, to the set up of mathematical equations, their numerical solution, both in-vivo and in-vitro validation. They address the flow in the systemic arterial tree and the complex electro-fluid-mechanical coupling in the human heart. Many examples of patient-specific simulations are addressed. This book is addressed to all scientists (from PhD level up to professional scientists) interested in the mathematical modeling and numerical simulation of the human cardiocirculatory system."

To celebrate the Center for Perinatal Biology s 40th Anniversary, an illustrious group gathered at Loma Linda University in February 2013. That gathering of experts and this volume of the proceedings are a tribute to the founder of the Center, Lawrence D. Longo, M.D. These chapters present contributions from individuals who in some way or another were influenced by Dr. Longo. Covering a wide range of topics, and illustrating the diversity of thinking and scientific interests, these proceedings address basic science through to clinical problems in the developmental programming of health and disease. "

The advances made in vascular biology in the last 25 years have considerably changed the perception that one could have of the endothelial cells. Once considered as a diffusion barrier preventing the access of the blood cells to the vascular matrix, the endothelium is now recognized as playing a major role in the control of blood fluidity, platelet aggregation, and vascular tone, but also in immunology, inflammation, angiogenesis, and for serving as a metabolizing and an endocrine organ.
-- from the preface
Cardiovascular diseases, so prevalent in the Western world during the twentieth century, could well become the scourge of the twenty-first century in emerging countries as well as the West. Endothelial dysfunction linked to an imbalance in the synthesis and/or release of contracting and relaxing factors is often evoked to explain the initiation of the cardiovascular pathology or its development and perpetuation. Two decades ago, when nitric oxide was demonstrated to mediate endothelium-dependent relaxations, the vascular world seemed convinced that nitric oxide was the ultimate and sole explanation for such relaxations. However not everyone agreed.
EDHF: The Complete Story is the work of two leading researchers who did not accept that simple conclusion, but instead continued to search, along with others, for a deeper understanding of the ways in which endothelial cells communicate with the underlying smooth muscle to signal it to hyperpolarize. Now with most, if not all, of those ways, uncovered, the authors offer this summary as way of bringing closure to the quest.
This monograph reports on the work of many researchers. It summarizes the significant recent discoveries concerning endothelium-dependent hyperpolarizations, which are likely to play a much more important role in cardiovascular physiology and pathology than was originally foreseen
Extensively illustrated with original diagrams and schematics that summarize the different steps of endothelium-dependent hyperpolarization, the text is designed for vascular biologists, and cardiologists, as well as graduate students looking to gain an understanding of the intimate functioning of the blood vessel wall.

Nelson Fausto The Greek myth of Prometheus with its picture of a vulture feasting on its chained victimhas traditionallyprovided a visualimageofliverregeneration. Itis apowerful and frightening representationbut ifone were to substitute the vulture by a surgeon and Prometheus by a patient laying on a properly prepared operating table, the outcomeoftheprocedurewould not differ significantlyfrom that describedbyGreek poets. Yet few of us who work in the field have stopped long enough to ask where this myth originated. Did the poet observe a case of liver regeneration in a human being? Was it brilliant intuition or perhaps, literally, just a 'gut feeling' of a poet looking for good rhymes that led to the prediction that livers grow when part of the tissueisremoved? Thisbookdoesnotattemptto solve these historical issues. Itdoes, instead, cover in detail some of the major modem themes of research on liver regen eration, injury and repair. As indicated in Dr. N. Bucher's chapter, the modem phase ofexperimental studies on liver regeneration started in 1931 with the publication by Higgins and Anderson of a method to perform a two-thirds resection of the liver of a rat. The technique described has 3 remarkable features: 1) it is highly reproducible, resulting in the removal of 68% of the liver, 2) it has minimal if any mortality, and 3) it consists only of blood vessel ligation and does not involve cutting through or wounding hepatic tissue.

HE IMPLANTABLE CARDIOVERTER DEFIBRILLATOR, or T"lCD," is arguably the most technologically challenging type of therapy that physicians utilize today. At the same time, engineers who design ICDs are being called upon by clinicians to extend even further the technological envelope in quest of building the "ideal" device. To the extent, however, that physicians who utilize ICDs are not sufficiently comfortable with or familiar with the engineering principles that guide ICD function, the full clinical potential of even an ideal device will not be realized. In comple mentary fashion, engineers require as full an appreciation as possi ble of the real world "boundary conditions" and clinical impact of various ICD features, if the latter are truly to be perfected. This book is intended to serve as an educational tool to foster mutual understanding and communication among physicians, engineers, and other professionals involved in ICD therapy, with the ultimate purpose of enhancing patient care. The highly varied backgrounds of such a diverse audience posed obvious challenges in the preparation of this volume. Given the overwhelmingly greater involvement of clinicians in the day-to day management and follow-up of ICD recipients, we gave high priority to the presentation of oftentimes complex yet relevant engi neering concepts in a manner that could be understandable to most clinicians."

This book is a colorful journey into the fascinatingly diverse world of interneurons, an important class of highly heterogeneous cells found in all cortical neuronal networks. Interneurons are known to play key roles in many brain functions, from sensory processing to neuronal oscillations linked to learning and memory. The central aim of the volume is to provide new insights into the striking degree of cellular diversity found in interneuronal microcircuits. The book discusses the history of research into interneuronal variability, the developmental origins of interneuronal diversity, the functional roles of heterogeneity in neuronal circuits, contemporary interneuronal classification systems, and the genetic and homeostatic mechanisms that shape the degree of cell to cell variability within interneuronal populations. It elaborates on new ideas about interneuronal diversity that rest upon theoretical and experimental results, with arguments touching upon evolution, animal behavior, and the mathematical theory of small world networks. This engaging volume is invaluable to neuroscientists and others interested in how neuronal newtworks function; electrical engineers, computational modelers, and physicists interested in neuronal network theory; neurologists and psychiatrists working on mechanisms of neurological and psychiatric disorders; and students and trainees in all of these fields.

This volume contains the proceedings of the Falk Workshop on Bile Acids in Hepatobiliary Disease, which took place at the Royal Society of Medicine (RSM) in London, UK, on 29-30 March 1999, and was held in association with the Section of Measurement in Medicine at the RSM. The main interest in bile acid therapy has been recently in cholestatic liver disease. The proceedings of the workshop not only discusses this, but moves on to examine its possible use in alcoholic liver disease, and moves back to re-examine its role in biliary disease. Leading world experts attempt to define its mechanism of action, and the current role of other non-surgical treatments in biliary disease. The physiology and pathogenesis of cholestatic and alcoholic liver disease and cholesterol gallstone disease is also examined.

Mitochondrial Case Studies: Underlying Mechanisms and Diagnosis offers the science behind mitochondrial disease with a case studies approach. Since mitochondrial diseases are diverse and influenced by genetic, environmental, and social-economic factors, this publication will help students, physicians, scientists, health care students, and families recognize and accurately diagnose mitochondrial disease and learn about potential treatments.

Clinical Exercise Science is an introduction to core principles and best practice in exercise science for students and practitioners working with clinical populations. Combining the latest scientific research with evidence-based, practitioner-led analysis, the book offers integrated coverage of the full clinical exercise curriculum, including: Pathophysiology of exercise and disease Exercise as a clinical intervention Exercise, nutrition, and lifestyle Health behaviour change Clinical skills in exercise science The book covers a wide range of conditions, including cardiovascular disease, pulmonary disease, metabolic disease and mental health problems, and includes an array of useful features to guide student learning, such as case studies, study tasks, definitions of key terms and suggestions for further reading. With contributions from leading researchers and health practitioners, this is an invaluable foundation text for any clinical exercise science course, and useful reading for any student or practitioner working in exercise science, exercise rehabilitation, health science or physical therapy.

How Does the Body's Motor Control System Deal with Repetition? While the presence of nonlinear dynamics can be explained and understood, it is difficult to be measured. A study of human movement variability with a focus on nonlinear dynamics, Nonlinear Analysis for Human Movement Variability, examines the characteristics of human movement within this framework, explores human movement in repetition, and explains how and why we analyze human movement data. It takes an in-depth look into the nonlinear dynamics of systems within and around us, investigates the temporal structure of variability, and discusses the properties of chaos and fractals as they relate to human movement. Providing a foundation for the use of nonlinear analysis and the study of movement variability in practice, the book describes the nonlinear dynamical features found in complex biological and physical systems, and introduces key concepts that help determine and identify patterns within the fluctuations of data that are repeated over time. It presents commonly used methods and novel approaches to movement analysis that reveal intriguing properties of the motor control system and introduce new ways of thinking about variability, adaptability, health, and motor learning. In addition, this text: Demonstrates how nonlinear measures can be used in a variety of different tasks and populations Presents a wide variety of nonlinear tools such as the Lyapunov exponent, surrogation, entropy, and fractal analysis Includes examples from research on how nonlinear analysis can be used to understand real-world applications Provides numerous case studies in postural control, gait, motor control, and motor development Nonlinear Analysis for Human Movement Variability advances the field of human movement variability research by dissecting human movement and studying the role of movement variability. The book proposes new ways to use nonlinear analysis and investigate the temporal structure of variability, and enables engineers, movement scientists, clinicians, and those in related disciplines to effectively apply nonlinear analysis in practice.

Selected as a Doody's Core Title for 2022! Delivering the most up-to-date information available in a rich, engaging presentation, Medical Physiology: Principles for Clinical Medicine, 6th Edition, instills a complete understanding of physiology essential to effective clinical practice. This robust text not only details how the human body reacts to internal and external changes but also provides a deep understanding of how physiologic systems coordinate to maintain optimal health, as well as the involvement of altered functions in disease processes. Extensively updated throughout and fully aligned with today's medical curriculum, the 6th Edition emphasizes the physiologic principles key to understanding human function, places them in their fundamental context in clinical medicine, and provides opportunities for student self-directed and team-based learning through case studies, clinical application exercises, and board-style review questions. NEW! Physiology of Aging and Organ Function chapter details the impact of aging on the body as it relates to human function. New and revised content throughout familiarizes you with the latest perspectives on cardiovascular physiology, neuromuscular physiology, gastrointestinal physiology, endocrine physiology, exercise physiology, and more. Updated USMLE-style review questions with answers provide valuable self-assessment and board exam prep. Clinical Focus essays clarify how and where physiology relates to clinical medicine and diagnosis. Integrated Medical Sciences essays alert you to important connections between physiology and other basic sciences. Clinical Applications exercises offer practice applying clinical knowledge and solving problems. Conceptual diagrams strengthen comprehension of difficult concepts and present both normal and abnormal clinical conditions. Active Learning Objectives, Chapter Summaries, and full-color artwork and tables make learning engaging and efficient. Additional online resources provide instant access to animations, additional review questions, additional clinical application exercises, advanced clinical problem-solving exercises, and suggested readings.