This volume of the Selected Papers is a product of the XIX Congress of the Portuguese Statistical Society, held at the Portuguese town of Nazare, from September 28 to October 1, 2011. All contributions were selected after a thorough peer-review process. It covers a broad scope of papers in the areas of Statistical Science, Probability and Stochastic Processes, Extremes and Statistical Applications."

This monograph surveys the theory of quantitative homogenization for second-order linear elliptic systems in divergence form with rapidly oscillating periodic coefficients in a bounded domain. It begins with a review of the classical qualitative homogenization theory, and addresses the problem of convergence rates of solutions. The main body of the monograph investigates various interior and boundary regularity estimates that are uniform in the small parameter e>0. Additional topics include convergence rates for Dirichlet eigenvalues and asymptotic expansions of fundamental solutions, Green functions, and Neumann functions. The monograph is intended for advanced graduate students and researchers in the general areas of analysis and partial differential equations. It provides the reader with a clear and concise exposition of an important and currently active area of quantitative homogenization.

This book is a collection of original research and survey articles on mathematical inequalities and their numerous applications in diverse areas of mathematics and engineering. It includes chapters on convexity and related concepts; inequalities for mean values, sums, functions, operators, functionals, integrals and their applications in various branches of mathematics and related sciences; fractional integral inequalities; and weighted type integral inequalities. It also presents their wide applications in biomathematics, boundary value problems, mechanics, queuing models, scattering, and geomechanics in a concise, but easily understandable way that makes the further ramifications and future directions clear. The broad scope and high quality of the contributions make this book highly attractive for graduates, postgraduates and researchers. All the contributing authors are leading international academics, scientists, researchers and scholars.

Applied Linear Regression for Business Analytics with R introduces regression analysis to business students using the R programming language with a focus on illustrating and solving real-time, topical problems. Specifically, this book presents modern and relevant case studies from the business world, along with clear and concise explanations of the theory, intuition, hands-on examples, and the coding required to employ regression modeling. Each chapter includes the mathematical formulation and details of regression analysis and provides in-depth practical analysis using the R programming language.

This book aims to present the impact of Artificial Intelligence (AI) and Big Data in healthcare for medical decision making and data analysis in myriad fields including Radiology, Radiomics, Radiogenomics, Oncology, Pharmacology, COVID-19 prognosis, Cardiac imaging, Neuroradiology, Psychiatry and others. This will include topics such as Artificial Intelligence of Thing (AIOT), Explainable Artificial Intelligence (XAI), Distributed learning, Blockchain of Internet of Things (BIOT), Cybersecurity, and Internet of (Medical) Things (IoTs). Healthcare providers will learn how to leverage Big Data analytics and AI as methodology for accurate analysis based on their clinical data repositories and clinical decision support. The capacity to recognize patterns and transform large amounts of data into usable information for precision medicine assists healthcare professionals in achieving these objectives. Intelligent Health has the potential to monitor patients at risk with underlying conditions and track their progress during therapy. Some of the greatest challenges in using these technologies are based on legal and ethical concerns of using medical data and adequately representing and servicing disparate patient populations. One major potential benefit of this technology is to make health systems more sustainable and standardized. Privacy and data security, establishing protocols, appropriate governance, and improving technologies will be among the crucial priorities for Digital Transformation in Healthcare.

With the critical role of statistics in the design, conduct, analysis and reporting of clinical trials or observational studies intended for regulatory purposes, numerous guidelines have been issued by regulatory authorities around the world focusing on statistical issues related to drug development. However, the available literature on this important topic is sporadic, and often not readily accessible to drug developers or regulatory personnel. This book provides a systematic exposition of the interplay between the two disciplines, including emerging themes pertaining to the acceleration of the development of pharmaceutical medicines to serve patients with unmet needs. Features: Regulatory and statistical interactions throughout the drug development continuum The critical role of the statistician in relation to the changing regulatory and healthcare landscapes Statistical issues that commonly arise in the course of drug development and regulatory interactions Trending topics in drug development, with emphasis on current regulatory thinking and the associated challenges and opportunities The book is designed to be accessible to readers with an intermediate knowledge of statistics, and can be a useful resource to statisticians, medical researchers, and regulatory personnel in drug development, as well as graduate students in the health sciences. The authors' decades of experience in the pharmaceutical industry and academia, and extensive regulatory experience, comes through in the many examples throughout the book.

In applications, and especially in mathematical finance, random time-dependent events are often modeled as stochastic processes. Assumptions are made about the structure of such processes, and serious researchers will want to justify those assumptions through the use of data. As statisticians are wont to say, "In God we trust; all others must bring data."
This book establishes the theory of how to go about estimating not just scalar parameters about a proposed model, but also the underlying structure of the model itself. Classic statistical tools are used: the law of large numbers, and the central limit theorem.Researchers have recently developed creative and original methods to use these tools in sophisticated (but highly technical) ways to reveal new details about the underlying structure. For the first time in book form, the authors present these latest techniques, based on research from the last 10 years. They include new findings.

This book will be of special interest to researchers, combining the theory of mathematical finance with its investigation using market data, and it will also prove to be useful in a broad range of applications, such as to mathematical biology, chemical engineering, and physics. "

'Et moi, ..., si. j'avail su comment en revenir. One service mathematics has rendered be human race. It has put common sense back jc n'y scrais point a1U: where it belongs, on the topmost sbelf next Jules Verne to \be dusty canister labelled 'discarded non- TIle series is divergent; therefore we may be sense'. able to do something with it Eric T. Bell O. Heaviside Mathematics is a tool for thought. A highly necessary tool in a world where both feedback and non linearities abound. Similarly, all kinds of parts of mathematics serve as tools for other parts and for other sciences. Applying a simple rewriting rule to the quote on the right above one finds such statements as: 'One service topology has rendered mathematical physics .. .'; 'One service logic bas rendered com puter science .. .'; 'One service category theory has rendered mathematics .. .'. All arguably true. And all statements obtainable this way form part of the raison d'etre of this series."

The present volume consists of papers written by students, colleagues and collaborators of Sreenivasa Rao Jammalamadaka from various countries, and covers a variety of research topics which he enjoys and contributed immensely to.

"Statistical Modeling, Analysis and Management of Fuzzy Data," or SMFD for short, is an important contribution to a better understanding of a basic issue -an issue which has been controversial, and still is though to a lesser degree. In substance, the issue is: are fuzziness and randomness distinct or coextensive facets of uncertainty? Are the theories of fuzziness and random ness competitive or complementary? In SMFD, these and related issues are addressed with rigor, authority and insight by prominent contributors drawn, in the main, from probability theory, fuzzy set theory and data analysis com munities. First, a historical perspective. The almost simultaneous births -close to half a century ago-of statistically-based information theory and cybernetics were two major events which marked the beginning of the steep ascent of probability theory and statistics in visibility, influence and importance. I was a student when information theory and cybernetics were born, and what is etched in my memory are the fascinating lectures by Shannon and Wiener in which they sketched their visions of the coming era of machine intelligence and automation of reasoning and decision processes. What I heard in those lectures inspired one of my first papers (1950) "An Extension of Wiener's Theory of Prediction," and led to my life-long interest in probability theory and its applications to information processing, decision analysis and control."

A carefully prepared account of the basic ideas in Fourier analysis and its applications to the study of partial differential equations. The author succeeds to make his exposition accessible to readers with a limited background, for example, those not acquainted with the Lebesgue integral. Readers should be familiar with calculus, linear algebra, and complex numbers. At the same time, the author has managed to include discussions of more advanced topics such as the Gibbs phenomenon, distributions, Sturm-Liouville theory, Cesaro summability and multi-dimensional Fourier analysis, topics which one usually does not find in books at this level. A variety of worked examples and exercises will help the readers to apply their newly acquired knowledge.

Outstanding User Interfaces with Shiny provides the reader with necessary knowledge to develop beautiful and highly interactive user interfaces. It gives the minimum requirements in HTML/JavaScript and CSS to be able to extend already existing Shiny layouts or develop new templates from scratch. Suitable for anyone with some experience of Shiny, package development and software engineering best practices, this book is an ideal guide for graduates and professionals who wish to bring their app design to the next level. Key Features: Provides a survival kit in web development to seamlessly get started with HTML/CSS/JavaScript Leverage CSS and Sass and higher-level tools like {bslib} to substantially enhance the design of your app in no time A comprehensive guide to the {htmltools} package to seamlessly customize existing layouts Describes in detail how Shiny inputs work and how R and JavaScript communicate Details all the necessary steps to create a production-grade custom template from scratch: packaging, shiny tags creation, validating and testing R components and JavaScript Expose common web development debugging technics Provides a list of existing templates, resources to get started and to explore

This monograph provides, for the first time, a most comprehensive statistical account of composite sampling as an ingenious environmental sampling method to help accomplish observational economy in a variety of environmental and ecological studies. Sampling consists of selection, acquisition, and quantification of a part of the population. But often what is desirable is not affordable, and what is affordable is not adequate. How do we deal with this dilemma? Operationally, composite sampling recognizes the distinction between selection, acquisition, and quantification. In certain applications, it is a common experience that the costs of selection and acquisition are not very high, but the cost of quantification, or measurement, is substantially high. In such situations, one may select a sample sufficiently large to satisfy the requirement of representativeness and precision and then, by combining several sampling units into composites, reduce the cost of measurement to an affordable level. Thus composite sampling offers an approach to deal with the classical dilemma of desirable versus affordable sample sizes, when conventional statistical methods fail to resolve the problem. Composite sampling, at least under idealized conditions, incurs no loss of information for estimating the population means. But an important limitation to the method has been the loss of information on individual sample values, such as the extremely large value. In many of the situations where individual sample values are of interest or concern, composite sampling methods can be suitably modified to retrieve the information on individual sample values that may be lost due to compositing. In this monograph, we present statistical solutions to these and other issues that arise in the context of applications of composite sampling. Content Level Research

This IMA Volume in Mathematics and its Applications RANDOM SETS: THEORY AND APPLICATIONS is based on the proceedings of a very successful 1996 three-day Summer Program on "Application and Theory of Random Sets." We would like to thank the scientific organizers: John Goutsias (Johns Hopkins University), Ronald P.S. Mahler (Lockheed Martin), and Hung T. Nguyen (New Mexico State University) for their excellent work as organizers of the meeting and for editing the proceedings. We also take this opportunity to thank the Army Research Office (ARO), the Office ofNaval Research (0NR), and the Eagan, MinnesotaEngineering Center ofLockheed Martin Tactical Defense Systems, whose financial support made the summer program possible. Avner Friedman Robert Gulliver v PREFACE "Later generations will regard set theory as a disease from which one has recovered. " - Henri Poincare Random set theory was independently conceived by D.G. Kendall and G. Matheron in connection with stochastic geometry. It was however G.

Recent developments show that probability methods have become a very powerful tool in such different areas as statistical physics, dynamical systems, Riemannian geometry, group theory, harmonic analysis, graph theory and computer science. This volume is an outcome of the special semester 2001 - Random Walks held at the Schroedinger Institute in Vienna, Austria. It contains original research articles with non-trivial new approaches based on applications of random walks and similar processes to Lie groups, geometric flows, physical models on infinite graphs, random number generators, Lyapunov exponents, geometric group theory, spectral theory of graphs and potential theory. Highlights are the first survey of the theory of the stochastic Loewner evolution and its applications to percolation theory (a new rapidly developing and very promising subject at the crossroads of probability, statistical physics and harmonic analysis), surveys on expander graphs, random matrices and quantum chaos, cellular automata and symbolic dynamical systems, and others. The contributors to the volume are the leading experts in the area. The book will provide a valuable source both for active researchers and graduate students in the respective fields.

This book provides quantitative and applied methodologies in the Covid-19 era exploring important issues in demography, population studies, and health. It provides insight into health and health measures as to the healthy life years lost and the healthy life expectancy related to Covid-19 pandemic. It also describes mortality and survival and focuses on data analysis in demography and population studies. Special methods and applications in demography and society are also described, thereby including applications in society, pension and insurance. As such, this book is a valuable guide for researchers, theoreticians and practitioners from various scientific fields.

Generalising classical concepts of probability theory, the investigation of operator (semi)-stable laws as possible limit distributions of operator-normalized sums of i.i.d. random variable on finite-dimensional vector space started in 1969. Currently, this theory is still in progress and promises interesting applications. Parallel to this, similar stability concepts for probabilities on groups were developed during recent decades. It turns out that the existence of suitable limit distributions has a strong impact on the structure of both the normalizing automorphisms and the underlying group. Indeed, investigations in limit laws led to contractable groups and - at least within the class of connected groups - to homogeneous groups, in particular to groups that are topologically isomorphic to a vector space. Moreover, it has been shown that (semi)-stable measures on groups have a vector space counterpart and vice versa. The purpose of this book is to describe the structure of limit laws and the limit behaviour of normalized i.i.d. random variables on groups and on finite-dimensional vector spaces from a common point of view. This will also shed a new light on the classical situation. Chapter 1 provides an introduction to stability problems on vector spaces. Chapter II is concerned with parallel investigations for homogeneous groups and in Chapter III the situation beyond homogeneous Lie groups is treated. Throughout, emphasis is laid on the description of features common to the group- and vector space situation. Chapter I can be understood by graduate students with some background knowledge in infinite divisibility. Readers of Chapters II and III are assumed to be familiar with basic techniques from probability theory on locally compact groups.

The aim of this graduate textbook is to provide a comprehensive advanced course in the theory of statistics covering those topics in estimation, testing, and large sample theory which a graduate student might typically need to learn as preparation for work on a Ph.D. An important strength of this book is that it provides a mathematically rigorous and even-handed account of both Classical and Bayesian inference in order to give readers a broad perspective. For example, the "uniformly most powerful" approach to testing is contrasted with available decision-theoretic approaches.

Machine learning is a novel discipline concerned with the analysis of large and multiple variables data. It involves computationally intensive methods, like factor analysis, cluster analysis, and discriminant analysis. It is currently mainly the domain of computer scientists, and is already commonly used in social sciences, marketing research, operational research and applied sciences. It is virtually unused in clinical research. This is probably due to the traditional belief of clinicians in clinical trials where multiple variables are equally balanced by the randomization process and are not further taken into account. In contrast, modern computer data files often involve hundreds of variables like genes and other laboratory values, and computationally intensive methods are required. This book was written as a hand-hold presentation accessible to clinicians, and as a must-read publication for those new to the methods.

This book provides, as simply as possible, sound foundations for an in-depth understanding of reliability engineering with regard to qualitative analysis, modelling, and probabilistic calculations of safety and production systems. Drawing on the authors' extensive experience within the field of reliability engineering, it addresses and discusses a variety of topics, including: * Background and overview of safety and dependability studies; * Explanation and critical analysis of definitions related to core concepts; * Risk identification through qualitative approaches (preliminary hazard analysis, HAZOP, FMECA, etc.); * Modelling of industrial systems through static (fault tree, reliability block diagram), sequential (cause-consequence diagrams, event trees, LOPA, bowtie), and dynamic (Markov graphs, Petri nets) approaches; * Probabilistic calculations through state-of-the-art analytical or Monte Carlo simulation techniques; * Analysis, modelling, and calculations of common cause failure and uncertainties; * Linkages and combinations between the various modelling and calculation approaches; * Reliability data collection and standardization. The book features illustrations, explanations, examples, and exercises to help readers gain a detailed understanding of the topic and implement it into their own work. Further, it analyses the production availability of production systems and the functional safety of safety systems (SIL calculations), showcasing specific applications of the general theory discussed. Given its scope, this book is a valuable resource for engineers, software designers, standard developers, professors, and students.

The 2017 PIMS-CRM Summer School in Probability was held at the Pacific Institute for the Mathematical Sciences (PIMS) at the University of British Columbia in Vancouver, Canada, during June 5-30, 2017. It had 125 participants from 20 different countries, and featured two main courses, three mini-courses, and twenty-nine lectures. The lecture notes contained in this volume provide introductory accounts of three of the most active and fascinating areas of research in modern probability theory, especially designed for graduate students entering research: Scaling limits of random trees and random graphs (Christina Goldschmidt) Lectures on the Ising and Potts models on the hypercubic lattice (Hugo Duminil-Copin) Extrema of the two-dimensional discrete Gaussian free field (Marek Biskup) Each of these contributions provides a thorough introduction that will be of value to beginners and experts alike.

A simplified approach to Malliavin calculus adapted to Poisson random measures is developed and applied in this book. Called the "lent particle method" it is based on perturbation of the position of particles. Poisson random measures describe phenomena involving random jumps (for instance in mathematical finance) or the random distribution of particles (as in statistical physics). Thanks to the theory of Dirichlet forms, the authors develop a mathematical tool for a quite general class of random Poisson measures and significantly simplify computations of Malliavin matrices of Poisson functionals. The method gives rise to a new explicit calculus that they illustrate on various examples: it consists in adding a particle and then removing it after computing the gradient. Using this method, one can establish absolute continuity of Poisson functionals such as Levy areas, solutions of SDEs driven by Poisson measure and, by iteration, obtain regularity of laws. The authors also give applications to error calculus theory. This book will be of interest to researchers and graduate students in the fields of stochastic analysis and finance, and in the domain of statistical physics. Professors preparing courses on these topics will also find it useful. The prerequisite is a knowledge of probability theory.

Over the last fifteen years fractal geometry has established itself as a substantial mathematical theory in its own right. The interplay between fractal geometry, analysis and stochastics has highly influenced recent developments in mathematical modeling of complicated structures. This process has been forced by problems in these areas related to applications in statistical physics, biomathematics and finance.

This book is a collection of survey articles covering many of the most recent developments, like Schramm-Loewner evolution, fractal scaling limits, exceptional sets for percolation, and heat kernels on fractals. The authors were the keynote speakers at the conference "Fractal Geometry and Stochastics IV" at Greifswald in September 2008.

Primary Audience for the Book * Specialists in numerical computations who are interested in algorithms with automatic result verification. * Engineers, scientists, and practitioners who desire results with automatic verification and who would therefore benefit from the experience of suc cessful applications. * Students in applied mathematics and computer science who want to learn these methods. Goal Of the Book This book contains surveys of applications of interval computations, i. e. , appli cations of numerical methods with automatic result verification, that were pre sented at an international workshop on the subject in EI Paso, Texas, February 23-25, 1995. The purpose of this book is to disseminate detailed and surveyed information about existing and potential applications of this new growing field. Brief Description of the Papers At the most fundamental level, interval arithmetic operations work with sets: The result of a single arithmetic operation is the set of all possible results as the operands range over the domain. For example, [0. 9,1. 1] + [2. 9,3. 1] = [3. 8,4. 2], where [3. 8,4. 2] = {x + ylx E [0. 9,1. 1] and y E [3. 8,4. 2]}. The power of interval arithmetic comes from the fact that (i) the elementary operations and standard functions can be computed for intervals with formulas and subroutines; and (ii) directed roundings can be used, so that the images of these operations (e. g.

The Accreditation Board for Engineering and Technology (ABET) introduced a criterion starting with their 1992-1993 site visits that ""Students must demonstrate a knowledge of the application of statistics to engineering problems." "Since most engineering curricula are filled with requirements in their own discipline, they generally do not have time for a traditional two semesters of probability and statistics. Attempts to condense that material into a single semester often results in so much time being spent on probability that the statistics useful for designing and analyzing engineering/scientific experiments is never covered. In developing a one-semester course whose purpose was to introduce engineering/scientific students to the most useful statistical methods, this book was created to satisfy those needs.
- Provides the statistical design and analysis of engineering experiments & problems
- Presents a student-friendly approach through providing statistical models for advanced learning techniques
- Covers essential and useful statistical methods used by engineers and scientists