"Data Science Foundations is most welcome and, indeed, a piece of literature that the field is very much in need of...quite different from most data analytics texts which largely ignore foundational concepts and simply present a cookbook of methods...a very useful text and I would certainly use it in my teaching." - Mark Girolami, Warwick University Data Science encompasses the traditional disciplines of mathematics, statistics, data analysis, machine learning, and pattern recognition. This book is designed to provide a new framework for Data Science, based on a solid foundation in mathematics and computational science. It is written in an accessible style, for readers who are engaged with the subject but not necessarily experts in all aspects. It includes a wide range of case studies from diverse fields, and seeks to inspire and motivate the reader with respect to data, associated information, and derived knowledge.

Absolute Risk: Methods and Applications in Clinical Management and Public Health provides theory and examples to demonstrate the importance of absolute risk in counseling patients, devising public health strategies, and clinical management. The book provides sufficient technical detail to allow statisticians, epidemiologists, and clinicians to build, test, and apply models of absolute risk. Features: Provides theoretical basis for modeling absolute risk, including competing risks and cause-specific and cumulative incidence regression Discusses various sampling designs for estimating absolute risk and criteria to evaluate models Provides details on statistical inference for the various sampling designs Discusses criteria for evaluating risk models and comparing risk models, including both general criteria and problem-specific expected losses in well-defined clinical and public health applications Describes many applications encompassing both disease prevention and prognosis, and ranging from counseling individual patients, to clinical decision making, to assessing the impact of risk-based public health strategies Discusses model updating, family-based designs, dynamic projections, and other topics Ruth M. Pfeiffer is a mathematical statistician and Fellow of the American Statistical Association, with interests in risk modeling, dimension reduction, and applications in epidemiology. She developed absolute risk models for breast cancer, colon cancer, melanoma, and second primary thyroid cancer following a childhood cancer diagnosis. Mitchell H. Gail developed the widely used "Gail model" for projecting the absolute risk of invasive breast cancer. He is a medical statistician with interests in statistical methods and applications in epidemiology and molecular medicine. He is a member of the National Academy of Medicine and former President of the American Statistical Association. Both are Senior Investigators in the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health.

Survival analysis uses statistics to calculate time to failure. Survival Analysis with Python takes a fresh look at this complex subject by explaining how to use the Python programming language to perform this type of analysis. As the subject itself is very mathematical and full of expressions and formulations, the book provides detailed explanations and examines practical implications. The book begins with an overview of the concepts underpinning statistical survival analysis. It then delves into Parametric models with coverage of Concept of maximum likelihood estimate (MLE) of a probability distribution parameter MLE of the survival function Common probability distributions and their analysis Analysis of exponential distribution as a survival function Analysis of Weibull distribution as a survival function Derivation of Gumbel distribution as a survival function from Weibull Non-parametric models including Kaplan-Meier (KM) estimator, a derivation of expression using MLE Fitting KM estimator with an example dataset, Python code and plotting curves Greenwood's formula and its derivation Models with covariates explaining The concept of time shift and the accelerated failure time (AFT) model Weibull-AFT model and derivation of parameters by MLE Proportional Hazard (PH) model Cox-PH model and Breslow's method Significance of covariates Selection of covariates The Python lifelines library is used for coding examples. By mapping theory to practical examples featuring datasets, this book is a hands-on tutorial as well as a handy reference.

Distribution-free resampling methods permutation tests, decision trees, and the bootstrap are used today in virtually every research area. A Practitioner s Guide to Resampling for Data Analysis, Data Mining, and Modeling explains how to use the bootstrap to estimate the precision of sample-based estimates and to determine sample size, data permutations to test hypotheses, and the readily-interpreted decision tree to replace arcane regression methods.

Highlights

• Each chapter contains dozens of thought provoking questions, along with applicable R and Stata code
• Methods are illustrated with examples from agriculture, audits, bird migration, clinical trials, epidemiology, image processing, immunology, medicine, microarrays and gene selection
• Lists of commercially available software for the bootstrap, decision trees, and permutation tests are incorporated in the text
• Access to APL, MATLAB, and SC code for many of the routines is provided on the author s website
• The text covers estimation, two-sample and k-sample univariate, and multivariate comparisons of means and variances, sample size determination, categorical data, multiple hypotheses, and model building

Statistics practitioners will find the methods described in the text easy to learn and to apply in a broad range of subject areas from A for Accounting, Agriculture, Anthropology, Aquatic science, Archaeology, Astronomy, and Atmospheric science to V for Virology and Vocational Guidance, and Z for Zoology.

Practitioners and research workers and in the biomedical, engineering and social sciences, as well as advanced students in biology, business, dentistry, medicine, psychology, public health, sociology, and statistics will find an easily-grasped guide to estimation, testing hypotheses and model building.

Although the popularity of the Bayesian approach to statistics has been growing for years, many still think of it as somewhat esoteric, not focused on practical issues, or generally too difficult to understand.

Bayesian Analysis Made Simple is aimed at those who wish to apply Bayesian methods but either are not experts or do not have the time to create WinBUGS code and ancillary files for every analysis they undertake. Accessible to even those who would not routinely use Excel, this book provides a custom-made Excel GUI, immediately useful to those users who want to be able to quickly apply Bayesian methods without being distracted by computing or mathematical issues.

From simple NLMs to complex GLMMs and beyond, Bayesian Analysis Made Simple describes how to use Excel for a vast range of Bayesian models in an intuitive manner accessible to the statistically savvy user. Packed with relevant case studies, this book is for any data analyst wishing to apply Bayesian methods to analyze their data, from professional statisticians to statistically aware scientists.

This book is a fresh approach to a calculus based, first course in probability and statistics, using R throughout to give a central role to data and simulation. The book introduces probability with Monte Carlo simulation as an essential tool. Simulation makes challenging probability questions quickly accessible and easily understandable. Mathematical approaches are included, using calculus when appropriate, but are always connected to experimental computations. Using R and simulation gives a nuanced understanding of statistical inference. The impact of departure from assumptions in statistical tests is emphasized, quantified using simulations, and demonstrated with real data. The book compares parametric and non-parametric methods through simulation, allowing for a thorough investigation of testing error and power. The text builds R skills from the outset, allowing modern methods of resampling and cross validation to be introduced along with traditional statistical techniques. Fifty-two data sets are included in the complementary R package fosdata. Most of these data sets are from recently published papers, so that you are working with current, real data, which is often large and messy. Two central chapters use powerful tidyverse tools (dplyr, ggplot2, tidyr, stringr) to wrangle data and produce meaningful visualizations. Preliminary versions of the book have been used for five semesters at Saint Louis University, and the majority of the more than 400 exercises have been classroom tested.

Modeled after Barbara Byrne's other best-selling structural equation modeling (SEM) books, this practical guide reviews the basic concepts and applications of SEM using Mplus Version 6. The author reviews SEM applications based on actual data taken from her own research. Using non-mathematical language, it is written for the novice SEM user. With each application chapter, the author "walks" the reader through all steps involved in testing the SEM model including:

• an explanation of the issues addressed
• illustrated and annotated testing of the hypothesized and post hoc models
• explanation and interpretation of all Mplus input and output files
• important caveats pertinent to the SEM application under study
• a description of the data and reference upon which the model was based
• the corresponding data and syntax files available at http: //www.psypress.com/sem-with-mplus/datasets .

The first two chapters introduce the fundamental concepts of SEM and important basics of the Mplus program. The remaining chapters focus on SEM applications and include a variety of SEM models presented within the context of three sections: Single-group analyses, Multiple-group analyses, and other important topics, the latter of which includes the multitrait-multimethod, latent growth curve, and multilevel models.

Intended for researchers, practitioners, and students who use SEM and Mplus, this book is an ideal resource for graduate level courses on SEM taught in psychology, education, business, and other social and health sciences and/or as a supplement for courses on applied statistics, multivariate statistics, intermediate or advanced statistics, and/or research design. Appropriate for those with limited exposure to SEM or Mplus, a prerequisite of basic statistics through regression analysis is recommended.

This book provides accessible treatment to state-of-the-art approaches to analyzing longitudinal studies. Comprehensive coverage of the most popular analysis tools allows readers to pick and choose the techniques that best fit their research. The analyses are illustrated with examples from major longitudinal data sets including practical information about their content and design. Illustrations from popular software packages offer tips on how to interpret the results. Each chapter features suggested readings for additional study and a list of articles that further illustrate how to implement the analysis and report the results. Syntax examples for several software packages for each of the chapter examples are provided at www.psypress.com/longitudinal-data-analysis .

Although many of the examples address health or social science questions related to aging, readers from other disciplines will find the analyses relevant to their work. In addition to demonstrating statistical analysis of longitudinal data, the book shows how to interpret and analyze the results within the context of the research design. The methods covered in this book are applicable to a range of applied problems including short- to long-term longitudinal studies using a range of sample sizes.

The book provides non-technical, practical introductions to the concepts and issues relevant to longitudinal analysis. Topics include use of publicly available data sets, weighting and adjusting for complex sampling designs with longitudinal studies, missing data and attrition, measurement issues related to longitudinal research, the use of ANOVA and regression for average change over time, mediation analysis, growth curve models, basic and advanced structural equation models, and survival analysis.

An ideal supplement for graduate level courses on data analysis and/or longitudinal modeling taught in psychology, gerontology, public health, human development, family studies, medicine, sociology, social work, and other behavioral, social, and health sciences, this multidisciplinary book will also appeal to researchers in these fields.

Applied Probability and Stochastic Processes, Second Edition presents a self-contained introduction to elementary probability theory and stochastic processes with a special emphasis on their applications in science, engineering, finance, computer science, and operations research. It covers the theoretical foundations for modeling time-dependent random phenomena in these areas and illustrates applications through the analysis of numerous practical examples. The author draws on his 50 years of experience in the field to give your students a better understanding of probability theory and stochastic processes and enable them to use stochastic modeling in their work. New to the Second Edition Completely rewritten part on probability theory-now more than double in size New sections on time series analysis, random walks, branching processes, and spectral analysis of stationary stochastic processes Comprehensive numerical discussions of examples, which replace the more theoretically challenging sections Additional examples, exercises, and figures Presenting the material in a student-friendly, application-oriented manner, this non-measure theoretic text only assumes a mathematical maturity that applied science students acquire during their undergraduate studies in mathematics. Many exercises allow students to assess their understanding of the topics. In addition, the book occasionally describes connections between probabilistic concepts and corresponding statistical approaches to facilitate comprehension. Some important proofs and challenging examples and exercises are also included for more theoretically interested readers.

This book focuses on the application of the partial hedging approach from modern math finance to equity-linked life insurance contracts. It provides an accessible, up-to-date introduction to quantifying financial and insurance risks. The book also explains how to price innovative financial and insurance products from partial hedging perspectives. Each chapter presents the problem, the mathematical formulation, theoretical results, derivation details, numerical illustrations, and references to further reading.

This book provides accessible treatment to state-of-the-art approaches to analyzing longitudinal studies. Comprehensive coverage of the most popular analysis tools allows readers to pick and choose the techniques that best fit their research. The analyses are illustrated with examples from major longitudinal data sets including practical information about their content and design. Illustrations from popular software packages offer tips on how to interpret the results. Each chapter features suggested readings for additional study and a list of articles that further illustrate how to implement the analysis and report the results. Syntax examples for several software packages for each of the chapter examples are provided at www.psypress.com/longitudinal-data-analysis .

Although many of the examples address health or social science questions related to aging, readers from other disciplines will find the analyses relevant to their work. In addition to demonstrating statistical analysis of longitudinal data, the book shows how to interpret and analyze the results within the context of the research design. The methods covered in this book are applicable to a range of applied problems including short- to long-term longitudinal studies using a range of sample sizes.

The book provides non-technical, practical introductions to the concepts and issues relevant to longitudinal analysis. Topics include use of publicly available data sets, weighting and adjusting for complex sampling designs with longitudinal studies, missing data and attrition, measurement issues related to longitudinal research, the use of ANOVA and regression for average change over time, mediation analysis, growth curve models, basic and advanced structural equation models, and survival analysis.

An ideal supplement for graduate level courses on data analysis and/or longitudinal modeling taught in psychology, gerontology, public health, human development, family studies, medicine, sociology, social work, and other behavioral, social, and health sciences, this multidisciplinary book will also appeal to researchers in these fields.

Statistical evaluation of diagnostic performance in general and Receiver Operating Characteristic (ROC) analysis in particular are important for assessing the performance of medical tests and statistical classifiers, as well as for evaluating predictive models or algorithms. This book presents innovative approaches in ROC analysis, which are relevant to a wide variety of applications, including medical imaging, cancer research, epidemiology, and bioinformatics. Statistical Evaluation of Diagnostic Performance: Topics in ROC Analysis covers areas including monotone-transformation techniques in parametric ROC analysis, ROC methods for combined and pooled biomarkers, Bayesian hierarchical transformation models, sequential designs and inferences in the ROC setting, predictive modeling, multireader ROC analysis, and free-response ROC (FROC) methodology. The book is suitable for graduate-level students and researchers in statistics, biostatistics, epidemiology, public health, biomedical engineering, radiology, medical imaging, biomedical informatics, and other closely related fields. Additionally, clinical researchers and practicing statisticians in academia, industry, and government could benefit from the presentation of such important and yet frequently overlooked topics.

In "SAS Statistics by Example," Ron Cody offers up a cookbook approach for doing statistics with SAS. Structured specifically around the most commonly used statistical tasks or techniques--for example, comparing two means, ANOVA, and regression--this book provides an easy-to-follow, how-to approach to statistical analysis not found in other books.

For each statistical task, Cody includes heavily annotated examples using ODS Statistical Graphics procedures such as SGPLOT, SGSCATTER, and SGPANEL that show how SAS can produce the required statistics. Also, you will learn how to test the assumptions for all relevant statistical tests. Major topics featured are correlation, inferential statistics, descriptive statistics, categorical data analysis, simple linear regression, comparing means, multiple regression, logistic regression, non-parametric tests, and power and sample size.

This is not a book that teaches statistics. Rather, "SAS Statistics by Example" is perfect for intermediate to advanced statistical programmers who know their statistics and want to use SAS to do their analyses.

Experimental design is often overlooked in the literature of applied and mathematical statistics: statistics is taught and understood as merely a collection of methods for analyzing data. Consequently, experimenters seldom think about optimal design, including prerequisites such as the necessary sample size needed for a precise answer for an experimental question. Providing a concise introduction to experimental design theory, Optimal Experimental Design with R: Introduces the philosophy of experimental design Provides an easy process for constructing experimental designs and calculating necessary sample size using R programs Teaches by example using a custom made R program package: OPDOE Consisting of detailed, data-rich examples, this book introduces experimenters to the philosophy of experimentation, experimental design, and data collection. It gives researchers and statisticians guidance in the construction of optimum experimental designs using R programs, including sample size calculations, hypothesis testing, and confidence estimation. A final chapter of in-depth theoretical details is included for interested mathematical statisticians.

This book provides an introduction to the use of statistical concepts and methods to model and analyze financial data. The ten chapters of the book fall naturally into three sections. Chapters 1 to 3 cover some basic concepts of finance, focusing on the properties of returns on an asset. Chapters 4 through 6 cover aspects of portfolio theory and the methods of estimation needed to implement that theory. The remainder of the book, Chapters 7 through 10, discusses several models for financial data, along with the implications of those models for portfolio theory and for understanding the properties of return data. The audience for the book is students majoring in Statistics and Economics as well as in quantitative fields such as Mathematics and Engineering. Readers are assumed to have some background in statistical methods along with courses in multivariate calculus and linear algebra.

Elementary Probability with Applications, Second Edition shows students how probability has practical uses in many different fields, such as business, politics, and sports. In the book, students learn about probability concepts from real-world examples rather than theory. The text explains how probability models with underlying assumptions are used to model actual situations. It contains examples of probability models as they relate to: Bloc voting Population genetics Doubling strategies in casinos Machine reliability Airline management Cryptology Blood testing Dogs resembling owners Drug detection Jury verdicts Coincidences Number of concert hall aisles 2000 U.S. presidential election Points after deuce in tennis Tests regarding intelligent dogs Music composition Based on the author’s course at The College of William and Mary, the text can be used in a one-semester or one-quarter course in discrete probability with a strong emphasis on applications. By studying the book, students will appreciate the subject of probability and its applications and develop their problem-solving and reasoning skills.

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Handbook of Survival Analysis presents modern techniques and research problems in lifetime data analysis. This area of statistics deals with time-to-event data that is complicated by censoring and the dynamic nature of events occurring in time. With chapters written by leading researchers in the field, the handbook focuses on advances in survival analysis techniques, covering classical and Bayesian approaches. It gives a complete overview of the current status of survival analysis and should inspire further research in the field. Accessible to a wide range of readers, the book provides: An introduction to various areas in survival analysis for graduate students and novices A reference to modern investigations into survival analysis for more established researchers A text or supplement for a second or advanced course in survival analysis A useful guide to statistical methods for analyzing survival data experiments for practicing statisticians

The recent rapid growth in the variety and complexity of new machine learning architectures requires the development of improved methods for designing, analyzing, evaluating, and communicating machine learning technologies. Statistical Machine Learning: A Unified Framework provides students, engineers, and scientists with tools from mathematical statistics and nonlinear optimization theory to become experts in the field of machine learning. In particular, the material in this text directly supports the mathematical analysis and design of old, new, and not-yet-invented nonlinear high-dimensional machine learning algorithms. Features: Unified empirical risk minimization framework supports rigorous mathematical analyses of widely used supervised, unsupervised, and reinforcement machine learning algorithms Matrix calculus methods for supporting machine learning analysis and design applications Explicit conditions for ensuring convergence of adaptive, batch, minibatch, MCEM, and MCMC learning algorithms that minimize both unimodal and multimodal objective functions Explicit conditions for characterizing asymptotic properties of M-estimators and model selection criteria such as AIC and BIC in the presence of possible model misspecification This advanced text is suitable for graduate students or highly motivated undergraduate students in statistics, computer science, electrical engineering, and applied mathematics. The text is self-contained and only assumes knowledge of lower-division linear algebra and upper-division probability theory. Students, professional engineers, and multidisciplinary scientists possessing these minimal prerequisites will find this text challenging yet accessible. About the Author: Richard M. Golden (Ph.D., M.S.E.E., B.S.E.E.) is Professor of Cognitive Science and Participating Faculty Member in Electrical Engineering at the University of Texas at Dallas. Dr. Golden has published articles and given talks at scientific conferences on a wide range of topics in the fields of both statistics and machine learning over the past three decades. His long-term research interests include identifying conditions for the convergence of deterministic and stochastic machine learning algorithms and investigating estimation and inference in the presence of possibly misspecified probability models.

Engineers are expected to design structures and machines that can operate in challenging and volatile environments, while allowing for variation in materials and noise in measurements and signals. Statistics in Engineering, Second Edition: With Examples in MATLAB and R covers the fundamentals of probability and statistics and explains how to use these basic techniques to estimate and model random variation in the context of engineering analysis and design in all types of environments. The first eight chapters cover probability and probability distributions, graphical displays of data and descriptive statistics, combinations of random variables and propagation of error, statistical inference, bivariate distributions and correlation, linear regression on a single predictor variable, and the measurement error model. This leads to chapters including multiple regression; comparisons of several means and split-plot designs together with analysis of variance; probability models; and sampling strategies. Distinctive features include: All examples based on work in industry, consulting to industry, and research for industry Examples and case studies include all engineering disciplines Emphasis on probabilistic modeling including decision trees, Markov chains and processes, and structure functions Intuitive explanations are followed by succinct mathematical justifications Emphasis on random number generation that is used for stochastic simulations of engineering systems, demonstration of key concepts, and implementation of bootstrap methods for inference Use of MATLAB and the open source software R, both of which have an extensive range of statistical functions for standard analyses and also enable programing of specific applications Use of multiple regression for times series models and analysis of factorial and central composite designs Inclusion of topics such as Weibull analysis of failure times and split-plot designs that are commonly used in industry but are not usually included in introductory textbooks Experiments designed to show fundamental concepts that have been tested with large classes working in small groups Website with additional materials that is regularly updated Andrew Metcalfe, David Green, Andrew Smith, and Jonathan Tuke have taught probability and statistics to students of engineering at the University of Adelaide for many years and have substantial industry experience. Their current research includes applications to water resources engineering, mining, and telecommunications. Mahayaudin Mansor worked in banking and insurance before teaching statistics and business mathematics at the Universiti Tun Abdul Razak Malaysia and is currently a researcher specializing in data analytics and quantitative research in the Health Economics and Social Policy Research Group at the Australian Centre for Precision Health, University of South Australia. Tony Greenfield, formerly Head of Process Computing and Statistics at the British Iron and Steel Research Association, is a statistical consultant. He has been awarded the Chambers Medal for outstanding services to the Royal Statistical Society; the George Box Medal by the European Network for Business and Industrial Statistics for Outstanding Contributions to Industrial Statistics; and the William G. Hunter Award by the American Society for

Statistical Methods, Fourth Edition, is designed to introduce students to a wide-range of popular and practical statistical techniques. Requiring a minimum of advanced mathematics, it is suitable for undergraduates in statistics, or graduate students in the physical, life, and social sciences. By providing an overview of statistical reasoning, this text equips readers with the insight needed to summarize data, recognize good experimental designs, implement appropriate analyses, and arrive at sound interpretations of statistical results.

Handbook of Cluster Analysis provides a comprehensive and unified account of the main research developments in cluster analysis. Written by active, distinguished researchers in this area, the book helps readers make informed choices of the most suitable clustering approach for their problem and make better use of existing cluster analysis tools. The book is organized according to the traditional core approaches to cluster analysis, from the origins to recent developments. After an overview of approaches and a quick journey through the history of cluster analysis, the book focuses on the four major approaches to cluster analysis. These approaches include methods for optimizing an objective function that describes how well data is grouped around centroids, dissimilarity-based methods, mixture models and partitioning models, and clustering methods inspired by nonparametric density estimation. The book also describes additional approaches to cluster analysis, including constrained and semi-supervised clustering, and explores other relevant issues, such as evaluating the quality of a cluster. This handbook is accessible to readers from various disciplines, reflecting the interdisciplinary nature of cluster analysis. For those already experienced with cluster analysis, the book offers a broad and structured overview. For newcomers to the field, it presents an introduction to key issues. For researchers who are temporarily or marginally involved with cluster analysis problems, the book gives enough algorithmic and practical details to facilitate working knowledge of specific clustering areas.

Multistate Models for the Analysis of Life History Data provides the first comprehensive treatment of multistate modeling and analysis, including parametric, nonparametric and semiparametric methods applicable to many types of life history data. Special models such as illness-death, competing risks and progressive processes are considered, as well as more complex models. The book provides both theoretical development and illustrations of analysis based on data from randomized trials and observational cohort studies in health research. It features: Discusses a wide range of applications of multistate models, Presents methods for both continuously and intermittently observed life history processes, Gives a thorough discussion of conditionally independent censoring and observation processes, Discusses models with random effects and joint models for two or more multistate processes, Discusses and illustrates software for multistate analysis that is available in R, Target audience includes those engaged in research and applications involving multistate models.

The Most Comprehensive Book on the Subject Chronicles the Development of the Weibull Distribution in Statistical Theory and Applied Statistics Exploring one of the most important distributions in statistics, The Weibull Distribution: A Handbook focuses on its origin, statistical properties, and related distributions. The book also presents various approaches to estimate the parameters of the Weibull distribution under all possible situations of sampling data as well as approaches to parameter and goodness-of-fit testing. Describes the Statistical Methods, Concepts, Theories, and Applications of This DistributionCompiling findings from dozens of scientific journals and hundreds of research papers, the author first gives a careful and thorough mathematical description of the Weibull distribution and all of its features. He then deals with Weibull analysis, using classical and Bayesian approaches along with graphical and linear maximum likelihood techniques to estimate the three Weibull parameters. The author also explores the inference of Weibull processes, Weibull parameter testing, and different types of goodness-of-fit tests and methods. Successfully Apply the Weibull ModelBy using inferential procedures for estimating, testing, forecasting, and simulating data, this self-contained, detailed handbook shows how to solve statistical life science and engineering problems.

Longitudinal studies often incur several problems that challenge standard statistical methods for data analysis. These problems include non-ignorable missing data in longitudinal measurements of one or more response variables, informative observation times of longitudinal data, and survival analysis with intermittently measured time-dependent covariates that are subject to measurement error and/or substantial biological variation. Joint modeling of longitudinal and time-to-event data has emerged as a novel approach to handle these issues. Joint Modeling of Longitudinal and Time-to-Event Data provides a systematic introduction and review of state-of-the-art statistical methodology in this active research field. The methods are illustrated by real data examples from a wide range of clinical research topics. A collection of data sets and software for practical implementation of the joint modeling methodologies are available through the book website. This book serves as a reference book for scientific investigators who need to analyze longitudinal and/or survival data, as well as researchers developing methodology in this field. It may also be used as a textbook for a graduate level course in biostatistics or statistics.